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Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Epb41l4a | Rat | 17alpha-ethynylestradiol | affects expression | ISO | Epb41l4a (Mus musculus) | 6480464 | Ethinyl Estradiol affects the expression of EPB41L4A mRNA | CTD | PMID:17555576 | Epb41l4a | Rat | 17beta-estradiol | multiple interactions | ISO | EPB41L4A (Homo sapiens) | 6480464 | [Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of EPB41L4A mRNA and [Progesterone co-treated with Estradiol] results in decreased expression of EPB41L4A mRNA | CTD | PMID:17404688 and PMID:20823114 | Epb41l4a | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Epb41l4a (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of EPB41L4A mRNA | CTD | PMID:21570461 | Epb41l4a | Rat | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Epb41l4a (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin affects the methylation of EPB41L4A intron] which results in decreased expression of EPB41L4A mRNA | CTD | PMID:33017471 | Epb41l4a | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Epb41l4a (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of EPB41L4A mRNA | CTD | PMID:19933214 | Epb41l4a | Rat | 3,4-methylenedioxymethamphetamine | affects expression | EXP | | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine affects the expression of EPB41L4A mRNA | CTD | PMID:30071829 | Epb41l4a | Rat | 4,4'-diaminodiphenylmethane | decreases expression | ISO | Epb41l4a (Mus musculus) | 6480464 | 4 and 4'-diaminodiphenylmethane results in decreased expression of EPB41L4A mRNA | CTD | PMID:18648102 | Epb41l4a | Rat | 4-hydroxyphenyl retinamide | increases expression | ISO | Epb41l4a (Mus musculus) | 6480464 | Fenretinide results in increased expression of EPB41L4A mRNA | CTD | PMID:28973697 | Epb41l4a | Rat | 6-propyl-2-thiouracil | decreases expression | EXP | | 6480464 | Propylthiouracil results in decreased expression of EPB41L4A mRNA | CTD | PMID:30047161 | Epb41l4a | Rat | afimoxifene | multiple interactions | ISO | EPB41L4A (Homo sapiens) | 6480464 | afimoxifene inhibits the reaction [Estrogens results in decreased expression of EPB41L4A mRNA] | CTD | PMID:21233418 | Epb41l4a | Rat | aflatoxin B1 | increases expression | EXP | | 6480464 | Aflatoxin B1 results in increased expression of EPB41L4A mRNA | CTD | PMID:23630614 | Epb41l4a | Rat | aflatoxin B1 | increases methylation | ISO | EPB41L4A (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased methylation of EPB41L4A intron | CTD | PMID:30157460 | Epb41l4a | Rat | aflatoxin B1 | decreases methylation | ISO | EPB41L4A (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased methylation of EPB41L4A gene | CTD | PMID:27153756 | Epb41l4a | Rat | all-trans-retinoic acid | increases expression | ISO | EPB41L4A (Homo sapiens) | 6480464 | Tretinoin results in increased expression of EPB41L4A mRNA | CTD | PMID:21934132 | Epb41l4a | Rat | all-trans-retinoic acid | increases expression | EXP | | 6480464 | Tretinoin results in increased expression of EPB41L4A mRNA | CTD | PMID:20488242 | Epb41l4a | Rat | amitrole | decreases expression | EXP | | 6480464 | Amitrole results in decreased expression of EPB41L4A mRNA | CTD | PMID:30047161 | Epb41l4a | Rat | benzo[a]pyrene | increases expression | ISO | EPB41L4A (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased expression of EPB41L4A mRNA | CTD | PMID:22316170 | Epb41l4a | Rat | benzo[a]pyrene | decreases methylation | ISO | EPB41L4A (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased methylation of EPB41L4A promoter | CTD | PMID:27901495 | Epb41l4a | Rat | benzo[a]pyrene | affects methylation | ISO | EPB41L4A (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of EPB41L4A intron | CTD | PMID:30157460 | Epb41l4a | Rat | benzo[a]pyrene | decreases methylation | ISO | Epb41l4a (Mus musculus) | 6480464 | Benzo(a)pyrene results in decreased methylation of EPB41L4A intron | CTD | PMID:27901495 | Epb41l4a | Rat | benzo[a]pyrene diol epoxide I | increases expression | ISO | EPB41L4A (Homo sapiens) | 6480464 | 7 more ... | CTD | PMID:20382639 | Epb41l4a | Rat | bisphenol A | affects expression | ISO | EPB41L4A (Homo sapiens) | 6480464 | bisphenol A affects the expression of EPB41L4A mRNA | CTD | PMID:22574217 | Epb41l4a | Rat | bisphenol A | increases expression | ISO | Epb41l4a (Mus musculus) | 6480464 | bisphenol A results in increased expression of EPB41L4A mRNA | CTD | PMID:32156529 | Epb41l4a | Rat | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of EPB41L4A mRNA | CTD | PMID:32145629 | Epb41l4a | Rat | bisphenol A | affects methylation | ISO | Epb41l4a (Mus musculus) | 6480464 | bisphenol A affects the methylation of EPB41L4A promoter | CTD | PMID:27334623 | Epb41l4a | Rat | bisphenol A | decreases expression | ISO | EPB41L4A (Homo sapiens) | 6480464 | bisphenol A results in decreased expression of EPB41L4A mRNA | CTD | PMID:27685785 | Epb41l4a | Rat | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of EPB41L4A mRNA | CTD | PMID:25181051 | Epb41l4a | Rat | bisphenol A | decreases expression | ISO | Epb41l4a (Mus musculus) | 6480464 | bisphenol A results in decreased expression of EPB41L4A mRNA | CTD | PMID:26063408 | Epb41l4a | Rat | bucladesine | multiple interactions | ISO | EPB41L4A (Homo sapiens) | 6480464 | [Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of EPB41L4A mRNA | CTD | PMID:20823114 | Epb41l4a | Rat | butanal | decreases expression | ISO | EPB41L4A (Homo sapiens) | 6480464 | butyraldehyde results in decreased expression of EPB41L4A mRNA | CTD | PMID:26079696 | Epb41l4a | Rat | CGP 52608 | multiple interactions | ISO | EPB41L4A (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to EPB41L4A gene] | CTD | PMID:28238834 | Epb41l4a | Rat | chlorpyrifos | increases expression | ISO | Epb41l4a (Mus musculus) | 6480464 | Chlorpyrifos results in increased expression of EPB41L4A mRNA | CTD | PMID:37019170 | Epb41l4a | Rat | choline | multiple interactions | ISO | Epb41l4a (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of EPB41L4A more ... | CTD | PMID:20938992 | Epb41l4a | Rat | cobalt dichloride | decreases expression | EXP | | 6480464 | cobaltous chloride results in decreased expression of EPB41L4A mRNA | CTD | PMID:24386269 | Epb41l4a | Rat | copper(II) chloride | decreases expression | ISO | EPB41L4A (Homo sapiens) | 6480464 | cupric chloride results in decreased expression of EPB41L4A mRNA | CTD | PMID:38568856 | Epb41l4a | Rat | crocidolite asbestos | decreases expression | ISO | EPB41L4A (Homo sapiens) | 6480464 | Asbestos and Crocidolite results in decreased expression of EPB41L4A mRNA | CTD | PMID:25351596 | Epb41l4a | Rat | crocidolite asbestos | decreases expression | ISO | Epb41l4a (Mus musculus) | 6480464 | Asbestos and Crocidolite results in decreased expression of EPB41L4A mRNA | CTD | PMID:29279043 | Epb41l4a | Rat | Cuprizon | increases expression | EXP | | 6480464 | Cuprizone results in increased expression of EPB41L4A mRNA | CTD | PMID:26577399 | Epb41l4a | Rat | DDE | decreases expression | ISO | EPB41L4A (Homo sapiens) | 6480464 | Dichlorodiphenyl Dichloroethylene results in decreased expression of EPB41L4A mRNA | CTD | PMID:38568856 | Epb41l4a | Rat | endosulfan | decreases expression | EXP | | 6480464 | Endosulfan results in decreased expression of EPB41L4A mRNA | CTD | PMID:29391264 | Epb41l4a | Rat | folic acid | multiple interactions | ISO | Epb41l4a (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of EPB41L4A more ... | CTD | PMID:20938992 | Epb41l4a | Rat | folic acid | decreases expression | ISO | Epb41l4a (Mus musculus) | 6480464 | Folic Acid results in decreased expression of EPB41L4A mRNA | CTD | PMID:25629700 | Epb41l4a | Rat | furan | increases expression | EXP | | 6480464 | furan results in increased expression of EPB41L4A mRNA | CTD | PMID:25539665 more ... | Epb41l4a | Rat | gentamycin | decreases expression | EXP | | 6480464 | Gentamicins results in decreased expression of EPB41L4A mRNA | CTD | PMID:33387578 | Epb41l4a | Rat | iron dichloride | decreases expression | ISO | EPB41L4A (Homo sapiens) | 6480464 | ferrous chloride results in decreased expression of EPB41L4A mRNA | CTD | PMID:35984750 | Epb41l4a | Rat | L-methionine | multiple interactions | ISO | Epb41l4a (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of EPB41L4A more ... | CTD | PMID:20938992 | Epb41l4a | Rat | medroxyprogesterone acetate | multiple interactions | ISO | EPB41L4A (Homo sapiens) | 6480464 | [Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of EPB41L4A mRNA | CTD | PMID:20823114 | Epb41l4a | Rat | methimazole | decreases expression | EXP | | 6480464 | Methimazole results in decreased expression of EPB41L4A mRNA | CTD | PMID:30047161 | Epb41l4a | Rat | methylmercury chloride | decreases expression | ISO | EPB41L4A (Homo sapiens) | 6480464 | methylmercuric chloride results in decreased expression of EPB41L4A mRNA | CTD | PMID:28001369 | Epb41l4a | Rat | N,N-diethyl-m-toluamide | multiple interactions | EXP | | 6480464 | [Permethrin co-treated with DEET] results in increased methylation of EPB41L4A gene | CTD | PMID:33148267 | Epb41l4a | Rat | paracetamol | decreases expression | EXP | | 6480464 | Acetaminophen results in decreased expression of EPB41L4A mRNA | CTD | PMID:33387578 | Epb41l4a | Rat | perfluorohexanesulfonic acid | decreases expression | ISO | Epb41l4a (Mus musculus) | 6480464 | perfluorohexanesulfonic acid results in decreased expression of EPB41L4A mRNA | CTD | PMID:37995155 | Epb41l4a | Rat | perfluorooctanoic acid | increases expression | ISO | Epb41l4a (Mus musculus) | 6480464 | perfluorooctanoic acid results in increased expression of EPB41L4A mRNA | CTD | PMID:30711707 | Epb41l4a | Rat | permethrin | multiple interactions | EXP | | 6480464 | [Permethrin co-treated with DEET] results in increased methylation of EPB41L4A gene | CTD | PMID:33148267 | Epb41l4a | Rat | pirinixic acid | multiple interactions | ISO | Epb41l4a (Mus musculus) | 6480464 | [pirinixic acid co-treated with PPARA] results in increased expression of EPB41L4A mRNA | CTD | PMID:20813756 | Epb41l4a | Rat | pirinixic acid | increases expression | ISO | Epb41l4a (Mus musculus) | 6480464 | pirinixic acid results in increased expression of EPB41L4A mRNA | CTD | PMID:20813756 | Epb41l4a | Rat | potassium dichromate | decreases expression | ISO | Epb41l4a (Mus musculus) | 6480464 | Potassium Dichromate results in decreased expression of EPB41L4A mRNA | CTD | PMID:23608068 | Epb41l4a | Rat | progesterone | multiple interactions | ISO | EPB41L4A (Homo sapiens) | 6480464 | [Progesterone co-treated with Estradiol] results in decreased expression of EPB41L4A mRNA | CTD | PMID:17404688 | Epb41l4a | Rat | silicon dioxide | decreases expression | ISO | EPB41L4A (Homo sapiens) | 6480464 | Silicon Dioxide analog results in decreased expression of EPB41L4A mRNA and Silicon Dioxide results in decreased expression of EPB41L4A mRNA | CTD | PMID:25351596 and PMID:25895662 | Epb41l4a | Rat | sulfadimethoxine | decreases expression | EXP | | 6480464 | Sulfadimethoxine results in decreased expression of EPB41L4A mRNA | CTD | PMID:30047161 | Epb41l4a | Rat | sulforaphane | decreases expression | ISO | EPB41L4A (Homo sapiens) | 6480464 | sulforaphane results in decreased expression of EPB41L4A mRNA | CTD | PMID:31838189 | Epb41l4a | Rat | sunitinib | increases expression | ISO | EPB41L4A (Homo sapiens) | 6480464 | Sunitinib results in increased expression of EPB41L4A mRNA | CTD | PMID:31533062 | Epb41l4a | Rat | tamoxifen | affects expression | ISO | Epb41l4a (Mus musculus) | 6480464 | Tamoxifen affects the expression of EPB41L4A mRNA | CTD | PMID:17555576 | Epb41l4a | Rat | thimerosal | decreases expression | ISO | EPB41L4A (Homo sapiens) | 6480464 | Thimerosal results in decreased expression of EPB41L4A mRNA | CTD | PMID:27188386 | Epb41l4a | Rat | thioacetamide | increases expression | EXP | | 6480464 | Thioacetamide results in increased expression of EPB41L4A mRNA | CTD | PMID:23411599 | Epb41l4a | Rat | trichloroethene | increases methylation | EXP | | 6480464 | Trichloroethylene results in increased methylation of EPB41L4A gene | CTD | PMID:27618143 | Epb41l4a | Rat | trichostatin A | increases expression | ISO | EPB41L4A (Homo sapiens) | 6480464 | trichostatin A results in increased expression of EPB41L4A mRNA | CTD | PMID:24935251 | Epb41l4a | Rat | triphenyl phosphate | affects expression | ISO | EPB41L4A (Homo sapiens) | 6480464 | triphenyl phosphate affects the expression of EPB41L4A mRNA | CTD | PMID:37042841 | Epb41l4a | Rat | urethane | decreases expression | ISO | EPB41L4A (Homo sapiens) | 6480464 | Urethane results in decreased expression of EPB41L4A mRNA | CTD | PMID:28818685 | Epb41l4a | Rat | valproic acid | decreases methylation | ISO | EPB41L4A (Homo sapiens) | 6480464 | Valproic Acid results in decreased methylation of EPB41L4A gene | CTD | PMID:29154799 | Epb41l4a | Rat | valproic acid | increases expression | ISO | EPB41L4A (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of EPB41L4A mRNA | CTD | PMID:23179753 more ... | Epb41l4a | Rat | valproic acid | affects expression | ISO | EPB41L4A (Homo sapiens) | 6480464 | Valproic Acid affects the expression of EPB41L4A mRNA | CTD | PMID:25979313 | Epb41l4a | Rat | vinclozolin | affects expression | EXP | | 6480464 | vinclozolin affects the expression of EPB41L4A mRNA | CTD | PMID:19015723 | |