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Gene: Mylip (myosin regulatory light chain interacting protein) Rattus norvegicus

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Symbol:

Mylip

Name:

myosin regulatory light chain interacting protein

RGD ID:

1305761

Description:

Predicted to enable cytoskeletal protein binding activity and ubiquitin protein ligase activity. Predicted to be involved in several processes, including cholesterol homeostasis; negative regulation of low-density lipoprotein particle clearance; and regulation of protein catabolic process. Predicted to be located in cytoplasm and plasma membrane. Orthologous to human MYLIP (myosin regulatory light chain interacting protein); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acetamide.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

E3 ubiquitin-protein ligase MYLIP; idol; inducible degrader of the LDL-receptor; LOC306825; MIR; RING-type E3 ubiquitin transferase MYLIP

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Allele / Splice:

Mylip^em2Mcwi ; Mylip^em3Mcwi ; Mylip^em1Mcwi

Genetic Models:

SS-Mylip^em2Mcwi ; SS-Mylip^em3Mcwi ; SS-Mylip^em1Mcwi

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	17	19,492,826 - 19,514,490 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	17	19,492,826 - 19,514,471 (-)	Ensembl				GRCr8
mRatBN7.2	17	19,286,649 - 19,308,295 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	19,286,650 - 19,308,295 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	17	19,171,096 - 19,192,723 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	17	20,774,907 - 20,796,527 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	17	19,098,217 - 19,119,846 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	17	19,682,040 - 19,703,681 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	19,682,040 - 19,703,681 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	17	21,703,590 - 21,725,205 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	17	25,308,147 - 25,329,887 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	17	18,989,082 - 19,010,552 (-)	NCBI		Celera
RGSC_v3.1	17	25,312,367 - 25,523,199 (-)	NCBI
Cytogenetic Map	17	p14	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

atherosclerosis (ISO)

endometriosis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-hydroxypropanoic acid (ISO)

2-methylcholine (ISO)

3,3',5,5'-tetrabromobisphenol A (ISO)

3,4-methylenedioxymethamphetamine (ISO)

4,4'-sulfonyldiphenol (ISO)

5-fluorouracil (ISO)

6-propyl-2-thiouracil (EXP)

8-Br-cAMP (ISO)

acetamide (EXP)

acrylamide (EXP,ISO)

afimoxifene (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (EXP,ISO)

allethrin (EXP)

Archazolid B (ISO)

aristolochic acid A (ISO)

Aroclor 1254 (ISO)

arsane (ISO)

arsenic atom (ISO)

atrazine (ISO)

belinostat (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

beta-hexachlorocyclohexane (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

Butylbenzyl phthalate (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

calcitriol (ISO)

carbon nanotube (ISO)

carnosic acid (ISO)

CGP 52608 (ISO)

chloropicrin (ISO)

chromium(6+) (ISO)

ciguatoxin CTX1B (ISO)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

coumestrol (ISO)

Cuprizon (EXP)

cyclosporin A (ISO)

cyhalothrin (EXP)

cypermethrin (EXP)

cytarabine (ISO)

DDE (ISO)

Dibutyl phosphate (ISO)

disulfiram (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

endosulfan (EXP)

Enterolactone (ISO)

entinostat (ISO)

ethyl methanesulfonate (ISO)

fenvalerate (EXP)

folic acid (ISO)

formaldehyde (ISO)

furan (EXP)

genistein (ISO)

gentamycin (EXP)

glyphosate (ISO)

GSK-J4 (ISO)

GW 3965 (ISO)

GW 4064 (ISO)

Heptachlor epoxide (ISO)

hydroquinone (ISO)

isoprenaline (ISO)

lead(0) (ISO)

Licochalcone B (ISO)

maneb (ISO)

methimazole (EXP)

methyl methanesulfonate (ISO)

methylisothiazolinone (ISO)

methylmercury chloride (ISO)

mifepristone (EXP)

mitomycin C (ISO)

mono(2-ethylhexyl) phthalate (ISO)

nickel sulfate (ISO)

okadaic acid (ISO)

ozone (ISO)

p-chloromercuribenzoic acid (ISO)

panobinostat (ISO)

paracetamol (EXP,ISO)

paraquat (ISO)

phenobarbital (ISO)

potassium chromate (ISO)

progesterone (ISO)

pyrethrins (EXP)

quercetin (ISO)

rac-lactic acid (ISO)

SB 431542 (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

sodium dichromate (ISO)

Soman (EXP)

sulfadimethoxine (EXP)

sunitinib (ISO)

temozolomide (ISO)

testosterone (ISO)

thioacetamide (EXP)

thiram (ISO)

titanium dioxide (ISO)

trichloroethene (EXP)

trichostatin A (ISO)

triclosan (ISO)

triphenyl phosphate (ISO)

triptonide (ISO)

tunicamycin (ISO)

urethane (ISO)

valproic acid (ISO)

zinc atom (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cholesterol homeostasis (IEA,ISO)

negative regulation of low-density lipoprotein particle clearance (IEA,ISO)

negative regulation of neuron projection development (IEA,ISO)

nervous system development (IEA,ISO)

positive regulation of protein catabolic process (IEA,ISO)

protein destabilization (IEA,ISO)

protein ubiquitination (IEA,ISO)

regulation of low-density lipoprotein particle receptor catabolic process (IEA,ISO)

ubiquitin-dependent protein catabolic process (IBA,IEA,ISO)

Cellular Component

cytoplasm (IEA)

plasma membrane (IEA)

Molecular Function

cytoskeletal protein binding (IEA,ISO)

metal ion binding (IEA)

protein binding (ISO)

transferase activity (IEA)

ubiquitin protein ligase activity (IEA,ISO)

ubiquitin-protein transferase activity (IBA,IEA,ISO)

zinc ion binding (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	GOA pipeline	RGD automated data pipeline
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
6.	(-)-Epigallocatechin-3-Gallate Ameliorates Atherosclerosis and Modulates Hepatic Lipid Metabolic Gene Expression in Apolipoprotein E Knockout Mice: Involvement of TTC39B.	Wang W, etal., Front Pharmacol. 2018 Mar 9;9:195. doi: 10.3389/fphar.2018.00195. eCollection 2018.

Additional References at PubMed

PMID:10593918	PMID:14550572	PMID:19028597	PMID:19520913	PMID:21685362	PMID:23990472	PMID:24166456

Genomics

Comparative Map Data

Mylip
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	17	19,492,826 - 19,514,490 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	17	19,492,826 - 19,514,471 (-)	Ensembl				GRCr8
mRatBN7.2	17	19,286,649 - 19,308,295 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	19,286,650 - 19,308,295 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	17	19,171,096 - 19,192,723 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	17	20,774,907 - 20,796,527 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	17	19,098,217 - 19,119,846 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	17	19,682,040 - 19,703,681 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	19,682,040 - 19,703,681 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	17	21,703,590 - 21,725,205 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	17	25,308,147 - 25,329,887 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	17	18,989,082 - 19,010,552 (-)	NCBI		Celera
RGSC_v3.1	17	25,312,367 - 25,523,199 (-)	NCBI
Cytogenetic Map	17	p14	NCBI

MYLIP
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	16,129,086 - 16,163,887 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	16,129,086 - 16,151,367 (+)	Ensembl			hg38	GRCh38
GRCh37	6	16,129,317 - 16,148,479 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	16,237,296 - 16,256,458 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	6	16,237,295 - 16,256,455	NCBI
Celera	6	17,367,147 - 17,386,309 (+)	NCBI		Celera
Cytogenetic Map	6	p22.3	NCBI
HuRef	6	16,076,513 - 16,095,715 (+)	NCBI		HuRef
CHM1_1	6	16,132,017 - 16,151,181 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	6	16,001,663 - 16,037,439 (+)	NCBI		T2T-CHM13v2.0

Mylip
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	13	45,543,197 - 45,565,498 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	13	45,543,218 - 45,565,498 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	13	45,389,742 - 45,411,940 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	13	45,389,742 - 45,412,022 (+)	Ensembl			mm10	GRCm38
MGSCv37	13	45,485,111 - 45,507,309 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	13	45,400,714 - 45,422,912 (+)	NCBI		MGSCv36	mm8
Celera	13	46,464,431 - 46,486,733 (+)	NCBI		Celera
Cytogenetic Map	13	A5	NCBI
cM Map	13	21.88	NCBI

Mylip
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955483	9,723,023 - 9,745,062 (-)	Ensembl
ChiLan1.0	NW_004955483	9,725,343 - 9,745,041 (-)	NCBI	ChiLan1.0	ChiLan1.0

MYLIP
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	5	30,794,914 - 30,816,026 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	6	26,780,496 - 26,801,629 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	15,985,844 - 16,005,043 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	16,350,852 - 16,370,253 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	16,350,852 - 16,370,253 (+)	Ensembl			panPan2	panpan1.1

MYLIP
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	35	15,257,633 - 15,276,771 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	35	15,256,885 - 15,275,424 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	35	15,205,869 - 15,225,698 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	35	15,352,342 - 15,372,171 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	35	15,352,164 - 15,370,824 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	35	15,177,056 - 15,196,883 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	35	15,228,888 - 15,248,707 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	35	16,555,131 - 16,574,958 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Mylip
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	9,389,585 - 9,405,771 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936552	2,325,378 - 2,339,867 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936552	2,325,161 - 2,341,356 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MYLIP
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	12,117,240 - 12,137,925 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	7	12,117,240 - 12,137,934 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	12,713,066 - 12,733,740 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MYLIP
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	17	56,021,151 - 56,040,175 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	17	56,022,369 - 56,040,169 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666044	16,181,768 - 16,200,965 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Mylip
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624756	10,324,021 - 10,343,787 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624756	10,324,275 - 10,343,047 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Mylip
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	14	64,380,071 - 64,401,941 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Mylip
146 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	223
Count of miRNA genes:	153
Interacting mature miRNAs:	181
Transcripts:	ENSRNOT00000024021
Prediction methods:	Miranda, Pita, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1354581	Bp247	Blood pressure QTL 247	4.5		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	17	1	43999106	Rat
2300002	Iddm36	Insulin dependent diabetes mellitus QTL 36	1.98		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	17	9266755	40968173	Rat
2293664	Bmd28	Bone mineral density QTL 28	5.1	0.0001	femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	17	4360057	27233623	Rat
8552966	Pigfal18	Plasma insulin-like growth factor 1 level QTL 18	8.7		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	17	12860942	57860942	Rat
1300123	Bp194	Blood pressure QTL 194	2.82		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	2120843	42054133	Rat
1582224	Epfw4	Epididymal fat weight QTL 4	3.5	0.0058	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	17	9206505	23859062	Rat
1582225	Bw67	Body weight QTL 67	6.2	0.0001	body mass (VT:0001259)	body weight (CMO:0000012)	17	9206505	23859062	Rat
2302377	Scl61	Serum cholesterol level QTL 61	4.36		blood HDL cholesterol amount (VT:0000184)	serum high density lipoprotein cholesterol level (CMO:0000361)	17	6221998	58177198	Rat
1582226	Bw64	Body weight QTL 64	4.2	0.0017	body mass (VT:0001259)	body weight (CMO:0000012)	17	9206505	23859062	Rat
9589151	Insul30	Insulin level QTL 30	8.82	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	17	12860942	57860942	Rat
10401807	Kidm52	Kidney mass QTL 52			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	17	1	31706603	Rat
10054088	Scort28	Serum corticosterone level QTL 28	2.04	0.0102	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	17	4733534	49733534	Rat
9589057	Scfw6	Subcutaneous fat weight QTL 6	8.62	0.001	subcutaneous adipose mass (VT:1000472)	abdominal subcutaneous fat pad weight (CMO:0002069)	17	12860942	57860942	Rat
1582208	Kidm32	Kidney mass QTL 32	3.9	0.0018	kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	17	9206505	23859062	Rat
9590154	Scort9	Serum corticosterone level QTL 9	23.57	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	17	12860942	57860942	Rat
9590088	Insglur7	Insulin/glucose ratio QTL 7	20.38	0.001	blood insulin amount (VT:0001560)	calculated plasma insulin level (CMO:0002170)	17	12860942	57860942	Rat
1549900	Iddm20	Insulin dependent diabetes mellitus QTL 20	3.7		pancreas integrity trait (VT:0010560)	percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)	17	1	22181410	Rat
1331720	Rf43	Renal function QTL 43	2.881		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	17	15537025	28637951	Rat
2317053	Aia25	Adjuvant induced arthritis QTL 25	2.69		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	17	10604694	55604694	Rat
1354613	Kidm14	Kidney mass QTL 14	6.2		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	17	1	36045694	Rat
1331765	Hrtrt15	Heart rate QTL 15	4.094		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	17	15537025	60531414	Rat
7411666	Foco31	Food consumption QTL 31	11.4	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	17	12860942	57860942	Rat
2324619	Coatc4	Coat color QTL 4		0.001	coat/hair pigmentation trait (VT:0010463)	pigmented dorsal coat/hair area to total dorsal coat/hair area ratio (CMO:0001811)	17	1	21499218	Rat
2303627	Vencon8	Ventilatory control QTL 8		0.001	respiration trait (VT:0001943)	tidal volume (CMO:0000222)	17	4733534	49733534	Rat
70184	BpQTLcluster14	Blood pressure QTL cluster 14	3.38		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	17	8574342	32199534	Rat
1582258	Bw76	Body weight QTL 76	4.6	0.0005	body mass (VT:0001259)	body weight (CMO:0000012)	17	9206505	23859062	Rat
631207	Niddm41	Non-insulin dependent diabetes mellitus QTL 41			blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	17	1	38037084	Rat
1582199	Insul5	Insulin level QTL 5	3.4	0.0119	blood insulin amount (VT:0001560)	calculated serum insulin level (CMO:0000359)	17	9206505	23859062	Rat
1354662	Rf49	Renal function QTL 49	2.9		blood creatinine amount (VT:0005328)	plasma creatinine level (CMO:0000537)	17	1	43999106	Rat
2293648	Bmd31	Bone mineral density QTL 31	4.5	0.0001	femur size trait (VT:1000369)	femoral neck cortical cross-sectional area (CMO:0001702)	17	4360057	27233623	Rat
1354658	Spl8	Serum phospholipid level QTL 8	3.8		blood VLDL phospholipid amount (VT:0010507)	blood very low density lipoprotein phospholipid level (CMO:0001571)	17	1	43999106	Rat
1641902	Colcr7	Colorectal carcinoma resistance QTL 7	3.35	0.0044	intestine integrity trait (VT:0010554)	benign colorectal tumor surface area measurement (CMO:0001799)	17	2120843	22087569	Rat
1582241	Bw70	Body weight QTL 70	4.6	0.0003	body mass (VT:0001259)	body weight (CMO:0000012)	17	9206505	23859062	Rat
1582245	Bw73	Body weight QTL 73	4.6	0.0004	body mass (VT:0001259)	body weight (CMO:0000012)	17	9206505	23859062	Rat
9590316	Scort21	Serum corticosterone level QTL 21	4.75	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	17	1	22877318	Rat

Markers in Region

AA818380

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	17	19,286,948 - 19,287,129 (+)	MAPPER	mRatBN7.2
Rnor_6.0	17	19,682,339 - 19,682,519	NCBI	Rnor6.0
Rnor_5.0	17	21,703,889 - 21,704,069	UniSTS	Rnor5.0
RGSC_v3.4	17	25,308,439 - 25,308,619	UniSTS	RGSC3.4
Celera	17	18,989,381 - 18,989,561	UniSTS
RH 3.4 Map	17	246.9	UniSTS
Cytogenetic Map	17	p12	UniSTS

AI411450

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	17	19,306,413 - 19,306,595 (+)	MAPPER	mRatBN7.2
Rnor_6.0	17	19,701,801 - 19,701,982	NCBI	Rnor6.0
Rnor_5.0	17	21,723,325 - 21,723,506	UniSTS	Rnor5.0
RGSC_v3.4	17	25,328,007 - 25,328,188	UniSTS	RGSC3.4
Celera	17	19,008,667 - 19,008,848	UniSTS
RH 3.4 Map	17	248.8	UniSTS
Cytogenetic Map	17	p12	UniSTS

Genetic Models

This gene Mylip is modified in the following models/strains:

SS-Mylip^em2Mcwi SS-Mylip^em3Mcwi SS-Mylip^em1Mcwi

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	356	192	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001107344	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063276374	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063276375	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473977	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ233472	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000017	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000024021 ⟹ ENSRNOP00000024021

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	17	19,492,826 - 19,514,471 (-)	Ensembl
mRatBN7.2 Ensembl	17	19,286,650 - 19,308,295 (-)	Ensembl
Rnor_6.0 Ensembl	17	19,682,040 - 19,703,681 (-)	Ensembl

RefSeq Acc Id:

NM_001107344 ⟹ NP_001100814

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	19,492,826 - 19,514,471 (-)	NCBI
mRatBN7.2	17	19,286,650 - 19,308,295 (-)	NCBI
Rnor_6.0	17	19,682,040 - 19,703,681 (-)	NCBI
Rnor_5.0	17	21,703,590 - 21,725,205 (-)	NCBI
RGSC_v3.4	17	25,308,147 - 25,329,887 (-)	RGD
Celera	17	18,989,082 - 19,010,552 (-)	NCBI

Sequence:

show sequence

CAGTGGGGCTGTCGGAGCGGCGCGGCCGTGTAGCTCCCGGGAACTGGCTGTCGTGGGGGGTGGC
GGGGACGCGAGTGGCGGCTGCGTGGGGTGCAGGGCGGGTGACCGCACGGCTGCACCTTCCTCGC
GGTGCCCGGAGCCGACTTGGAGCAATTGCAGTGAGGCGACAGCCCCGGCGCACACCGGAGAAGA
AGCGGCCGTGGCGGCGGTGGCGGCGGCCCCAGCCATGCTGTGCTATGTGACGAGGCCGGACGCG
GTGCTGATGGAGGTGGAGGTGGAGGCAAAAGCCAACGGCGAGGACTGTCTCAACCAGGTGTGCA
GGCGATTGGGAATCATAGAAGTTGATTATTTTGGGCTGCAGTTCACGGGTAGCAAAGGTGAAAG
CTTATGGCTGAATCTGAGAAACCGGATCTCCCAGCAGATGGATGGGCTGGCACCTTACCGGCTT
AAACTGAGGGTCAAGTTCTTTGTGGAGCCCCATCTCATCTTACAGGAGCAGACAAGGCATATCT
TTTTCTTGCACATTAAAGAGTCCCTCTTGGCAGGCCACCTCCAGTGTTCCCCAGAGCAGGCAGT
GGAACTTAGTGCCCTCCTGGCCCAGACCAAATTCGGAGACTACAACCAGAACACTGCCCAATAC
AGCTATGAGGACCTGTGTGAGAAAGAGCTCTCCAGCTCCACATTGAACAGCATTGTTGGGAAGC
ATAAGGAGCTGGAGGGCATCAGCCAGGCTTCTGCAGAATACCAAGTTCTGCAGATTGTGTCAGC
AATGGAGAACTACGGCATAGAGTGGCATGCCGTGAGGGACAGCGAAGGACAGAAACTCCTCATT
GGGGTCGGACCTGAAGGCATCTCAATTTGTAAAGAGGACTTTAGCCCTATTAACAGGATAGCTT
ATCCTGTGGTGCAGATGGCCACCCAGTCAGGAAAGAATGTCTACTTGACCGTCACCAAGGAGTC
CGGTAACAGCATCGTGCTCCTGTTTAAAATGATCAGCACCCGAGCTGCCAGTGGGCTCTACCGA
GCTATCACGGAAACACATGCATTCTACAGGTGTGACACAGTCACCAGTGCCGTCATGATGCAGT
ACAGTCGTGACTTGAAGGGCCACTTGGCGTCTCTGTTTCTGAATGAGAACATTAATCTTGGCAA
GAAATATGTCTTTGATATTAAAAGAACATCCAAAGAGGTATATGACCATGCCAGGAGGGCTCTG
TACAACGCCGGTGTTGTGGACCTTGTCTCTCGAAATGACCAGAGCCCTCCCAGCTCGCCTCTGA
AGTCCTCTGACAGCAGCATGAGCTGCAGCAGCTGCGAGGGCCTCAGCTGCCAGCAGACCAGAGT
