Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Plcl2 | Rat | (+)-catechin | multiple interactions | ISO | PLCL2 (Homo sapiens) | 6480464 | [Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of PLCL2 mRNA | CTD | PMID:24763279 | Plcl2 | Rat | (1->4)-beta-D-glucan | multiple interactions | ISO | Plcl2 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of PLCL2 mRNA | CTD | PMID:36331819 | Plcl2 | Rat | 1,2-dimethylhydrazine | decreases expression | ISO | Plcl2 (Mus musculus) | 6480464 | 1,2-Dimethylhydrazine results in decreased expression of PLCL2 mRNA | CTD | PMID:22206623 | Plcl2 | Rat | 1,2-dimethylhydrazine | multiple interactions | ISO | Plcl2 (Mus musculus) | 6480464 | [1,2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of PLCL2 mRNA | CTD | PMID:22206623 | Plcl2 | Rat | 17beta-estradiol | multiple interactions | EXP | | 6480464 | [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of PLCL2 mRNA | CTD | PMID:32741896 | Plcl2 | Rat | 17beta-estradiol 3-benzoate | multiple interactions | EXP | | 6480464 | [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of PLCL2 mRNA | CTD | PMID:32741896 | Plcl2 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of PLCL2 mRNA | CTD | PMID:32109520|PMID:33387578 | Plcl2 | Rat | 2,4-dinitrotoluene | affects expression | EXP | | 6480464 | 2,4-dinitrotoluene affects the expression of PLCL2 mRNA | CTD | PMID:21346803 | Plcl2 | Rat | 4,4'-diaminodiphenylmethane | affects expression | ISO | Plcl2 (Mus musculus) | 6480464 | 4,4'-diaminodiphenylmethane affects the expression of PLCL2 mRNA | CTD | PMID:18648102 | Plcl2 | Rat | 6-propyl-2-thiouracil | decreases expression | EXP | | 6480464 | Propylthiouracil results in decreased expression of PLCL2 mRNA | CTD | PMID:30047161 | Plcl2 | Rat | acrylamide | increases expression | EXP | | 6480464 | Acrylamide results in increased expression of PLCL2 mRNA | CTD | PMID:28959563 | Plcl2 | Rat | aflatoxin B1 | affects expression | ISO | PLCL2 (Homo sapiens) | 6480464 | Aflatoxin B1 affects the expression of PLCL2 protein | CTD | PMID:20106945 | Plcl2 | Rat | aflatoxin B1 | decreases expression | ISO | Plcl2 (Mus musculus) | 6480464 | Aflatoxin B1 results in decreased expression of PLCL2 mRNA | CTD | PMID:19770486 | Plcl2 | Rat | amitrole | decreases expression | EXP | | 6480464 | Amitrole results in decreased expression of PLCL2 mRNA | CTD | PMID:30047161 | Plcl2 | Rat | atrazine | decreases expression | ISO | PLCL2 (Homo sapiens) | 6480464 | Atrazine results in decreased expression of PLCL2 mRNA | CTD | PMID:22378314 | Plcl2 | Rat | benzo[a]pyrene | decreases expression | ISO | PLCL2 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of PLCL2 mRNA | CTD | PMID:20106945 | Plcl2 | Rat | benzo[a]pyrene | increases methylation | ISO | PLCL2 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of PLCL2 promoter | CTD | PMID:27901495 | Plcl2 | Rat | benzo[a]pyrene | decreases methylation | ISO | PLCL2 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased methylation of PLCL2 exon | CTD | PMID:27901495 | Plcl2 | Rat | benzo[a]pyrene | multiple interactions | ISO | Plcl2 (Mus musculus) | 6480464 | AHR protein affects the reaction [Benzo(a)pyrene affects the expression of PLCL2 mRNA] | CTD | PMID:22228805 | Plcl2 | Rat | benzo[a]pyrene diol epoxide I | decreases expression | ISO | PLCL2 (Homo sapiens) | 6480464 | 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PLCL2 mRNA | CTD | PMID:19150397 | Plcl2 | Rat | bis(2-ethylhexyl) phthalate | multiple interactions | ISO | Plcl2 (Mus musculus) | 6480464 | [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with Dibutyl Phthalate co-treated more ... | CTD | PMID:39150890 | Plcl2 | Rat | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of PLCL2 mRNA | CTD | PMID:25181051 | Plcl2 | Rat | buta-1,3-diene | decreases expression | ISO | Plcl2 (Mus musculus) | 6480464 | 1,3-butadiene results in decreased expression of PLCL2 mRNA | CTD | PMID:29038090 | Plcl2 | Rat | Butylbenzyl phthalate | multiple interactions | ISO | Plcl2 (Mus musculus) | 6480464 | [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with Dibutyl Phthalate co-treated more ... | CTD | PMID:39150890 | Plcl2 | Rat | Butylbenzyl phthalate | increases methylation | ISO | Plcl2 (Mus musculus) | 6480464 | butylbenzyl phthalate results in increased methylation of PLCL2 intron | CTD | PMID:28392331 | Plcl2 | Rat | carbamazepine | affects expression | ISO | PLCL2 (Homo sapiens) | 6480464 | Carbamazepine affects the expression of PLCL2 mRNA | CTD | PMID:25979313 | Plcl2 | Rat | carbon nanotube | increases expression | ISO | Plcl2 (Mus musculus) | 6480464 | Nanotubes, Carbon analog results in increased expression of PLCL2 mRNA | CTD | PMID:25554681 | Plcl2 | Rat | CGP 52608 | multiple interactions | ISO | PLCL2 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to PLCL2 gene] | CTD | PMID:28238834 | Plcl2 | Rat | ciguatoxin CTX1B | affects expression | ISO | Plcl2 (Mus musculus) | 6480464 | Ciguatoxins affects the expression of PLCL2 mRNA | CTD | PMID:18353800 | Plcl2 | Rat | cisplatin | increases expression | ISO | PLCL2 (Homo sapiens) | 6480464 | Cisplatin results in increased expression of PLCL2 mRNA | CTD | PMID:27392435 | Plcl2 | Rat | cisplatin | multiple interactions | ISO | PLCL2 (Homo sapiens) | 6480464 | [Cisplatin co-treated with jinfukang] results in increased expression of PLCL2 mRNA | CTD | PMID:27392435 | Plcl2 | Rat | copper atom | multiple interactions | ISO | PLCL2 (Homo sapiens) | 6480464 | [NSC 689534 binds to Copper] which results in decreased expression of PLCL2 mRNA | CTD | PMID:20971185 | Plcl2 | Rat | copper atom | decreases expression | EXP | | 6480464 | Copper deficiency results in decreased expression of PLCL2 mRNA | CTD | PMID:19821111 | Plcl2 | Rat | copper(0) | multiple interactions | ISO | PLCL2 (Homo sapiens) | 6480464 | [NSC 689534 binds to Copper] which results in decreased expression of PLCL2 mRNA | CTD | PMID:20971185 | Plcl2 | Rat | copper(0) | decreases expression | EXP | | 6480464 | Copper deficiency results in decreased expression of PLCL2 mRNA | CTD | PMID:19821111 | Plcl2 | Rat | coumarin | decreases phosphorylation | ISO | PLCL2 (Homo sapiens) | 6480464 | coumarin results in decreased phosphorylation of PLCL2 protein | CTD | PMID:35688186 | Plcl2 | Rat | cyclosporin A | decreases expression | ISO | PLCL2 (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of PLCL2 mRNA | CTD | PMID:20106945 | Plcl2 | Rat | D-mannitol | decreases expression | ISO | Plcl2 (Mus musculus) | 6480464 | Mannitol results in decreased expression of PLCL2 mRNA | CTD | PMID:25270620 | Plcl2 | Rat | Dibutyl phosphate | affects expression | ISO | PLCL2 (Homo sapiens) | 6480464 | di-n-butylphosphoric acid affects the expression of PLCL2 mRNA | CTD | PMID:37042841 | Plcl2 | Rat | dibutyl phthalate | increases expression | ISO | Plcl2 (Mus musculus) | 6480464 | Dibutyl Phthalate results in increased expression of PLCL2 mRNA | CTD | PMID:21266533 | Plcl2 | Rat | dibutyl phthalate | multiple interactions | ISO | Plcl2 (Mus musculus) | 6480464 | [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with Dibutyl Phthalate co-treated more ... | CTD | PMID:39150890 | Plcl2 | Rat | diethyl phthalate | multiple interactions | ISO | Plcl2 (Mus musculus) | 6480464 | [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with Dibutyl Phthalate co-treated more ... | CTD | PMID:39150890 | Plcl2 | Rat | diisobutyl phthalate | multiple interactions | ISO | Plcl2 (Mus musculus) | 6480464 | [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with Dibutyl Phthalate co-treated more ... | CTD | PMID:39150890 | Plcl2 | Rat | diisononyl phthalate | multiple interactions | ISO | Plcl2 (Mus musculus) | 6480464 | [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with Dibutyl Phthalate co-treated more ... | CTD | PMID:39150890 | Plcl2 | Rat | dimethylselenide | multiple interactions | ISO | PLCL2 (Homo sapiens) | 6480464 | [[Hydroxyl Radical results in increased oxidation of dimethylselenide] which results in increased expression of PLCL2-AS1 more ... | CTD | PMID:33656867 | Plcl2 | Rat | dorsomorphin | multiple interactions | ISO | PLCL2 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ... | CTD | PMID:27188386 | Plcl2 | Rat | ethanol | affects splicing | ISO | Plcl2 (Mus musculus) | 6480464 | Ethanol affects the splicing of PLCL2 mRNA | CTD | PMID:30319688 | Plcl2 | Rat | ethanol | affects expression | ISO | Plcl2 (Mus musculus) | 6480464 | Ethanol affects the expression of PLCL2 mRNA | CTD | PMID:30319688 | Plcl2 | Rat | fluoranthene | multiple interactions | ISO | Plcl2 (Mus musculus) | 6480464 | [1-methylanthracene co-treated with fluoranthene] results in increased expression of PLCL2 mRNA | CTD | PMID:28329830 | Plcl2 | Rat | folic acid | multiple interactions | ISO | Plcl2 (Mus musculus) | 6480464 | [1,2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of PLCL2 mRNA | CTD | PMID:22206623 | Plcl2 | Rat | formaldehyde | decreases expression | ISO | PLCL2 (Homo sapiens) | 6480464 | Formaldehyde results in decreased expression of PLCL2 mRNA | CTD | PMID:23416264 | Plcl2 | Rat | formaldehyde | increases expression | ISO | PLCL2 (Homo sapiens) | 6480464 | Formaldehyde results in increased expression of PLCL2 mRNA | CTD | PMID:23649840 | Plcl2 | Rat | FR900359 | increases phosphorylation | ISO | PLCL2 (Homo sapiens) | 6480464 | FR900359 results in increased phosphorylation of PLCL2 protein | CTD | PMID:37730182 | Plcl2 | Rat | gentamycin | decreases expression | EXP | | 6480464 | Gentamicins results in decreased expression of PLCL2 mRNA | CTD | PMID:22061828 | Plcl2 | Rat | GSK-J4 | increases expression | ISO | PLCL2 (Homo sapiens) | 6480464 | GSK-J4 results in increased expression of PLCL2 mRNA | CTD | PMID:29301935 | Plcl2 | Rat | hydroxyl | multiple interactions | ISO | PLCL2 (Homo sapiens) | 6480464 | [[Hydroxyl Radical results in increased oxidation of dimethylselenide] which results in increased expression of PLCL2-AS1 more ... | CTD | PMID:33656867 | Plcl2 | Rat | inulin | multiple interactions | ISO | Plcl2 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Inulin] results in increased expression of PLCL2 mRNA | CTD | PMID:36331819 | Plcl2 | Rat | isotretinoin | increases expression | ISO | PLCL2 (Homo sapiens) | 6480464 | Isotretinoin results in increased expression of PLCL2 mRNA | CTD | PMID:20436886 | Plcl2 | Rat | melphalan | decreases expression | ISO | PLCL2 (Homo sapiens) | 6480464 | Melphalan results in decreased expression of PLCL2 mRNA | CTD | PMID:22363485 | Plcl2 | Rat | methimazole | decreases expression | EXP | | 6480464 | Methimazole results in decreased expression of PLCL2 mRNA | CTD | PMID:30047161 | Plcl2 | Rat | methyl methanesulfonate | increases expression | ISO | PLCL2 (Homo sapiens) | 6480464 | Methyl Methanesulfonate results in increased expression of PLCL2 mRNA | CTD | PMID:23649840 | Plcl2 | Rat | methylmercury chloride | decreases expression | ISO | PLCL2 (Homo sapiens) | 6480464 | methylmercuric chloride results in decreased expression of PLCL2 mRNA | CTD | PMID:28001369 | Plcl2 | Rat | nickel atom | increases expression | ISO | PLCL2 (Homo sapiens) | 6480464 | Nickel results in increased expression of PLCL2 mRNA | CTD | PMID:24768652 | Plcl2 | Rat | okadaic acid | decreases expression | ISO | PLCL2 (Homo sapiens) | 6480464 | Okadaic Acid results in decreased expression of PLCL2 mRNA | CTD | PMID:38832940 | Plcl2 | Rat | oxaliplatin | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of PLCL2 mRNA | CTD | PMID:25729387 | Plcl2 | Rat | ozone | multiple interactions | ISO | Plcl2 (Mus musculus) | 6480464 | [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in decreased more ... | CTD | PMID:34911549 | Plcl2 | Rat | ozone | multiple interactions | ISO | PLCL2 (Homo sapiens) | 6480464 | [Air Pollutants results in increased abundance of Ozone] which affects the expression of PLCL2 mRNA | CTD | PMID:35430440 | Plcl2 | Rat | paracetamol | decreases expression | ISO | PLCL2 (Homo sapiens) | 6480464 | Acetaminophen results in decreased expression of PLCL2 mRNA | CTD | PMID:21420995 | Plcl2 | Rat | perfluorooctane-1-sulfonic acid | multiple interactions | ISO | Plcl2 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of PLCL2 mRNA; [perfluorooctane sulfonic more ... | CTD | PMID:36331819 | Plcl2 | Rat | phenobarbital | multiple interactions | ISO | Plcl2 (Mus musculus) | 6480464 | NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of PLCL2 mRNA] | CTD | PMID:19482888 | Plcl2 | Rat | phenobarbital | decreases expression | ISO | Plcl2 (Mus musculus) | 6480464 | Phenobarbital results in decreased expression of PLCL2 mRNA | CTD | PMID:19482888 | Plcl2 | Rat | phenylmercury acetate | decreases expression | ISO | PLCL2 (Homo sapiens) | 6480464 | Phenylmercuric Acetate results in decreased expression of PLCL2 mRNA | CTD | PMID:26272509 | Plcl2 | Rat | phenylmercury acetate | multiple interactions | ISO | PLCL2 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ... | CTD | PMID:27188386 | Plcl2 | Rat | pirinixic acid | increases expression | ISO | Plcl2 (Mus musculus) | 6480464 | pirinixic acid results in increased expression of PLCL2 mRNA | CTD | PMID:17950772 | Plcl2 | Rat | pirinixic acid | multiple interactions | ISO | Plcl2 (Mus musculus) | 6480464 | PPARA protein promotes the reaction [pirinixic acid results in increased expression of PLCL2 mRNA] | CTD | PMID:17950772 | Plcl2 | Rat | pirinixic acid | multiple interactions | ISO | PLCL2 (Homo sapiens) | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in more ... | CTD | PMID:19710929 | Plcl2 | Rat | potassium chromate | increases expression | ISO | PLCL2 (Homo sapiens) | 6480464 | potassium chromate(VI) results in increased expression of PLCL2 mRNA | CTD | PMID:22714537 | Plcl2 | Rat | pregnenolone 16alpha-carbonitrile | decreases expression | EXP | | 6480464 | Pregnenolone Carbonitrile results in decreased expression of PLCL2 mRNA | CTD | PMID:30047161 | Plcl2 | Rat | SB 431542 | multiple interactions | ISO | PLCL2 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ... | CTD | PMID:27188386 | Plcl2 | Rat | sulfadimethoxine | decreases expression | EXP | | 6480464 | Sulfadimethoxine results in decreased expression of PLCL2 mRNA | CTD | PMID:30047161 | Plcl2 | Rat | testosterone | multiple interactions | EXP | | 6480464 | [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of PLCL2 mRNA | CTD | PMID:32741896 | Plcl2 | Rat | thioacetamide | decreases expression | EXP | | 6480464 | Thioacetamide results in decreased expression of PLCL2 mRNA | CTD | PMID:34492290 | Plcl2 | Rat | titanium dioxide | increases expression | ISO | Plcl2 (Mus musculus) | 6480464 | titanium dioxide results in increased expression of PLCL2 mRNA | CTD | PMID:23557971 | Plcl2 | Rat | topotecan | decreases expression | EXP | | 6480464 | Topotecan results in decreased expression of PLCL2 mRNA | CTD | PMID:25729387 | Plcl2 | Rat | topotecan | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of PLCL2 mRNA | CTD | PMID:25729387 | Plcl2 | Rat | trichostatin A | decreases expression | ISO | PLCL2 (Homo sapiens) | 6480464 | trichostatin A results in decreased expression of PLCL2 mRNA | CTD | PMID:24935251 | Plcl2 | Rat | triclosan | decreases expression | ISO | PLCL2 (Homo sapiens) | 6480464 | Triclosan results in decreased expression of PLCL2 mRNA | CTD | PMID:30510588 | Plcl2 | Rat | triptonide | decreases expression | ISO | Plcl2 (Mus musculus) | 6480464 | triptonide results in decreased expression of PLCL2 mRNA | CTD | PMID:33045310 | Plcl2 | Rat | valproic acid | decreases methylation | ISO | PLCL2 (Homo sapiens) | 6480464 | Valproic Acid results in decreased methylation of PLCL2 gene | CTD | PMID:29154799 | Plcl2 | Rat | valproic acid | affects expression | ISO | PLCL2 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of PLCL2 mRNA | CTD | PMID:25979313 | Plcl2 | Rat | valproic acid | decreases expression | ISO | PLCL2 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of PLCL2 mRNA | CTD | PMID:23179753|PMID:24383497|PMID:24935251|PMID:27188386|PMID:28001369|PMID:29154799 | Plcl2 | Rat | zoledronic acid | increases expression | ISO | PLCL2 (Homo sapiens) | 6480464 | zoledronic acid results in increased expression of PLCL2 mRNA | CTD | PMID:24714768 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||






















