Klf7 (KLF transcription factor 7) - Rat Genome Database

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Gene: Klf7 (KLF transcription factor 7) Rattus norvegicus
Analyze
Symbol: Klf7
Name: KLF transcription factor 7
RGD ID: 1306029
Description: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including negative regulation of adipose tissue development; negative regulation of insulin secretion involved in cellular response to glucose stimulus; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within axon guidance; dendrite morphogenesis; and positive regulation of DNA-templated transcription. Predicted to be located in nucleus. Orthologous to human KLF7 (KLF transcription factor 7); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; acetamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Krueppel-like factor 7; Kruppel like factor 7; Kruppel-like factor 7 (ubiquitous); LOC363243
RGD Orthologs
Human
Mouse
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8972,927,485 - 73,020,167 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl972,933,136 - 73,020,056 (-)EnsemblGRCr8
mRatBN7.2965,433,683 - 65,526,372 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl965,437,167 - 65,526,261 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx973,952,187 - 74,039,273 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0979,089,971 - 79,177,093 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0977,480,973 - 77,568,080 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0970,740,480 - 70,787,913 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl970,740,480 - 70,787,913 (-)Ensemblrn6Rnor6.0
Rnor_5.0971,787,156 - 71,834,589 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4962,690,536 - 62,738,089 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera962,847,936 - 62,895,117 (-)NCBICelera
RGSC_v3.1962,837,684 - 62,931,073 (-)NCBI
Cytogenetic Map9q32NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
cefaloridine  (EXP)
CGP 52608  (ISO)
cisplatin  (EXP,ISO)
cobalt dichloride  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
CU-O LINKAGE  (ISO)
Cuprizon  (EXP)
DDE  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
divanadium pentaoxide  (ISO)
fenthion  (ISO)
flutamide  (EXP)
formaldehyde  (ISO)
furan  (EXP)
geraniol  (ISO)
hydroquinone  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
methamphetamine  (ISO)
methidathion  (ISO)
methylmercury chloride  (ISO)
morphine  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
naloxone  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
potassium chromate  (ISO)
rac-lactic acid  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
Soman  (EXP)
sotorasib  (ISO)
styrene  (ISO)
succimer  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
torcetrapib  (ISO)
trametinib  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9774444   PMID:15964824   PMID:16339272   PMID:20580711   PMID:27714571   PMID:28916725   PMID:33969678   PMID:35321971   PMID:36566916  


Genomics

Comparative Map Data
Klf7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8972,927,485 - 73,020,167 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl972,933,136 - 73,020,056 (-)EnsemblGRCr8
mRatBN7.2965,433,683 - 65,526,372 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl965,437,167 - 65,526,261 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx973,952,187 - 74,039,273 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0979,089,971 - 79,177,093 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0977,480,973 - 77,568,080 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0970,740,480 - 70,787,913 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl970,740,480 - 70,787,913 (-)Ensemblrn6Rnor6.0
Rnor_5.0971,787,156 - 71,834,589 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4962,690,536 - 62,738,089 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera962,847,936 - 62,895,117 (-)NCBICelera
RGSC_v3.1962,837,684 - 62,931,073 (-)NCBI
Cytogenetic Map9q32NCBI
KLF7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382207,074,137 - 207,173,851 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2207,074,137 - 207,173,856 (-)Ensemblhg38GRCh38
GRCh372207,938,861 - 208,031,970 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362207,653,774 - 207,738,859 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342207,771,034 - 207,856,120NCBI
Celera2201,706,987 - 201,792,085 (-)NCBICelera
Cytogenetic Map2q33.3NCBI
HuRef2199,788,743 - 199,882,048 (-)NCBIHuRef
CHM1_12207,944,767 - 208,037,841 (-)NCBICHM1_1
T2T-CHM13v2.02207,556,313 - 207,657,581 (-)NCBIT2T-CHM13v2.0
Klf7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39164,068,607 - 64,161,504 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl164,068,606 - 64,161,441 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38164,029,448 - 64,122,345 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl164,029,447 - 64,122,282 (-)Ensemblmm10GRCm38
MGSCv37164,082,237 - 64,167,963 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36163,969,939 - 64,055,665 (-)NCBIMGSCv36mm8
Celera164,551,954 - 64,637,590 (-)NCBICelera
Cytogenetic Map1C2NCBI
cM Map132.31NCBI
Klf7
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v14137,952,088 - 138,045,828 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Klf7
691 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:87
Count of miRNA genes:81
Interacting mature miRNAs:86
Transcripts:ENSRNOT00000017901, ENSRNOT00000072007
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)9671488884474983Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)956047863101047863Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)94002992585029925Rat
1582203Gluco19Glucose level QTL 193.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)963376862108376862Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)965657365108376720Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)94445825699506504Rat
61450Ciaa3CIA Autoantibody QTL 36.5blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)92956766474567664Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)94445825685262605Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92956766483835942Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)94172029586720295Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)964220169109220169Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)964220169109220169Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)944458256121768150Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)964220169109220169Rat
1581517Bp284Blood pressure QTL 284arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)93922018684220186Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)968875497121768150Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)948718864108376862Rat
1598849Memor17Memory QTL 172.2exploratory behavior trait (VT:0010471)difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)95746049778547958Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)94002992585029925Rat
1578659Tspe1Trichinella spiralis expulsion QTL 14.8parasite quantity (VT:0010441)logarithm of the intestinal adult Trichinella spiralis count (CMO:0002024)96887549773185088Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)964220169109220169Rat
4889943Bss90Bone structure and strength QTL 904.1tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)95450650499506504Rat
1641894Alcrsp12Alcohol response QTL 12response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)93496059079960590Rat

Markers in Region
AI229204  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2965,439,254 - 65,439,453 (+)MAPPERmRatBN7.2
Rnor_6.0970,742,200 - 70,742,398NCBIRnor6.0
Rnor_5.0971,832,671 - 71,832,869UniSTSRnor5.0
RGSC_v3.4962,692,256 - 62,692,454UniSTSRGSC3.4
Celera962,849,656 - 62,849,854UniSTS
RH 3.4 Map9536.8UniSTS
Cytogenetic Map9q32UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000072007   ⟹   ENSRNOP00000067389
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl965,437,167 - 65,526,261 (-)Ensembl
Rnor_6.0 Ensembl970,740,480 - 70,787,913 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000099684   ⟹   ENSRNOP00000084533
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl965,437,167 - 65,485,330 (-)Ensembl
RefSeq Acc Id: NM_001399681   ⟹   NP_001386610
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8972,933,136 - 73,020,056 (-)NCBI
mRatBN7.2965,439,337 - 65,526,261 (-)NCBI
RefSeq Acc Id: XM_039084860   ⟹   XP_038940788
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8972,927,485 - 73,020,167 (-)NCBI
mRatBN7.2965,433,683 - 65,526,372 (-)NCBI
RefSeq Acc Id: XM_063267384   ⟹   XP_063123454
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8972,927,485 - 73,020,165 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001386610 (Get FASTA)   NCBI Sequence Viewer  
  XP_038940788 (Get FASTA)   NCBI Sequence Viewer  
  XP_063123454 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL98884 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000067389
  ENSRNOP00000067389.3
  ENSRNOP00000084533.2
Ensembl Acc Id: ENSRNOP00000067389   ⟸   ENSRNOT00000072007
Ensembl Acc Id: ENSRNOP00000084533   ⟸   ENSRNOT00000099684
RefSeq Acc Id: XP_038940788   ⟸   XM_039084860
- Peptide Label: isoform X1
- UniProtKB: M0RCR2 (UniProtKB/TrEMBL),   A0A8I5ZZK8 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001386610   ⟸   NM_001399681
- UniProtKB: A0A8I5ZZK8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063123454   ⟸   XM_063267384
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZZK8 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0RCR2-F1-model_v2 AlphaFold M0RCR2 1-94 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306029 AgrOrtholog
BioCyc Gene G2FUF-27332 BioCyc
Ensembl Genes ENSRNOG00000046242 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000072007 ENTREZGENE
  ENSRNOT00000072007.4 UniProtKB/TrEMBL
  ENSRNOT00000099684.2 UniProtKB/TrEMBL
Gene3D-CATH Classic Zinc Finger UniProtKB/TrEMBL
InterPro Znf_C2H2_sf UniProtKB/TrEMBL
  Znf_C2H2_type UniProtKB/TrEMBL
NCBI Gene 363243 ENTREZGENE
PANTHER KRUEPPEL-LIKE FACTOR 7 UniProtKB/TrEMBL
  KRUEPPEL-LIKE TRANSCRIPTION FACTOR UniProtKB/TrEMBL
Pfam zf-C2H2 UniProtKB/TrEMBL
PhenoGen Klf7 PhenoGen
PROSITE ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000046242 RatGTEx
SMART ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP SSF57667 UniProtKB/TrEMBL
UniProt A0A8I5ZZK8 ENTREZGENE, UniProtKB/TrEMBL
  M0RCR2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-10-03 Klf7  KLF transcription factor 7  Klf7  Kruppel like factor 7  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-06-08 Klf7  Kruppel like factor 7  Klf7  Kruppel-like factor 7 (ubiquitous)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Klf7  Kruppel-like factor 7 (ubiquitous)   Klf7_predicted  Kruppel-like factor 7 (ubiquitous) (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Klf7_predicted  Kruppel-like factor 7 (ubiquitous) (predicted)      Symbol and Name status set to approved 70820 APPROVED