Drc5 (dynein regulatory complex subunit 5) - Rat Genome Database

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Pathways
Gene: Drc5 (dynein regulatory complex subunit 5) Rattus norvegicus
Analyze
Symbol: Drc5 (Ensembl: Tcte1)
Name: dynein regulatory complex subunit 5 (Ensembl:t-complex-associated testis expressed 1)
RGD ID: 1305744
Description: Predicted to be involved in flagellated sperm motility. Predicted to be located in sperm flagellum. Orthologous to human TCTE1 (t-complex-associated-testis-expressed 1); INTERACTS WITH bis(2-ethylhexyl) phthalate; bisphenol A; Butylbenzyl phthalate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC316242; t-complex-associated testis expressed 1; T-complex-associated testis-expressed protein 1; Tcte1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8922,961,005 - 22,979,711 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl922,961,176 - 22,970,391 (-)EnsemblGRCr8
mRatBN7.2915,463,573 - 15,482,258 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl915,463,739 - 15,472,954 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx924,050,175 - 24,059,500 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0929,112,853 - 29,122,178 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0927,413,615 - 27,422,940 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0917,847,866 - 17,867,276 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl917,846,364 - 17,866,927 (-)Ensemblrn6Rnor6.0
Rnor_5.0916,736,973 - 16,755,762 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4911,064,068 - 11,073,283 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera913,206,878 - 13,216,093 (-)NCBICelera
RGSC_v3.1911,062,520 - 11,070,536 (-)NCBI
Cytogenetic Map9q12NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
sperm flagellum  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:28630322  


Genomics

Comparative Map Data
Drc5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8922,961,005 - 22,979,711 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl922,961,176 - 22,970,391 (-)EnsemblGRCr8
mRatBN7.2915,463,573 - 15,482,258 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl915,463,739 - 15,472,954 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx924,050,175 - 24,059,500 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0929,112,853 - 29,122,178 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0927,413,615 - 27,422,940 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0917,847,866 - 17,867,276 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl917,846,364 - 17,866,927 (-)Ensemblrn6Rnor6.0
Rnor_5.0916,736,973 - 16,755,762 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4911,064,068 - 11,073,283 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera913,206,878 - 13,216,093 (-)NCBICelera
RGSC_v3.1911,062,520 - 11,070,536 (-)NCBI
Cytogenetic Map9q12NCBI
DRC5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38644,278,734 - 44,297,698 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl644,278,734 - 44,297,698 (-)Ensemblhg38GRCh38
GRCh37644,246,471 - 44,265,435 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36644,355,880 - 44,373,405 (-)NCBIBuild 36Build 36hg18NCBI36
Celera645,801,050 - 45,818,612 (-)NCBICelera
Cytogenetic Map6p21.1NCBI
HuRef643,969,874 - 43,987,548 (-)NCBIHuRef
CHM1_1644,251,609 - 44,269,093 (-)NCBICHM1_1
T2T-CHM13v2.0644,112,859 - 44,131,845 (-)NCBIT2T-CHM13v2.0
Tcte1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391745,834,360 - 45,853,605 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1745,834,360 - 45,853,606 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381745,523,434 - 45,542,679 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1745,523,434 - 45,542,680 (+)Ensemblmm10GRCm38
MGSCv371745,660,383 - 45,679,628 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361744,996,634 - 45,006,261 (+)NCBIMGSCv36mm8
Celera1748,956,144 - 48,975,339 (+)NCBICelera
Cytogenetic Map17B3NCBI
cM Map1722.54NCBI
Tcte1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554379,900,301 - 9,908,379 (-)Ensembl
ChiLan1.0NW_0049554379,900,295 - 9,913,955 (-)NCBIChiLan1.0ChiLan1.0
TCTE1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2558,784,133 - 58,801,738 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1654,652,815 - 54,671,821 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0643,874,469 - 43,894,227 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1645,157,695 - 45,175,956 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl645,154,203 - 45,175,699 (-)EnsemblpanPan2panpan1.1
TCTE1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11212,686,459 - 12,704,388 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1212,687,749 - 12,704,687 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1212,714,686 - 12,732,841 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01213,172,364 - 13,190,526 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1213,173,658 - 13,187,646 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11212,697,791 - 12,715,939 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01212,785,240 - 12,803,394 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01212,879,460 - 12,897,618 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Tcte1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494648,153,902 - 48,173,653 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647615,795,358 - 15,804,887 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647615,795,358 - 15,807,563 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TCTE1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl739,275,950 - 39,299,507 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1739,275,595 - 39,288,326 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2745,145,068 - 45,170,453 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DRC5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11727,870,456 - 27,888,073 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1727,880,057 - 27,888,052 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604444,330,788 - 44,350,987 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tcte1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475415,573,595 - 15,585,760 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475415,574,833 - 15,586,432 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Tcte1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1484,353,816 - 84,363,346 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Drc5
150 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:329
Count of miRNA genes:186
Interacting mature miRNAs:219
Transcripts:ENSRNOT00000027031
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)9671488884474983Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9534647950346479Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9875049253750492Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)9131250552Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)949664545496645Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9621499551214995Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9875049253750492Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9141763315Rat
61425Cia15Collagen induced arthritis QTL 154.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)9534647950416711Rat
631643Bp120Blood pressure QTL 12030.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)9671488829567695Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)949664545496645Rat
1600365Mcs20Mammary carcinoma susceptibility QTL 203mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)92103143049025574Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)949664545496645Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9621499551214995Rat

Markers in Region
RH135153  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2915,463,926 - 15,464,113 (+)MAPPERmRatBN7.2
Rnor_6.0917,848,593 - 17,848,779NCBIRnor6.0
Rnor_5.0916,737,428 - 16,737,614UniSTSRnor5.0
RGSC_v3.4911,064,256 - 11,064,442UniSTSRGSC3.4
Celera913,207,066 - 13,207,252UniSTS
RH 3.4 Map979.4UniSTS
Cytogenetic Map9q12UniSTS
D17Mit35  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2915,463,583 - 15,463,799 (+)MAPPERmRatBN7.2
Rnor_6.0917,848,250 - 17,848,465NCBIRnor6.0
Rnor_5.0916,737,085 - 16,737,300UniSTSRnor5.0
Cytogenetic Map9q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
12 12 30 127 58 57 26 57 26 6 192 114 5 105 32 49 31 12 12

Sequence


Ensembl Acc Id: ENSRNOT00000027031   ⟹   ENSRNOP00000027031
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl915,455,801 - 15,464,302 (+)Ensembl
Rnor_6.0 Ensembl917,846,364 - 17,866,927 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000114547   ⟹   ENSRNOP00000096980
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl922,961,176 - 22,970,391 (-)Ensembl
mRatBN7.2 Ensembl915,463,739 - 15,472,954 (-)Ensembl
RefSeq Acc Id: NM_001108206   ⟹   NP_001101676
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8922,961,176 - 22,970,391 (-)NCBI
mRatBN7.2915,463,739 - 15,472,954 (-)NCBI
Rnor_6.0917,848,405 - 17,857,620 (-)NCBI
Rnor_5.0916,736,973 - 16,755,762 (-)NCBI
RGSC_v3.4911,064,068 - 11,073,283 (-)RGD
Celera913,206,878 - 13,216,093 (-)RGD
Sequence:
RefSeq Acc Id: XM_006244539   ⟹   XP_006244601
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8922,961,005 - 22,979,710 (-)NCBI
mRatBN7.2915,463,573 - 15,482,258 (-)NCBI
Rnor_6.0917,847,866 - 17,867,276 (-)NCBI
Rnor_5.0916,736,973 - 16,755,762 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006244540   ⟹   XP_006244602
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8922,961,005 - 22,979,686 (-)NCBI
mRatBN7.2915,463,573 - 15,482,254 (-)NCBI
Rnor_6.0917,847,866 - 17,867,276 (-)NCBI
Rnor_5.0916,736,973 - 16,755,762 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039083535   ⟹   XP_038939463
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8922,963,996 - 22,979,711 (-)NCBI
mRatBN7.2915,466,419 - 15,482,258 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001101676 (Get FASTA)   NCBI Sequence Viewer  
  XP_006244601 (Get FASTA)   NCBI Sequence Viewer  
  XP_006244602 (Get FASTA)   NCBI Sequence Viewer  
  XP_038939463 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM18734 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000096980
  ENSRNOP00000096980.1
RefSeq Acc Id: NP_001101676   ⟸   NM_001108206
- UniProtKB: A0A8I6ART2 (UniProtKB/TrEMBL),   A6JIZ8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006244601   ⟸   XM_006244539
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006244602   ⟸   XM_006244540
- Peptide Label: isoform X1
- UniProtKB: A0A8I6ART2 (UniProtKB/TrEMBL),   A6JIZ8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000027031   ⟸   ENSRNOT00000027031
RefSeq Acc Id: XP_038939463   ⟸   XM_039083535
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000096980   ⟸   ENSRNOT00000114547

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZQW5-F1-model_v2 AlphaFold D3ZQW5 1-498 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696545
Promoter ID:EPDNEW_R7069
Type:initiation region
Name:Tcte1_1
Description:t-complex-associated testis expressed 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0917,866,887 - 17,866,947EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305744 AgrOrtholog
BioCyc Gene G2FUF-28171 BioCyc
Ensembl Genes ENSRNOG00000019961 Ensembl
  ENSRNOG00000065569 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000114547 ENTREZGENE
  ENSRNOT00000114547.2 UniProtKB/TrEMBL
Gene3D-CATH 3.80.10.10 UniProtKB/TrEMBL
InterPro DRC5 UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/TrEMBL
KEGG Report rno:316242 UniProtKB/TrEMBL
NCBI Gene 316242 ENTREZGENE
PANTHER DYNEIN REGULATORY COMPLEX SUBUNIT 5 UniProtKB/TrEMBL
  YNEIN REGULATORY COMPLEX SUBUNIT 5 UniProtKB/TrEMBL
Pfam LRR_6 UniProtKB/TrEMBL
PhenoGen Drc5 PhenoGen
RatGTEx ENSRNOG00000019961 RatGTEx
  ENSRNOG00000065569 RatGTEx
SMART LRR_RI UniProtKB/TrEMBL
Superfamily-SCOP RNI-like UniProtKB/TrEMBL
UniProt A0A8I6ART2 ENTREZGENE, UniProtKB/TrEMBL
  A6JIZ8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2025-11-13 Drc5  dynein regulatory complex subunit 5  Tcte1  t-complex-associated testis expressed 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Tcte1  t-complex-associated testis expressed 1   Tcte1_predicted  t-complex-associated testis expressed 1 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Tcte1_predicted  t-complex-associated testis expressed 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED