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Gene: Cd320 (CD320 molecule) Rattus norvegicus

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Symbol:

Cd320 (Ensembl: Ndufa7)

Name:

CD320 molecule (Ensembl:NADH:ubiquinone oxidoreductase subunit A7)

RGD ID:

1305860

Description:

Predicted to enable calcium ion binding activity; cargo receptor activity; and cobalamin binding activity. Predicted to be involved in B cell costimulation; cobalamin transport; and positive regulation of B cell proliferation. Predicted to act upstream of or within regulation of vitamin metabolic process. Predicted to be located in membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in methylmalonic acidemia due to transcobalamin receptor defect. Orthologous to human CD320 (CD320 molecule); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

CD320 antigen; CD320 antigen-like; LOC362851; RGD1305860; similar to 8D6 antigen; TCblR; transcobalamin receptor

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CD320 (CD320 molecule)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Cd320 (CD320 antigen)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Cd320 (CD320 molecule)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	CD320 (CD320 molecule)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CD320 (CD320 molecule)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Cd320 (CD320 molecule)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CD320 (CD320 molecule)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CD320 (CD320 molecule)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Cd320 (CD320 molecule)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Cd320 (CD320 molecule)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	NDUFA7 (NADH:ubiquinone oxidoreductase subunit A7)	HGNC	EggNOG, Inparanoid, PhylomeDB, Treefam
Alliance orthologs ³
Homo sapiens (human):	CD320 (CD320 molecule)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	CD320 (CD320 molecule)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Cd320 (CD320 antigen)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Cd320 (CD320 antigen)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG6739	Alliance	DIOPT (OrthoFinder\|PANTHER)
Drosophila melanogaster (fruit fly):	Culd	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Caenorhabditis elegans (roundworm):	lrx-1	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Caenorhabditis elegans (roundworm):	lrx-1	Alliance	DIOPT (Ensembl Compara\|PANTHER)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	15,328,320 - 15,334,138 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	7	15,311,286 - 15,334,138 (+)	Ensembl				GRCr8
mRatBN7.2	7	14,626,171 - 14,631,976 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	14,609,146 - 14,631,976 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	7	17,634,732 - 17,640,527 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	19,500,017 - 19,505,812 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	17,380,359 - 17,386,154 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	18,700,445 - 18,706,244 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	18,700,344 - 18,706,244 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	7	18,878,058 - 18,883,844 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	7	16,338,136 - 16,343,892	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
RGSC_v3.1	7	16,338,135 - 16,343,892	NCBI
Cytogenetic Map	7	q13	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

methylmalonic acidemia due to transcobalamin receptor defect (ISO,ISS)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4,4'-trichlorobiphenyl (ISO)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

4,4'-sulfonyldiphenol (ISO)

acetamide (EXP)

acrylamide (ISO)

all-trans-retinoic acid (ISO)

alpha-Zearalanol (EXP)

amiodarone (ISO)

ammonium chloride (EXP)

Aroclor 1254 (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenite(3-) (ISO)

benzo[a]pyrene (ISO)

beta-lapachone (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

cadmium dichloride (EXP)

carbon nanotube (ISO)

chlorpyrifos (ISO)

chromium(6+) (ISO)

copper atom (ISO)

copper(0) (ISO)

coumestrol (ISO)

cyclosporin A (ISO)

Dibutyl phosphate (ISO)

dibutyl phthalate (ISO)

doxorubicin (ISO)

ethyl methanesulfonate (ISO)

flutamide (EXP)

folic acid (ISO)

manganese atom (ISO)

manganese(0) (ISO)

manganese(II) chloride (ISO)

methyl methanesulfonate (ISO)

okadaic acid (ISO)

ozone (ISO)

paracetamol (EXP)

PCB138 (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (EXP)

sodium arsenate (ISO)

sodium arsenite (ISO)

sunitinib (ISO)

tamoxifen (ISO)

tert-butyl hydroperoxide (ISO)

testosterone (EXP,ISO)

tetrachloromethane (EXP)

thiram (ISO)

titanium dioxide (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

B cell costimulation (ISO,ISS)

cobalamin transport (ISO,ISS)

positive regulation of B cell proliferation (ISO,ISS)

regulation of vitamin metabolic process (ISO)

signal transduction (IEA)

vesicle-mediated transport (IEA)

Cellular Component

endomembrane system (IEA)

endoplasmic reticulum (ISO)

membrane (IEA)

plasma membrane (IBA,IEA,ISO,ISS)

Molecular Function

calcium ion binding (ISO,ISS)

cargo receptor activity (ISO)

cobalamin binding (ISO)

growth factor activity (IEA)

metal ion binding (IEA)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
3.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
5.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:10727470	PMID:18779389	PMID:19946888	PMID:20524213	PMID:23376485	PMID:23430977	PMID:27411955

Genomics

Comparative Map Data

Cd320
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	15,328,320 - 15,334,138 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	7	15,311,286 - 15,334,138 (+)	Ensembl				GRCr8
mRatBN7.2	7	14,626,171 - 14,631,976 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	14,609,146 - 14,631,976 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	7	17,634,732 - 17,640,527 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	19,500,017 - 19,505,812 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	17,380,359 - 17,386,154 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	18,700,445 - 18,706,244 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	18,700,344 - 18,706,244 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	7	18,878,058 - 18,883,844 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	7	16,338,136 - 16,343,892	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
RGSC_v3.1	7	16,338,135 - 16,343,892	NCBI
Cytogenetic Map	7	q13	NCBI

CD320
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	8,302,127 - 8,308,358 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	8,302,126 - 8,308,366 (-)	Ensembl			hg38	GRCh38
GRCh37	19	8,367,011 - 8,373,242 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	8,273,011 - 8,279,239 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	19	8,273,010 - 8,279,239	NCBI
Celera	19	8,223,534 - 8,229,765 (-)	NCBI		Celera
Cytogenetic Map	19	p13.2	NCBI
HuRef	19	8,021,040 - 8,027,272 (-)	NCBI		HuRef
CHM1_1	19	8,366,510 - 8,372,742 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	19	8,288,656 - 8,294,880 (-)	NCBI		T2T-CHM13v2.0

Cd320
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	34,062,065 - 34,068,748 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	34,062,065 - 34,068,748 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	17	33,843,091 - 33,849,774 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	33,843,091 - 33,849,774 (+)	Ensembl			mm10	GRCm38
MGSCv37	17	33,980,036 - 33,986,719 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	17	33,449,214 - 33,456,005 (+)	NCBI		MGSCv36	mm8
Celera	17	36,600,303 - 36,608,793 (+)	NCBI		Celera
Cytogenetic Map	17	B1	NCBI
cM Map	17	17.98	NCBI

Cd320
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955563	1,084,474 - 1,093,111 (+)	Ensembl
ChiLan1.0	NW_004955563	1,084,523 - 1,089,395 (+)	NCBI	ChiLan1.0	ChiLan1.0

CD320
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	12,969,658 - 12,975,998 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	12,086,331 - 12,092,672 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	7,587,760 - 7,594,055 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	8,438,955 - 8,445,464 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	8,438,955 - 8,445,464 (-)	Ensembl			panPan2	panpan1.1

CD320
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	52,886,087 - 52,890,361 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	52,886,087 - 52,890,366 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	52,687,555 - 52,691,829 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	53,414,068 - 53,418,342 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	53,414,068 - 53,418,348 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	52,616,774 - 52,621,039 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	53,062,048 - 53,066,321 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	53,293,654 - 53,297,928 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Cd320
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	212,687,660 - 212,692,222 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936588	5,142,561 - 5,147,074 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936588	5,142,561 - 5,147,111 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CD320
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	70,965,672 - 70,970,288 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	2	70,961,897 - 70,970,289 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

CD320
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	7,666,201 - 7,673,088 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	7,665,895 - 7,673,599 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666074	12,617,008 - 12,624,955 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Cd320
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624828	1,102,306 - 1,106,211 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624828	1,102,016 - 1,106,314 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Cd320
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	1	158,568,912 - 158,574,590 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Cd320
35 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	184
Count of miRNA genes:	131
Interacting mature miRNAs:	139
Transcripts:	ENSRNOT00000009067
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
61410	Bw19	Body weight QTL 19	6.2	0.001	body mass (VT:0001259)	body weight (CMO:0000012)	7	1669658	46669658	Rat
1300176	Hrtrt10	Heart rate QTL 10	3.19		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	7	1	23748937	Rat
9590102	Sffal5	Serum free fatty acids level QTL 5	8.62	0.001	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	7	7216097	52216097	Rat
1578652	Bmd15	Bone mineral density QTL 15	5.2		femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	7	10517086	62346019	Rat
1643004	Pain2	Pain QTL 2	1		mechanical nociception trait (VT:0002734)	self mutilation severity score (CMO:0002145)	7	10112916	99900612	Rat
2290372	Gluco33	Glucose level QTL 33	2.71		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	7	1	31777942	Rat
1300149	Cm6	Cardiac mass QTL 6	4.09		heart mass (VT:0007028)	heart left ventricle weight to body weight ratio (CMO:0000530)	7	1	104117804	Rat
631503	Bp102	Blood pressure QTL 102	1.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	1709527	46709527	Rat
634336	Anxrr17	Anxiety related response QTL 17	3.66		locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	7	1509236	116977875	Rat
9590142	Scort5	Serum corticosterone level QTL 5	24.4	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	7	1	32612984	Rat
1582260	Bw72	Body weight QTL 72	3.2	0.0043	body mass (VT:0001259)	body weight (CMO:0000012)	7	1	39960528	Rat
1582261	Bw69	Body weight QTL 69	3.2	0.0048	body mass (VT:0001259)	body weight (CMO:0000012)	7	1	39960528	Rat
1582262	Bw75	Body weight QTL 75	3	0.0038	body mass (VT:0001259)	body weight (CMO:0000012)	7	1	39960528	Rat
2298547	Neuinf5	Neuroinflammation QTL 5	3.7		nervous system integrity trait (VT:0010566)	spinal cord Cd74 protein level (CMO:0002131)	7	10112916	60150541	Rat
10059592	Kidm45	Kidney mass QTL 45	3.95	0.025	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	7	9460877	54460877	Rat
2298550	Neuinf6	Neuroinflammation QTL 6	3.3		nervous system integrity trait (VT:0010566)	spinal cord RT1-B protein level (CMO:0002132)	7	1	29716167	Rat
1300138	Hrtrt9	Heart rate QTL 9	4.72		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	7	10498820	55498820	Rat
724560	Plsm3	Polydactyly-luxate syndrome (PLS) morphotypes QTL 3		0.0003	tibia length (VT:0004357)	tibia length (CMO:0000450)	7	1	34650782	Rat
7411566	Bw136	Body weight QTL 136	10.4	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	7	1	32612984	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	161	91	90	59	92	59	6	356	192	11	140	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001014201	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001393847	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006241128	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC088861	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ219198	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ234194	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000007	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000009067 ⟹ ENSRNOP00000009067

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	7	15,311,286 - 15,334,138 (+)	Ensembl
mRatBN7.2 Ensembl	7	14,626,183 - 14,631,971 (+)	Ensembl
Rnor_6.0 Ensembl	7	18,700,344 - 18,706,244 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000009425 ⟹ ENSRNOP00000009425

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	7	15,311,437 - 15,324,748 (+)	Ensembl
mRatBN7.2 Ensembl	7	14,609,262 - 14,622,564 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000095587 ⟹ ENSRNOP00000084734

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	14,609,240 - 14,622,598 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000104433 ⟹ ENSRNOP00000090950

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	7	15,311,286 - 15,334,138 (+)	Ensembl
mRatBN7.2 Ensembl	7	14,609,146 - 14,631,976 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000119702 ⟹ ENSRNOP00000094620

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	14,628,707 - 14,631,976 (+)	Ensembl

RefSeq Acc Id:

NM_001014201 ⟹ NP_001014223

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	15,328,343 - 15,334,138 (+)	NCBI
mRatBN7.2	7	14,626,181 - 14,631,976 (+)	NCBI
Rnor_6.0	7	18,700,488 - 18,706,244 (+)	NCBI
Rnor_5.0	7	18,878,058 - 18,883,844 (+)	NCBI
RGSC_v3.4	7	16,338,136 - 16,343,892 (+)	RGD

Sequence:

show sequence

CGCGGCTGGAGCGGAGCCGAGCGGTTCAGCCAGCGGTTGGATGGCGCGGTGCGGAGCTGGGCGG
GCAGCCGCCCTGGGCCTGGTGCTGCGGCTGCTCTTGGGTCTTAGAACAGGTCCCGAGGCCGCTC
CGGCTCCAACCTCGGCTCCGGCCCATACCCTAGTCCAAGTCTCGGGCCCTAGAGCTGGCTCCTG
CCCAACAGACACCTTCAAGTGTCTTACCAGTGGCTACTGTGTGCCCCTCTCCTGGCGCTGCGAT
GGGGACCGGGATTGCTCTGATGGCAGTGACGAGGAAGAGTGTAGAATTGAGCCATGTGCTCAGA
ATAGGCAGTGCCAGCCACAGCCTGCCCTTCCTTGCTCCTGTGACAACATCAGTGGTTGCTCCGC
TGGCTCAGACAAGAACCTCAACTGTAGCCGCTCACCCTGTCAGGAGGGCGAGCTGCGTTGCATA
CTGGATGATGTCTGTATCCCACACACGTGGCGCTGTGATGGCCACCCAGACTGTCCTGACTCCA
GTGATGAGCTCAGCTGTGACACCGACACAGAAACTGACAAGATATTCCAGGAGGAGAATGCCAC
AACCTCAATGTCTTCTATGATTGTGGAGAAAGAGACCTCTTTCAGAAATGTCACAGTTGCTTCT
GCTGGGCACCCATCCCGAAACCCAAATGCCTATGGGGTTATCGCAGCTGCTGGGGTGTTGAGTG
CCATCCTGGTTTCAGCTACCATTCTCATATTGCTACGACTCAGAGGTCAGGGTTATCTACCCCC
AACAGGGCTGTTGGTGGCTGTGAAGGAGTCGCTGCTGCTGTCAGAAAGGAAAACCTCTTTGATC
TGAGGACATGGTTCCCACCTGGCCCTGAGTACAGTCAGACTGGAACAAAGCTGCAGTGGAACAT
GCAGGTAGCAACTGGCTTCTCAGCTCCGAGACCTGGGCTCTTTTGGCCACAGAGAACTTTGATT
TTTAAACTTCTTCAGATGTGGTCCTGGAGACTGGAGGTCGTCAGACACTCCCTTTGTATGTGGT
GAGCTTTGCTGGAAAATCGCCATAGCCAGGACTGAGGGGCCAGTCCCAGGATGCTCCCAAGAAA
TGGGGCCACCCTGATCTAAACACTCCTTCTGCTCACATTGATGGGCAGCTATTAAAGTTTCTTC
ACCCCCTCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAGG

hide sequence

RefSeq Acc Id:

NM_001393847 ⟹ NP_001380776

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	15,328,343 - 15,334,138 (+)	NCBI
mRatBN7.2	7	14,626,181 - 14,631,976 (+)	NCBI

RefSeq Acc Id:

XM_006241128 ⟹ XP_006241190

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	15,328,320 - 15,334,138 (+)	NCBI
mRatBN7.2	7	14,626,171 - 14,631,976 (+)	NCBI
Rnor_6.0	7	18,700,445 - 18,706,244 (+)	NCBI
Rnor_5.0	7	18,878,058 - 18,883,844 (+)	NCBI

Sequence:

show sequence

CTTTGTGTGCGCGTGCGCGAGAATCAGCGCACCTCTGTGCAGTCGCGGCTGGAGCGGAGCCGAG
CGGTTCAGCCAGCGGTTGGATGGCGCGGTGCGGAGCTGGGCGGGCAGCCGCCCTGGGCCTGGTG
CTGCGGCTGCTCTTGGGTCTTAGAACAGGTCCCGAGGCCGCTCCGGCTCCAACCTCGGCTCCGG
CCCATACCCTAGTCCAAGTCTCGGGCCCTAGAGCTGGCTCCTGCCCAACAGACACCTTCAAGTG
TCTTACCAGTGGCTACTGTGTGCCCCTCTCCTGGCGCTGCGATGGGGACCGGGATTGCTCTGAT
GGCAGTGACGAGGAAGAGTGTAGAATTGAGCCATGTGCTCAGAATAGGCAGTGCCAGCCACAGC
CTGCCCTTCCTTGCTCCTGTGACAACATCAGTGGTTGCTCCGCTGGCTCAGACAAGAACCTCAA
CTGTAGCCGCTCACCCTGTCAGGAGGGCGAGCTGCGTTGCATACTGGATGATGTCTGTATCCCA
CACACGTGGCGCTGTGATGGCCACCCAGACTGTCCTGACTCCAGTGATGAGCTCAGCTGTGACA
CCGACACAGAAACTGACAAGATATTCCAGGAGGAGAATGCCACAACCTCAATGTCTTCTATGAT
TGTGGAGAAAGAGACCTCTTTCAGAAATGTCACAGTTGCTTCTGCTGGGCACCCATCCCGAAAC
CCAAATGCCTATGGGGTTATCGCAGCTGCTGGGCTGTTGGTGGCTGTGAAGGAGTCGCTGCTGC
TGTCAGAAAGGAAAACCTCTTTGATCTGAGGACATGGTTCCCACCTGGCCCTGAGTACAGTCAG
ACTGGAACAAAGCTGCAGTGGAACATGCAGGTAGCAACTGGCTTCTCAGCTCCGAGACCTGGGC
TCTTTTGGCCACAGAGAACTTTGATTTTTAAACTTCTTCAGATGTGGTCCTGGAGACTGGAGGT
CGTCAGACACTCCCTTTGTATGTGGTGAGCTTTGCTGGAAAATCGCCATAGCCAGGACTGAGGG
GCCAGTCCCAGGATGCTCCCAAGAAATGGGGCCACCCTGATCTAAACACTCCTTCTGCTCACAT
TGATGGGCAGCTATTAAAGTTTCTTCACCCCCTC

hide sequence

Protein Sequences


Protein RefSeqs	NP_001014223	(Get FASTA)	NCBI Sequence Viewer
	NP_001380776	(Get FASTA)	NCBI Sequence Viewer
	XP_006241190	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH88861	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000009067.4
GenBank Protein	Q5HZW5	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_001014223 ⟸ NM_001014201
- Peptide Label:	isoform 1 precursor
- UniProtKB:	Q5HZW5 (UniProtKB/Swiss-Prot), A0A8I6AK05 (UniProtKB/TrEMBL)
- Sequence:	show sequence MARCGAGRAAALGLVLRLLLGLRTGPEAAPAPTSAPAHTLVQVSGPRAGSCPTDTFKCLTSGYC VPLSWRCDGDRDCSDGSDEEECRIEPCAQNRQCQPQPALPCSCDNISGCSAGSDKNLNCSRSPC QEGELRCILDDVCIPHTWRCDGHPDCPDSSDELSCDTDTETDKIFQEENATTSMSSMIVEKETS FRNVTVASAGHPSRNPNAYGVIAAAGVLSAILVSATILILLRLRGQGYLPPTGLLVAVKESLLL SERKTSLI hide sequence

RefSeq Acc Id:

XP_006241190 ⟸ XM_006241128

- Peptide Label:

isoform X1

- Sequence:

show sequence

MARCGAGRAAALGLVLRLLLGLRTGPEAAPAPTSAPAHTLVQVSGPRAGSCPTDTFKCLTSGYC
VPLSWRCDGDRDCSDGSDEEECRIEPCAQNRQCQPQPALPCSCDNISGCSAGSDKNLNCSRSPC
QEGELRCILDDVCIPHTWRCDGHPDCPDSSDELSCDTDTETDKIFQEENATTSMSSMIVEKETS
FRNVTVASAGHPSRNPNAYGVIAAAGLLVAVKESLLLSERKTSLI

hide sequence

Ensembl Acc Id:

ENSRNOP00000009067 ⟸ ENSRNOT00000009067

Ensembl Acc Id:

ENSRNOP00000084734 ⟸ ENSRNOT00000095587

Ensembl Acc Id:

ENSRNOP00000090950 ⟸ ENSRNOT00000104433

Ensembl Acc Id:

ENSRNOP00000009425 ⟸ ENSRNOT00000009425

Ensembl Acc Id:

ENSRNOP00000094620 ⟸ ENSRNOT00000119702

RefSeq Acc Id:	NP_001380776 ⟸ NM_001393847
- Peptide Label:	isoform 2 precursor
- UniProtKB:	A0A8I6AK05 (UniProtKB/TrEMBL)

Protein Domains

LDL-receptor class A

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q5HZW5-F1-model_v2	AlphaFold	Q5HZW5	1-264	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13695090

Promoter ID:

EPDNEW_R5614

Type:

initiation region

Name:

Cd320_1

Description:

CD320 molecule

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	7	18,700,475 - 18,700,535	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1305860	AgrOrtholog
BioCyc Gene	G2FUF-34705	BioCyc
Ensembl Genes	ENSRNOG00000006901	Ensembl, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000009067.7	UniProtKB/Swiss-Prot
Gene3D-CATH	4.10.400.10	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7310701	IMAGE-MGC_LOAD
InterPro	LDL_receptor-like_sf	UniProtKB/Swiss-Prot
	LDLR	UniProtKB/Swiss-Prot
	LDLR_class-A_CS	UniProtKB/Swiss-Prot
	LDrepeatLR_classA_rpt	UniProtKB/Swiss-Prot
KEGG Report	rno:362851	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:105707	IMAGE-MGC_LOAD
NCBI Gene	362851	ENTREZGENE
PANTHER	CD320 ANTIGEN	UniProtKB/Swiss-Prot
	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED	UniProtKB/Swiss-Prot
Pfam	Ldl_recept_a	UniProtKB/Swiss-Prot
PhenoGen	Cd320	PhenoGen
PRINTS	LDLRECEPTOR	UniProtKB/Swiss-Prot
PROSITE	LDLRA_1	UniProtKB/Swiss-Prot
	LDLRA_2	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000006901	RatGTEx
SMART	LDLa	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF57424	UniProtKB/Swiss-Prot
UniProt	A0A8I6AEH1_RAT	UniProtKB/TrEMBL
	A0A8I6AK05	ENTREZGENE
	CD320_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2013-05-24	Cd320	CD320 molecule	LOC100365110	CD320 antigen-like	Data merged from RGD:2319663	1643240	APPROVED
2013-05-24	Cd320	CD320 molecule	LOC688345	similar to 8D6 antigen	Data merged from RGD:1590028	1643240	APPROVED
2010-05-05	LOC100365110	CD320 antigen-like			Symbol and Name status set to provisional	70820	PROVISIONAL
2008-06-27	Cd320	CD320 molecule	Cd320	CD320 antigen	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-11-20	LOC688345	similar to 8D6 antigen			Symbol and Name status set to provisional	70820	PROVISIONAL
2006-03-30	Cd320	CD320 antigen	RGD1305860	similar to 8D6 antigen	Symbol and Name updated	1299863	APPROVED
2005-12-06	RGD1305860	similar to 8D6 antigen	RGD1305860_predicted	similar to 8D6 antigen (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-20	RGD1305860_predicted	similar to 8D6 antigen (predicted)	LOC362851_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC362851_predicted	similar to 8D6 antigen (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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