Tpte2 (transmembrane phosphoinositide 3-phosphatase and tensin homolog 2) - Rat Genome Database

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Gene: Tpte2 (transmembrane phosphoinositide 3-phosphatase and tensin homolog 2) Rattus norvegicus
Analyze
Symbol: Tpte2
Name: transmembrane phosphoinositide 3-phosphatase and tensin homolog 2
RGD ID: 1305825
Description: Predicted to enable phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity. Predicted to be involved in dephosphorylation. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in cytosol. Orthologous to several human genes including TPTE2 (transmembrane phosphoinositide 3-phosphatase and tensin homolog 2); INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; acrylamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC102551183; LOC364629; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase TPTE2; Tpte; transmembrane phosphatase with tensin homology; uncharacterized LOC102551183
RGD Orthologs
Human
Bonobo
Dog
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81676,361,330 - 76,455,664 (-)NCBIGRCr8
mRatBN7.21669,658,874 - 69,756,571 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1669,658,875 - 69,752,949 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1674,932,556 - 75,026,628 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01678,363,525 - 78,463,480 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01673,612,811 - 73,712,758 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01674,552,859 - 74,662,194 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1674,558,529 - 74,662,194 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01674,195,701 - 74,298,014 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41674,307,504 - 74,404,175 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11674,307,942 - 74,407,908 (-)NCBI
Celera1667,548,914 - 67,642,237 (-)NCBICelera
Cytogenetic Map16q12.5NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11716755  


Genomics

Comparative Map Data
Tpte2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81676,361,330 - 76,455,664 (-)NCBIGRCr8
mRatBN7.21669,658,874 - 69,756,571 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1669,658,875 - 69,752,949 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1674,932,556 - 75,026,628 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01678,363,525 - 78,463,480 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01673,612,811 - 73,712,758 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01674,552,859 - 74,662,194 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1674,558,529 - 74,662,194 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01674,195,701 - 74,298,014 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41674,307,504 - 74,404,175 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11674,307,942 - 74,407,908 (-)NCBI
Celera1667,548,914 - 67,642,237 (-)NCBICelera
Cytogenetic Map16q12.5NCBI
TPTE2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381319,422,877 - 19,561,574 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1319,422,876 - 19,561,625 (-)EnsemblGRCh38hg38GRCh38
GRCh371319,997,017 - 20,135,714 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361318,895,017 - 19,008,903 (-)NCBINCBI36Build 36hg18NCBI36
Build 341318,895,020 - 19,008,903NCBI
Celera131,058,879 - 1,172,750 (-)NCBICelera
Cytogenetic Map13q12.11NCBI
HuRef13801,874 - 940,548 (-)NCBIHuRef
CHM1_11319,965,075 - 20,103,633 (-)NCBICHM1_1
T2T-CHM13v2.01318,618,970 - 18,757,628 (-)NCBIT2T-CHM13v2.0
TPTE2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21419,063,578 - 19,152,830 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11310,176,165 - 10,265,322 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v013760,622 - 868,521 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11319,080,873 - 19,129,893 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1319,081,026 - 19,154,174 (-)Ensemblpanpan1.1panPan2
LOC606856
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.125309,450 - 474,236 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha25411,707 - 572,107 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.025411,857 - 572,403 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.125313,553 - 474,954 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.025307,507 - 467,897 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.025375,093 - 535,495 (+)NCBIUU_Cfam_GSD_1.0
LOC100625564
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11115,550,458 - 15,628,655 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21115,846,539 - 15,902,180 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TPTE2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.131,358,633 - 1,475,992 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605743,100,075 - 43,171,060 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Tpte2
1082 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:19
Count of miRNA genes:16
Interacting mature miRNAs:17
Transcripts:ENSRNOT00000034670
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)161900443575226532Rat
6903294Stl30Serum triglyceride level QTL 302.60.0013blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)162515279370152793Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)163528887080288870Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)163775215682752156Rat
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)163775215682752156Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164239634584729064Rat
8694429Bw164Body weight QTL 16450.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)165272646484729064Rat
8694364Abfw7Abdominal fat weight QTL 712.220.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)165272646484729064Rat
7411648Foco22Food consumption QTL 22150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)165272646484729064Rat
631525Pia14Pristane induced arthritis QTL 144.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)165571108783402471Rat
1298527Arunc2Aerobic running capacity QTL 22.9exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)166853271675029966Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 5
Low 2 2 2 8 5
Below cutoff 1 14 8 2 8 2 2 13 6 15 3 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000034670   ⟹   ENSRNOP00000029743
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1669,658,875 - 69,752,949 (-)Ensembl
Rnor_6.0 Ensembl1674,558,529 - 74,662,194 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000084351
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1674,985,868 - 74,987,202 (-)Ensembl
RefSeq Acc Id: NM_001419184   ⟹   NP_001406113
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81676,361,333 - 76,455,646 (-)NCBI
mRatBN7.21669,658,877 - 69,753,193 (-)NCBI
RefSeq Acc Id: NM_001419185   ⟹   NP_001406114
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81676,361,333 - 76,455,646 (-)NCBI
mRatBN7.21669,658,877 - 69,753,193 (-)NCBI
RefSeq Acc Id: XM_017600201   ⟹   XP_017455690
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81676,361,330 - 76,455,663 (-)NCBI
mRatBN7.21669,658,874 - 69,753,193 (-)NCBI
Rnor_6.01674,556,851 - 74,630,712 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017600202   ⟹   XP_017455691
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81676,361,330 - 76,436,654 (-)NCBI
mRatBN7.21669,658,874 - 69,734,203 (-)NCBI
Rnor_6.01674,556,851 - 74,630,155 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039094736   ⟹   XP_038950664
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81676,361,330 - 76,455,664 (-)NCBI
mRatBN7.21669,658,874 - 69,753,193 (-)NCBI
RefSeq Acc Id: XM_063275620   ⟹   XP_063131690
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81676,361,330 - 76,455,663 (-)NCBI
RefSeq Acc Id: XM_063275621   ⟹   XP_063131691
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81676,361,330 - 76,455,663 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_017455690   ⟸   XM_017600201
- Peptide Label: isoform X3
- UniProtKB: A6IW76 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017455691   ⟸   XM_017600202
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: ENSRNOP00000029743   ⟸   ENSRNOT00000034670
RefSeq Acc Id: XP_038950664   ⟸   XM_039094736
- Peptide Label: isoform X2
- UniProtKB: A6IW76 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001406113   ⟸   NM_001419184
- UniProtKB: D4ADC8 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001406114   ⟸   NM_001419185
- UniProtKB: D4ADC8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063131690   ⟸   XM_063275620
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063131691   ⟸   XM_063275621
- Peptide Label: isoform X3
Protein Domains
C2 tensin-type   Phosphatase tensin-type   Tyrosine specific protein phosphatases

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4ADC8-F1-model_v2 AlphaFold D4ADC8 1-673 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305825 AgrOrtholog
BioCyc Gene G2FUF-10867 BioCyc
BioCyc Pathway PWY-6368 [3-phosphoinositide degradation] BioCyc
BioCyc Pathway Image PWY-6368 BioCyc
Ensembl Genes ENSRNOG00000024837 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00000059629 Ensembl
Ensembl Transcript ENSRNOT00000034670 ENTREZGENE
  ENSRNOT00000034670.6 UniProtKB/TrEMBL
Gene3D-CATH 1.20.120.350 UniProtKB/TrEMBL
  2.60.40.1110 UniProtKB/TrEMBL
  3.90.190.10 UniProtKB/TrEMBL
InterPro C2_domain_sf UniProtKB/TrEMBL
  Ion_trans UniProtKB/TrEMBL
  Prot-tyrosine_phosphatase-like UniProtKB/TrEMBL
  PTP_cat UniProtKB/TrEMBL
  PTP_VSP_TPTE UniProtKB/TrEMBL
  Tensin_lipid_phosphatase_dom UniProtKB/TrEMBL
  Tensin_phosphatase_C2-dom UniProtKB/TrEMBL
  Tyr_Pase_AS UniProtKB/TrEMBL
  TYR_PHOSPHATASE_dom UniProtKB/TrEMBL
  Volt_channel_dom_sf UniProtKB/TrEMBL
KEGG Report rno:364629 UniProtKB/TrEMBL
NCBI Gene 364629 ENTREZGENE
PANTHER PHOSPHATASE WITH HOMOLOGY TO TENSIN UniProtKB/TrEMBL
  PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE TPTE2-RELATED UniProtKB/TrEMBL
Pfam Ion_trans UniProtKB/TrEMBL
  PTEN_C2 UniProtKB/TrEMBL
  Y_phosphatase UniProtKB/TrEMBL
PhenoGen Tpte2 PhenoGen
PROSITE C2_TENSIN UniProtKB/TrEMBL
  PPASE_TENSIN UniProtKB/TrEMBL
  TYR_PHOSPHATASE_1 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000024837 RatGTEx
  ENSRNOG00000059629 RatGTEx
SMART PTEN_C2 UniProtKB/TrEMBL
Superfamily-SCOP SSF49562 UniProtKB/TrEMBL
  SSF52799 UniProtKB/TrEMBL
  Voltage-gated potassium channels UniProtKB/TrEMBL
UniProt A6IW76 ENTREZGENE, UniProtKB/TrEMBL
  D4ADC8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Tpte2  transmembrane phosphoinositide 3-phosphatase and tensin homolog 2  LOC102551183  uncharacterized LOC102551183  Data merged from RGD:7666555 737654 PROVISIONAL
2013-12-18 LOC102551183  uncharacterized LOC102551183      Symbol and Name status set to provisional 70820 PROVISIONAL
2012-10-16 Tpte2  transmembrane phosphoinositide 3-phosphatase and tensin homolog 2  Tpte  transmembrane phosphatase with tensin homology  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Tpte  transmembrane phosphatase with tensin homology   Tpte_predicted  transmembrane phosphatase with tensin homology (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Tpte_predicted  transmembrane phosphatase with tensin homology (predicted)      Symbol and Name status set to approved 70820 APPROVED