Fbxl4 (F-box and leucine-rich repeat protein 4) - Rat Genome Database

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Gene: Fbxl4 (F-box and leucine-rich repeat protein 4) Rattus norvegicus
Analyze
Symbol: Fbxl4
Name: F-box and leucine-rich repeat protein 4
RGD ID: 1305724
Description: Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process and negative regulation of mitophagy. Predicted to act upstream of or within mitophagy. Predicted to be located in mitochondrial intermembrane space. Predicted to be part of SCF ubiquitin ligase complex. Predicted to be active in mitochondrial outer membrane. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome 13. Orthologous to human FBXL4 (F-box and leucine rich repeat protein 4); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 6-propyl-2-thiouracil; amitrole.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: F-box/LRR-repeat protein 4; LOC313101
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8540,752,513 - 40,826,154 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl540,752,521 - 40,850,826 (+)EnsemblGRCr8
mRatBN7.2535,955,801 - 36,029,446 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl535,955,812 - 36,029,443 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx538,081,930 - 38,155,709 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0539,674,526 - 39,748,301 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0539,614,187 - 39,687,968 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0536,555,061 - 36,628,920 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl536,555,109 - 36,629,689 (+)Ensemblrn6Rnor6.0
Rnor_5.0541,196,912 - 41,270,903 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4537,156,876 - 37,230,228 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera534,966,228 - 35,039,999 (+)NCBICelera
RGSC_v3.1537,157,055 - 37,230,404 (+)NCBI
Cytogenetic Map5q21NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amitrole  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bisphenol A  (EXP)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (ISO)
copper(II) sulfate  (ISO)
CU-O LINKAGE  (ISO)
diarsenic trioxide  (ISO)
dicrotophos  (ISO)
dimethyl sulfoxide  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
finasteride  (EXP)
fipronil  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
gentamycin  (EXP)
hydrogen peroxide  (ISO)
lead(0)  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (EXP,ISO)
methamphetamine  (EXP)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sulfadimethoxine  (EXP)
sulindac  (EXP)
sunitinib  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
torcetrapib  (ISO)
tributylstannane  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (EXP)
triptonide  (ISO)
valproic acid  (ISO)
vincristine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:19028597   PMID:23993194   PMID:34800366  


Genomics

Comparative Map Data
Fbxl4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8540,752,513 - 40,826,154 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl540,752,521 - 40,850,826 (+)EnsemblGRCr8
mRatBN7.2535,955,801 - 36,029,446 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl535,955,812 - 36,029,443 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx538,081,930 - 38,155,709 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0539,674,526 - 39,748,301 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0539,614,187 - 39,687,968 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0536,555,061 - 36,628,920 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl536,555,109 - 36,629,689 (+)Ensemblrn6Rnor6.0
Rnor_5.0541,196,912 - 41,270,903 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4537,156,876 - 37,230,228 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera534,966,228 - 35,039,999 (+)NCBICelera
RGSC_v3.1537,157,055 - 37,230,404 (+)NCBI
Cytogenetic Map5q21NCBI
FBXL4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38698,868,535 - 98,947,946 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl698,868,535 - 98,948,006 (-)Ensemblhg38GRCh38
GRCh37699,316,411 - 99,395,822 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36699,428,322 - 99,502,570 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34699,428,321 - 99,502,570NCBI
Celera699,965,788 - 100,040,008 (-)NCBICelera
Cytogenetic Map6q16.1-q16.2NCBI
HuRef696,760,379 - 96,835,106 (-)NCBIHuRef
CHM1_1699,584,542 - 99,658,828 (-)NCBICHM1_1
T2T-CHM13v2.06100,042,904 - 100,122,314 (-)NCBIT2T-CHM13v2.0
Fbxl4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39422,357,526 - 22,434,091 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl422,357,543 - 22,434,091 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38422,357,526 - 22,434,091 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl422,357,543 - 22,434,091 (+)Ensemblmm10GRCm38
MGSCv37422,284,712 - 22,361,193 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36422,448,400 - 22,524,881 (+)NCBIMGSCv36mm8
Celera422,111,884 - 22,188,205 (+)NCBICelera
Cytogenetic Map4A3NCBI
cM Map49.69NCBI
Fbxl4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541124,757,445 - 24,814,643 (-)Ensembl
ChiLan1.0NW_00495541124,757,445 - 24,814,642 (-)NCBIChiLan1.0ChiLan1.0
FBXL4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25118,922,871 - 118,996,545 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16116,801,917 - 116,877,758 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0696,717,103 - 96,790,932 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16100,599,381 - 100,661,249 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6100,599,390 - 100,661,249 (-)EnsemblpanPan2panpan1.1
FBXL4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11257,139,183 - 57,211,157 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1257,139,491 - 57,211,137 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1256,897,651 - 56,975,979 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01257,960,791 - 58,039,209 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1257,960,791 - 58,039,197 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11257,320,719 - 57,399,019 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01257,164,097 - 57,242,411 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01257,408,790 - 57,487,147 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Fbxl4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494692,074,873 - 92,153,958 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936651530,197 - 609,417 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936651530,296 - 609,443 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FBXL4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl165,872,123 - 65,935,703 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1165,872,119 - 65,936,442 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2174,422,380 - 74,485,593 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FBXL4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11374,916,756 - 74,993,959 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1374,916,869 - 74,997,462 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604047,249,024 - 47,326,291 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fbxl4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248106,185,748 - 6,239,481 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248106,172,807 - 6,238,045 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Fbxl4
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11120,897,501 - 120,980,791 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Fbxl4
652 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:174
Count of miRNA genes:139
Interacting mature miRNAs:163
Transcripts:ENSRNOT00000061128
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2293666Bmd38Bone mineral density QTL 384.4femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)51373115343590997Rat
1578776Stresp18Stress response QTL 182.9thymus mass (VT:0004954)thymus wet weight (CMO:0000855)53275164977751649Rat
1298067Scl15Serum cholesterol level QTL 154.80.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53801167083011670Rat
6907115Mcs29Mammary carcinoma susceptibility QTL 29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)53800433183004331Rat
1358353Srcrtb2Stress Responsive Cort Basal QTL 23.480.003blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)52367149379046465Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)538207390136631402Rat
1300117Hrtrt8Heart rate QTL 83.49heart pumping trait (VT:2000009)heart rate (CMO:0000002)5862723052665523Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)51757663362576633Rat
1578774Tcas8Tongue tumor susceptibility QTL 83.47tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)51570745160707451Rat
1598807Glom12Glomerulus QTL 122.7kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)53801167083011670Rat
1302786Kidm8Kidney mass QTL 828.15kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)53801167083011670Rat
1331782Rf36Renal function QTL 363.296kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)539019942102105896Rat
6903292Stl28Serum triglyceride level QTL 282.60.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)53331167378311673Rat
1578767Stresp17Stress response QTL 174.30.01blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)53275164977751649Rat
1549901Neudeg2Neurodegradation QTL 240nervous system integrity trait (VT:0010566)mononuclear cell count (CMO:0002119)53113042148841739Rat
1641922Alcrsp8Alcohol response QTL 8alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)51748608062486080Rat
2313085Bss59Bone structure and strength QTL 592.90.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)5862723053627230Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)53998594884985948Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)5692228281330203Rat
6903306Scl35Serum cholesterol QTL 352.60.0073blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53331167378311673Rat
1576317Eutr2Estrogen induced uterine response QTL 20.01uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)53952692484526924Rat
7394712Emca13Estrogen-induced mammary cancer QTL 13mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)51460607859606078Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)51001906491770353Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5706553574335773Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)536460764136631402Rat
1641903Alcrsp3Alcohol response QTL 3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)51748608062486080Rat
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)51001906487027358Rat
8552954Pigfal14Plasma insulin-like growth factor 1 level QTL 149blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)52602321171023211Rat
2303577Gluco47Glucose level QTL 473blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51652001961520019Rat
1600358Mamtr5Mammary tumor resistance QTL 5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)52367149368671493Rat

Markers in Region
RH129913  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2536,029,121 - 36,029,334 (+)MAPPERmRatBN7.2
Rnor_6.0536,628,596 - 36,628,808NCBIRnor6.0
Rnor_5.0541,270,579 - 41,270,791UniSTSRnor5.0
RGSC_v3.4537,229,904 - 37,230,116UniSTSRGSC3.4
Celera535,039,675 - 35,039,887UniSTS
RH 3.4 Map5169.1UniSTS
Cytogenetic Map5q21UniSTS
RH129423  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2535,986,522 - 35,986,729 (+)MAPPERmRatBN7.2
Rnor_6.0536,585,997 - 36,586,203NCBIRnor6.0
Rnor_5.0541,227,830 - 41,228,036UniSTSRnor5.0
RGSC_v3.4537,187,609 - 37,187,815UniSTSRGSC3.4
Celera534,997,078 - 34,997,284UniSTS
RH 3.4 Map5181.8UniSTS
Cytogenetic Map5q21UniSTS
RH131368  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2535,954,379 - 35,954,563 (+)MAPPERmRatBN7.2
Rnor_6.0536,553,643 - 36,553,826NCBIRnor6.0
Rnor_5.0541,195,476 - 41,195,659UniSTSRnor5.0
RGSC_v3.4537,155,440 - 37,155,623UniSTSRGSC3.4
Celera534,964,792 - 34,964,975UniSTS
RH 3.4 Map5181.8UniSTS
Cytogenetic Map5q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 92 59 6 356 192 11 141 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000061128   ⟹   ENSRNOP00000057843
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl540,759,026 - 40,826,154 (+)Ensembl
mRatBN7.2 Ensembl535,955,812 - 36,029,443 (+)Ensembl
Rnor_6.0 Ensembl536,555,109 - 36,628,917 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000077650   ⟹   ENSRNOP00000069859
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl540,759,026 - 40,850,826 (+)Ensembl
mRatBN7.2 Ensembl535,955,812 - 36,024,469 (+)Ensembl
Rnor_6.0 Ensembl536,566,783 - 36,629,689 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000102239   ⟹   ENSRNOP00000076415
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl540,752,521 - 40,826,154 (+)Ensembl
mRatBN7.2 Ensembl535,955,828 - 36,029,441 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000164102   ⟹   ENSRNOP00000101703
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl540,759,026 - 40,821,884 (+)Ensembl
RefSeq Acc Id: NM_001395576   ⟹   NP_001382505
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8540,752,521 - 40,826,154 (+)NCBI
mRatBN7.2535,955,809 - 36,029,446 (+)NCBI
RefSeq Acc Id: NM_001395577   ⟹   NP_001382506
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8540,752,521 - 40,826,154 (+)NCBI
mRatBN7.2535,955,809 - 36,029,446 (+)NCBI
RefSeq Acc Id: NR_172642
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8540,752,521 - 40,826,154 (+)NCBI
mRatBN7.2535,955,809 - 36,029,446 (+)NCBI
RefSeq Acc Id: XM_017593342   ⟹   XP_017448831
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8540,752,517 - 40,826,154 (+)NCBI
mRatBN7.2535,955,805 - 36,029,446 (+)NCBI
Rnor_6.0536,555,062 - 36,628,920 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017593343   ⟹   XP_017448832
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8540,752,513 - 40,826,154 (+)NCBI
mRatBN7.2535,955,801 - 36,029,446 (+)NCBI
Rnor_6.0536,555,062 - 36,628,920 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039109815   ⟹   XP_038965743
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8540,752,517 - 40,826,154 (+)NCBI
mRatBN7.2535,955,805 - 36,029,446 (+)NCBI
RefSeq Acc Id: XM_063287582   ⟹   XP_063143652
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8540,752,517 - 40,826,154 (+)NCBI
RefSeq Acc Id: XM_063287583   ⟹   XP_063143653
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8540,752,513 - 40,826,154 (+)NCBI
RefSeq Acc Id: XP_017448831   ⟸   XM_017593342
- Peptide Label: isoform X1
- UniProtKB: B1WBR8 (UniProtKB/TrEMBL),   F7FMX3 (UniProtKB/TrEMBL),   A0A0G2JWF5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017448832   ⟸   XM_017593343
- Peptide Label: isoform X1
- UniProtKB: B1WBR8 (UniProtKB/TrEMBL),   F7FMX3 (UniProtKB/TrEMBL),   A0A0G2JWF5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000057843   ⟸   ENSRNOT00000061128
Ensembl Acc Id: ENSRNOP00000069859   ⟸   ENSRNOT00000077650
RefSeq Acc Id: XP_038965743   ⟸   XM_039109815
- Peptide Label: isoform X1
- UniProtKB: B1WBR8 (UniProtKB/TrEMBL),   F7FMX3 (UniProtKB/TrEMBL),   A0A0G2JWF5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000076415   ⟸   ENSRNOT00000102239
RefSeq Acc Id: NP_001382505   ⟸   NM_001395576
- Peptide Label: isoform 1
- UniProtKB: B1WBR8 (UniProtKB/TrEMBL),   F7FMX3 (UniProtKB/TrEMBL),   A0A0G2JWF5 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001382506   ⟸   NM_001395577
- Peptide Label: isoform 2
- UniProtKB: A0A8I5Y8W0 (UniProtKB/TrEMBL),   A0A0G2JWF5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063143653   ⟸   XM_063287583
- Peptide Label: isoform X2
- UniProtKB: A0A0G2JWF5 (UniProtKB/TrEMBL),   A0A8I5Y8W0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063143652   ⟸   XM_063287582
- Peptide Label: isoform X2
- UniProtKB: A0A0G2JWF5 (UniProtKB/TrEMBL),   A0A8I5Y8W0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000101703   ⟸   ENSRNOT00000164102
Protein Domains
F-box

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B1WBR8-F1-model_v2 AlphaFold B1WBR8 1-621 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693600
Promoter ID:EPDNEW_R4125
Type:initiation region
Name:Fbxl4_1
Description:F-box and leucine-rich repeat protein 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0536,555,102 - 36,555,162EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305724 AgrOrtholog
BioCyc Gene G2FUF-41804 BioCyc
Ensembl Genes ENSRNOG00000005641 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000061128 ENTREZGENE
  ENSRNOT00000061128.6 UniProtKB/TrEMBL
  ENSRNOT00000077650.3 UniProtKB/TrEMBL
  ENSRNOT00000102239 ENTREZGENE
  ENSRNOT00000102239.2 UniProtKB/TrEMBL
  ENSRNOT00000164102.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1280.50 UniProtKB/TrEMBL
  3.80.10.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7096047 IMAGE-MGC_LOAD
InterPro F-box_dom_cyclin-like UniProtKB/TrEMBL
  F-box_dom_like UniProtKB/TrEMBL
  L_dom-like UniProtKB/TrEMBL
  Leu-rich_rpt_Cys-con_subtyp UniProtKB/TrEMBL
MGC_CLONE MGC:187392 IMAGE-MGC_LOAD
NCBI Gene 313101 ENTREZGENE
PANTHER F-BOX/LRR-REPEAT PROTEIN 4 UniProtKB/TrEMBL
  UNCHARACTERIZED UniProtKB/TrEMBL
Pfam F-box-like UniProtKB/TrEMBL
PhenoGen Fbxl4 PhenoGen
PROSITE FBOX UniProtKB/TrEMBL
RatGTEx ENSRNOG00000005641 RatGTEx
SMART FBOX UniProtKB/TrEMBL
  LRR_CC UniProtKB/TrEMBL
Superfamily-SCOP F-box_dom_Skp2-like UniProtKB/TrEMBL
  RNI-like UniProtKB/TrEMBL
UniProt A0A0G2JWF5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5Y8W0 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0L0P9_RAT UniProtKB/TrEMBL
  B1WBR8 ENTREZGENE, UniProtKB/TrEMBL
  F7FMX3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Fbxl4  F-box and leucine-rich repeat protein 4   Fbxl4_predicted  F-box and leucine-rich repeat protein 4 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Fbxl4_predicted  F-box and leucine-rich repeat protein 4 (predicted)      Symbol and Name status set to approved 70820 APPROVED