Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Card6 | Rat | (-)-alpha-phellandrene | increases expression | ISO | CARD6 (Homo sapiens) | 6480464 | alpha phellandrene results in increased expression of CARD6 mRNA | CTD | PMID:25075043 | Card6 | Rat | (1->4)-beta-D-glucan | multiple interactions | ISO | Card6 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of CARD6 mRNA | CTD | PMID:36331819 | Card6 | Rat | 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane | decreases expression | EXP | | 6480464 | o,p'-DDT analog results in decreased expression of CARD6 mRNA | CTD | PMID:22937105 | Card6 | Rat | 17beta-estradiol | decreases expression | ISO | CARD6 (Homo sapiens) | 6480464 | Estradiol results in decreased expression of CARD6 mRNA | CTD | PMID:20106945 | Card6 | Rat | 17beta-estradiol | decreases expression | ISO | Card6 (Mus musculus) | 6480464 | Estradiol results in decreased expression of CARD6 mRNA | CTD | PMID:39298647 | Card6 | Rat | 17beta-estradiol | decreases expression | EXP | | 6480464 | Estradiol results in decreased expression of CARD6 mRNA | CTD | PMID:32145629 | Card6 | Rat | 17beta-estradiol | increases expression | ISO | CARD6 (Homo sapiens) | 6480464 | Estradiol results in increased expression of CARD6 mRNA | CTD | PMID:23373633 | Card6 | Rat | 17beta-estradiol | affects expression | ISO | CARD6 (Homo sapiens) | 6480464 | Estradiol affects the expression of CARD6 mRNA | CTD | PMID:22574217 | Card6 | Rat | 2,2',4,4'-Tetrabromodiphenyl ether | decreases expression | ISO | CARD6 (Homo sapiens) | 6480464 | 2,2',4,4'-tetrabromodiphenyl ether analog results in decreased expression of CARD6 mRNA | CTD | PMID:19095052 | Card6 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of CARD6 mRNA | CTD | PMID:19520675|PMID:34747641 | Card6 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of CARD6 mRNA | CTD | PMID:33387578 | Card6 | Rat | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | CARD6 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] more ... | CTD | PMID:28628672 | Card6 | Rat | 4,4'-sulfonyldiphenol | multiple interactions | ISO | CARD6 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] more ... | CTD | PMID:28628672 | Card6 | Rat | 4,4'-sulfonyldiphenol | decreases expression | ISO | Card6 (Mus musculus) | 6480464 | bisphenol S results in decreased expression of CARD6 mRNA | CTD | PMID:39298647 | Card6 | Rat | afimoxifene | increases expression | ISO | CARD6 (Homo sapiens) | 6480464 | afimoxifene results in increased expression of CARD6 mRNA | CTD | PMID:23373633 | Card6 | Rat | aflatoxin B1 | affects expression | ISO | CARD6 (Homo sapiens) | 6480464 | Aflatoxin B1 affects the expression of CARD6 protein | CTD | PMID:20106945 | Card6 | Rat | aflatoxin B1 | increases expression | ISO | CARD6 (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased expression of CARD6 mRNA | CTD | PMID:21641981 | Card6 | Rat | aflatoxin B1 | increases expression | ISO | Card6 (Mus musculus) | 6480464 | Aflatoxin B1 results in increased expression of CARD6 mRNA | CTD | PMID:19770486 | Card6 | Rat | all-trans-retinoic acid | increases expression | ISO | CARD6 (Homo sapiens) | 6480464 | Tretinoin results in increased expression of CARD6 mRNA | CTD | PMID:23830798|PMID:33167477 | Card6 | Rat | alpha-phellandrene | increases expression | ISO | CARD6 (Homo sapiens) | 6480464 | alpha phellandrene results in increased expression of CARD6 mRNA | CTD | PMID:25075043 | Card6 | Rat | aristolochic acid A | decreases expression | ISO | CARD6 (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of CARD6 mRNA | CTD | PMID:33212167 | Card6 | Rat | arsenous acid | multiple interactions | ISO | CARD6 (Homo sapiens) | 6480464 | [sanguinarine co-treated with Arsenic Trioxide] results in increased expression of CARD6 mRNA | CTD | PMID:24345465 | Card6 | Rat | benzo[a]pyrene | increases expression | ISO | CARD6 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased expression of CARD6 mRNA | CTD | PMID:20106945 | Card6 | Rat | benzo[a]pyrene | increases expression | ISO | Card6 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of CARD6 mRNA | CTD | PMID:22610609 | Card6 | Rat | bis(2-ethylhexyl) phthalate | increases expression | ISO | Card6 (Mus musculus) | 6480464 | Diethylhexyl Phthalate results in increased expression of CARD6 mRNA | CTD | PMID:34319233 | Card6 | Rat | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of CARD6 mRNA | CTD | PMID:25181051|PMID:30816183|PMID:32528016|PMID:34947998 | Card6 | Rat | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of CARD6 mRNA | CTD | PMID:32145629 | Card6 | Rat | bisphenol A | multiple interactions | ISO | CARD6 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] more ... | CTD | PMID:28628672 | Card6 | Rat | Brevetoxin B | increases expression | ISO | CARD6 (Homo sapiens) | 6480464 | brevetoxin 2 results in increased expression of CARD6 mRNA | CTD | PMID:20498034 | Card6 | Rat | buta-1,3-diene | decreases expression | ISO | Card6 (Mus musculus) | 6480464 | 1,3-butadiene results in decreased expression of CARD6 mRNA | CTD | PMID:29038090 | Card6 | Rat | cadmium atom | multiple interactions | ISO | Card6 (Mus musculus) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CARD6 more ... | CTD | PMID:37236586 | Card6 | Rat | cadmium dichloride | increases expression | ISO | CARD6 (Homo sapiens) | 6480464 | Cadmium Chloride results in increased expression of CARD6 mRNA | CTD | PMID:38174414|PMID:38382870 | Card6 | Rat | cadmium dichloride | multiple interactions | ISO | Card6 (Mus musculus) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CARD6 more ... | CTD | PMID:37236586 | Card6 | Rat | calcitriol | increases expression | ISO | CARD6 (Homo sapiens) | 6480464 | Calcitriol results in increased expression of CARD6 mRNA | CTD | PMID:21592394 | Card6 | Rat | calcitriol | multiple interactions | ISO | CARD6 (Homo sapiens) | 6480464 | [Testosterone co-treated with Calcitriol] results in increased expression of CARD6 mRNA | CTD | PMID:21592394 | Card6 | Rat | carbon nanotube | decreases expression | ISO | Card6 (Mus musculus) | 6480464 | Nanotubes, Carbon results in decreased expression of CARD6 mRNA | CTD | PMID:25554681 | Card6 | Rat | chromium(6+) | multiple interactions | ISO | CARD6 (Homo sapiens) | 6480464 | [zinc chromate results in increased abundance of chromium hexavalent ion] which results in increased expression more ... | CTD | PMID:38479592 | Card6 | Rat | copper atom | multiple interactions | ISO | CARD6 (Homo sapiens) | 6480464 | [NSC 689534 binds to Copper] which results in increased expression of CARD6 mRNA | CTD | PMID:20971185 | Card6 | Rat | copper(0) | multiple interactions | ISO | CARD6 (Homo sapiens) | 6480464 | [NSC 689534 binds to Copper] which results in increased expression of CARD6 mRNA | CTD | PMID:20971185 | Card6 | Rat | copper(II) sulfate | increases expression | ISO | CARD6 (Homo sapiens) | 6480464 | Copper Sulfate results in increased expression of CARD6 mRNA | CTD | PMID:19549813 | Card6 | Rat | CU-O LINKAGE | increases expression | ISO | CARD6 (Homo sapiens) | 6480464 | cupric oxide results in increased expression of CARD6 mRNA | CTD | PMID:22077320 | Card6 | Rat | cyclosporin A | decreases expression | ISO | CARD6 (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of CARD6 mRNA | CTD | PMID:20106945 | Card6 | Rat | cylindrospermopsin | increases expression | ISO | CARD6 (Homo sapiens) | 6480464 | cylindrospermopsin results in increased expression of CARD6 mRNA | CTD | PMID:24921660 | Card6 | Rat | DDE | affects expression | EXP | | 6480464 | Dichlorodiphenyl Dichloroethylene affects the expression of CARD6 mRNA | CTD | PMID:24576310 | Card6 | Rat | DDE | decreases expression | ISO | CARD6 (Homo sapiens) | 6480464 | Dichlorodiphenyl Dichloroethylene results in decreased expression of CARD6 mRNA | CTD | PMID:38568856 | Card6 | Rat | dexamethasone | multiple interactions | ISO | CARD6 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] more ... | CTD | PMID:28628672 | Card6 | Rat | diarsenic trioxide | multiple interactions | ISO | CARD6 (Homo sapiens) | 6480464 | [sanguinarine co-treated with Arsenic Trioxide] results in increased expression of CARD6 mRNA | CTD | PMID:24345465 | Card6 | Rat | dorsomorphin | multiple interactions | ISO | CARD6 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ... | CTD | PMID:27188386 | Card6 | Rat | doxorubicin | decreases expression | ISO | CARD6 (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of CARD6 mRNA | CTD | PMID:29803840 | Card6 | Rat | epoxiconazole | decreases expression | ISO | Card6 (Mus musculus) | 6480464 | epoxiconazole results in decreased expression of CARD6 mRNA | CTD | PMID:35436446 | Card6 | Rat | fructose | multiple interactions | EXP | | 6480464 | benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Fructose results in decreased expression of CARD6 protein]; nuciferine inhibits more ... | CTD | PMID:37186242 | Card6 | Rat | fructose | decreases expression | EXP | | 6480464 | Fructose results in decreased expression of CARD6 protein | CTD | PMID:37186242 | Card6 | Rat | gentamycin | decreases expression | EXP | | 6480464 | Gentamicins results in decreased expression of CARD6 mRNA | CTD | PMID:33387578 | Card6 | Rat | GSK-J4 | decreases expression | ISO | CARD6 (Homo sapiens) | 6480464 | GSK-J4 results in decreased expression of CARD6 mRNA | CTD | PMID:29301935 | Card6 | Rat | indometacin | multiple interactions | ISO | CARD6 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] more ... | CTD | PMID:28628672 | Card6 | Rat | methylmercury chloride | increases expression | ISO | CARD6 (Homo sapiens) | 6480464 | methylmercuric chloride results in increased expression of CARD6 mRNA | CTD | PMID:28001369 | Card6 | Rat | N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal | multiple interactions | EXP | | 6480464 | benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Fructose results in decreased expression of CARD6 protein] | CTD | PMID:37186242 | Card6 | Rat | nickel atom | decreases expression | ISO | CARD6 (Homo sapiens) | 6480464 | Nickel results in decreased expression of CARD6 mRNA | CTD | PMID:23195993 | Card6 | Rat | nitrates | multiple interactions | ISO | Card6 (Mus musculus) | 6480464 | [Particulate Matter results in increased abundance of Nitrates] which results in increased expression of CARD6 more ... | CTD | PMID:35964746 | Card6 | Rat | ozone | multiple interactions | ISO | Card6 (Mus musculus) | 6480464 | [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in decreased more ... | CTD | PMID:34911549 | Card6 | Rat | p-menthan-3-ol | decreases expression | ISO | CARD6 (Homo sapiens) | 6480464 | Menthol results in decreased expression of CARD6 mRNA | CTD | PMID:26760959 | Card6 | Rat | paracetamol | decreases expression | ISO | CARD6 (Homo sapiens) | 6480464 | Acetaminophen results in decreased expression of CARD6 mRNA | CTD | PMID:21420995|PMID:29067470 | Card6 | Rat | paracetamol | decreases expression | EXP | | 6480464 | Acetaminophen results in decreased expression of CARD6 mRNA | CTD | PMID:33387578 | Card6 | Rat | paraquat | decreases expression | ISO | CARD6 (Homo sapiens) | 6480464 | Paraquat results in decreased expression of CARD6 mRNA | CTD | PMID:18836921 | Card6 | Rat | perfluorononanoic acid | decreases expression | ISO | CARD6 (Homo sapiens) | 6480464 | perfluoro-n-nonanoic acid results in decreased expression of CARD6 mRNA | CTD | PMID:32588087 | Card6 | Rat | perfluorooctane-1-sulfonic acid | multiple interactions | ISO | Card6 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of CARD6 mRNA | CTD | PMID:36331819 | Card6 | Rat | PF-3758309 | decreases expression | ISO | CARD6 (Homo sapiens) | 6480464 | PF 3758309 results in decreased expression of CARD6 mRNA | CTD | PMID:29048629 | Card6 | Rat | phenobarbital | affects expression | ISO | CARD6 (Homo sapiens) | 6480464 | Phenobarbital affects the expression of CARD6 mRNA | CTD | PMID:19159669 | Card6 | Rat | phenylmercury acetate | multiple interactions | ISO | CARD6 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ... | CTD | PMID:27188386 | Card6 | Rat | sanguinarine | multiple interactions | ISO | CARD6 (Homo sapiens) | 6480464 | [sanguinarine co-treated with arsenic trioxide] results in increased expression of CARD6 mRNA | CTD | PMID:24345465 | Card6 | Rat | SB 431542 | multiple interactions | ISO | CARD6 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ... | CTD | PMID:27188386 | Card6 | Rat | silicon dioxide | decreases expression | ISO | CARD6 (Homo sapiens) | 6480464 | Silicon Dioxide analog results in decreased expression of CARD6 mRNA | CTD | PMID:25895662 | Card6 | Rat | sodium arsenite | increases expression | ISO | CARD6 (Homo sapiens) | 6480464 | sodium arsenite results in increased expression of CARD6 mRNA | CTD | PMID:38568856|PMID:39719251 | Card6 | Rat | testosterone | multiple interactions | ISO | CARD6 (Homo sapiens) | 6480464 | [Testosterone co-treated with Calcitriol] results in increased expression of CARD6 mRNA | CTD | PMID:21592394 | Card6 | Rat | testosterone | increases expression | ISO | CARD6 (Homo sapiens) | 6480464 | Testosterone results in increased expression of CARD6 mRNA | CTD | PMID:21592394 | Card6 | Rat | troglitazone | decreases expression | ISO | Card6 (Mus musculus) | 6480464 | troglitazone results in decreased expression of CARD6 mRNA | CTD | PMID:17569031|PMID:28973697 | Card6 | Rat | tungsten | decreases expression | ISO | Card6 (Mus musculus) | 6480464 | Tungsten results in decreased expression of CARD6 mRNA | CTD | PMID:30912803 | Card6 | Rat | urethane | decreases expression | ISO | CARD6 (Homo sapiens) | 6480464 | Urethane results in decreased expression of CARD6 mRNA | CTD | PMID:28818685 | Card6 | Rat | valproic acid | decreases expression | ISO | CARD6 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of CARD6 mRNA | CTD | PMID:29154799 | Card6 | Rat | valproic acid | decreases methylation | ISO | CARD6 (Homo sapiens) | 6480464 | Valproic Acid results in decreased methylation of CARD6 gene | CTD | PMID:29154799 | Card6 | Rat | vinclozolin | increases expression | EXP | | 6480464 | vinclozolin results in increased expression of CARD6 mRNA | CTD | PMID:23555832 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||






















