Dpy19l1 (dpy-19 like C-mannosyltransferase 1) - Rat Genome Database

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Gene: Dpy19l1 (dpy-19 like C-mannosyltransferase 1) Rattus norvegicus
Analyze
Symbol: Dpy19l1
Name: dpy-19 like C-mannosyltransferase 1
RGD ID: 1305822
Description: Predicted to enable mannosyltransferase activity. Predicted to be involved in protein C-linked glycosylation. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human DPY19L1 (dpy-19 like C-mannosyltransferase 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: dpy-19 like 1; dpy-19-like 1 (C. elegans); dpy-19-like protein 1; LOC315496; probable C-mannosyltransferase DPY19L1; protein dpy-19 homolog 1; RGD1305822; similar to KIAA0877 protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8831,209,025 - 31,297,485 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl831,209,025 - 31,297,518 (-)EnsemblGRCr8
mRatBN7.2822,933,163 - 23,021,461 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl822,933,163 - 23,021,751 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx826,967,212 - 27,055,504 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0825,264,454 - 25,352,748 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0823,163,977 - 23,252,275 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0825,582,938 - 25,669,394 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl825,582,938 - 25,669,394 (-)Ensemblrn6Rnor6.0
Rnor_5.0825,614,114 - 25,700,693 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4824,072,769 - 24,160,500 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera824,511,253 - 24,598,078 (-)NCBICelera
RGSC_v3.1824,073,528 - 24,160,078 (-)NCBI
Cytogenetic Map8q13NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:19946888  


Genomics

Comparative Map Data
Dpy19l1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8831,209,025 - 31,297,485 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl831,209,025 - 31,297,518 (-)EnsemblGRCr8
mRatBN7.2822,933,163 - 23,021,461 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl822,933,163 - 23,021,751 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx826,967,212 - 27,055,504 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0825,264,454 - 25,352,748 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0823,163,977 - 23,252,275 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0825,582,938 - 25,669,394 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl825,582,938 - 25,669,394 (-)Ensemblrn6Rnor6.0
Rnor_5.0825,614,114 - 25,700,693 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4824,072,769 - 24,160,500 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera824,511,253 - 24,598,078 (-)NCBICelera
RGSC_v3.1824,073,528 - 24,160,078 (-)NCBI
Cytogenetic Map8q13NCBI
DPY19L1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38734,928,881 - 35,038,041 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl734,921,469 - 35,038,271 (-)Ensemblhg38GRCh38
GRCh37734,968,493 - 35,077,653 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36734,935,018 - 35,044,178 (-)NCBIBuild 36Build 36hg18NCBI36
Celera734,950,233 - 35,064,182 (-)NCBICelera
Cytogenetic Map7p14.2NCBI
HuRef734,850,682 - 34,959,739 (-)NCBIHuRef
CHM1_1734,968,025 - 35,077,232 (-)NCBICHM1_1
T2T-CHM13v2.0735,069,558 - 35,178,714 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2735,013,501 - 35,122,613 (-)NCBI
Dpy19l1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39924,323,074 - 24,414,436 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl924,323,072 - 24,414,436 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38924,411,778 - 24,503,140 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl924,411,776 - 24,503,140 (-)Ensemblmm10GRCm38
MGSCv37924,216,222 - 24,307,584 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36924,162,456 - 24,238,321 (-)NCBIMGSCv36mm8
Celera921,668,614 - 21,759,826 (-)NCBICelera
Cytogenetic Map9A4NCBI
cM Map910.15NCBI
Dpy19l1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955560910,499 - 995,059 (+)Ensembl
ChiLan1.0NW_004955560895,807 - 997,538 (+)NCBIChiLan1.0ChiLan1.0
DPY19L1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2639,742,575 - 39,851,291 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1788,067,310 - 88,176,026 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0735,544,932 - 35,653,628 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1735,934,363 - 36,024,127 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl735,937,045 - 36,024,129 (-)EnsemblpanPan2panpan1.1
DPY19L1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11446,657,691 - 46,762,531 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1446,658,539 - 46,753,748 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1446,053,500 - 46,195,410 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01446,551,784 - 46,693,618 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1446,599,443 - 46,693,881 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11446,659,557 - 46,801,368 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01446,381,887 - 46,477,726 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01446,709,616 - 46,851,600 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Dpy19l2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511891,583,893 - 91,658,710 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647810,795,658 - 10,870,303 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647810,626,328 - 10,870,360 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DPY19L1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1838,801,334 - 38,903,662 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11838,801,343 - 39,084,190 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21842,632,534 - 42,735,195 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DPY19L1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12123,390,290 - 23,497,607 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366619617,572 - 64,334 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dpy19l1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624953613,729 - 703,252 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624953614,690 - 703,119 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Dpy19l1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1820,413,059 - 20,501,810 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Dpy19l1
783 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:602
Count of miRNA genes:271
Interacting mature miRNAs:331
Transcripts:ENSRNOT00000036738
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357398Slep3Serum leptin concentration QTL 33.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)81799410550763951Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)81699464261994642Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)81038254055382540Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)81296416557964165Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)81595227960952279Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)81296416557964165Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)81799386262252873Rat
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)81038254055382540Rat
9590084Insglur5Insulin/glucose ratio QTL 518.540.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)8132882639Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)81038254055382540Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)81699464261994642Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)81296416557964165Rat
2302367Slep5Serum leptin concentration QTL 53.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)81799410550763951Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)81038254055382540Rat

Markers in Region
RH142243  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2822,935,095 - 22,935,245 (+)MAPPERmRatBN7.2
Rnor_6.0825,584,946 - 25,585,095NCBIRnor6.0
Rnor_5.0825,616,122 - 25,616,271UniSTSRnor5.0
RGSC_v3.4824,074,702 - 24,074,851UniSTSRGSC3.4
Celera824,513,186 - 24,513,335UniSTS
RH 3.4 Map8205.09UniSTS
Cytogenetic Map8q13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000036738   ⟹   ENSRNOP00000033222
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl831,209,025 - 31,297,518 (-)Ensembl
mRatBN7.2 Ensembl822,933,163 - 23,021,751 (-)Ensembl
Rnor_6.0 Ensembl825,582,938 - 25,669,394 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000112774   ⟹   ENSRNOP00000078838
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl831,209,025 - 31,297,518 (-)Ensembl
mRatBN7.2 Ensembl822,933,163 - 23,021,751 (-)Ensembl
RefSeq Acc Id: NM_001191791   ⟹   NP_001178720
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8831,209,025 - 31,297,319 (-)NCBI
mRatBN7.2822,933,163 - 23,021,461 (-)NCBI
Rnor_6.0825,582,938 - 25,669,394 (-)NCBI
Rnor_5.0825,614,114 - 25,700,693 (-)NCBI
Celera824,511,253 - 24,598,078 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039081362   ⟹   XP_038937290
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8831,209,025 - 31,297,485 (-)NCBI
mRatBN7.2822,933,163 - 23,021,461 (-)NCBI
RefSeq Acc Id: XM_039081363   ⟹   XP_038937291
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8831,209,025 - 31,297,157 (-)NCBI
mRatBN7.2822,933,163 - 23,021,291 (-)NCBI
RefSeq Acc Id: NP_001178720   ⟸   NM_001191791
- UniProtKB: D4AD75 (UniProtKB/TrEMBL),   A0A8I6G3Y6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000033222   ⟸   ENSRNOT00000036738
RefSeq Acc Id: XP_038937290   ⟸   XM_039081362
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038937291   ⟸   XM_039081363
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000078838   ⟸   ENSRNOT00000112774

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4AD75-F1-model_v2 AlphaFold D4AD75 1-746 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695811
Promoter ID:EPDNEW_R6335
Type:initiation region
Name:Dpy19l1_1
Description:dpy-19 like C-mannosyltransferase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0825,669,454 - 25,669,514EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305822 AgrOrtholog
BioCyc Gene G2FUF-31347 BioCyc
Ensembl Genes ENSRNOG00000026589 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000036738 ENTREZGENE
  ENSRNOT00000036738.7 UniProtKB/Swiss-Prot
InterPro Dpy-19/Dpy-19-like UniProtKB/Swiss-Prot
  Dpy19L1 UniProtKB/Swiss-Prot
KEGG Report rno:315496 UniProtKB/Swiss-Prot
NCBI Gene 315496 ENTREZGENE
PANTHER C-MANNOSYLTRANSFERASE DPY19L1-RELATED UniProtKB/Swiss-Prot
  DPY-19-LIKE 1, LIKE (H. SAPIENS) UniProtKB/Swiss-Prot
Pfam Dpy19 UniProtKB/Swiss-Prot
PhenoGen Dpy19l1 PhenoGen
RatGTEx ENSRNOG00000026589 RatGTEx
UniProt A0A8I6G3Y6 ENTREZGENE, UniProtKB/TrEMBL
  D19L1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-08-16 Dpy19l1  dpy-19 like C-mannosyltransferase 1  Dpy19l1  dpy-19 like 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-08-18 Dpy19l1  dpy-19 like 1  Dpy19l1  dpy-19-like 1 (C. elegans)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Dpy19l1  dpy-19-like 1 (C. elegans)   Dpy19l1_predicted  dpy-19-like 1 (C. elegans) (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Dpy19l1_predicted  dpy-19-like 1 (C. elegans) (predicted)  RGD1305822_predicted  similar to KIAA0877 protein (predicted)  Symbol and Name updated 1299863 APPROVED
2005-01-20 RGD1305822_predicted  similar to KIAA0877 protein (predicted)  LOC315496_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC315496_predicted  similar to KIAA0877 protein (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL