Lats2 (large tumor suppressor kinase 2) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Lats2 (large tumor suppressor kinase 2) Rattus norvegicus
Analyze
Symbol: Lats2
Name: large tumor suppressor kinase 2
RGD ID: 1305906
Description: Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Predicted to be involved in several processes, including G1/S transition of mitotic cell cycle; hippo signaling; and regulation of signal transduction. Predicted to act upstream of or within several processes, including inner cell mass cell differentiation; keratinocyte differentiation; and regulation of signal transduction. Predicted to be located in centriolar satellite; cytosol; and spindle. Predicted to be active in cytoplasm; nucleus; and spindle pole. Orthologous to human LATS2 (large tumor suppressor kinase 2); INTERACTS WITH 2-methoxyethanol; 6-propyl-2-thiouracil; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: large tumor suppressor 2; large tumor suppressor, homolog 2; large tumor suppressor, homolog 2 (Drosophila); LOC305922; serine/threonine-protein kinase LATS2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81535,940,632 - 35,992,225 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1535,940,632 - 35,980,842 (-)EnsemblGRCr8
mRatBN7.21531,825,068 - 31,877,193 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1531,825,092 - 31,877,220 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1533,816,404 - 33,856,618 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01534,967,073 - 35,007,296 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01533,225,167 - 33,265,374 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01537,943,609 - 37,995,175 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1537,943,609 - 37,983,882 (-)Ensemblrn6Rnor6.0
Rnor_5.01541,788,720 - 41,828,866 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41536,720,000 - 36,761,065 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1531,535,661 - 31,575,853 (-)NCBICelera
RGSC_v3.11536,737,366 - 36,776,640 (-)NCBI
Cytogenetic Map15p12NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(20S)-ginsenoside Rg3  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-methoxyethanol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
antirheumatic drug  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Butylbenzyl phthalate  (ISO)
C60 fullerene  (EXP)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
choline  (ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
CU-O LINKAGE  (ISO)
cyclosporin A  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
diethyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
epoxiconazole  (ISO)
ethyl methanesulfonate  (ISO)
fenamidone  (ISO)
fisetin  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
hydrogen cyanide  (ISO)
hydrogen peroxide  (ISO)
iron dichloride  (ISO)
L-methionine  (ISO)
menadione  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
nitrates  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (ISO)
perfluorobutanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
potassium chloride  (ISO)
potassium chromate  (ISO)
potassium cyanide  (ISO)
SB 431542  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
tetrachloromethane  (ISO)
thalidomide  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trichostatin A  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
centrosome  (IEA)
cytoplasm  (IEA,ISO)
cytosol  (IEA,ISO)
microtubule cytoskeleton  (IEA)
nucleus  (IBA,IEA,ISO)
spindle  (IEA)
spindle pole  (IBA,IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. LINC00689 participates in proliferation, chemoresistance and metastasis via miR-31-5p/YAP/β-catenin axis in colorectal cancer. Du YL, etal., Exp Cell Res. 2020 Oct 1;395(1):112176. doi: 10.1016/j.yexcr.2020.112176. Epub 2020 Jul 16.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10673337   PMID:10871863   PMID:12853976   PMID:15131260   PMID:15343267   PMID:18369314   PMID:19289085   PMID:20412773   PMID:21512031   PMID:22020941   PMID:23824537   PMID:31829064  
PMID:32054526   PMID:32375631  


Genomics

Comparative Map Data
Lats2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81535,940,632 - 35,992,225 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1535,940,632 - 35,980,842 (-)EnsemblGRCr8
mRatBN7.21531,825,068 - 31,877,193 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1531,825,092 - 31,877,220 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1533,816,404 - 33,856,618 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01534,967,073 - 35,007,296 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01533,225,167 - 33,265,374 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01537,943,609 - 37,995,175 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1537,943,609 - 37,983,882 (-)Ensemblrn6Rnor6.0
Rnor_5.01541,788,720 - 41,828,866 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41536,720,000 - 36,761,065 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1531,535,661 - 31,575,853 (-)NCBICelera
RGSC_v3.11536,737,366 - 36,776,640 (-)NCBI
Cytogenetic Map15p12NCBI
LATS2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381320,973,036 - 21,061,586 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1320,973,029 - 21,061,603 (-)Ensemblhg38GRCh38
GRCh371321,547,175 - 21,635,725 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361320,445,175 - 20,533,722 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341320,446,578 - 20,533,654NCBI
Celera132,609,110 - 2,697,695 (-)NCBICelera
Cytogenetic Map13q12.11NCBI
HuRef132,350,083 - 2,438,773 (-)NCBIHuRef
CHM1_11321,515,524 - 21,603,910 (-)NCBICHM1_1
T2T-CHM13v2.01320,166,164 - 20,254,674 (-)NCBIT2T-CHM13v2.0
Lats2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391457,927,119 - 57,983,669 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1457,879,534 - 57,983,560 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm39 Ensembl1457,927,119 - 57,995,845 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381457,689,662 - 57,746,212 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1457,642,077 - 57,746,103 (-)Ensemblmm10GRCm38
GRCm38.p6 Ensembl1457,689,662 - 57,758,388 (-)Ensemblmm10GRCm38
MGSCv371458,308,499 - 58,364,960 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361456,643,772 - 56,700,233 (-)NCBIMGSCv36mm8
Celera1455,491,594 - 55,547,812 (-)NCBICelera
Cytogenetic Map14C3NCBI
cM Map1430.28NCBI
Lats2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554971,711,205 - 1,761,584 (-)Ensembl
ChiLan1.0NW_0049554971,711,882 - 1,768,177 (-)NCBIChiLan1.0ChiLan1.0
LATS2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21420,603,749 - 20,692,154 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11311,716,816 - 11,805,130 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0132,300,625 - 2,389,027 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11320,610,022 - 20,698,810 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1320,611,861 - 20,683,083 (-)EnsemblpanPan2panpan1.1
LATS2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12517,110,620 - 17,169,826 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2517,110,637 - 17,169,291 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2517,188,801 - 17,201,953 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02517,237,244 - 17,308,678 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2517,237,178 - 17,307,295 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12517,109,498 - 17,180,871 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02517,120,566 - 17,191,969 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02517,176,853 - 17,248,494 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Lats2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945119,187,750 - 119,248,054 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936720735,524 - 793,696 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936720735,326 - 795,596 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LATS2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl111,225,527 - 1,265,946 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1111,225,523 - 1,265,970 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
LATS2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.13124,520 - 215,426 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605744,396,305 - 44,490,502 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lats2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477616,585,025 - 16,638,520 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462477616,572,598 - 16,640,412 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Lats2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11267,104,176 - 67,155,101 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Lats2
397 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:232
Count of miRNA genes:150
Interacting mature miRNAs:183
Transcripts:ENSRNOT00000014031
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)15231575947315759Rat
5684946Bss98Bone structure and strength QTL 983.90.0026tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)15139411584Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15144836456Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15231575953331089Rat
152025253Hrtrt24Heart rate QTL 243.82heart pumping trait (VT:2000009)153185580392671517Rat
10755503Bp391Blood pressure QTL 3912.37arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)152272835342072050Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152852773273527732Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1525285835104695021Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)152233635152597086Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)1525285835104695021Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151915576287086765Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)15278592347785923Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151492659471614418Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)152233635167336351Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)1525285835104695021Rat

Markers in Region
RH139371  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21531,825,194 - 31,825,286 (+)MAPPERmRatBN7.2
Rnor_6.01537,943,736 - 37,943,827NCBIRnor6.0
Rnor_5.01541,788,847 - 41,788,938UniSTSRnor5.0
RGSC_v3.41536,720,127 - 36,720,218UniSTSRGSC3.4
Celera1531,535,788 - 31,535,879UniSTS
Cytogenetic Map15p12UniSTS
AI233961  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21531,825,106 - 31,825,286 (+)MAPPERmRatBN7.2
Rnor_6.01537,943,648 - 37,943,827NCBIRnor6.0
Rnor_5.01541,788,759 - 41,788,938UniSTSRnor5.0
RGSC_v3.41536,720,039 - 36,720,218UniSTSRGSC3.4
Celera1531,535,700 - 31,535,879UniSTS
Cytogenetic Map15p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
18 13 85 200 91 90 59 104 59 6 425 232 21 175 108 123 31 27 27

Sequence


Ensembl Acc Id: ENSRNOT00000087978   ⟹   ENSRNOP00000072969
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1535,940,632 - 35,980,842 (-)Ensembl
mRatBN7.2 Ensembl1531,825,092 - 31,877,220 (-)Ensembl
Rnor_6.0 Ensembl1537,943,609 - 37,983,882 (-)Ensembl
RefSeq Acc Id: NM_001107267   ⟹   NP_001100737
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81535,940,632 - 35,980,842 (-)NCBI
mRatBN7.21531,825,068 - 31,865,286 (-)NCBI
Rnor_6.01537,943,609 - 37,983,882 (-)NCBI
Rnor_5.01541,788,720 - 41,828,866 (-)NCBI
RGSC_v3.41536,720,000 - 36,761,065 (-)RGD
Celera1531,535,661 - 31,575,853 (-)RGD
Sequence:
RefSeq Acc Id: XM_008770748   ⟹   XP_008768970
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81535,940,641 - 35,992,225 (-)NCBI
mRatBN7.21531,825,077 - 31,876,668 (-)NCBI
Rnor_6.01537,943,618 - 37,995,175 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001100737 (Get FASTA)   NCBI Sequence Viewer  
  XP_008768970 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM14356 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000072969
  ENSRNOP00000072969.1
RefSeq Acc Id: NP_001100737   ⟸   NM_001107267
- UniProtKB: A0A0G2K4A8 (UniProtKB/TrEMBL),   A6KHC7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008768970   ⟸   XM_008770748
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K4A8 (UniProtKB/TrEMBL),   A6KHC7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000072969   ⟸   ENSRNOT00000087978
Protein Domains
AGC-kinase C-terminal   Protein kinase   UBA

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K4A8-F1-model_v2 AlphaFold A0A0G2K4A8 1-1042 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305906 AgrOrtholog
BioCyc Gene G2FUF-13598 BioCyc
Ensembl Genes ENSRNOG00000056343 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000087978 ENTREZGENE
  ENSRNOT00000087978.3 UniProtKB/TrEMBL
Gene3D-CATH DNA helicase RuvA subunit, C-terminal domain UniProtKB/TrEMBL
  Phosphorylase Kinase, domain 1 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro AGC-kinase_C UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/TrEMBL
  Pkinase_C UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
  Ser_Thr_kinase_AGC UniProtKB/TrEMBL
  UBA-like UniProtKB/TrEMBL
  UBA/transl_elong_EF1B_N_euk UniProtKB/TrEMBL
KEGG Report rno:305922 UniProtKB/TrEMBL
NCBI Gene 305922 ENTREZGENE
PANTHER PTHR24356:SF149 UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN KINASE UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
  Pkinase_C UniProtKB/TrEMBL
PhenoGen Lats2 PhenoGen
PROSITE AGC_KINASE_CTER UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
  UBA UniProtKB/TrEMBL
RatGTEx ENSRNOG00000056343 RatGTEx
SMART S_TK_X UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/TrEMBL
  UBA_like UniProtKB/TrEMBL
UniProt A0A0G2K4A8 ENTREZGENE, UniProtKB/TrEMBL
  A6KHC7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-02-26 Lats2  large tumor suppressor kinase 2  Lats2  large tumor suppressor 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-19 Lats2  large tumor suppressor 2  Lats2  large tumor suppressor, homolog 2 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-01-17 Lats2  large tumor suppressor, homolog 2 (Drosophila)  Lats2  large tumor suppressor 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Lats2  large tumor suppressor 2   Lats2_predicted  large tumor suppressor 2 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Lats2_predicted  large tumor suppressor 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED