Arhgap44 (Rho GTPase activating protein 44) - Rat Genome Database

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Gene: Arhgap44 (Rho GTPase activating protein 44) Rattus norvegicus
Analyze
Symbol: Arhgap44
Name: Rho GTPase activating protein 44
RGD ID: 1305664
Description: Enables GTPase activator activity. Involved in negative regulation of filopodium assembly. Located in dendrite; postsynapse; and presynapse. Is active in glutamatergic synapse; postsynaptic density; and presynaptic active zone. Human ortholog(s) of this gene implicated in acquired immunodeficiency syndrome and skin melanoma. Orthologous to human ARHGAP44 (Rho GTPase activating protein 44); INTERACTS WITH 1,3-dinitrobenzene; atrazine; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC303222; RGD1305664; rho GTPase-activating protein 44; rho-type GTPase-activating protein RICH2; rhoGAP interacting with CIP4 homologs protein 2; RICH-2; similar to KIAA0672 gene product
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81050,154,724 - 50,322,027 (-)NCBIGRCr8
mRatBN7.21049,655,583 - 49,822,876 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1049,655,584 - 49,824,297 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01051,501,547 - 51,669,546 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1051,502,894 - 51,669,297 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01051,259,533 - 51,425,933 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41051,313,035 - 51,479,556 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11051,328,436 - 51,494,957 (-)NCBI
Celera1048,871,532 - 49,038,827 (-)NCBICelera
Cytogenetic Map10q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Dynamic recruitment of the curvature-sensitive protein ArhGAP44 to nanoscale membrane deformations limits exploratory filopodia initiation in neurons. Galic M, etal., Elife. 2014 Dec 15;3:e03116. doi: 10.7554/eLife.03116.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Screening low-frequency SNPS from genome-wide association study reveals a new risk allele for progression to AIDS. Le Clerc S, etal., J Acquir Immune Defic Syndr. 2011 Mar 1;56(3):279-84. doi: 10.1097/QAI.0b013e318204982b.
4. Genetic variants in the genes encoding rho GTPases and related regulators predict cutaneous melanoma-specific survival. Liu S, etal., Int J Cancer. 2017 Aug 15;141(4):721-730. doi: 10.1002/ijc.30785. Epub 2017 Jun 1.
5. A comprehensive landscape of transcription profiles and data resources for human leukemia. Luo M, etal., Blood Adv. 2023 Jul 25;7(14):3435-3449. doi: 10.1182/bloodadvances.2022008410.
6. RICH2 is implicated in viraemic control of HIV-1 in black South African individuals. Paximadis M, etal., Infect Genet Evol. 2017 Apr;49:78-87. doi: 10.1016/j.meegid.2017.01.007. Epub 2017 Jan 6.
7. Shank3-Rich2 interaction regulates AMPA receptor recycling and synaptic long-term potentiation. Raynaud F, etal., J Neurosci. 2013 Jun 5;33(23):9699-715. doi: 10.1523/JNEUROSCI.2725-12.2013.
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Mutant p53 promotes cell spreading and migration via ARHGAP44. Xu J, etal., Sci China Life Sci. 2017 Sep;60(9):1019-1029. doi: 10.1007/s11427-016-9040-8. Epub 2017 May 16.
11. RICH2, a potential tumor suppressor in hepatocellular carcinoma. Zhang J, etal., Front Biosci (Landmark Ed). 2019 Jun 1;24(8):1363-1376. doi: 10.2741/4784.
Additional References at PubMed
PMID:12477932   PMID:22750946   PMID:24352656   PMID:26969129   PMID:30053369  


Genomics

Comparative Map Data
Arhgap44
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81050,154,724 - 50,322,027 (-)NCBIGRCr8
mRatBN7.21049,655,583 - 49,822,876 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1049,655,584 - 49,824,297 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01051,501,547 - 51,669,546 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1051,502,894 - 51,669,297 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01051,259,533 - 51,425,933 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41051,313,035 - 51,479,556 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11051,328,436 - 51,494,957 (-)NCBI
Celera1048,871,532 - 49,038,827 (-)NCBICelera
Cytogenetic Map10q24NCBI
ARHGAP44
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381712,789,498 - 12,991,643 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1712,789,498 - 12,991,643 (+)EnsemblGRCh38hg38GRCh38
GRCh371712,692,815 - 12,894,960 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361712,633,554 - 12,835,685 (+)NCBINCBI36Build 36hg18NCBI36
Celera1712,718,166 - 12,920,275 (+)NCBICelera
Cytogenetic Map17p12NCBI
HuRef1712,588,245 - 12,790,668 (+)NCBIHuRef
CHM1_11712,701,589 - 12,903,719 (+)NCBICHM1_1
T2T-CHM13v2.01712,696,985 - 12,899,110 (+)NCBIT2T-CHM13v2.0
Arhgap44
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391164,892,865 - 65,053,779 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1164,892,865 - 65,053,787 (-)EnsemblGRCm39 Ensembl
GRCm381165,002,039 - 65,162,972 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1165,002,039 - 65,162,961 (-)EnsemblGRCm38mm10GRCm38
MGSCv371164,815,541 - 64,976,463 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361164,818,234 - 64,979,156 (-)NCBIMGSCv36mm8
Celera1171,938,015 - 72,099,074 (-)NCBICelera
Cytogenetic Map11B3NCBI
cM Map1140.42NCBI
Arhgap44
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554674,430,087 - 4,522,611 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554674,428,738 - 4,590,877 (-)NCBIChiLan1.0ChiLan1.0
ARHGAP44
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21960,757,445 - 60,959,269 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11765,564,061 - 65,765,878 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01738,657,824 - 38,859,591 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11743,357,438 - 43,558,355 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1743,357,438 - 43,453,457 (-)Ensemblpanpan1.1panPan2
ARHGAP44
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1536,790,059 - 36,957,932 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl536,789,814 - 36,957,411 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha536,933,812 - 37,101,416 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0536,898,675 - 37,066,421 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl536,898,649 - 37,066,421 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1536,871,586 - 37,039,378 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0536,818,449 - 36,986,578 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0537,008,878 - 37,176,525 (+)NCBIUU_Cfam_GSD_1.0
Arhgap44
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560251,899,406 - 52,068,726 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365955,373,476 - 5,543,073 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365955,373,645 - 5,542,915 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARHGAP44
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1257,049,895 - 57,206,889 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11257,049,900 - 57,206,706 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21260,167,786 - 60,195,211 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ARHGAP44
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11612,125,543 - 12,328,203 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1612,125,574 - 12,330,501 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660598,910,762 - 9,113,230 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Arhgap44
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624877661,998 - 850,431 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624877662,595 - 851,762 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Arhgap44
591 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:731
Count of miRNA genes:246
Interacting mature miRNAs:305
Transcripts:ENSRNOT00000004829, ENSRNOT00000057583, ENSRNOT00000071595
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10538701450387014Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10538701450387014Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101502851360430477Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
6893350Bw99Body weight QTL 990.870.16body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
6893352Bw100Body weight QTL 1000.330.6body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101790711351786432Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101816784163167841Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)101960648364606483Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)101960648364606483Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102132980561345413Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102652195761345413Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102694462871944628Rat
10402859Bp381Blood pressure QTL 3810.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2292441Bp308Blood pressure QTL 308arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102845313673453136Rat
1600371Mcs21Mammary carcinoma susceptibility QTL 213mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)102887565052200160Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102929950464155584Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103122402675632053Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
1576319Cia29Collagen induced arthritis QTL 29joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103397392178973921Rat
1354614Hpcl1Hepatic cholesterol level QTL 13.3liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)103539226751793994Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103539226764155584Rat
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103539245763642539Rat
2317042Aia20Adjuvant induced arthritis QTL 203.38joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)103756507982565079Rat
2317043Aia7Adjuvant induced arthritis QTL 73.82joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)103756507982565079Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104133325886333258Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104194452678307017Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14232313287323132Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104232313287323132Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)104287676679813922Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104444169989441699Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104444169989441699Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104444169989441699Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104736947092369470Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)104944455181709989Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104944455181709989Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)104944455181709989Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat

Markers in Region
RH131220  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21049,655,607 - 49,655,763 (+)MAPPERmRatBN7.2
Rnor_6.01051,501,572 - 51,501,727NCBIRnor6.0
Rnor_5.01051,259,558 - 51,259,713UniSTSRnor5.0
RGSC_v3.41051,313,511 - 51,313,666UniSTSRGSC3.4
Celera1048,871,557 - 48,871,712UniSTS
RH 3.4 Map10582.4UniSTS
Cytogenetic Map10q24UniSTS
RH137170  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21049,654,974 - 49,655,155 (+)MAPPERmRatBN7.2
Rnor_6.01051,500,939 - 51,501,119NCBIRnor6.0
Rnor_5.01051,258,925 - 51,259,105UniSTSRnor5.0
RGSC_v3.41051,312,878 - 51,313,058UniSTSRGSC3.4
Celera1048,870,924 - 48,871,104UniSTS
RH 3.4 Map10580.6UniSTS
Cytogenetic Map10q24UniSTS
RH138269  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21049,811,947 - 49,812,075 (+)MAPPERmRatBN7.2
Rnor_6.01051,658,597 - 51,658,724NCBIRnor6.0
Rnor_5.01051,415,000 - 51,415,127UniSTSRnor5.0
RGSC_v3.41051,470,537 - 51,470,664UniSTSRGSC3.4
Celera1049,027,911 - 49,028,038UniSTS
RH 3.4 Map10583.8UniSTS
Cytogenetic Map10q24UniSTS
RH11339  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21049,720,872 - 49,720,955 (+)MAPPERmRatBN7.2
Rnor_6.01051,566,835 - 51,566,917NCBIRnor6.0
Rnor_5.01051,324,821 - 51,324,903UniSTSRnor5.0
RGSC_v3.41051,378,775 - 51,378,857UniSTSRGSC3.4
Celera1048,936,838 - 48,936,920UniSTS
Cytogenetic Map10q24UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 19 6 3 54 16 11
Low 3 24 28 18 19 18 8 8 20 35 25 8
Below cutoff 23 23 23

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001419596 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006220697 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006220698 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006246835 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008767895 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008767896 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008774998 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008774999 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039087288 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063269017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063269018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063269020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063269021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063269022 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC089950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC107933 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000004829   ⟹   ENSRNOP00000004829
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1049,655,584 - 49,824,297 (-)Ensembl
Rnor_6.0 Ensembl1051,502,894 - 51,576,376 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000071595   ⟹   ENSRNOP00000066638
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1049,656,070 - 49,824,297 (-)Ensembl
Rnor_6.0 Ensembl1051,505,137 - 51,669,297 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000101528   ⟹   ENSRNOP00000096546
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1049,655,584 - 49,824,297 (-)Ensembl
RefSeq Acc Id: NM_001419596   ⟹   NP_001406525
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81050,154,724 - 50,322,009 (-)NCBI
mRatBN7.21049,655,583 - 49,822,872 (-)NCBI
RefSeq Acc Id: XM_039087288   ⟹   XP_038943216
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81050,154,724 - 50,256,208 (-)NCBI
mRatBN7.21049,656,930 - 49,757,066 (-)NCBI
RefSeq Acc Id: XM_063269017   ⟹   XP_063125087
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81050,154,724 - 50,322,027 (-)NCBI
RefSeq Acc Id: XM_063269018   ⟹   XP_063125088
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81050,156,071 - 50,322,015 (-)NCBI
RefSeq Acc Id: XM_063269020   ⟹   XP_063125090
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81050,154,724 - 50,322,015 (-)NCBI
RefSeq Acc Id: XM_063269021   ⟹   XP_063125091
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81050,154,724 - 50,322,026 (-)NCBI
RefSeq Acc Id: XM_063269022   ⟹   XP_063125092
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81050,154,724 - 50,221,894 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000004829   ⟸   ENSRNOT00000004829
RefSeq Acc Id: ENSRNOP00000066638   ⟸   ENSRNOT00000071595
RefSeq Acc Id: XP_038943216   ⟸   XM_039087288
- Peptide Label: isoform X2
- UniProtKB: A0A0H2UHC0 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000096546   ⟸   ENSRNOT00000101528
RefSeq Acc Id: NP_001406525   ⟸   NM_001419596
- UniProtKB: F1LST2 (UniProtKB/Swiss-Prot),   F1LQX4 (UniProtKB/Swiss-Prot),   M0RAT0 (UniProtKB/Swiss-Prot),   A0A0H2UHC0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063125087   ⟸   XM_063269017
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063125091   ⟸   XM_063269021
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063125090   ⟸   XM_063269020
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063125092   ⟸   XM_063269022
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063125088   ⟸   XM_063269018
- Peptide Label: isoform X3
Protein Domains
BAR   Rho-GAP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LQX4-F1-model_v2 AlphaFold F1LQX4 1-814 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305664 AgrOrtholog
BioCyc Gene G2FUF-24716 BioCyc
Ensembl Genes ENSRNOG00000003603 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055031138 UniProtKB/Swiss-Prot
  ENSRNOG00060025258 UniProtKB/Swiss-Prot
  ENSRNOG00065008210 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000004829 UniProtKB/TrEMBL
  ENSRNOT00000004829.9 UniProtKB/Swiss-Prot
  ENSRNOT00000071595.3 UniProtKB/TrEMBL
  ENSRNOT00000101528 ENTREZGENE
  ENSRNOT00000101528.1 UniProtKB/Swiss-Prot
  ENSRNOT00055054139 UniProtKB/Swiss-Prot
  ENSRNOT00060044260 UniProtKB/Swiss-Prot
  ENSRNOT00065013010 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.555.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.20.1270.60 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7312152 IMAGE-MGC_LOAD
InterPro AH/BAR_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BAR_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RHG17/44/SH3BP1-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rho_GTPase_activation_prot UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RhoGAP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:303222 UniProtKB/Swiss-Prot
MGC_CLONE MGC:109276 IMAGE-MGC_LOAD
NCBI Gene 303222 ENTREZGENE
PANTHER 3BP-1 RELATED RHOGAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RHO GTPASE-ACTIVATING PROTEIN 44 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam BAR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RhoGAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Arhgap44 PhenoGen
PROSITE BAR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RHOGAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000003603 RatGTEx
  ENSRNOG00055031138 RatGTEx
  ENSRNOG00060025258 RatGTEx
  ENSRNOG00065008210 RatGTEx
SMART BAR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RhoGAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF103657 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48350 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0H2UHC0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QXS1_RAT UniProtKB/TrEMBL
  A6HFF1_RAT UniProtKB/TrEMBL
  A6HFF2_RAT UniProtKB/TrEMBL
  F1LQX4 ENTREZGENE
  F1LST2 ENTREZGENE
  M0RAT0 ENTREZGENE
  RHG44_RAT UniProtKB/Swiss-Prot
UniProt Secondary F1LST2 UniProtKB/Swiss-Prot
  M0RAT0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-10-10 Arhgap44  Rho GTPase activating protein 44  RGD1305664  similar to KIAA0672 gene product  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 RGD1305664  similar to KIAA0672 gene product  RGD1305664_predicted  similar to KIAA0672 gene product (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1305664_predicted  similar to KIAA0672 gene product (predicted)  LOC303222_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC303222_predicted  similar to KIAA0672 gene product (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL