Nat8l (N-acetyltransferase 8-like) - Rat Genome Database

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Gene: Nat8l (N-acetyltransferase 8-like) Rattus norvegicus
Analyze
Symbol: Nat8l
Name: N-acetyltransferase 8-like
RGD ID: 1305719
Description: Enables aspartate N-acetyltransferase activity. Predicted to be involved in acetate metabolic process; aspartate metabolic process; and positive regulation of dopamine uptake involved in synaptic transmission. Located in mitochondrion. Orthologous to human NAT8L (N-acetyltransferase 8 like); INTERACTS WITH 1,2-dimethylhydrazine; 6-propyl-2-thiouracil; amphetamine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC289727; N-acetylaspartate synthetase; NAA synthetase; RGD1305719; similar to putative N-acetyltransferase Camello 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81480,980,629 - 80,987,264 (-)NCBIGRCr8
mRatBN7.21476,756,077 - 76,762,712 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1476,756,077 - 76,763,411 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1481,208,268 - 81,214,903 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01482,448,910 - 82,455,545 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01478,894,162 - 78,900,797 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01482,041,616 - 82,048,251 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1482,041,616 - 82,048,251 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01482,725,856 - 82,732,491 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41482,450,004 - 82,456,639 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11482,452,871 - 82,459,041 (-)NCBI
Celera1475,679,651 - 75,686,286 (-)NCBICelera
Cytogenetic Map14q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. N-acetylaspartate synthesis in the brain: mitochondria vs. microsomes. Ariyannur PS, etal., Brain Res. 2008 Aug 28;1227:34-41. doi: 10.1016/j.brainres.2008.06.040. Epub 2008 Jun 21.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:19014384   PMID:19524112   PMID:19807691   PMID:20385109   PMID:20643647   PMID:24515258  


Genomics

Comparative Map Data
Nat8l
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81480,980,629 - 80,987,264 (-)NCBIGRCr8
mRatBN7.21476,756,077 - 76,762,712 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1476,756,077 - 76,763,411 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1481,208,268 - 81,214,903 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01482,448,910 - 82,455,545 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01478,894,162 - 78,900,797 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01482,041,616 - 82,048,251 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1482,041,616 - 82,048,251 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01482,725,856 - 82,732,491 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41482,450,004 - 82,456,639 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11482,452,871 - 82,459,041 (-)NCBI
Celera1475,679,651 - 75,686,286 (-)NCBICelera
Cytogenetic Map14q21NCBI
NAT8L
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3842,059,327 - 2,069,089 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl42,059,327 - 2,069,089 (+)EnsemblGRCh38hg38GRCh38
GRCh3742,061,054 - 2,070,816 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3642,031,385 - 2,037,433 (+)NCBINCBI36Build 36hg18NCBI36
Celera41,973,294 - 1,982,873 (+)NCBICelera
Cytogenetic Map4p16.3NCBI
HuRef42,002,444 - 2,011,663 (+)NCBIHuRef
CHM1_142,059,837 - 2,069,384 (+)NCBICHM1_1
T2T-CHM13v2.042,057,805 - 2,067,569 (+)NCBIT2T-CHM13v2.0
Nat8l
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39534,153,328 - 34,163,260 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl534,153,328 - 34,163,260 (+)EnsemblGRCm39 Ensembl
GRCm38533,995,984 - 34,005,916 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl533,995,984 - 34,005,916 (+)EnsemblGRCm38mm10GRCm38
MGSCv37534,338,633 - 34,348,565 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36534,312,841 - 34,322,771 (+)NCBIMGSCv36mm8
Celera531,465,700 - 31,475,650 (+)NCBICelera
Cytogenetic Map5B2NCBI
cM Map517.83NCBI
Nat8l
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555141,207,310 - 1,213,732 (+)NCBIChiLan1.0ChiLan1.0
NAT8L
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v232,392,168 - 2,401,971 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan142,328,762 - 2,338,464 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v042,201,326 - 2,211,302 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.142,111,100 - 2,114,512 (+)NCBIpanpan1.1PanPan1.1panPan2
NAT8L
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1362,107,060 - 62,113,807 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl362,108,003 - 62,113,737 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha364,625,039 - 64,631,752 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0362,582,678 - 62,589,391 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl362,579,869 - 62,589,356 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1362,075,250 - 62,081,962 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0362,278,911 - 62,285,622 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0362,638,914 - 62,645,627 (-)NCBIUU_Cfam_GSD_1.0
Nat8l
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528567,696,037 - 67,703,423 (-)NCBIHiC_Itri_2
SpeTri2.0NW_00493647721,397,729 - 21,405,098 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NAT8L
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl81,063,824 - 1,072,189 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.181,063,917 - 1,072,191 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28448,361 - 456,975 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NAT8L
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12746,697,086 - 46,703,494 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2746,698,845 - 46,703,413 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660513,064,403 - 3,073,881 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nat8l
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475525,468,658 - 25,472,837 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475525,465,154 - 25,472,906 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nat8l
21 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:388
Count of miRNA genes:200
Interacting mature miRNAs:258
Transcripts:ENSRNOT00000074734
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
70187Pancm5Pancreatic morphology QTL 516.7pancreas mass (VT:0010144)pancreas weight to body weight ratio (CMO:0000630)143032009280829842Rat
2313048Bss84Bone structure and strength QTL 843.10.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143766971982669719Rat
2313084Bss83Bone structure and strength QTL 832.90.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143766971982669719Rat
2313089Bss81Bone structure and strength QTL 813.40.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)143766971982669719Rat
2313100Bss82Bone structure and strength QTL 8230.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143766971982669719Rat
738037Hcas6Hepatocarcinoma susceptibility QTL 62.93liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)143905723783368335Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)144079346098037301Rat
1300136Rf22Renal function QTL 223.9renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)144226252995023211Rat
1549834Scl45Serum cholesterol level QTL 455.8blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)145002321195023211Rat
2300197Scl59Serum cholesterol level QTL 59blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1455147478100147478Rat
9590294Uminl4Urine mineral level QTL 45.660.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)1455624247100624247Rat
9589034Epfw11Epididymal fat weight QTL 1160.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1455624247100624247Rat
2317879Alcrsp27Alcohol response QTL 273.30.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1456631369101631369Rat
634328Hc5Hypercalciuria QTL 52.3urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1458184885103184885Rat
70153Bp59Blood pressure QTL 593.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)146875779683368335Rat
1582259Gluco23Glucose level QTL 233.10.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1470053989104886043Rat
1641900Alcrsp11Alcohol response QTL 11alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)1470053989104886043Rat
1582197Gluco27Glucose level QTL 273.40.0006blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)147341532392554092Rat
1582209Gluco20Glucose level QTL 203.80.0005blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532392554092Rat
1582236Gluco22Glucose level QTL 223.30.0164blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532392554092Rat
1582255Gluco29Glucose level QTL 293.10.0025blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)147341532392554092Rat
1582250Gluco26Glucose level QTL 263.30.0009blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532395876975Rat

