Tymp (thymidine phosphorylase) - Rat Genome Database

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Gene: Tymp (thymidine phosphorylase) Rattus norvegicus
Analyze
Symbol: Tymp
Name: thymidine phosphorylase
RGD ID: 1305756
Description: Predicted to enable protein homodimerization activity and thymidine phosphorylase activity. Predicted to be involved in several processes, including nucleobase-containing small molecule metabolic process; regulation of myelination; and regulation of transmission of nerve impulse. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); cytochrome-c oxidase deficiency disease (multiple); mitochondrial DNA depletion syndrome 1; mitochondrial encephalomyopathy; and myopia. Orthologous to several human genes including TYMP (thymidine phosphorylase); PARTICIPATES IN beta-ureidopropionase deficiency pathway; capecitabine pharmacodynamics pathway; capecitabine pharmacokinetics pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Ecgf1; endothelial cell growth factor 1 (platelet-derived); LOC315219; MGC108801; MGC112734; tdRPase; TP
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Squirrel
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87122,318,396 - 122,323,716 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7122,316,520 - 122,324,003 (-)EnsemblGRCr8
mRatBN7.27120,438,768 - 120,444,088 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7120,438,125 - 120,447,429 (-)EnsemblmRatBN7.2
mRatBN7.2 Ensembl7120,438,770 - 120,443,874 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7122,190,265 - 122,195,391 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07124,416,419 - 124,421,545 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07124,379,128 - 124,384,252 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07130,342,481 - 130,347,845 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7130,342,483 - 130,347,587 (-)Ensemblrn6Rnor6.0
Rnor_5.07130,027,662 - 130,033,050 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47127,666,518 - 127,671,624 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7116,911,732 - 116,916,838 (-)NCBICelera
RGSC_v3.17127,700,749 - 127,705,854 (-)NCBI
Cytogenetic Map7q34NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dimethoxyphenol  (ISO)
2-amino-4,6-dinitrotoluene  (EXP)
2-deoxy-alpha-D-ribose 1-phosphate  (ISO)
2-deoxy-D-ribofuranose 1-phosphate  (ISO)
4'-epidoxorubicin  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
5-fluorouracil  (ISO)
5-formyltetrahydrofolic acid  (ISO)
acetamide  (EXP)
acetylleucyl-leucyl-norleucinal  (ISO)
acetylsalicylic acid  (ISO)
actinomycin D  (ISO)
antirheumatic drug  (ISO)
arsenous acid  (ISO)
Aurothioglucose  (ISO)
benzo[a]pyrene  (ISO)
beta-carotene  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dioxygen  (ISO)
doxifluridine  (EXP,ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
fenthion  (ISO)
fipronil  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fumonisin B1  (ISO)
furan  (EXP)
furfural  (ISO)
gemcitabine  (ISO)
glyphosate  (EXP)
gossypol  (ISO)
GSK-J4  (ISO)
hexadecanoic acid  (ISO)
hydrazine  (ISO)
irinotecan  (ISO)
iron dichloride  (ISO)
ivermectin  (ISO)
Lasiocarpine  (ISO)
lipopolysaccharide  (ISO)
methidathion  (ISO)
mitomycin C  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
nitrofen  (EXP)
nocodazole  (ISO)
obeticholic acid  (ISO)
okadaic acid  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
pemetrexed  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
phenylephrine  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
propiconazole  (ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
Salinomycin  (ISO)
SB 203580  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sodium dodecyl sulfate  (ISO)
stavudine  (ISO)
sulfasalazine  (ISO)
tanespimycin  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
thioacetamide  (EXP)
thymidine  (ISO)
thymine  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
triclosan  (ISO)
triphenyl phosphate  (ISO)
valproic acid  (ISO)
vincristine  (ISO)
vitamin E  (ISO)
zalcitabine  (ISO)
zidovudine  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IBA)

References

References - curated
# Reference Title Reference Citation
1. The role of thymidine phosphorylase and thrombospondin-1 in angiogenesis and progression of intrahepatic cholangiocarcinoma. Aishima S, etal., Int J Surg Pathol. 2002 Jan;10(1):47-56.
2. Cooperative stimulation of vascular endothelial growth factor expression by hypoxia and reactive oxygen species: the effect of targeting vascular endothelial growth factor and oxidative stress in an orthotopic xenograft model of bladder carcinoma. Brown NS, etal., Br J Cancer. 2005 May 9;92(9):1696-701.
3. Up-regulation of thymidine phosphorylase expression is associated with a discrete pattern of angiogenesis in ductal carcinomas in situ of the breast. Engels K, etal., J Pathol. 1997 Aug;182(4):414-20.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Role of tumor angiogenesis in gallbladder carcinoma: with special reference to thymidine phosphorylase. Harino Y, etal., Int J Clin Oncol. 2008 Oct;13(5):452-7. Epub 2008 Oct 23.
7. Prognostic value of thymidine phosphorylase expression for pancreatic cancer. Hong SP, etal., Hepatogastroenterology. 2009 Jul-Aug;56(93):1178-82.
8. Angiogenesis and lymphangiogenesis in stage 1 germ cell tumours of the testis. Jones A, etal., BJU Int. 2000 Jul;86(1):80-6.
9. The activity of thymidine phosphorylase correlates with tumor size and lymph nodes status in breast carcinoma. Kubiak R, etal., Z Naturforsch C. 1999 Dec;54(12):1096-102.
10. Antiangiogenic and antitumor activity of 6-(2-aminoethyl)amino-5-chlorouracil, a novel small-molecule inhibitor of thymidine phosphorylase, in combination with the vascular endothelial growth factor-trap. Lu H, etal., Clin Cancer Res. 2009 Aug 15;15(16):5136-44. Epub 2009 Aug 11.
11. A role of thymidine phosphorylase and P53 tissue protein expression in biology of endometrial cancer. Mazurek A, etal., Neoplasma. 2008;55(3):261-5.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. The activity of thymidine phosphorylase as a new ovarian tumor marker. Miszczak-Zaborska E, etal., Gynecol Oncol. 2004 Jul;94(1):86-92.
14. Gan to kagaku ryoho. Cancer & chemotherapy Morimoto Y, etal., Gan To Kagaku Ryoho. 2004 Dec;31(13):2195-8.
15. Expression of thymidine phosphorylase as an effect prediction factor for uterine cervical squamous cell carcinoma after radiotherapy: an immunohistochemical study. Nakashima M, etal., Int J Gynecol Cancer. 2006 May-Jun;16(3):1309-13.
16. Thymidine phosphorylase gene mutations in MNGIE, a human mitochondrial disorder. Nishino I, etal., Science. 1999 Jan 29;283(5402):689-92.
17. The expression of thymidine phosphorylase is a prognostic predictor for the intravesical recurrence of superficial bladder cancer. Nonomura N, etal., Int J Clin Oncol. 2006 Aug;11(4):297-302.
18. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
19. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
20. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
21. Thymidine phosphorylase expression is associated with time to progression in patients receiving low-dose, docetaxel-modulated capecitabine for metastatic breast cancer. Puglisi F, etal., Ann Oncol. 2008 Apr 25;.
22. GOA pipeline RGD automated data pipeline
23. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
24. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
25. Comprehensive gene review and curation RGD comprehensive gene curation
26. High levels of thymidine phosphorylase as an independent prognostic factor in renal cell carcinoma. Takayama T, etal., Jpn J Clin Oncol. 2006 Sep;36(9):564-9. Epub 2006 Jul 22.
27. Thymidine phosphorylase levels as a prognostic factor in renal cell carcinoma. Wada S, etal., BJU Int. 2003 Jan;91(1):105-8.
28. Subconjunctival doxifluridine administration suppresses rat choroidal neovascularization through activated thymidine phosphorylase. Yanagi Y, etal., Invest Ophthalmol Vis Sci. 2003 Feb;44(2):751-4.
29. [Relationships among the expression of thymidylate synthase, thymidine phosphorylase, and dihydropyrimidine dehydrogenase and the prognosis of breast cancer] Yu ZG, etal., Zhonghua Yi Xue Za Zhi. 2006 Jun 13;86(22):1558-63.
30. Significance of thymidine phosphorylase/platelet-derived endothelial cell growth factor in carcinoma of the papilla of Vater. Zhao B, etal., Jpn J Cancer Res. 2000 Mar;91(3):331-6.
Additional References at PubMed
PMID:1590793   PMID:7284378   PMID:12477932   PMID:17681069  


Genomics

Comparative Map Data
Tymp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87122,318,396 - 122,323,716 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7122,316,520 - 122,324,003 (-)EnsemblGRCr8
mRatBN7.27120,438,768 - 120,444,088 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7120,438,125 - 120,447,429 (-)EnsemblmRatBN7.2
mRatBN7.2 Ensembl7120,438,770 - 120,443,874 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7122,190,265 - 122,195,391 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07124,416,419 - 124,421,545 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07124,379,128 - 124,384,252 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07130,342,481 - 130,347,845 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7130,342,483 - 130,347,587 (-)Ensemblrn6Rnor6.0
Rnor_5.07130,027,662 - 130,033,050 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47127,666,518 - 127,671,624 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7116,911,732 - 116,916,838 (-)NCBICelera
RGSC_v3.17127,700,749 - 127,705,854 (-)NCBI
Cytogenetic Map7q34NCBI
TYMP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382250,525,752 - 50,530,085 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2250,525,752 - 50,530,326 (-)Ensemblhg38GRCh38
GRCh372250,964,181 - 50,968,514 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362249,311,047 - 49,315,321 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342249,254,324 - 49,258,599NCBI
Celera2234,840,208 - 34,844,541 (-)NCBICelera
Cytogenetic Map22q13.33ENTREZGENE
HuRef2233,855,199 - 33,859,532 (-)NCBIHuRef
CHM1_12250,922,918 - 50,927,220 (-)NCBICHM1_1
T2T-CHM13v2.02251,036,317 - 51,040,646 (-)NCBIT2T-CHM13v2.0
Tymp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391589,255,834 - 89,261,282 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1589,256,134 - 89,261,242 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381589,371,631 - 89,377,036 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1589,371,931 - 89,377,039 (-)Ensemblmm10GRCm38
MGSCv371589,202,362 - 89,207,467 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361589,199,698 - 89,204,803 (-)NCBIMGSCv36mm8
Celera1591,501,072 - 91,506,177 (-)NCBICelera
Cytogenetic Map15E3NCBI
cM Map1544.86NCBI
Tymp
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541333,505,446 - 33,508,748 (-)Ensembl
ChiLan1.0NW_00495541333,505,424 - 33,509,095 (-)NCBIChiLan1.0ChiLan1.0
TYMP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22360,443,429 - 60,450,209 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12263,136,432 - 63,140,968 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02230,772,088 - 30,776,618 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12249,883,129 - 49,886,996 (-)NCBIPanPan1.1PanPan1.1panPan2
Tymp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945315,033 - 319,093 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936629315,610 - 319,076 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936629315,609 - 320,356 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TYMP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11932,997,337 - 33,001,558 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1932,997,304 - 33,001,215 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604592,341,070 - 92,345,265 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tymp
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624752252,937 - 256,244 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624752251,670 - 256,243 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Tymp
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11258,672,522 - 258,675,666 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Tymp
54 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:100
Count of miRNA genes:84
Interacting mature miRNAs:88
Transcripts:ENSRNOT00000040541
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354582Stl11Serum triglyceride level QTL 113.42blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7121393075137014596Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7119280025135560836Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)782111245123048330Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7104186212135371468Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)793302009131686183Rat
61397Bw17Body weight QTL 176.3body mass (VT:0001259)body weight (CMO:0000012)795485047137014596Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7115313999136544683Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)746307490127866166Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)785043242130043242Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)785497398130497398Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)792362341137014596Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)783626689128626689Rat
631529Tls2T-lymphoma susceptibility QTL 200.001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)782111382132099989Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)798549867137014596Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)777807807122807807Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)782111245123048330Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)740540077123682549Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7110725024135371468Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)7100548246137014596Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)782111245134948181Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)777807807122807807Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)7116269196132020414Rat
1582240Sffal1Serum free fatty acids level QTL 13.40.0021blood free fatty acid amount (VT:0001553)serum free fatty acids level (CMO:0000547)7118556868125929417Rat
10402855Bp379Blood pressure QTL 3790.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)778682549123682549Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)771827901136544683Rat

Markers in Region
RH128722  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27120,438,507 - 120,438,709 (+)MAPPERmRatBN7.2
Rnor_6.07130,342,221 - 130,342,422NCBIRnor6.0
Rnor_5.07130,027,402 - 130,027,603UniSTSRnor5.0
RGSC_v3.47127,666,258 - 127,666,459UniSTSRGSC3.4
Celera7116,911,472 - 116,911,673UniSTS
RH 3.4 Map7948.7UniSTS
Cytogenetic Map7q34UniSTS
RH129073  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr87122,319,377 - 122,319,531 (+)Marker Load Pipeline
mRatBN7.27120,439,749 - 120,439,903 (+)MAPPERmRatBN7.2
Rnor_6.07130,343,463 - 130,343,616NCBIRnor6.0
Rnor_5.07130,028,644 - 130,028,797UniSTSRnor5.0
RGSC_v3.47127,667,500 - 127,667,653UniSTSRGSC3.4
Celera7116,912,714 - 116,912,867UniSTS
RH 3.4 Map7958.5UniSTS
Cytogenetic Map7q34UniSTS
RH139883  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27120,438,861 - 120,439,050 (+)MAPPERmRatBN7.2
Rnor_6.07130,342,575 - 130,342,763NCBIRnor6.0
Rnor_5.07130,027,756 - 130,027,944UniSTSRnor5.0
RGSC_v3.47127,666,612 - 127,666,800UniSTSRGSC3.4
Celera7116,911,826 - 116,912,014UniSTS
RH 3.4 Map7961.8UniSTS
Cytogenetic Map7q34UniSTS
RH136025  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27120,439,191 - 120,439,377 (+)MAPPERmRatBN7.2
Rnor_6.07130,342,905 - 130,343,090NCBIRnor6.0
Rnor_5.07130,028,086 - 130,028,271UniSTSRnor5.0
RGSC_v3.47127,666,942 - 127,667,127UniSTSRGSC3.4
Celera7116,912,156 - 116,912,341UniSTS
Cytogenetic Map7q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 11 67 162 91 90 59 91 59 6 354 190 9 141 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000040541   ⟹   ENSRNOP00000039935
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7122,318,396 - 122,323,521 (-)Ensembl
mRatBN7.2 Ensembl7120,438,770 - 120,443,874 (-)Ensembl
Rnor_6.0 Ensembl7130,342,483 - 130,347,587 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000095915   ⟹   ENSRNOP00000091776
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7120,438,125 - 120,441,206 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000096628   ⟹   ENSRNOP00000084065
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7120,438,125 - 120,447,429 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000120878   ⟹   ENSRNOP00000098487
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7122,317,624 - 122,321,190 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000125477   ⟹   ENSRNOP00000111466
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7122,316,520 - 122,324,003 (-)Ensembl
RefSeq Acc Id: NM_001012122   ⟹   NP_001012122
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87122,318,396 - 122,323,521 (-)NCBI
mRatBN7.27120,438,768 - 120,443,893 (-)NCBI
Rnor_6.07130,342,481 - 130,347,587 (-)NCBI
Rnor_5.07130,027,662 - 130,033,050 (-)NCBI
RGSC_v3.47127,666,518 - 127,671,624 (-)RGD
Celera7116,911,732 - 116,916,838 (-)RGD
Sequence:
RefSeq Acc Id: XM_006242209   ⟹   XP_006242271
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87122,318,396 - 122,323,586 (-)NCBI
mRatBN7.27120,438,768 - 120,444,088 (-)NCBI
Rnor_6.07130,342,481 - 130,347,685 (-)NCBI
Rnor_5.07130,027,662 - 130,033,050 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008765730   ⟹   XP_008763952
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87122,318,396 - 122,323,586 (-)NCBI
mRatBN7.27120,438,768 - 120,444,088 (-)NCBI
Rnor_6.07130,342,481 - 130,347,685 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039079309   ⟹   XP_038935237
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87122,318,396 - 122,323,586 (-)NCBI
mRatBN7.27120,438,768 - 120,444,088 (-)NCBI
RefSeq Acc Id: XM_039079310   ⟹   XP_038935238
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87122,318,396 - 122,323,586 (-)NCBI
mRatBN7.27120,438,768 - 120,444,088 (-)NCBI
RefSeq Acc Id: XM_039079311   ⟹   XP_038935239
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87122,318,396 - 122,321,760 (-)NCBI
mRatBN7.27120,438,768 - 120,442,030 (-)NCBI
RefSeq Acc Id: XM_039079313   ⟹   XP_038935241
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87122,320,075 - 122,323,716 (-)NCBI
mRatBN7.27120,439,462 - 120,444,088 (-)NCBI
RefSeq Acc Id: XM_063263653   ⟹   XP_063119723
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87122,320,075 - 122,323,716 (-)NCBI
RefSeq Acc Id: NP_001012122   ⟸   NM_001012122
- UniProtKB: Q5FVR2 (UniProtKB/Swiss-Prot),   A6K7M1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006242271   ⟸   XM_006242209
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_008763952   ⟸   XM_008765730
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000039935   ⟸   ENSRNOT00000040541
RefSeq Acc Id: XP_038935238   ⟸   XM_039079310
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038935237   ⟸   XM_039079309
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038935239   ⟸   XM_039079311
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038935241   ⟸   XM_039079313
- Peptide Label: isoform X7
Ensembl Acc Id: ENSRNOP00000091776   ⟸   ENSRNOT00000095915
Ensembl Acc Id: ENSRNOP00000084065   ⟸   ENSRNOT00000096628
RefSeq Acc Id: XP_063119723   ⟸   XM_063263653
- Peptide Label: isoform X6
Ensembl Acc Id: ENSRNOP00000098487   ⟸   ENSRNOT00000120878
Ensembl Acc Id: ENSRNOP00000111466   ⟸   ENSRNOT00000125477
Protein Domains
Pyrimidine nucleoside phosphorylase C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5FVR2-F1-model_v2 AlphaFold Q5FVR2 1-476 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695587
Promoter ID:EPDNEW_R6111
Type:multiple initiation site
Name:Tymp_1
Description:thymidine phosphorylase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07130,347,611 - 130,347,671EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305756 AgrOrtholog
BioCyc Gene G2FUF-32439 BioCyc
BioCyc Pathway PWY-7181 [pyrimidine deoxyribonucleosides degradation] BioCyc
BioCyc Pathway Image PWY-7181 BioCyc
Ensembl Genes ENSRNOG00000032394 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00000066458 Ensembl
Ensembl Transcript ENSRNOT00000040541 ENTREZGENE
  ENSRNOT00000040541.5 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.1030.10 UniProtKB/Swiss-Prot
  3.90.1170.30 UniProtKB/Swiss-Prot
  Transferase, Pyrimidine Nucleoside Phosphorylase, Chain C UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7323197 IMAGE-MGC_LOAD
InterPro Glycosyl_Trfase_fam3 UniProtKB/Swiss-Prot
  Glycosyl_Trfase_fam3_N_dom UniProtKB/Swiss-Prot
  Glycosyl_Trfase_fam3_N_dom)sf UniProtKB/Swiss-Prot
  Nuc_phospho_transferase UniProtKB/Swiss-Prot
  PYNP-like_C_sf UniProtKB/Swiss-Prot
  PYNP_C UniProtKB/Swiss-Prot
  Pyrmidine_PPas_bac/euk UniProtKB/Swiss-Prot
  Thymidine/pyrmidine_PPase UniProtKB/Swiss-Prot
KEGG Report rno:315219 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108801 IMAGE-MGC_LOAD
NCBI Gene 315219 ENTREZGENE
PANTHER PTHR10515 UniProtKB/Swiss-Prot
  THYMIDINE PHOSPHORYLASE UniProtKB/Swiss-Prot
Pfam Glycos_trans_3N UniProtKB/Swiss-Prot
  Glycos_transf_3 UniProtKB/Swiss-Prot
  PYNP_C UniProtKB/Swiss-Prot
PharmGKB TYMP RGD
PhenoGen Tymp PhenoGen
PIRSF TP_PyNP UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000032394 RatGTEx
  ENSRNOG00000066458 RatGTEx
SMART PYNP_C UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47648 UniProtKB/Swiss-Prot
  SSF52418 UniProtKB/Swiss-Prot
  SSF54680 UniProtKB/Swiss-Prot
UniProt A6K7M1 ENTREZGENE, UniProtKB/TrEMBL
  Q5FVR2 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-04 Tymp  thymidine phosphorylase  Ecgf1  endothelial cell growth factor 1 (platelet-derived)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Ecgf1  endothelial cell growth factor 1 (platelet-derived)  Ecgf1_predicted  endothelial cell growth factor 1 (platelet-derived) (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Ecgf1_predicted  endothelial cell growth factor 1 (platelet-derived) (predicted)      Symbol and Name status set to approved 70820 APPROVED