GCTGCAGGAGAAGCTGCGCAAACTGAAGGAAGCCATGCTGTGCATGGTGTGCTGCGAGGAGGAG
ATCAACTCTACCTTTTGCCCCTGTGGCCATACTGTGTGCTGTGAGAGCTGTGCAGCCCAGCTGC
AGTCATGTCCCGTCTGCAGATCACGTGTGGAACATGTCCAGCACGTCTACCTGCCCACCCACAC
CAGTCTTCTCAATCTGACTGTCATCTAATGCGTCCTGTGCTTACTGGGCATGCCATGTCCCCAC
AAGCTGCAGTATTGTAAACTAGAAGAAGAGTAACTCTGTGAAGAAATAGTTCACTCTCAACACC
CATTTGCCATGAGACGTTTCCAGAAACGAGGAGGAAAGGAAAGAATGCGACCACACCTCTTCTG
TGAGGAGAAGCAACAGTTCCCATGGCAACCAGGAAGAGATCTGGAACATGGACACATTCCTTGG
GCTTTGGGGTTTTTTTAATGATCAAGTAAAGGAGTAGATAAAATTGTCTCTGTCAGTCAAGTGG
CAACATGGCCCAACCGTGGGCACCTTTAAGGAAATGATGTCATATGTCTCCTTCACTTGTCCCG
AGGCAGCAGATTTTGTAAGAGTTTTAAGGATTTCCTTGGTTCTTTTTGTATGGTCATGGAGCGC
TGAACATTTTTAATAGGATTTTTTTTTTTTTGTCTTAAAGAAATAGTCCTCATTAGAAAGTCAT
TTCTGTCTTTATAACTCATTCAAGAACAACTGGAAAGCTGGTAGTTTGGAAAGCAATCCCGTGA
CTTCTCAAGGGTTGAGAGCAACGTGGTCAGATTGGAACCAGTCTGGCTGAGAGTCAACAGGTAA
CCCACCGTGGGTGACTTCGCTCCTAGCTCCCCTGTTTCCCTCACTCCACATCCCATGCCTTTCA
CTGATAAAAATGCTACCAGTTTGGTTACATACATGGCATGGTCAAGCACTCCCTGGGCTTTGGA
GCTAGTGGACTATTTGCAGATCGGAAAGGGAGAGTGGCAGAGAGGCTTCCTTGGAAGGGAAGGG
GGGGGGAGAGAGAGAGAAAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGGGGAGCCAGAGAGCCA
GAGTGAGTTTTCACTTCCCCCAAGCACTCACTCCAGCAGCACCCATGGGTGTCGCCGTGCTTGA
AGATCAAACTTTCTACAGCCTTATAGGTTTCTAGGTTGTATCTCCTCTTTGTGTCTGTCTTAAT
TCCCTTTGTTGGTGTTTTCTTAGGTCAGTGCTTCCGTATTCATTGTACTGCCTCCTCGGCATCT
TCCAGAGGTGGGGCCACTTCATTATGTTTCTATATTCTTCGTCATAATTTCACCCCCACTTGGG
CATTTTGGAAGCTAGTGAGCTAGGGGGTTTTCTAGGGTGTCCGGAAGCCTAGCTGACCTCATCG
GGTGCAATACTAGCTACATTAAAGCTAGAAACCTACACTGTCACTTTACTGAGCTCTGAGTCTA
CGTTTCATATTGCCTTAATGTAGCAGTAATGTGTTTATGCATTTGTTTCTTTGCACAGACATTT
TGTCAGATATTAAAACTCTACTTTTTTATGGCACATATTAGCATATAAGCCTTTATTCCAAGAG
GTATTTATTTTTTCACTTGTAAAAAAAAATAATGTTTCCACATTTAAAAAAAAATCAACTCTGT
TATATCCTAGAGGACTTCTGTCTTTTATATTCAGGATAATAAAGACTTTAAAGCAAACTGG

hide sequence

RefSeq Acc Id:

XM_063276374 ⟹ XP_063132444

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	19,492,830 - 19,514,490 (-)	NCBI

RefSeq Acc Id:

XM_063276375 ⟹ XP_063132445

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	19,492,830 - 19,500,989 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001100814	(Get FASTA)	NCBI Sequence Viewer
	XP_063132444	(Get FASTA)	NCBI Sequence Viewer
	XP_063132445	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	D3ZDI6	(Get FASTA)	NCBI Sequence Viewer
	EDL98172	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000024021
	ENSRNOP00000024021.4

RefSeq Acc Id:

NP_001100814 ⟸ NM_001107344

- UniProtKB:

D3ZDI6 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MLCYVTRPDAVLMEVEVEAKANGEDCLNQVCRRLGIIEVDYFGLQFTGSKGESLWLNLRNRISQ
QMDGLAPYRLKLRVKFFVEPHLILQEQTRHIFFLHIKESLLAGHLQCSPEQAVELSALLAQTKF
GDYNQNTAQYSYEDLCEKELSSSTLNSIVGKHKELEGISQASAEYQVLQIVSAMENYGIEWHAV
RDSEGQKLLIGVGPEGISICKEDFSPINRIAYPVVQMATQSGKNVYLTVTKESGNSIVLLFKMI
STRAASGLYRAITETHAFYRCDTVTSAVMMQYSRDLKGHLASLFLNENINLGKKYVFDIKRTSK
EVYDHARRALYNAGVVDLVSRNDQSPPSSPLKSSDSSMSCSSCEGLSCQQTRVLQEKLRKLKEA
MLCMVCCEEEINSTFCPCGHTVCCESCAAQLQSCPVCRSRVEHVQHVYLPTHTSLLNLTVI

hide sequence

Ensembl Acc Id:

ENSRNOP00000024021 ⟸ ENSRNOT00000024021

RefSeq Acc Id:	XP_063132444 ⟸ XM_063276374
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_063132445 ⟸ XM_063276375
- Peptide Label:	isoform X2

Protein Domains

FERM

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZDI6-F1-model_v2	AlphaFold	D3ZDI6	1-445	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13700372

Promoter ID:

EPDNEW_R10895

Type:

single initiation site

Name:

Mylip_1

Description:

myosin regulatory light chain interacting protein

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	17	19,703,680 - 19,703,740	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1305761	AgrOrtholog
BioCyc Gene	G2FUF-9860	BioCyc
Ensembl Genes	ENSRNOG00000017579	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000024021	ENTREZGENE
	ENSRNOT00000024021.7	UniProtKB/Swiss-Prot
Gene3D-CATH	1.20.80.10	UniProtKB/Swiss-Prot
	2.30.29.30	UniProtKB/Swiss-Prot
	3.30.40.10	UniProtKB/Swiss-Prot
	Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1	UniProtKB/Swiss-Prot
InterPro	Band_41_domain	UniProtKB/Swiss-Prot
	Ez/rad/moesin-like	UniProtKB/Swiss-Prot
	FERM/acyl-CoA-bd_prot_sf	UniProtKB/Swiss-Prot
	FERM_2	UniProtKB/Swiss-Prot
	FERM_central	UniProtKB/Swiss-Prot
	FERM_domain	UniProtKB/Swiss-Prot
	FERM_N	UniProtKB/Swiss-Prot
	FERM_PH-like_C	UniProtKB/Swiss-Prot
	MYLIP_FERM_C	UniProtKB/Swiss-Prot
	PH-like_dom_sf	UniProtKB/Swiss-Prot
	Ubiquitin-like_domsf	UniProtKB/Swiss-Prot
	Znf_RING	UniProtKB/Swiss-Prot
	Znf_RING/FYVE/PHD	UniProtKB/Swiss-Prot
KEGG Report	rno:306825	UniProtKB/Swiss-Prot
NCBI Gene	306825	ENTREZGENE
PANTHER	4.1 G PROTEIN	UniProtKB/Swiss-Prot
	E3 UBIQUITIN-PROTEIN LIGASE MYLIP	UniProtKB/Swiss-Prot
Pfam	FERM_C	UniProtKB/Swiss-Prot
	FERM_M	UniProtKB/Swiss-Prot
	FERM_N	UniProtKB/Swiss-Prot
	zf-C3HC4_3	UniProtKB/Swiss-Prot
PhenoGen	Mylip	PhenoGen
PRINTS	BAND41	UniProtKB/Swiss-Prot
	ERMFAMILY	UniProtKB/Swiss-Prot
PROSITE	FERM_3	UniProtKB/Swiss-Prot
	ZF_RING_2	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000017579	RatGTEx
SMART	B41	UniProtKB/Swiss-Prot
	FERM_C	UniProtKB/Swiss-Prot
Superfamily-SCOP	PH domain-like	UniProtKB/Swiss-Prot
	RING/U-box	UniProtKB/Swiss-Prot
	SSF47031	UniProtKB/Swiss-Prot
	SSF54236	UniProtKB/Swiss-Prot
UniProt	D3ZDI6	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-04-30	Mylip	myosin regulatory light chain interacting protein	Mylip_predicted	myosin regulatory light chain interacting protein (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Mylip_predicted	myosin regulatory light chain interacting protein (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD