Cep20 (centrosomal protein 20) - Rat Genome Database

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Gene: Cep20 (centrosomal protein 20) Rattus norvegicus
Analyze
Symbol: Cep20
Name: centrosomal protein 20
RGD ID: 1305823
Description: Predicted to enable identical protein binding activity. Predicted to be involved in cilium assembly. Predicted to be located in centriolar satellite. Predicted to be active in centrosome; ciliary basal body; and motile cilium. Orthologous to human CEP20 (centrosomal protein 20); INTERACTS WITH acetamide; bisphenol A; buspirone.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: FGFR1OP N-terminal like; Fopnl; hypothetical protein LOC360461; lisH domain-containing protein FOPNL; LOC360461; RGD1305823; similar to RIKEN cDNA 0610037P05
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8101,221,294 - 1,243,144 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl101,221,371 - 1,245,241 (+)EnsemblGRCr8
mRatBN7.210714,051 - 736,826 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10714,151 - 736,837 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx105,410,887 - 5,432,672 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01035,133,171 - 35,154,956 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010725,419 - 747,073 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.010730,215 - 751,061 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10730,247 - 751,061 (+)Ensemblrn6Rnor6.0
Rnor_5.01011,412,910 - 11,433,757 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.410635,532 - 658,264 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1011,303,582 - 11,325,817 (+)NCBICelera
RGSC_v3.110635,549 - 657,924 (+)NCBI
Cytogenetic Map10q11NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:15616553   PMID:20551181   PMID:21399614  


Genomics

Comparative Map Data
Cep20
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8101,221,294 - 1,243,144 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl101,221,371 - 1,245,241 (+)EnsemblGRCr8
mRatBN7.210714,051 - 736,826 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10714,151 - 736,837 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx105,410,887 - 5,432,672 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01035,133,171 - 35,154,956 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010725,419 - 747,073 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.010730,215 - 751,061 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10730,247 - 751,061 (+)Ensemblrn6Rnor6.0
Rnor_5.01011,412,910 - 11,433,757 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.410635,532 - 658,264 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1011,303,582 - 11,325,817 (+)NCBICelera
RGSC_v3.110635,549 - 657,924 (+)NCBI
Cytogenetic Map10q11NCBI
CEP20
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381615,865,719 - 15,888,603 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1615,865,719 - 15,888,644 (-)Ensemblhg38GRCh38
GRCh371615,959,576 - 15,982,460 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361615,867,078 - 15,889,948 (-)NCBIBuild 36Build 36hg18NCBI36
Celera1615,640,063 - 15,662,935 (-)NCBICelera
Cytogenetic Map16p13.11NCBI
HuRef1615,353,088 - 15,375,951 (-)NCBIHuRef
CHM1_11616,043,945 - 16,066,817 (-)NCBICHM1_1
T2T-CHM13v2.01615,870,661 - 15,893,544 (-)NCBIT2T-CHM13v2.0
Cep20
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391614,117,105 - 14,136,093 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1614,117,108 - 14,135,269 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381614,299,241 - 14,318,229 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1614,299,244 - 14,317,405 (-)Ensemblmm10GRCm38
MGSCv371614,299,337 - 14,317,425 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361614,212,822 - 14,230,910 (-)NCBIMGSCv36mm8
Celera1614,904,358 - 14,922,440 (-)NCBICelera
Cytogenetic Map16A1NCBI
cM Map169.74NCBI
Cep20
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955442649,272 - 665,714 (-)Ensembl
ChiLan1.0NW_004955442650,033 - 665,540 (-)NCBIChiLan1.0ChiLan1.0
CEP20
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21815,923,923 - 15,963,472 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11619,706,953 - 19,730,350 (-)NCBINHGRI_mPanPan1
CEP20
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1628,016,253 - 28,035,117 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl628,016,317 - 28,033,720 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha629,380,040 - 29,398,898 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0628,179,496 - 28,198,376 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl628,179,551 - 28,198,376 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1627,982,823 - 28,001,681 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0627,873,052 - 27,891,925 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0628,278,273 - 28,297,132 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Cep20
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344115,222,806 - 115,235,917 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365013,318,701 - 3,333,845 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365013,320,671 - 3,333,705 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CEP20
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl36,977,215 - 6,996,022 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.136,977,195 - 6,996,024 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CEP20
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1514,887,676 - 14,911,655 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl514,887,680 - 14,911,601 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366606815,126,785 - 15,150,271 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cep20
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624782376,018 - 397,751 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624782378,772 - 432,863 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Cep20
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v197,924,094 - 7,940,285 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Cep20
100 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135730538Rat
7387235Uae41Urinary albumin excretion QTL 415.260.1874urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)10130004247Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1092219745922197Rat
1549898Neuinf3Neuroinflammation QTL 326.4nervous system integrity trait (VT:0010566)MHC Class II RT1A-positive spinal cord ventral horn area to total spinal cord ventral horn area ratio (CMO:0001980)1015893911Rat
631828Alc5Alcohol consumption QTL 52.4consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10117749933Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138832698Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000083714   ⟹   ENSRNOP00000070710
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl101,221,371 - 1,245,241 (+)Ensembl
mRatBN7.2 Ensembl10714,151 - 736,837 (+)Ensembl
Rnor_6.0 Ensembl10730,247 - 751,061 (+)Ensembl
RefSeq Acc Id: NM_001108261   ⟹   NP_001101731
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8101,221,360 - 1,243,144 (+)NCBI
mRatBN7.210714,125 - 735,912 (+)NCBI
Rnor_6.010730,247 - 751,061 (+)NCBI
Rnor_5.01011,412,910 - 11,433,757 (+)NCBI
RGSC_v3.410635,532 - 658,264 (+)RGD
Celera1011,303,582 - 11,325,817 (+)RGD
Sequence:
RefSeq Acc Id: XM_006245848   ⟹   XP_006245910
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8101,221,294 - 1,243,139 (+)NCBI
mRatBN7.210714,051 - 735,910 (+)NCBI
Rnor_6.010730,215 - 751,059 (+)NCBI
Rnor_5.01011,412,910 - 11,433,757 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039086246   ⟹   XP_038942174
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8101,221,346 - 1,243,139 (+)NCBI
mRatBN7.210714,051 - 736,826 (+)NCBI
RefSeq Acc Id: XM_039086247   ⟹   XP_038942175
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8101,221,366 - 1,243,139 (+)NCBI
mRatBN7.210714,051 - 736,826 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001101731 (Get FASTA)   NCBI Sequence Viewer  
  XP_006245910 (Get FASTA)   NCBI Sequence Viewer  
  XP_038942174 (Get FASTA)   NCBI Sequence Viewer  
  XP_038942175 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI58663 (Get FASTA)   NCBI Sequence Viewer  
  EDL84096 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000070710.2
RefSeq Acc Id: NP_001101731   ⟸   NM_001108261
- UniProtKB: B0BN31 (UniProtKB/TrEMBL),   A0A0G2JYM1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006245910   ⟸   XM_006245848
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000070710   ⟸   ENSRNOT00000083714
RefSeq Acc Id: XP_038942175   ⟸   XM_039086247
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038942174   ⟸   XM_039086246
- Peptide Label: isoform X2
Protein Domains
FGFR1 oncogene partner (FOP) N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B0BN31-F1-model_v2 AlphaFold B0BN31 1-174 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696920
Promoter ID:EPDNEW_R7445
Type:multiple initiation site
Name:Fopnl_1
Description:FGFR1OP N-terminal like
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.010730,273 - 730,333EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305823 AgrOrtholog
BioCyc Gene G2FUF-26259 BioCyc
Ensembl Genes ENSRNOG00000053230 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000083714.3 UniProtKB/TrEMBL
Gene3D-CATH 1.20.960.40 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7191394 IMAGE-MGC_LOAD
  IMAGE:8369763 IMAGE-MGC_LOAD
InterPro FOP_dimerisation-dom_N UniProtKB/TrEMBL
  LisH_dimerisation UniProtKB/TrEMBL
KEGG Report rno:360461 UniProtKB/TrEMBL
MGC_CLONE MGC:187652 IMAGE-MGC_LOAD
  MGC:94637 IMAGE-MGC_LOAD
NCBI Gene 360461 ENTREZGENE
PANTHER CENTROSOMAL PROTEIN 20 UniProtKB/TrEMBL
  FGFR1 ONCOGENE PARTNER/LISH DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
Pfam FOP_dimer UniProtKB/TrEMBL
PhenoGen Cep20 PhenoGen
PROSITE LISH UniProtKB/TrEMBL
RatGTEx ENSRNOG00000053230 RatGTEx
SMART LisH UniProtKB/TrEMBL
UniProt A0A0G2JYM1 ENTREZGENE, UniProtKB/TrEMBL
  B0BN31 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-01-17 Cep20  centrosomal protein 20  Fopnl  FGFR1OP N-terminal like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-05-26 Fopnl  FGFR1OP N-terminal like  RGD1305823  similar to RIKEN cDNA 0610037P05  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 RGD1305823  similar to RIKEN cDNA 0610037P05  RGD1305823_predicted  similar to RIKEN cDNA 0610037P05 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1305823_predicted  similar to RIKEN cDNA 0610037P05 (predicted)  LOC360461_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC360461_predicted  similar to RIKEN cDNA 0610037P05 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL