Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Osr2 | Rat | 17alpha-ethynylestradiol | decreases expression | EXP | | 6480464 | Ethinyl Estradiol results in decreased expression of OSR2 mRNA | CTD | PMID:17557909 | Osr2 | Rat | 17beta-estradiol | increases expression | ISO | OSR2 (Homo sapiens) | 6480464 | Estradiol results in increased expression of OSR2 mRNA | CTD | PMID:21795739 | Osr2 | Rat | 17beta-estradiol | decreases expression | ISO | OSR2 (Homo sapiens) | 6480464 | Estradiol results in decreased expression of OSR2 mRNA | CTD | PMID:31614463 | Osr2 | Rat | 17beta-estradiol | multiple interactions | ISO | OSR2 (Homo sapiens) | 6480464 | Progesterone inhibits the reaction [Estradiol results in increased expression of OSR2 mRNA] | CTD | PMID:21795739 | Osr2 | Rat | 17beta-estradiol | increases expression | ISO | Osr2 (Mus musculus) | 6480464 | Estradiol results in increased expression of OSR2 mRNA | CTD | PMID:19484750 | Osr2 | Rat | 17beta-estradiol 3-benzoate | decreases methylation | EXP | | 6480464 | estradiol 3-benzoate results in decreased methylation of OSR2 promoter | CTD | PMID:27415467 | Osr2 | Rat | 17beta-hydroxy-17-methylestra-4,9,11-trien-3-one | decreases expression | ISO | OSR2 (Homo sapiens) | 6480464 | Metribolone results in decreased expression of OSR2 mRNA | CTD | PMID:16751804 | Osr2 | Rat | 2,2',5,5'-tetrachlorobiphenyl | decreases expression | ISO | OSR2 (Homo sapiens) | 6480464 | 2,5,2',5'-tetrachlorobiphenyl results in decreased expression of OSR2 mRNA | CTD | PMID:36804509 | Osr2 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of OSR2 mRNA | CTD | PMID:32109520|PMID:34747641 | Osr2 | Rat | 2,3,7,8-Tetrachlorodibenzofuran | decreases expression | EXP | | 6480464 | 2,3,7,8-tetrachlorodibenzofuran results in decreased expression of OSR2 mRNA | CTD | PMID:32109520 | Osr2 | Rat | 2,4-dibromophenyl 2,4,5-tribromophenyl ether | decreases expression | ISO | OSR2 (Homo sapiens) | 6480464 | 2,2',4,4',5-brominated diphenyl ether results in decreased expression of OSR2 mRNA | CTD | PMID:26705709 | Osr2 | Rat | 2,4-dibromophenyl 2,4,5-tribromophenyl ether | affects expression | ISO | Osr2 (Mus musculus) | 6480464 | 2,2',4,4',5-brominated diphenyl ether affects the expression of OSR2 mRNA | CTD | PMID:38648751 | Osr2 | Rat | 3,3',4,4',5-pentachlorobiphenyl | decreases expression | EXP | | 6480464 | 3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of OSR2 mRNA | CTD | PMID:23196670 | Osr2 | Rat | 3-chloropropane-1,2-diol | increases expression | EXP | | 6480464 | alpha-Chlorohydrin results in increased expression of OSR2 mRNA | CTD | PMID:28522335 | Osr2 | Rat | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | OSR2 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] more ... | CTD | PMID:28628672 | Osr2 | Rat | 3-methylcholanthrene | decreases expression | ISO | Osr2 (Mus musculus) | 6480464 | Methylcholanthrene results in decreased expression of OSR2 mRNA | CTD | PMID:20713471 | Osr2 | Rat | 4,4'-sulfonyldiphenol | multiple interactions | ISO | OSR2 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] more ... | CTD | PMID:28628672 | Osr2 | Rat | acrylamide | decreases expression | EXP | | 6480464 | Acrylamide results in decreased expression of OSR2 mRNA | CTD | PMID:28959563 | Osr2 | Rat | actinomycin D | multiple interactions | ISO | OSR2 (Homo sapiens) | 6480464 | [Dactinomycin co-treated with nutlin 3] results in increased expression of OSR2 mRNA | CTD | PMID:38460933 | Osr2 | Rat | aflatoxin B1 | affects expression | ISO | OSR2 (Homo sapiens) | 6480464 | Aflatoxin B1 affects the expression of OSR2 protein | CTD | PMID:20106945 | Osr2 | Rat | aflatoxin B1 | decreases methylation | ISO | OSR2 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased methylation of OSR2 gene | CTD | PMID:27153756 | Osr2 | Rat | aflatoxin B1 | increases expression | ISO | OSR2 (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased expression of OSR2 mRNA | CTD | PMID:22100608 | Osr2 | Rat | aldrin | increases expression | ISO | Osr2 (Mus musculus) | 6480464 | Aldrin results in increased expression of OSR2 mRNA | CTD | PMID:18579281 | Osr2 | Rat | amphetamine | increases expression | EXP | | 6480464 | Amphetamine results in increased expression of OSR2 mRNA | CTD | PMID:30779732 | Osr2 | Rat | aristolochic acid A | increases expression | ISO | OSR2 (Homo sapiens) | 6480464 | aristolochic acid I results in increased expression of OSR2 mRNA | CTD | PMID:33212167 | Osr2 | Rat | Azaspiracid | decreases expression | ISO | OSR2 (Homo sapiens) | 6480464 | azaspiracid results in decreased expression of OSR2 mRNA | CTD | PMID:28939011 | Osr2 | Rat | benzo[a]pyrene | decreases expression | ISO | Osr2 (Mus musculus) | 6480464 | Benzo(a)pyrene results in decreased expression of OSR2 mRNA | CTD | PMID:20713471 | Osr2 | Rat | benzo[a]pyrene | affects methylation | ISO | OSR2 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of OSR2 promoter | CTD | PMID:27901495 | Osr2 | Rat | benzo[a]pyrene | increases expression | ISO | OSR2 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased expression of OSR2 mRNA | CTD | PMID:20106945|PMID:21632981|PMID:32234424 | Osr2 | Rat | benzo[a]pyrene | multiple interactions | ISO | Osr2 (Mus musculus) | 6480464 | AHR protein affects the reaction [Benzo(a)pyrene affects the expression of OSR2 mRNA] | CTD | PMID:22228805 | Osr2 | Rat | benzo[a]pyrene diol epoxide I | increases expression | ISO | OSR2 (Homo sapiens) | 6480464 | 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of OSR2 mRNA | CTD | PMID:20382639 | Osr2 | Rat | beta-lapachone | decreases expression | ISO | OSR2 (Homo sapiens) | 6480464 | beta-lapachone results in decreased expression of OSR2 mRNA | CTD | PMID:38218311 | Osr2 | Rat | beta-lapachone | increases expression | ISO | OSR2 (Homo sapiens) | 6480464 | beta-lapachone results in increased expression of OSR2 mRNA | CTD | PMID:38218311 | Osr2 | Rat | bisphenol A | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Testosterone] results in decreased expression of OSR2 mRNA | CTD | PMID:26496021 | Osr2 | Rat | bisphenol A | affects methylation | ISO | Osr2 (Mus musculus) | 6480464 | bisphenol A affects the methylation of OSR2 promoter | CTD | PMID:27334623 | Osr2 | Rat | bisphenol A | affects methylation | EXP | | 6480464 | bisphenol A affects the methylation of OSR2 promoter | CTD | PMID:27415467 | Osr2 | Rat | bisphenol A | decreases expression | ISO | OSR2 (Homo sapiens) | 6480464 | bisphenol A results in decreased expression of OSR2 mRNA | CTD | PMID:27685785 | Osr2 | Rat | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of OSR2 mRNA | CTD | PMID:25181051 | Osr2 | Rat | bisphenol F | increases expression | ISO | Osr2 (Mus musculus) | 6480464 | bisphenol F results in increased expression of OSR2 mRNA | CTD | PMID:30951980 | Osr2 | Rat | butanal | increases expression | ISO | OSR2 (Homo sapiens) | 6480464 | butyraldehyde results in increased expression of OSR2 mRNA | CTD | PMID:26079696 | Osr2 | Rat | cadmium atom | multiple interactions | ISO | OSR2 (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of OSR2 more ... | CTD | PMID:35301059 | Osr2 | Rat | cadmium atom | decreases expression | ISO | Osr2 (Mus musculus) | 6480464 | Cadmium results in decreased expression of OSR2 mRNA | CTD | PMID:34953275 | Osr2 | Rat | cadmium dichloride | multiple interactions | ISO | OSR2 (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of OSR2 more ... | CTD | PMID:35301059 | Osr2 | Rat | calcitriol | increases expression | ISO | OSR2 (Homo sapiens) | 6480464 | Calcitriol results in increased expression of OSR2 mRNA | CTD | PMID:16002434|PMID:21592394 | Osr2 | Rat | calcitriol | multiple interactions | ISO | OSR2 (Homo sapiens) | 6480464 | [Testosterone co-treated with Calcitriol] results in increased expression of OSR2 mRNA | CTD | PMID:21592394 | Osr2 | Rat | carbamazepine | affects expression | ISO | OSR2 (Homo sapiens) | 6480464 | Carbamazepine affects the expression of OSR2 mRNA | CTD | PMID:25979313 | Osr2 | Rat | choline | multiple interactions | ISO | Osr2 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation more ... | CTD | PMID:20938992 | Osr2 | Rat | cisplatin | increases expression | ISO | OSR2 (Homo sapiens) | 6480464 | Cisplatin results in increased expression of OSR2 mRNA | CTD | PMID:19561079|PMID:27392435 | Osr2 | Rat | cisplatin | multiple interactions | ISO | OSR2 (Homo sapiens) | 6480464 | [Cisplatin co-treated with jinfukang] results in increased expression of OSR2 mRNA; [Cisplatin co-treated with Paclitaxel] more ... | CTD | PMID:20705681|PMID:27392435 | Osr2 | Rat | copper atom | multiple interactions | ISO | OSR2 (Homo sapiens) | 6480464 | [NSC 689534 binds to Copper] which results in decreased expression of OSR2 mRNA | CTD | PMID:20971185 | Osr2 | Rat | copper atom | increases expression | EXP | | 6480464 | Copper results in increased expression of OSR2 mRNA | CTD | PMID:30556269 | Osr2 | Rat | copper(0) | multiple interactions | ISO | OSR2 (Homo sapiens) | 6480464 | [NSC 689534 binds to Copper] which results in decreased expression of OSR2 mRNA | CTD | PMID:20971185 | Osr2 | Rat | copper(0) | increases expression | EXP | | 6480464 | Copper results in increased expression of OSR2 mRNA | CTD | PMID:30556269 | Osr2 | Rat | copper(II) sulfate | decreases expression | ISO | OSR2 (Homo sapiens) | 6480464 | Copper Sulfate results in decreased expression of OSR2 mRNA | CTD | PMID:19549813 | Osr2 | Rat | cyclosporin A | decreases expression | ISO | OSR2 (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of OSR2 mRNA | CTD | PMID:25562108 | Osr2 | Rat | dexamethasone | increases expression | ISO | OSR2 (Homo sapiens) | 6480464 | Dexamethasone results in increased expression of OSR2 mRNA | CTD | PMID:25047013 | Osr2 | Rat | dexamethasone | multiple interactions | ISO | OSR2 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] more ... | CTD | PMID:28628672 | Osr2 | Rat | diallyl trisulfide | increases expression | EXP | | 6480464 | diallyl trisulfide results in increased expression of OSR2 mRNA | CTD | PMID:34014027 | Osr2 | Rat | dibutyl phthalate | decreases expression | EXP | | 6480464 | Dibutyl Phthalate results in decreased expression of OSR2 mRNA | CTD | PMID:21266533 | Osr2 | Rat | dimethylarsinic acid | multiple interactions | ISO | Osr2 (Mus musculus) | 6480464 | [sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results more ... | CTD | PMID:34876320 | Osr2 | Rat | dinophysistoxin 1 | increases expression | ISO | OSR2 (Homo sapiens) | 6480464 | dinophysistoxin 1 results in increased expression of OSR2 mRNA | CTD | PMID:21853993 | Osr2 | Rat | ethyl methanesulfonate | increases expression | ISO | OSR2 (Homo sapiens) | 6480464 | Ethyl Methanesulfonate results in increased expression of OSR2 mRNA | CTD | PMID:23649840 | Osr2 | Rat | folic acid | multiple interactions | ISO | Osr2 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation more ... | CTD | PMID:20938992 | Osr2 | Rat | folic acid | decreases expression | ISO | Osr2 (Mus musculus) | 6480464 | Folic Acid results in decreased expression of OSR2 mRNA | CTD | PMID:25629700 | Osr2 | Rat | formaldehyde | decreases expression | ISO | Osr2 (Mus musculus) | 6480464 | Formaldehyde results in decreased expression of OSR2 mRNA | CTD | PMID:33233951 | Osr2 | Rat | gentamycin | increases expression | EXP | | 6480464 | Gentamicins results in increased expression of OSR2 mRNA | CTD | PMID:33387578 | Osr2 | Rat | hydrogen peroxide | affects expression | ISO | OSR2 (Homo sapiens) | 6480464 | Hydrogen Peroxide affects the expression of OSR2 mRNA | CTD | PMID:20044591 | Osr2 | Rat | indometacin | multiple interactions | ISO | OSR2 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] more ... | CTD | PMID:28628672 | Osr2 | Rat | L-methionine | multiple interactions | ISO | Osr2 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation more ... | CTD | PMID:20938992 | Osr2 | Rat | Licochalcone B | increases expression | ISO | OSR2 (Homo sapiens) | 6480464 | licochalcone B results in increased expression of OSR2 mRNA | CTD | PMID:33647349 | Osr2 | Rat | lipopolysaccharide | multiple interactions | ISO | OSR2 (Homo sapiens) | 6480464 | [S-(1,2-dichlorovinyl)cysteine co-treated with Lipopolysaccharides] results in increased expression of OSR2 mRNA | CTD | PMID:35811015 | Osr2 | Rat | manganese(II) chloride | decreases expression | EXP | | 6480464 | manganese chloride results in decreased expression of OSR2 mRNA | CTD | PMID:28801915 | Osr2 | Rat | methyl methanesulfonate | increases expression | ISO | OSR2 (Homo sapiens) | 6480464 | Methyl Methanesulfonate results in increased expression of OSR2 mRNA | CTD | PMID:23649840 | Osr2 | Rat | methylarsonic acid | multiple interactions | ISO | Osr2 (Mus musculus) | 6480464 | [sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results more ... | CTD | PMID:34876320 | Osr2 | Rat | methylisothiazolinone | increases expression | ISO | OSR2 (Homo sapiens) | 6480464 | 2-methyl-4-isothiazolin-3-one results in increased expression of OSR2 mRNA | CTD | PMID:31629900 | Osr2 | Rat | mono(2-ethylhexyl) phthalate | decreases expression | ISO | OSR2 (Homo sapiens) | 6480464 | mono-(2-ethylhexyl)phthalate results in decreased expression of OSR2 mRNA | CTD | PMID:22017230 | Osr2 | Rat | N-methyl-4-phenylpyridinium | decreases expression | EXP | | 6480464 | 1-Methyl-4-phenylpyridinium results in decreased expression of OSR2 mRNA | CTD | PMID:28801915 | Osr2 | Rat | nickel atom | decreases expression | ISO | OSR2 (Homo sapiens) | 6480464 | Nickel results in decreased expression of OSR2 mRNA | CTD | PMID:25583101 | Osr2 | Rat | Nutlin-3 | multiple interactions | ISO | OSR2 (Homo sapiens) | 6480464 | [Dactinomycin co-treated with nutlin 3] results in increased expression of OSR2 mRNA | CTD | PMID:38460933 | Osr2 | Rat | okadaic acid | increases expression | ISO | OSR2 (Homo sapiens) | 6480464 | Okadaic Acid results in increased expression of OSR2 mRNA | CTD | PMID:38832940 | Osr2 | Rat | paclitaxel | multiple interactions | ISO | OSR2 (Homo sapiens) | 6480464 | [Cisplatin co-treated with Paclitaxel] results in decreased expression of OSR2 mRNA | CTD | PMID:20705681 | Osr2 | Rat | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of OSR2 mRNA | CTD | PMID:33387578 | Osr2 | Rat | perfluorooctanoic acid | decreases expression | ISO | OSR2 (Homo sapiens) | 6480464 | perfluorooctanoic acid results in decreased expression of OSR2 mRNA | CTD | PMID:36326898 | Osr2 | Rat | potassium chromate | increases expression | ISO | OSR2 (Homo sapiens) | 6480464 | potassium chromate(VI) results in increased expression of OSR2 mRNA | CTD | PMID:22714537 | Osr2 | Rat | progesterone | increases expression | ISO | OSR2 (Homo sapiens) | 6480464 | Progesterone results in increased expression of OSR2 mRNA | CTD | PMID:20864642 | Osr2 | Rat | progesterone | multiple interactions | ISO | OSR2 (Homo sapiens) | 6480464 | Progesterone inhibits the reaction [Estradiol results in increased expression of OSR2 mRNA] | CTD | PMID:21795739 | Osr2 | Rat | quercetin | decreases expression | ISO | OSR2 (Homo sapiens) | 6480464 | Quercetin results in decreased expression of OSR2 mRNA | CTD | PMID:21632981 | Osr2 | Rat | S-(1,2-dichlorovinyl)-L-cysteine | multiple interactions | ISO | OSR2 (Homo sapiens) | 6480464 | [S-(1,2-dichlorovinyl)cysteine co-treated with Lipopolysaccharides] results in increased expression of OSR2 mRNA | CTD | PMID:35811015 | Osr2 | Rat | silicon dioxide | decreases expression | ISO | OSR2 (Homo sapiens) | 6480464 | Silicon Dioxide analog results in decreased expression of OSR2 mRNA | CTD | PMID:25895662 | Osr2 | Rat | sodium arsenate | multiple interactions | ISO | Osr2 (Mus musculus) | 6480464 | [sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results more ... | CTD | PMID:34876320 | Osr2 | Rat | sodium arsenite | decreases expression | ISO | OSR2 (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of OSR2 mRNA | CTD | PMID:34032870 | Osr2 | Rat | sodium arsenite | multiple interactions | ISO | Osr2 (Mus musculus) | 6480464 | [sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results more ... | CTD | PMID:34876320 | Osr2 | Rat | tert-butyl hydroperoxide | decreases expression | ISO | OSR2 (Homo sapiens) | 6480464 | tert-Butylhydroperoxide results in decreased expression of OSR2 mRNA | CTD | PMID:15336504 | Osr2 | Rat | testosterone | decreases expression | ISO | OSR2 (Homo sapiens) | 6480464 | Testosterone results in decreased expression of OSR2 mRNA | CTD | PMID:21592394 | Osr2 | Rat | testosterone | multiple interactions | ISO | OSR2 (Homo sapiens) | 6480464 | [Testosterone co-treated with Calcitriol] results in increased expression of OSR2 mRNA | CTD | PMID:21592394 | Osr2 | Rat | testosterone | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Testosterone] results in decreased expression of OSR2 mRNA | CTD | PMID:26496021 | Osr2 | Rat | titanium dioxide | decreases methylation | ISO | Osr2 (Mus musculus) | 6480464 | titanium dioxide results in decreased methylation of OSR2 gene; titanium dioxide results in decreased methylation more ... | CTD | PMID:35295148 | Osr2 | Rat | urethane | increases expression | ISO | OSR2 (Homo sapiens) | 6480464 | Urethane results in increased expression of OSR2 mRNA | CTD | PMID:28818685 | Osr2 | Rat | valproic acid | increases expression | ISO | OSR2 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of OSR2 mRNA | CTD | PMID:28001369 | Osr2 | Rat | vinclozolin | increases expression | EXP | | 6480464 | vinclozolin results in increased expression of OSR2 mRNA | CTD | PMID:23034163 | Osr2 | Rat | vitamin E | increases expression | ISO | OSR2 (Homo sapiens) | 6480464 | Vitamin E results in increased expression of OSR2 mRNA | CTD | PMID:19244175 | |






