Markers in Region
RH143045  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21476,756,615 - 76,756,832 (+)MAPPERmRatBN7.2
Rnor_6.01482,042,155 - 82,042,371NCBIRnor6.0
Rnor_5.01482,726,395 - 82,726,611UniSTSRnor5.0
RGSC_v3.41482,450,543 - 82,450,759UniSTSRGSC3.4
Celera1475,680,190 - 75,680,406UniSTS
Cytogenetic Map14q21UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 4 2 74 2
Low 2 33 14 2 12 2 3 4 27 39 11 3
Below cutoff 1 10 27 27 5 27 5 7 8 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000074734   ⟹   ENSRNOP00000066413
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1476,756,077 - 76,763,411 (-)Ensembl
Rnor_6.0 Ensembl1482,041,616 - 82,048,251 (-)Ensembl
RefSeq Acc Id: NM_001191681   ⟹   NP_001178610
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81480,980,629 - 80,987,264 (-)NCBI
mRatBN7.21476,756,077 - 76,762,712 (-)NCBI
Rnor_6.01482,041,616 - 82,048,251 (-)NCBI
Rnor_5.01482,725,856 - 82,732,491 (-)NCBI
Celera1475,679,651 - 75,686,286 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001178610 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein D3ZVU9 (Get FASTA)   NCBI Sequence Viewer  
  EDM00108 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000066413
  ENSRNOP00000066413.1
  ENSRNOP00055023311
  ENSRNOP00060023318
  ENSRNOP00065041989
Reference Protein Sequences
RefSeq Acc Id: NP_001178610   ⟸   NM_001191681
- UniProtKB: D3ZVU9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000066413   ⟸   ENSRNOT00000074734
Protein Domains
N-acetyltransferase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZVU9-F1-model_v2 AlphaFold D3ZVU9 1-299 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305719 AgrOrtholog
BioCyc Gene G2FUF-15278 BioCyc
Ensembl Genes ENSRNOG00000049351 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055017058 UniProtKB/Swiss-Prot
  ENSRNOG00060016939 UniProtKB/Swiss-Prot
  ENSRNOG00065029566 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000074734 ENTREZGENE
  ENSRNOT00000074734.2 UniProtKB/Swiss-Prot
  ENSRNOT00055028959 UniProtKB/Swiss-Prot
  ENSRNOT00060028962 UniProtKB/Swiss-Prot
  ENSRNOT00065051044 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.630.30 UniProtKB/Swiss-Prot
InterPro Acyl_CoA_acyltransferase UniProtKB/Swiss-Prot
  GNAT_dom UniProtKB/Swiss-Prot
KEGG Report rno:289727 UniProtKB/Swiss-Prot
NCBI Gene 289727 ENTREZGENE
PANTHER GNAT FAMILY N-ACETYLTRANSFERASE UniProtKB/Swiss-Prot
  N-ACETYLASPARTATE SYNTHETASE UniProtKB/Swiss-Prot
Pfam Acetyltransf_1 UniProtKB/Swiss-Prot
PhenoGen Nat8l PhenoGen
PROSITE GNAT UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000049351 RatGTEx
  ENSRNOG00055017058 RatGTEx
  ENSRNOG00060016939 RatGTEx
  ENSRNOG00065029566 RatGTEx
Superfamily-SCOP SSF55729 UniProtKB/Swiss-Prot
UniProt D3ZVU9 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Nat8l  N-acetyltransferase 8-like   Nat8l_predicted  N-acetyltransferase 8-like (predicted)  'predicted' is removed 2292626 APPROVED
2007-12-17 Nat8l_predicted    Nat8l _predicted  N-acetyltransferase 8-like (predicted)  Symbol updated 1299863 APPROVED
2007-03-29 Nat8l _predicted  N-acetyltransferase 8-like (predicted)  RGD1305719_predicted  similar to putative N-acetyltransferase Camello 2 (predicted)  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2005-01-20 RGD1305719_predicted  similar to putative N-acetyltransferase Camello 2 (predicted)  LOC289727_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC289727_predicted  similar to putative N-acetyltransferase Camello 2 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL