Gene: Spock3 (SPARC/osteonectin, cwcv and kazal like domains proteoglycan 3) Rattus norvegicus
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Symbol:
Spock3
Name:
SPARC/osteonectin, cwcv and kazal like domains proteoglycan 3
RGD ID:
1305672
Description:
Predicted to enable calcium ion binding activity; glycosaminoglycan binding activity; and metalloendopeptidase inhibitor activity. Predicted to be involved in negative regulation of endopeptidase activity and regulation of cell-substrate adhesion. Predicted to be active in extracellular matrix and extracellular space. Orthologous to human SPOCK3 (SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil.
Type:
protein-coding
RefSeq Status:
VALIDATED
Previously known as:
LOC306404; sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3; sparc/osteonectin, cwcv and kazal-like domains proteoglycan 3; testican-3
RGD Orthologs
Alliance Orthologs
More Info
more info ...
More Info
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
SPOCK3 (SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3)
HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):
Spock3 (sparc/osteonectin, cwcv and kazal-like domains proteoglycan 3)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):
Spock3 (SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
SPOCK3 (SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
SPOCK3 (SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Spock3 (SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
SPOCK3 (SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):
SPOCK3 (SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Spock3 (SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Rattus rattus (black rat):
Spock3 (SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Other homologs 2
Homo sapiens (human):
SPOCK1 (SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1)
HGNC
OrthoDB
Homo sapiens (human):
BARHL2 (BarH like homeobox 2)
HGNC
OMA
Alliance orthologs 3
Homo sapiens (human):
SPOCK3 (SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3)
Alliance
DIOPT (Ensembl Compara|HGNC|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Mus musculus (house mouse):
Spock3 (sparc/osteonectin, cwcv and kazal-like domains proteoglycan 3)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Danio rerio (zebrafish):
spock3 (SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB)
Danio rerio (zebrafish):
spock3 (SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Drosophila melanogaster (fruit fly):
Cow
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OrthoFinder|OrthoInspector|SonicParanoid)
Caenorhabditis elegans (roundworm):
test-1
Alliance
DIOPT (Ensembl Compara|InParanoid|OrthoFinder|OrthoInspector|SonicParanoid)
Caenorhabditis elegans (roundworm):
test-1
Alliance
DIOPT (Ensembl Compara|OrthoFinder|OrthoInspector|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):
spock3
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):
spock3
Alliance
DIOPT (Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER)
Latest Assembly:
GRCr8 - GRCr8 Assembly
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 16 31,149,698 - 31,582,280 (-) NCBI GRCr8 GRCr8 GRCr8 GRCr8 Ensembl 16 31,149,702 - 31,582,398 (-) Ensembl GRCr8 mRatBN7.2 16 26,382,895 - 26,815,943 (-) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl 16 26,383,383 - 26,815,205 (-) Ensembl mRatBN7.2 UTH_Rnor_SHR_Utx 16 29,739,811 - 30,166,034 (-) NCBI UTH_Rnor_SHR_Utx UTH_Rnor_SHR_Utx UTH_Rnor_SHRSP_BbbUtx_1.0 16 33,174,030 - 33,600,260 (-) NCBI UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_WKY_Bbb_1.0 16 29,125,663 - 29,558,060 (-) NCBI UTH_Rnor_WKY_Bbb_1.0 UTH_Rnor_WKY_Bbb_1.0 Dahl_SR_JrHsd 16 31,029,163 - 31,455,345 (-) NCBI Dahl_SR_JrHsd Lyon_Normotensive 16 32,400,006 - 32,826,189 (-) NCBI Lyon_Normotensive Lyon_Hypertensive 16 32,817,179 - 33,243,353 (-) NCBI Lyon_Hypertensive F344_StmMcwi 16 30,044,311 - 30,464,961 (-) NCBI F344_StmMcwi Rnor_6.0 16 28,372,067 - 28,716,762 (-) NCBI Rnor_6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 16 28,372,411 - 28,716,885 (-) Ensembl rn6 Rnor6.0 Rnor_5.0 16 28,585,376 - 28,585,974 (-) NCBI Rnor_5.0 Rnor_5.0 rn5 Rnor_5.0 16 28,243,878 - 28,508,371 (-) NCBI Rnor_5.0 Rnor_5.0 rn5 RGSC_v3.4 16 29,337,211 - 29,751,950 (-) NCBI RGSC_v3.4 RGSC_v3.4 rn4 Celera 16 26,444,211 - 26,865,494 (-) NCBI Celera RGSC_v3.1 16 29,338,682 - 29,751,934 (-) NCBI Cytogenetic Map 16 p13 NCBI
JBrowse:
Only show annotations with direct experimental evidence (0 objects hidden)
Spock3 Rat 1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene multiple interactions ISO Spock3 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Spock3 Rat 1,2-dichloroethane decreases expression ISO Spock3 (Mus musculus) 6480464 ethylene dichloride results in decreased expression of SPOCK3 mRNA CTD PMID:28960355 Spock3 Rat 17beta-estradiol increases expression ISO SPOCK3 (Homo sapiens) 6480464 Estradiol results in increased expression of SPOCK3 mRNA CTD PMID:19429434 Spock3 Rat 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions ISO Spock3 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Spock3 Rat 2,2',5,5'-tetrachlorobiphenyl multiple interactions ISO Spock3 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Spock3 Rat 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO SPOCK3 (Homo sapiens) 6480464 Tetrachlorodibenzodioxin results in increased expression of SPOCK3 mRNA CTD PMID:21296121 Spock3 Rat 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of SPOCK3 mRNA CTD PMID:32109520 Spock3 Rat 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO Spock3 (Mus musculus) 6480464 Tetrachlorodibenzodioxin affects the expression of SPOCK3 mRNA CTD PMID:21570461|PMID:24680724 Spock3 Rat 2,3,7,8-Tetrachlorodibenzofuran decreases expression EXP 6480464 2,3,7,8-tetrachlorodibenzofuran results in decreased expression of SPOCK3 mRNA CTD PMID:32109520 Spock3 Rat 2,4,4'-trichlorobiphenyl multiple interactions ISO Spock3 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Spock3 Rat 2,4-dibromophenyl 2,4,5-tribromophenyl ether affects expression ISO Spock3 (Mus musculus) 6480464 2,2',4,4',5-brominated diphenyl ether affects the expression of SPOCK3 mRNA CTD PMID:38648751 Spock3 Rat 3-Nitrobenzanthrone decreases expression ISO SPOCK3 (Homo sapiens) 6480464 3-nitrobenzanthrone results in decreased expression of SPOCK3 mRNA CTD PMID:34036453 Spock3 Rat 6-propyl-2-thiouracil decreases expression EXP 6480464 Propylthiouracil results in decreased expression of SPOCK3 mRNA CTD PMID:24780913 Spock3 Rat acetohydrazide decreases expression ISO Spock3 (Mus musculus) 6480464 acetylhydrazine results in decreased expression of SPOCK3 mRNA CTD PMID:15282401 Spock3 Rat aflatoxin B1 decreases expression ISO SPOCK3 (Homo sapiens) 6480464 Aflatoxin B1 results in decreased expression of SPOCK3 mRNA CTD PMID:22100608|PMID:32234424|PMID:35690182 Spock3 Rat all-trans-retinoic acid increases expression ISO SPOCK3 (Homo sapiens) 6480464 Tretinoin results in increased expression of SPOCK3 mRNA CTD PMID:21934132 Spock3 Rat antirheumatic drug increases expression ISO SPOCK3 (Homo sapiens) 6480464 Antirheumatic Agents results in increased expression of SPOCK3 mRNA CTD PMID:24449571 Spock3 Rat aristolochic acid A decreases expression ISO SPOCK3 (Homo sapiens) 6480464 aristolochic acid I results in decreased expression of SPOCK3 mRNA CTD PMID:33212167 Spock3 Rat benzo[a]pyrene multiple interactions ISO Spock3 (Mus musculus) 6480464 Benzo(a)pyrene promotes the reaction [AHR protein binds to SPOCK3 promoter] CTD PMID:19654925 Spock3 Rat benzo[a]pyrene decreases expression ISO SPOCK3 (Homo sapiens) 6480464 Benzo(a)pyrene results in decreased expression of SPOCK3 mRNA CTD PMID:32234424|PMID:35690182 Spock3 Rat benzo[a]pyrene increases methylation ISO SPOCK3 (Homo sapiens) 6480464 Benzo(a)pyrene results in increased methylation of SPOCK3 promoter CTD PMID:27901495 Spock3 Rat bis(2-ethylhexyl) phthalate multiple interactions EXP 6480464 [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of SPOCK3 more ... CTD PMID:23359474 Spock3 Rat bisphenol A multiple interactions EXP 6480464 [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of SPOCK3 more ... CTD PMID:23359474 Spock3 Rat bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of SPOCK3 mRNA CTD PMID:25181051|PMID:34947998|PMID:41034487 Spock3 Rat Butylbenzyl phthalate increases methylation ISO Spock3 (Mus musculus) 6480464 butylbenzyl phthalate results in increased methylation of SPOCK3 intron CTD PMID:28392331 Spock3 Rat cadmium dichloride decreases methylation EXP 6480464 Cadmium Chloride results in decreased methylation of SPOCK3 promoter CTD PMID:22457795 Spock3 Rat CGP 52608 multiple interactions ISO SPOCK3 (Homo sapiens) 6480464 CGP 52608 promotes the reaction [RORA protein binds to SPOCK3 gene] CTD PMID:28238834 Spock3 Rat chlordecone increases expression ISO Spock3 (Mus musculus) 6480464 Chlordecone results in increased expression of SPOCK3 mRNA CTD PMID:33711761 Spock3 Rat copper(II) sulfate increases expression ISO SPOCK3 (Homo sapiens) 6480464 Copper Sulfate results in increased expression of SPOCK3 mRNA CTD PMID:19549813 Spock3 Rat dibutyl phthalate multiple interactions EXP 6480464 [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of SPOCK3 more ... CTD PMID:23359474 Spock3 Rat dioxygen increases expression ISO Spock3 (Mus musculus) 6480464 Oxygen deficiency results in increased expression of SPOCK3 mRNA CTD PMID:24205000 Spock3 Rat dorsomorphin multiple interactions ISO SPOCK3 (Homo sapiens) 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ... CTD PMID:27188386 Spock3 Rat ethanol affects splicing ISO Spock3 (Mus musculus) 6480464 Ethanol affects the splicing of SPOCK3 mRNA CTD PMID:30319688 Spock3 Rat ethylparaben increases expression ISO SPOCK3 (Homo sapiens) 6480464 ethyl-p-hydroxybenzoate results in increased expression of SPOCK3 mRNA CTD PMID:37690743 Spock3 Rat fenamidone decreases expression ISO Spock3 (Mus musculus) 6480464 fenamidone results in decreased expression of SPOCK3 mRNA CTD PMID:27029645 Spock3 Rat folic acid decreases expression ISO Spock3 (Mus musculus) 6480464 Folic Acid results in decreased expression of SPOCK3 mRNA CTD PMID:25629700 Spock3 Rat folic acid increases expression ISO SPOCK3 (Homo sapiens) 6480464 Folic Acid results in increased expression of SPOCK3 mRNA CTD PMID:21867686 Spock3 Rat fulvestrant decreases methylation ISO SPOCK3 (Homo sapiens) 6480464 Fulvestrant results in decreased methylation of SPOCK3 gene CTD PMID:31601247 Spock3 Rat Lasiocarpine decreases expression ISO SPOCK3 (Homo sapiens) 6480464 lasiocarpine results in decreased expression of SPOCK3 mRNA CTD PMID:32234424|PMID:35690182 Spock3 Rat N-methyl-4-phenylpyridinium decreases expression ISO SPOCK3 (Homo sapiens) 6480464 1-Methyl-4-phenylpyridinium results in decreased expression of SPOCK3 mRNA CTD PMID:24810058 Spock3 Rat N-Nitrosopyrrolidine decreases expression ISO SPOCK3 (Homo sapiens) 6480464 N-Nitrosopyrrolidine results in decreased expression of SPOCK3 mRNA CTD PMID:32234424|PMID:35690182 Spock3 Rat O-methyleugenol decreases expression ISO SPOCK3 (Homo sapiens) 6480464 methyleugenol results in decreased expression of SPOCK3 mRNA CTD PMID:32234424|PMID:35690182 Spock3 Rat okadaic acid decreases expression ISO SPOCK3 (Homo sapiens) 6480464 Okadaic Acid results in decreased expression of SPOCK3 mRNA CTD PMID:38832940 Spock3 Rat paracetamol increases expression EXP 6480464 Acetaminophen results in increased expression of SPOCK3 mRNA CTD PMID:33387578 Spock3 Rat paraquat decreases expression EXP 6480464 Paraquat results in decreased expression of SPOCK3 mRNA CTD PMID:32680482 Spock3 Rat PCB138 multiple interactions ISO Spock3 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Spock3 Rat phenylmercury acetate increases expression ISO SPOCK3 (Homo sapiens) 6480464 Phenylmercuric Acetate results in increased expression of SPOCK3 mRNA CTD PMID:26272509 Spock3 Rat phenylmercury acetate multiple interactions ISO SPOCK3 (Homo sapiens) 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ... CTD PMID:27188386 Spock3 Rat raloxifene increases expression ISO SPOCK3 (Homo sapiens) 6480464 Raloxifene Hydrochloride results in increased expression of SPOCK3 mRNA CTD PMID:19429434 Spock3 Rat SB 431542 multiple interactions ISO SPOCK3 (Homo sapiens) 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ... CTD PMID:27188386 Spock3 Rat sodium arsenate increases expression ISO Spock3 (Mus musculus) 6480464 sodium arsenate results in increased expression of SPOCK3 mRNA CTD PMID:21795629 Spock3 Rat sodium arsenite affects methylation ISO SPOCK3 (Homo sapiens) 6480464 sodium arsenite affects the methylation of SPOCK3 gene CTD PMID:28589171 Spock3 Rat titanium dioxide decreases expression ISO Spock3 (Mus musculus) 6480464 titanium dioxide results in decreased expression of SPOCK3 mRNA CTD PMID:29264374 Spock3 Rat trichloroethene increases expression EXP 6480464 Trichloroethylene results in increased expression of SPOCK3 mRNA CTD PMID:33387578 Spock3 Rat trichostatin A increases expression ISO SPOCK3 (Homo sapiens) 6480464 trichostatin A results in increased expression of SPOCK3 mRNA CTD PMID:24935251|PMID:27188386 Spock3 Rat valproic acid affects expression ISO SPOCK3 (Homo sapiens) 6480464 Valproic Acid affects the expression of SPOCK3 mRNA CTD PMID:25979313 Spock3 Rat valproic acid decreases expression ISO Spock3 (Mus musculus) 6480464 Valproic Acid results in decreased expression of SPOCK3 mRNA CTD PMID:24896083 Spock3 Rat valproic acid increases expression ISO SPOCK3 (Homo sapiens) 6480464 Valproic Acid results in increased expression of SPOCK3 mRNA CTD PMID:23179753|PMID:24383497|PMID:26272509|PMID:28001369 Spock3 Rat valproic acid multiple interactions ISO SPOCK3 (Homo sapiens) 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ... CTD PMID:27188386