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Gene: Oaf (out at first homolog) Rattus norvegicus

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Symbol:

Oaf

Name:

out at first homolog

RGD ID:

1305890

Description:

Orthologous to human OAF (out at first homolog); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC315594; OAF homolog; OAF homolog (Drosophila); out at first protein homolog; RGD1305890; similar to RIKEN cDNA D130038B21

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	OAF (out at first homolog)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Oaf (out at first homolog)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Oaf (out at first homolog)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	OAF (out at first homolog)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	OAF (out at first homolog)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Oaf (out at first homolog)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	OAF (out at first homolog)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	OAF (out at first homolog)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Oaf (out at first homolog)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Oaf (out at first homolog)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	PLA2G4C (phospholipase A2 group IVC)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	OAF (out at first homolog)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Oaf (out at first homolog)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	oafa (OAF homolog a (Drosophila))	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	oafb (OAF homolog b (Drosophila))	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	oaf	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	oaf	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	oaf	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	oaf	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	52,491,314 - 52,509,285 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	8	52,491,315 - 52,509,285 (-)	Ensembl				GRCr8
mRatBN7.2	8	43,594,362 - 43,612,334 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	43,594,363 - 43,612,334 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	8	49,092,153 - 49,110,146 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	47,370,822 - 47,388,815 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	45,238,440 - 45,256,433 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	47,511,718 - 47,529,689 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	47,511,719 - 47,529,689 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	8	45,980,601 - 45,998,572 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	8	46,224,861 - 46,242,832 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	8	43,184,283 - 43,202,190 (-)	NCBI		Celera
RGSC_v3.1	8	46,233,627 - 46,251,598 (-)	NCBI
Cytogenetic Map	8	q22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

(1->4)-beta-D-glucan (ISO)

1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane (ISO)

17beta-estradiol (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

2-palmitoylglycerol (ISO)

4,4'-sulfonyldiphenol (ISO)

5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole (EXP)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

acrylamide (ISO)

aflatoxin B1 (ISO)

Aflatoxin B2 alpha (ISO)

all-trans-retinoic acid (ISO)

alpha-Zearalanol (EXP)

amiodarone (EXP)

amitriptyline (EXP)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

atrazine (ISO)

benzbromarone (EXP)

benzo[a]pyrene (ISO)

beta-lapachone (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

cadmium dichloride (ISO)

calcium silicate (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

clofibrate (EXP)

clomipramine (EXP)

copper(II) sulfate (ISO)

coumarin (EXP)

cyclosporin A (ISO)

dibutyl phthalate (EXP)

diethyl maleate (EXP)

dioxygen (ISO)

diuron (EXP)

dorsomorphin (ISO)

doxorubicin (ISO)

ethanol (ISO)

fenthion (ISO)

fipronil (EXP)

flutamide (EXP)

fulvestrant (ISO)

furan (EXP)

glafenine (EXP)

glutathione (EXP)

hexadecanoic acid (ISO)

imipramine (EXP)

ketoconazole (EXP)

L-ethionine (EXP)

leflunomide (EXP)

N-methyl-N-nitrosourea (EXP)

N-nitrosodiethylamine (EXP)

nefazodone (EXP)

nimesulide (EXP)

omeprazole (EXP)

p-toluidine (EXP)

paracetamol (EXP,ISO)

parathion (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (EXP)

phenformin (EXP)

piperonyl butoxide (EXP)

pirinixic acid (EXP,ISO)

quercetin (ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

Soman (EXP)

sunitinib (ISO)

tetrachloromethane (EXP,ISO)

thapsigargin (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

triphenyl phosphate (EXP,ISO)

troglitazone (ISO)

urethane (ISO)

ursodeoxycholic acid (ISO)

valdecoxib (EXP)

valproic acid (ISO)

vinclozolin (EXP)

References

References - curated

#	Reference Title	Reference Citation
1.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
2.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:23376485

Genomics

Comparative Map Data

Oaf
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	52,491,314 - 52,509,285 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	8	52,491,315 - 52,509,285 (-)	Ensembl				GRCr8
mRatBN7.2	8	43,594,362 - 43,612,334 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	43,594,363 - 43,612,334 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	8	49,092,153 - 49,110,146 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	47,370,822 - 47,388,815 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	45,238,440 - 45,256,433 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	47,511,718 - 47,529,689 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	47,511,719 - 47,529,689 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	8	45,980,601 - 45,998,572 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	8	46,224,861 - 46,242,832 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	8	43,184,283 - 43,202,190 (-)	NCBI		Celera
RGSC_v3.1	8	46,233,627 - 46,251,598 (-)	NCBI
Cytogenetic Map	8	q22	NCBI

OAF
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	120,211,032 - 120,230,334 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	120,211,032 - 120,230,334 (+)	Ensembl			hg38	GRCh38
GRCh37	11	120,081,740 - 120,101,043 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	119,586,957 - 119,605,860 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	11	117,239,997 - 117,258,863 (+)	NCBI		Celera
Cytogenetic Map	11	q23.3	NCBI
HuRef	11	116,021,485 - 116,040,231 (+)	NCBI		HuRef
CHM1_1	11	119,969,201 - 119,988,096 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	11	120,233,870 - 120,253,135 (+)	NCBI		T2T-CHM13v2.0

Oaf
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	43,132,575 - 43,151,113 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	43,132,532 - 43,151,208 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	9	43,221,278 - 43,239,816 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	43,221,235 - 43,239,911 (-)	Ensembl			mm10	GRCm38
MGSCv37	9	43,029,361 - 43,047,899 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	9	42,972,273 - 42,990,811 (-)	NCBI		MGSCv36	mm8
Celera	9	40,474,322 - 40,492,817 (-)	NCBI		Celera
Cytogenetic Map	9	A5.1	NCBI
cM Map	9	24.24	NCBI

Oaf
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955412	21,235,927 - 21,251,182 (+)	Ensembl
ChiLan1.0	NW_004955412	21,235,927 - 21,251,100 (+)	NCBI	ChiLan1.0	ChiLan1.0

OAF
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	9	120,912,578 - 120,931,955 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	11	122,016,468 - 122,035,657 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	115,045,790 - 115,065,032 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	118,972,578 - 118,991,550 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	118,972,574 - 118,991,170 (+)	Ensembl			panPan2	panpan1.1

OAF
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	13,771,208 - 13,798,387 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	5	13,771,659 - 13,783,190 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	13,826,247 - 13,842,926 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	5	13,717,188 - 13,733,860 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	5	13,717,197 - 13,734,236 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	5	13,854,790 - 13,871,452 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	5	13,758,765 - 13,785,700 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	5	13,797,892 - 13,814,560 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Oaf
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	102,149,586 - 102,166,267 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936542	5,070,468 - 5,091,298 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936542	5,070,995 - 5,087,676 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

OAF
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	47,345,165 - 47,362,998 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	9	47,344,916 - 47,363,768 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	52,413,284 - 52,431,295 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

OAF
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	111,614,890 - 111,634,309 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	1	111,615,001 - 111,638,431 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666043	14,425,828 - 14,444,899 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Oaf
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624784	15,571,402 - 15,589,246 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624784	15,571,765 - 15,587,589 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Oaf
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	8	37,796,524 - 37,814,672 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Oaf
105 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	397
Count of miRNA genes:	202
Interacting mature miRNAs:	230
Transcripts:	ENSRNOT00000012826
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1298065	Scl16	Serum cholesterol level QTL 16	3.8		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	8	39752803	84752803	Rat
2313057	Bss76	Bone structure and strength QTL 76	3	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	8	39106258	91341052	Rat
2317030	Wbc5	White blood cell count QTL 5	3.21	0.005	leukocyte quantity (VT:0000217)	white blood cell count (CMO:0000027)	8	16994642	61994642	Rat
1554321	Bmd3	Bone mineral density QTL 3	7.9	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	49849908	118871671	Rat
2313067	Bss77	Bone structure and strength QTL 77	3.1	0.0001	tibia size trait (VT:0100001)	tibia midshaft endosteal cross-sectional area (CMO:0001716)	8	39106258	91341052	Rat
1578769	Uae31	Urinary albumin excretion QTL 31	3.3	0.001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	8	39106363	103375781	Rat
2301416	Bp315	Blood pressure QTL 315		0.008	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	15952279	60952279	Rat
2317032	Ginf2	Gastrointestinal inflammation QTL 2	3.21	0.005	liver integrity trait (VT:0010547)	liver granuloma severity score (CMO:0002157)	8	12964165	57964165	Rat
1298079	Activ2	Activity QTL 2	9.5	0.000001	voluntary movement trait (VT:0003491)	rearing measurement (CMO:0001515)	8	50763951	95763951	Rat
11556286	Cm81	Cardiac mass QTL 81		0.01	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	8	39106258	84106258	Rat
2317036	Livw3	Liver weight QTL 3	2.43	0.01	liver mass (VT:0003402)	liver weight to body weight ratio (CMO:0000633)	8	12964165	57964165	Rat
70161	Bp62	Blood pressure QTL 62	2.9	0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	51589699	99045312	Rat
12880023	Bw184	Body weight QTL 184		0.001	body mass (VT:0001259)	body weight (CMO:0000012)	8	10382540	55382540	Rat
1578765	Klgr1	Kidney lesion grade QTL 1	3.3	0.0001	kidney morphology trait (VT:0002135)	organ lesion measurement (CMO:0000677)	8	39106363	103375781	Rat
5684993	Bmd84	Bone mineral density QTL 84	4.1		tibia mineral mass (VT:1000283)	bone mineral content (CMO:0001554)	8	51589699	58991895	Rat
61464	Niddm11	Non-insulin dependent diabetes mellitus QTL 11	3.1	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	8	44477926	89477926	Rat
2317051	Aia18	Adjuvant induced arthritis QTL 18	2.42		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	8	16994642	61994642	Rat
12880028	Cm103	Cardiac mass QTL 103		0.02	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	8	10382540	55382540	Rat
1578755	Pur5	Proteinuria QTL 5	3.3	0.0001	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	8	39106258	103375958	Rat
2317048	Ginf1	Gastrointestinal inflammation QTL 1	3.52	0.005	cecum mucosa thickness (VT:0010234)	enterocolitis severity score (CMO:0002138)	8	12964165	57964165	Rat
12880025	Cm102	Cardiac mass QTL 102		0.044	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	8	10382540	55382540	Rat
2313088	Bss75	Bone structure and strength QTL 75	3.1	0.0001	body length (VT:0001256)	body length, nose to rump (CMO:0000079)	8	39106258	91341052	Rat
1358896	Bp262	Blood pressure QTL 262	2.89		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	35464071	107982864	Rat
731182	Uae24	Urinary albumin excretion QTL 24	6.4		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	8	47541419	92541419	Rat
2302278	Gluco36	Glucose level QTL 36	4.2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	8	37760859	58991895	Rat
12880044	Am9	Aortic mass QTL 9		0.007	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	8	10382540	55382540	Rat
724514	Uae15	Urinary albumin excretion QTL 15	2.9		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	8	37760859	61459705	Rat
631648	Stl5	Serum triglyceride level QTL 5	4	0.0003	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	8	35464071	71842899	Rat
61353	Bp35	Blood pressure QTL 35		0.001	arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	8	39106258	84106258	Rat
737824	Hcar10	Hepatocarcinoma resistance QTL 10	2.9		liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	8	49610204	68373388	Rat
631842	Inf1	Infertility severity QTL 1	4.1	0.001	seminal gland mass (VT:0010524)	seminal vesicle wet weight (CMO:0001603)	8	31543661	76543661	Rat
1331769	Rf39	Renal function QTL 39	3.871		urine output (VT:0003620)	timed urine volume (CMO:0000260)	8	50763951	107970527	Rat
1359033	Bp273	Blood pressure QTL 273			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	39106258	84106258	Rat
1358906	Bp253	Blood pressure QTL 253	4	0.0004	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	49610204	94610204	Rat
61358	Bp39	Blood pressure QTL 39	2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	44447837	89447837	Rat
1358907	Cm40	Cardiac mass QTL 40	1.89		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	8	35464071	107982864	Rat
1598824	Memor4	Memory QTL 4	2.5		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	8	17993862	62252873	Rat
1331744	Bp217	Blood pressure QTL 217	3.398		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	39106258	67378345	Rat
2316950	Scl66	Serum cholesterol level QTL 66	4.1		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	8	39106363	114525825	Rat
2313046	Bss78	Bone structure and strength QTL 78	3.5	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	8	39106258	91341052	Rat
1582254	Kidm31	Kidney mass QTL 31	3		kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	8	49245178	94245178	Rat
724540	Uae8	Urinary albumin excretion QTL 8	5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	8	39106258	103375958	Rat
1358892	Kidm26	Kidney mass QTL 26	3.69		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	8	35464071	107982864	Rat
631216	Stl9	Serum triglyceride level QTL 9	4.71	0.0001	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	8	50763951	67219641	Rat
1359021	Bp271	Blood pressure QTL 271	1.8		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	34125902	55607752	Rat
1582243	Bw66	Body weight QTL 66	3.4	0.0048	body mass (VT:0001259)	body weight (CMO:0000012)	8	49245178	94245178	Rat
61373	Mcs4	Mammary carcinoma susceptibility QTL 4	1.1		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	8	44475043	89475043	Rat

Markers in Region

D8Rat161

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	43,604,498 - 43,604,640 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	47,521,855 - 47,521,996	NCBI	Rnor6.0
Rnor_5.0	8	45,990,738 - 45,990,879	UniSTS	Rnor5.0
RGSC_v3.4	8	46,234,997 - 46,235,139	RGD	RGSC3.4
RGSC_v3.4	8	46,234,998 - 46,235,139	UniSTS	RGSC3.4
Celera	8	43,194,410 - 43,194,497	UniSTS
RGSC_v3.1	8	46,243,764 - 46,243,905	RGD
RH 3.4 Map	8	411.0	RGD
RH 3.4 Map	8	411.0	UniSTS
RH 2.0 Map	8	325.8	RGD
SHRSP x BN Map	8	33.5	RGD
Cytogenetic Map	8	q22	UniSTS

RH127585

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	43,594,441 - 43,594,638 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	47,511,798 - 47,511,994	NCBI	Rnor6.0
Rnor_5.0	8	45,980,681 - 45,980,877	UniSTS	Rnor5.0
RGSC_v3.4	8	46,224,941 - 46,225,137	UniSTS	RGSC3.4
Celera	8	43,184,363 - 43,184,559	UniSTS
RH 3.4 Map	8	412.3	UniSTS
Cytogenetic Map	8	q22	UniSTS

RH129251

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	43,594,440 - 43,594,636 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	47,511,797 - 47,511,992	NCBI	Rnor6.0
Rnor_5.0	8	45,980,680 - 45,980,875	UniSTS	Rnor5.0
RGSC_v3.4	8	46,224,940 - 46,225,135	UniSTS	RGSC3.4
Celera	8	43,184,362 - 43,184,557	UniSTS
RH 3.4 Map	8	408.8	UniSTS
Cytogenetic Map	8	q22	UniSTS

RH125503

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	43,594,974 - 43,595,132 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	47,512,331 - 47,512,488	NCBI	Rnor6.0
Rnor_5.0	8	45,981,214 - 45,981,371	UniSTS	Rnor5.0
RGSC_v3.4	8	46,225,474 - 46,225,631	UniSTS	RGSC3.4
Celera	8	43,184,896 - 43,185,053	UniSTS
Cytogenetic Map	8	q22	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	158	91	90	59	92	59	6	356	192	11	137	81	92	31	14	14

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001014090	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC079082	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473975	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ227630	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000012826 ⟹ ENSRNOP00000012825

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	8	52,491,315 - 52,509,285 (-)	Ensembl
mRatBN7.2 Ensembl	8	43,594,363 - 43,612,334 (-)	Ensembl
Rnor_6.0 Ensembl	8	47,511,719 - 47,529,689 (-)	Ensembl

RefSeq Acc Id:

NM_001014090 ⟹ NP_001014112

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	52,491,314 - 52,509,285 (-)	NCBI
mRatBN7.2	8	43,594,362 - 43,612,334 (-)	NCBI
Rnor_6.0	8	47,511,718 - 47,529,689 (-)	NCBI
Rnor_5.0	8	45,980,601 - 45,998,572 (-)	NCBI
RGSC_v3.4	8	46,224,861 - 46,242,832 (-)	RGD
Celera	8	43,184,283 - 43,202,190 (-)	RGD

Sequence:

show sequence

GCGCGACCCACGTGAATTCGCAGCACGTCGTGGGGGAACCTCCGGATTGAGTCTCTCCTCTCGA
GGTGGGGACTGCCGGGAATCCCCGAACCGGACCCCCAACTTCGGGCAAACTTTGTAGGCGCGTC
TCCCCTCCCCCACGCGGCGCGCCGGGGGCCCCGGGGATGCGGCCCCCTGGCCGCCGCGACGTCC
CCTCGGCGCGCCCCGCGCTGCCGCTGCTGCTGCTGCTGCTGTCGCCGCTGCTGCTTGGGGCGCC
GCACGGCGTGGGCGCGAGTAGCGGCGCTCCGGCCGAGCTGCGGGTTCGTGTGAGGCTGCCCGAC
GGCCAGGTGACTGAGGAGAGTCTGCAAGCGGACAGCGACGCCGACAGCATCAGCCTTGATCTGC
GCAAACCGGACGGCACTCTCATCTCCTTCATCGCGGATTTCAAGAAGGATGTGAAGATCTTCCG
AGCCCTGATCCTGGGGGAGCTGGAGAAGGGGCAAAGTCAGTTCCAGGCACTCTGCTTTGTCACA
CGACTGTACCACAATGAGATCATCCCCAGTGAGGCCATGGCCAAGCTCCGGCAGAAAAACCCCC
GCGCGGTGCGGCAGGCTGAAGAAGTGCGCGGTCTGGAGCAGCTACACATGGACATTGCCGTTAA
CTTCAGTCAGGGAGGCCTGCTGAGTCCCCATCTCCGCAACGTGTGTGCCGAGGCCACCGATGCC
ATCTACACGCGCCAGGAGGATGCCCAGTTCTGGACAGAGCGAGGTGTGGACAGTTCTGTGTTCG
AGCCTCTGCTCAAGGAGTTAGAACAGGTGGAATTACCTCGTTGTGGACAAGTGGGGGACCGAGG
AAAGCCCTGCATCTGCCATTACAGTCTGAGCCTGGCCTGGTACCCCTGCATGCTCAAGTACTGC
CACAGCCGTGACCGGCCAGCGCCCTACAAGTGTGGTATCCGAAGCTGCAGAAAAAGCTACCGCT
TTGACTTCTATGTACCTCAGAGGCAGTTGTGCCTCTGGGATGAGGACCCCTAACTGCAGGACCC
AGGACCAAGGACCCAGGATGGATGCTTGGGCCCGCAAGTCCTTCACTGACCACCAGAGGGCGAT
GCAACCCAATCTGAGACCTTAGGTCTCTTCCTGAGCCTCTGCCCCTGAAGCCACGGCCTCATCT
GCATGAATTGAGAGAGGGTTGCAGTGTGGGCAACCCTGAGGCAGCCCTGAAGCCTAACTGCGCC
CATCTTGAGGCAGAGGGGGTTAAAGCAGTTCTCCAGACTGGTACCCTTGCCTCTCCTTTCCCCT
GAAGTGCTCACATATGTGGAATCAAAAGGTACCAGCCTAGGCTGCTTTTGTGGAACTTGTTCTG
GAGGCGTGGCCCTGCAGCAAGGGAACCTTTTCACCAGCAAGGGAACCAGAGAGGGACAGCTGGG
GACTCATGCCCCAGCTCTTGTGTCCAGTTACAGTGCCTTCTTTCTACCCTGGGGGCAACGGGGA
GCAGGGATGCCGCCCCCAAGACCCAATTTGTGTGCCTTTTCTGAGACCCAACTTGGATACTTCA
GCAGGCACCGATTCTTCCTGCCTCTGGGCTGAAGAACTTTGGCAAGGTTCTGGGGCAGGGAGGG
AGCATGAAGTACAAGGAAAACTTGAATTCCAGATTTTTAATACAAAATATTTATCATTTGTACC
AGAAATAAAAGTCGTTTAAGTTTTCACTCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001014112	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH79082	(Get FASTA)	NCBI Sequence Viewer
	EDL95263	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000012825
	ENSRNOP00000012825.4
GenBank Protein	Q6AYE5	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_001014112 ⟸ NM_001014090
- Peptide Label:	precursor
- UniProtKB:	Q6AYE5 (UniProtKB/Swiss-Prot), A6J3U0 (UniProtKB/TrEMBL)
- Sequence:	show sequence MRPPGRRDVPSARPALPLLLLLLSPLLLGAPHGVGASSGAPAELRVRVRLPDGQVTEESLQADS DADSISLDLRKPDGTLISFIADFKKDVKIFRALILGELEKGQSQFQALCFVTRLYHNEIIPSEA MAKLRQKNPRAVRQAEEVRGLEQLHMDIAVNFSQGGLLSPHLRNVCAEATDAIYTRQEDAQFWT ERGVDSSVFEPLLKELEQVELPRCGQVGDRGKPCICHYSLSLAWYPCMLKYCHSRDRPAPYKCG IRSCRKSYRFDFYVPQRQLCLWDEDP hide sequence

Ensembl Acc Id:

ENSRNOP00000012825 ⟸ ENSRNOT00000012826

Protein Domains

Out at first C-terminal Out at first protein BRICHOS-like

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q6AYE5-F1-model_v2	AlphaFold	Q6AYE5	1-282	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13695878

Promoter ID:

EPDNEW_R6403

Type:

multiple initiation site

Name:

Oaf_1

Description:

out at first homolog

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	8	47,529,754 - 47,529,814	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1305890	AgrOrtholog
BioCyc Gene	G2FUF-30760	BioCyc
Ensembl Genes	ENSRNOG00000009243	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000012826	ENTREZGENE
	ENSRNOT00000012826.5	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7122787	IMAGE-MGC_LOAD
InterPro	Oaf	UniProtKB/Swiss-Prot
	Oaf_C	UniProtKB/Swiss-Prot
	OAF_N	UniProtKB/Swiss-Prot
KEGG Report	rno:315594	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:94042	IMAGE-MGC_LOAD
NCBI Gene	315594	ENTREZGENE
PANTHER	OUT AT FIRST PROTEIN HOMOLOG	UniProtKB/Swiss-Prot
	PTHR13423	UniProtKB/Swiss-Prot
Pfam	OAF	UniProtKB/Swiss-Prot
	OAF_C	UniProtKB/Swiss-Prot
PhenoGen	Oaf	PhenoGen
RatGTEx	ENSRNOG00000009243	RatGTEx
UniProt	A6J3U0	ENTREZGENE, UniProtKB/TrEMBL
	OAF_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-07-09	Oaf	out at first homolog	Oaf	OAF homolog (Drosophila)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-07	Oaf	OAF homolog (Drosophila)	RGD1305890	similar to RIKEN cDNA D130038B21	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-12-06	RGD1305890	similar to RIKEN cDNA D130038B21	RGD1305890_predicted	similar to RIKEN cDNA D130038B21 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-20	RGD1305890_predicted	similar to RIKEN cDNA D130038B21 (predicted)	LOC315594_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC315594_predicted	similar to RIKEN cDNA D130038B21 (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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