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Gene: Reep5 (receptor accessory protein 5) Rattus norvegicus

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Symbol:

Reep5

Name:

receptor accessory protein 5

RGD ID:

1306047

Description:

Predicted to be involved in endoplasmic reticulum membrane organization. Predicted to be located in endoplasmic reticulum tubular network and junctional sarcoplasmic reticulum membrane. Orthologous to human REEP5 (receptor accessory protein 5); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,2',4,4'-Tetrabromodiphenyl ether.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

deleted in polyposis 1; Dp1; LOC364838; polyposis locus protein 1 homolog; receptor expression-enhancing protein 5

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	REEP5 (receptor accessory protein 5)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Reep5 (receptor accessory protein 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Reep5 (receptor accessory protein 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	REEP5 (receptor accessory protein 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	REEP5 (receptor accessory protein 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Reep5 (receptor accessory protein 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	REEP5 (receptor accessory protein 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	REEP5 (receptor accessory protein 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Reep5 (receptor accessory protein 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Reep5 (receptor accessory protein 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	REEP5 (receptor accessory protein 5)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	REEP5 (receptor accessory protein 5)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Mus musculus (house mouse):	Reep5 (receptor accessory protein 5)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	reep5 (receptor accessory protein 5)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	F56B3.6	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	CG4960	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	ReepB	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	YOP1	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	YOP1	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PANTHER)
Caenorhabditis elegans (roundworm):	T03F6.6	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	yop-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	yop-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	reep5	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	18	26,219,528 - 26,257,505 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	18	26,219,530 - 26,250,660 (-)	Ensembl				GRCr8
mRatBN7.2	18	25,945,375 - 25,983,271 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	18	25,945,381 - 25,976,509 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	18	26,072,793 - 26,103,921 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	18	26,835,714 - 26,866,958 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	18	26,170,617 - 26,201,861 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	18	27,128,462 - 27,159,693 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	18	27,128,464 - 27,159,693 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	18	26,842,001 - 26,873,146 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	18	26,813,889 - 26,845,178 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	18	25,686,468 - 25,716,712 (-)	NCBI		Celera
RGSC_v3.1	18	26,745,661 - 26,871,790 (-)	NCBI
Cytogenetic Map	18	p12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Chemical and Drug Induced Liver Injury (ISO)

cholestasis (ISO)

Experimental Liver Cirrhosis (ISO)

Hereditary Neoplastic Syndromes (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

1-naphthyl isothiocyanate (EXP)

17beta-estradiol (EXP,ISO)

2,2',4,4'-Tetrabromodiphenyl ether (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

2-bromohexadecanoic acid (ISO)

3,4-methylenedioxymethamphetamine (EXP)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-diaminodiphenylmethane (EXP)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

acetamide (EXP)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

Aroclor 1254 (ISO)

atazanavir sulfate (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol AF (ISO)

Bisphenol B (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

CGP 52608 (ISO)

chenodeoxycholic acid (ISO)

chlorpyrifos (EXP,ISO)

choline (ISO)

cisplatin (ISO)

clobetasol (ISO)

coumestrol (ISO)

cyclosporin A (ISO)

delta8-THC (ISO)

deoxycholic acid (ISO)

dexamethasone (ISO)

diazinon (ISO)

dicrotophos (ISO)

diethylstilbestrol (ISO)

diquat (ISO)

dorsomorphin (ISO)

Enterolactone (ISO)

finasteride (EXP)

flutamide (EXP)

folic acid (ISO)

furfural (ISO)

genistein (ISO)

glafenine (EXP)

glycochenodeoxycholic acid (ISO)

glycocholic acid (ISO)

glycodeoxycholic acid (ISO)

hydrogen peroxide (ISO)

indole-3-methanol (EXP)

indometacin (ISO)

inulin (ISO)

ivermectin (ISO)

ketamine (EXP)

L-methionine (ISO)

lead(0) (ISO)

methyl methanesulfonate (ISO)

methylparaben (ISO)

N-nitrosodiethylamine (EXP)

nefazodone (EXP,ISO)

nitrates (ISO)

ozone (ISO)

p-toluidine (EXP)

paracetamol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

phenethyl isothiocyanate (EXP)

phenobarbital (EXP)

phenylmercury acetate (ISO)

pirinixic acid (ISO)

piroxicam (ISO)

SB 431542 (ISO)

sodium chloride (ISO)

tert-butyl hydroperoxide (ISO)

tetrachloromethane (EXP,ISO)

tetrahydropalmatine (ISO)

thioacetamide (EXP)

thiram (ISO)

titanium dioxide (ISO)

trichostatin A (ISO)

triphenyl phosphate (EXP,ISO)

troglitazone (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

endoplasmic reticulum membrane organization (ISO,ISS)

Cellular Component

endoplasmic reticulum (IEA,ISO)

endoplasmic reticulum membrane (IEA)

endoplasmic reticulum tubular network (IEA,ISO,ISS)

junctional sarcoplasmic reticulum membrane (ISO)

membrane (IEA)

sarcoplasmic reticulum membrane (IEA,ISO)

Molecular Function

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:8889548	PMID:12477932	PMID:23376485	PMID:23969831	PMID:24668814	PMID:29431104

Genomics

Comparative Map Data

Reep5
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	18	26,219,528 - 26,257,505 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	18	26,219,530 - 26,250,660 (-)	Ensembl				GRCr8
mRatBN7.2	18	25,945,375 - 25,983,271 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	18	25,945,381 - 25,976,509 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	18	26,072,793 - 26,103,921 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	18	26,835,714 - 26,866,958 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	18	26,170,617 - 26,201,861 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	18	27,128,462 - 27,159,693 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	18	27,128,464 - 27,159,693 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	18	26,842,001 - 26,873,146 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	18	26,813,889 - 26,845,178 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	18	25,686,468 - 25,716,712 (-)	NCBI		Celera
RGSC_v3.1	18	26,745,661 - 26,871,790 (-)	NCBI
Cytogenetic Map	18	p12	NCBI

REEP5
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	112,876,385 - 112,922,227 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	112,876,385 - 112,922,328 (-)	Ensembl			hg38	GRCh38
GRCh37	5	112,212,082 - 112,257,924 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	112,239,980 - 112,285,930 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	5	112,239,979 - 112,285,811	NCBI
Celera	5	108,157,648 - 108,203,589 (-)	NCBI		Celera
Cytogenetic Map	5	q22.2	NCBI
HuRef	5	107,391,179 - 107,437,747 (-)	NCBI		HuRef
CHM1_1	5	111,645,384 - 111,691,318 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	5	113,386,924 - 113,432,758 (-)	NCBI		T2T-CHM13v2.0

Reep5
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	18	34,477,938 - 34,508,044 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	18	34,477,938 - 34,507,123 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	18	34,344,885 - 34,374,991 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	18	34,344,885 - 34,374,070 (-)	Ensembl			mm10	GRCm38
MGSCv37	18	34,504,539 - 34,533,069 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	18	34,469,686 - 34,498,130 (-)	NCBI		MGSCv36	mm8
Celera	18	34,796,396 - 34,824,927 (-)	NCBI		Celera
Cytogenetic Map	18	B1	NCBI
cM Map	18	18.57	NCBI

Reep5
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955418	2,502,674 - 2,536,817 (+)	Ensembl
ChiLan1.0	NW_004955418	2,504,028 - 2,539,574 (+)	NCBI	ChiLan1.0	ChiLan1.0

REEP5
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	108,132,741 - 108,176,801 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	106,286,399 - 106,330,458 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	108,236,654 - 108,280,724 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	114,039,800 - 114,083,009 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2

REEP5
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	3	6,733 - 25,840 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	3	8,236 - 25,824 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	3	1,602,460 - 1,633,739 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	3	43,921 - 75,278 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	3	42,909 - 75,273 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	3	37,196 - 68,444 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	3	36,214 - 67,530 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	3	199,600 - 230,984 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Reep5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	154,507,727 - 154,555,416 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936531	7,053,039 - 7,104,288 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936531	7,055,841 - 7,103,810 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

REEP5
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	116,845,571 - 116,886,358 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	2	116,845,681 - 116,886,361 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	121,468,329 - 121,507,942 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

REEP5
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	23	16,165,233 - 16,210,082 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	23	16,167,557 - 16,210,050 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666034	62,245,545 - 62,290,681 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Reep5
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624743	30,690,350 - 30,729,785 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624743	30,690,339 - 30,729,229 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Reep5
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	15	9,985,295 - 10,015,017 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Reep5
134 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	562
Count of miRNA genes:	277
Interacting mature miRNAs:	344
Transcripts:	ENSRNOT00000027345
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2301410	Bp317	Blood pressure QTL 317		0.004	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	12219237	26822399	Rat
1331733	Bp233	Blood pressure QTL 233	3.97196		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	25071126	83910656	Rat
2301409	Cm70	Cardiac mass QTL 70		0.001	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	18	7065728	52065728	Rat
1358358	Sradr6	Stress Responsive Adrenal Weight QTL 6	2.49		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	18	22015562	61600538	Rat
1331735	Rf44	Renal function QTL 44	2.981		urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	18	15642280	31610627	Rat
61382	Bp46	Blood pressure QTL 46	18.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	12216684	31644508	Rat
12904716	Am21	Aortic mass QTL 21		0.005	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	18	7065728	52065728	Rat
1331741	Bp232	Blood pressure QTL 232	3.59112		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	18	23494057	85487725	Rat
12904714	Cm131	Cardiac mass QTL 131		0.002	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	18	7065728	52065728	Rat
12904715	Cm132	Cardiac mass QTL 132		0.001	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	18	7065728	52065728	Rat
6903345	Bp349	Blood pressure QTL 349	3.9		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	3917226	48917226	Rat
2313082	Bss85	Bone structure and strength QTL 85	0.8	0.0001	long bone metaphysis morphology trait (VT:0000133)	tibia midshaft total cross-sectional area (CMO:0001715)	18	15226101	42690662	Rat
6903347	Bp350	Blood pressure QTL 350	4.4		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	1	31610627	Rat
2312568	Glom21	Glomerulus QTL 21	2	0.005	kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	18	5460455	42690191	Rat
6903349	Bp351	Blood pressure QTL 351	3.5		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	3917226	48917226	Rat
6903351	Bp352	Blood pressure QTL 352	3.3		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	3917226	48917226	Rat
1331766	Bp236	Blood pressure QTL 236	3.022		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	1	31610627	Rat
631264	Scl22	Serum cholesterol level QTL 22	6.2		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	18	12216684	31644508	Rat
1331775	Bp235	Blood pressure QTL 235	3.201		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	15642280	31610627	Rat
2325839	Bp348	Blood pressure QTL 348		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	1	44930869	Rat
12904680	Bw189	Body weight QTL 189		0.019	body mass (VT:0001259)	body weight (CMO:0000012)	18	12219237	26822399	Rat
1600373	Mamtr6	Mammary tumor resistance QTL 6			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	18	19553532	85493247	Rat
2293708	Bss46	Bone structure and strength QTL 46	8.8	0.0001	lumbar vertebra morphology trait (VT:0010494)	lumbar vertebra cortical cross-sectional area (CMO:0001690)	18	12066482	57066482	Rat
12904693	Am20	Aortic mass QTL 20		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	18	12219237	26822399	Rat
1578667	Bss21	Bone structure and strength QTL 21	3.5		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	18	12066482	85493247	Rat
12904695	Kidm73	Kidney mass QTL 73		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	18	12219237	26822399	Rat
2312598	Bp340	Blood pressure QTL 340		0.05	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	3811902	30809809	Rat
12904689	Cm128	Cardiac mass QTL 128		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	18	12219237	26822399	Rat
12904690	Cm129	Cardiac mass QTL 129		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	18	12219237	26822399	Rat
2300180	Bmd67	Bone mineral density QTL 67	4.8	0.0001	femur mineral mass (VT:0010011)	bone mineral density (CMO:0001226)	18	1	34566578	Rat
12904691	Cm130	Cardiac mass QTL 130		0.001	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	18	12219237	26822399	Rat
2299160	Iddm35	Insulin dependent diabetes mellitus QTL 35	2.79		blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	18	4482648	49482648	Rat
1331753	Bp231	Blood pressure QTL 231	3.643		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	1	54490981	Rat
1578661	Bss20	Bone structure and strength QTL 20	3.7		femur morphology trait (VT:0000559)	femoral neck cross-sectional area (CMO:0001697)	18	12066482	85493247	Rat
11565454	Kidm59	Kidney mass QTL 59		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	18	7065728	52065728	Rat
1331754	Bp230	Blood pressure QTL 230	4.61609		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	15642280	86134022	Rat
2293661	Bss50	Bone structure and strength QTL 50	4.64	0.0003	lumbar vertebra size trait (VT:0010518)	lumbar vertebra trabecular cross-sectional area (CMO:0001692)	18	1	34566578	Rat
61375	Bp41	Blood pressure QTL 41	2.4		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	18	4307354	49307354	Rat

Markers in Region

BI279301

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	18	25,945,530 - 25,945,705 (+)	MAPPER	mRatBN7.2
Rnor_6.0	18	27,128,616 - 27,128,790	NCBI	Rnor6.0
Rnor_5.0	18	26,842,155 - 26,842,329	UniSTS	Rnor5.0
RGSC_v3.4	18	26,814,043 - 26,814,217	UniSTS	RGSC3.4
Celera	18	25,686,622 - 25,686,796	UniSTS
RH 3.4 Map	18	362.4	UniSTS
Cytogenetic Map	18	p12	UniSTS

AI228530

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	103,835,819 - 103,836,072 (+)	MAPPER	mRatBN7.2
mRatBN7.2	18	25,951,336 - 25,951,586 (+)	MAPPER	mRatBN7.2
Rnor_6.0	18	27,134,422 - 27,134,671	NCBI	Rnor6.0
Rnor_6.0	10	107,631,211 - 107,631,463	NCBI	Rnor6.0
Rnor_5.0	18	26,847,961 - 26,848,210	UniSTS	Rnor5.0
Rnor_5.0	10	107,265,698 - 107,265,950	UniSTS	Rnor5.0
RGSC_v3.4	10	108,608,479 - 108,608,731	UniSTS	RGSC3.4
RGSC_v3.4	18	26,819,849 - 26,820,098	UniSTS	RGSC3.4
Celera	18	25,692,430 - 25,692,679	UniSTS
Celera	10	102,395,754 - 102,396,006	UniSTS
RH 3.4 Map	18	346.4	UniSTS
Cytogenetic Map	10	q32.3	UniSTS
Cytogenetic Map	18	p12	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	356	192	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001108888	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039097000	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AA819308	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC167013	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BE126660	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BP503102	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473974	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FM032375	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ212593	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ213789	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ235123	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000018	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000027345 ⟹ ENSRNOP00000027345

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	18	26,219,530 - 26,250,660 (-)	Ensembl
mRatBN7.2 Ensembl	18	25,945,381 - 25,976,446 (-)	Ensembl
Rnor_6.0 Ensembl	18	27,128,464 - 27,159,693 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000108864 ⟹ ENSRNOP00000094460

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	18	26,223,467 - 26,250,660 (-)	Ensembl
mRatBN7.2 Ensembl	18	25,949,316 - 25,976,509 (-)	Ensembl

RefSeq Acc Id:

NM_001108888 ⟹ NP_001102358

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	26,219,528 - 26,250,660 (-)	NCBI
mRatBN7.2	18	25,945,377 - 25,976,509 (-)	NCBI
Rnor_6.0	18	27,128,462 - 27,159,693 (-)	NCBI
Rnor_5.0	18	26,842,001 - 26,873,146 (-)	NCBI
RGSC_v3.4	18	26,813,889 - 26,845,178 (-)	RGD
Celera	18	25,686,468 - 25,716,712 (-)	RGD

Sequence:

show sequence

CGCCGCGGCGCCGCCCGCCCCCGCCCCGCCCCGGTCAGCTGGGTTCCGCGTCCAGCCAGCTGAG
GAGCATCCCGGGCGGCGCGAACGGCCCAGCCATGTCCGCAGCCATGAGGGAGAGGTTCGACCGG
TTCCTGCACGAGAAGAACTGCATGACTGATCTCCTGGCCAAGCTCGAGGCCAAGACTGGAGTGA
ACCGGAGCTTCATCGCGCTCGGTGTCATCGGACTGGTGGCTTTGTATCTGGTGTTCGGTTATGG
AGCCTCTCTCCTCTGCAACCTGATAGGTTTCGGATACCCAGCCTACATCTCAATGAAAGCCATC
GAGAGCCCCAACAAAGATGATGACACCCAGTGGCTGACGTACTGGGTGGTGTATGGTGTGTTCA
GCATCGCCGAGTTCTTCTCCGACCTTTTCCTGTCCTGGTTCCCCTTCTACTACATGCTGAAGTG
CGGCTTCCTGTTGTGGTGCATGGCTCCCAGCCCGTCCAACGGGGCTGAACTGCTGTACCGGCGT
GTCATCCGTCCCATCTTCCTGAAGCACGAGTCCCAGGTAGACAGTGTGGTGAAGGACGTGAAGG
ACAAAGCCAAAGAGACTGCAGACGCCATCAGCAAAGAAGTCAAGAAGGCTACGGTGAACTTGCT
GGGCGACGAGAAGAAGAGCACCTGAGTCCTGGCTGGGCGGCCCCTCCCCCACTCACCCCCTTAG
AGCTCCGTGTTATGCTAGGGACAGTGGCACAGGTGTTGGATAATGTTGCCTTGGAAACTTTCTG
ATGTATTAAAAATGGAATGTGTTGTAAGGTGTTTCGCTTTTATTGTCATATATGTAGGGAACGT
TTTCATTTAAATCTAACAGAGTGGGCAGTACCTAAAATTTTTAAATATGAGTCTGAAGACACGT
CACTATATTCCAGGAAATTCAAACCGAGATTGGAAATCTCTGTCCGTAGGCCCTGTGCTCTGCG
GGGCTCACCTGCATGCGTCTTCCTGTGCTTACAGTTTGGAAACCTTTGTGTTGTGCTTCACTCG
GTGTATGATTTTATATAGTTCTGTGTTTTAATGTATCTGTGTATATACATATATATGGAAAATG
TTATAGTTTGGCTAGAACATGCGTAGTGCTTGTGAGAAGAGGCCAAGGAAGGTTGCAGACACCA
CCTGTGACCTGTGAAGCAAGATCCCCCCCCCCCCAAGGCTGGAATGCTGTCGTGATGAGTGCAC
TTCCAAATACCATTTCAGAAAGTGATACAGATGGGATTGGGGATTTAGCTCAGTGGTAGAGCGC
TTGCCTAGGAAGCGCAAGGCCCTGGGTTCGGTCCCCAGCTCTGAAAAAAAGAGCCAAAAAAAAA
AAAAAGTGATACAGATGAGTAAGACATCCCATCCCCCAAGACAGCCCATCCCCCAAGACAGCCC
ATCCCCCAAGACTTCCCACCCCCCCAAGACAGCCCATCCCCCAAGACAGCCCACCTCCCAAGAC
TTCCCGCCTCCCATTGCATACCTCAGTTTTTAAAAACATGATCCCATGTAGCCCAGGAGAACTC
TGAAGTCCTGATCCTCCTGCTGCCTCCACCTCCCAGCTTCTGCTCACTGCAGGCTGGTGCCCCA
TGGTGGCTTACGTGTGCCGTCTTGTTCGTGTAACAGCACATTGTATACTGATAGCATCCAGCTC
TAAGAGCAGTTCTGGACAAGTGAGGGGCAGCGGCGGCTGGGATGAACTTTTCACTCTTTGTTTT
TATGGCCAACCTCAAGAGGTCTCCCTACTTTATAATTTGTAATTATTAGCATTCCCTTACAGAT
GCTTCAGTCTATGTTTCGTTTAAGTGACCGCCTGTCAAAGTGGCTTGCTGGGTCAGAGGTTTGG
ATCTAAGAGTCTGTGCTTTGCACCTCAGGCCAGCTTTTCAGCCTTTGAGTTGGTCTGAAGGAGC
TGTCTGCCAAAGCCAACAGCAGGAGTTACCTTCAGGACAATGGGCAATGATTCTCCTACAGATG
ACTCAGATCACAATAATATACAATACTAACAATACAAAATAAGAGGGTCACAGGGTTCGTTTTC
CTGGGAATACTAGTAATCATTAGGCATCTTCTGACTTAAGGTGGGGGGATCTTTTTAGAAAATA
AAAACAGTTGTTTATAGAAAACCAATTGTTAGGTCTTAAAAATATTTAGGTCCTTATAAGTAAA
AGCACGTTTTTCTTGTTGGCAGAGTGAAAATTAACATCGACGATGTAATCTATAAGAACAGTGT
TAATATACAACATACTCTATGTGAGGGGATGGGCAGGCAGGGACTCACAGTTACTTAGAGGTTC
TTGGTGGAAACACTGCTGCAGTGAAGTAAACCCCAAAAGCAATTTTGCCCTATCAACCCCACAG
CTTTCACCAGAGCAGGCGCCGGGAAGTCATTACTTCTAGCAGCTGTTAGTAGGAGAAATCATTG
ACTTCTGCCTGCCCGTCCTTCCCAAATAAAACAGTGTCATGACTACGAGTGTTGACAGTGAGCT
GGCTGGAAACAAAGTGTTTATTTGTATCTGAGTGGTATTTCAAAGACATATAAAGTTCCAGAAT
TCTTGCTACACTTTAAAGCTTGCTGTTGTAGGGCAATTCTTTCCTGTCAGTCATTTGGACTGCA
TTGCTGCTGTTGTGGGGAAGAATCCTCCATCCACACCTCAGAAAACAGTCACGGCCTAAATAAA
ATATCGCCTGGCCTCAGATGTGAATAGGAGTGCCCGGGCCTTCCTTACGTGTTCCCAGACTCCC
CTGGCTGCCATACCTGGAGAGAACACTGAACTCTGTGTGGACTGTTCCTTCCTGTGCGTGTATC
TCTGACAAAAGTTACTGACTGGACAAAGTGAGAATGAGAATTACAACATATACTCAAATAAAGA
TTATGTTTATGTGGTCTGTCAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039097000 ⟹ XP_038952928

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	26,221,635 - 26,257,505 (-)	NCBI
mRatBN7.2	18	25,945,375 - 25,983,271 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001102358	(Get FASTA)	NCBI Sequence Viewer
	XP_038952928	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI67013	(Get FASTA)	NCBI Sequence Viewer
	B2RZ37	(Get FASTA)	NCBI Sequence Viewer
	EDL76223	(Get FASTA)	NCBI Sequence Viewer
	EDL76224	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000027345

RefSeq Acc Id:	NP_001102358 ⟸ NM_001108888
- UniProtKB:	B2RZ37 (UniProtKB/Swiss-Prot), A0A8I6AL10 (UniProtKB/TrEMBL)
- Sequence:	show sequence MSAAMRERFDRFLHEKNCMTDLLAKLEAKTGVNRSFIALGVIGLVALYLVFGYGASLLCNLIGF GYPAYISMKAIESPNKDDDTQWLTYWVVYGVFSIAEFFSDLFLSWFPFYYMLKCGFLLWCMAPS PSNGAELLYRRVIRPIFLKHESQVDSVVKDVKDKAKETADAISKEVKKATVNLLGDEKKST hide sequence

Ensembl Acc Id:

ENSRNOP00000027345 ⟸ ENSRNOT00000027345

RefSeq Acc Id:	XP_038952928 ⟸ XM_039097000
- Peptide Label:	isoform X1

Ensembl Acc Id:

ENSRNOP00000094460 ⟸ ENSRNOT00000108864

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-B2RZ37-F1-model_v2	AlphaFold	B2RZ37	1-189	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13700691

Promoter ID:

EPDNEW_R11215

Type:

initiation region

Name:

Reep5_1

Description:

receptor accessory protein 5

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	18	27,159,625 - 27,159,685	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1306047	AgrOrtholog
BioCyc Gene	G2FUF-7960	BioCyc
Ensembl Genes	ENSRNOG00000020167	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000027345	ENTREZGENE
IMAGE_CLONE	IMAGE:9032688	IMAGE-MGC_LOAD
InterPro	TB2_DP1_HVA22	UniProtKB/Swiss-Prot
KEGG Report	rno:364838	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:189206	IMAGE-MGC_LOAD
NCBI Gene	364838	ENTREZGENE
PANTHER	PTHR12300	UniProtKB/Swiss-Prot
	RECEPTOR EXPRESSION-ENHANCING PROTEIN 5	UniProtKB/Swiss-Prot
Pfam	TB2_DP1_HVA22	UniProtKB/Swiss-Prot
PhenoGen	Reep5	PhenoGen
RatGTEx	ENSRNOG00000020167	RatGTEx
UniProt	A0A8I6AL10	ENTREZGENE, UniProtKB/TrEMBL
	A0A8L2QEM8_RAT	UniProtKB/TrEMBL
	B2RZ37	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-04-30	Reep5	receptor accessory protein 5	Reep5_predicted	receptor accessory protein 5 (predicted)	'predicted' is removed	2292626	APPROVED
2006-03-30	Reep5_predicted	receptor accessory protein 5 (predicted)	Dp1_predicted	deleted in polyposis 1 (predicted)	Symbol and Name updated	1299863	APPROVED
2005-01-12	Dp1_predicted	deleted in polyposis 1 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD