Crybg3 (crystallin beta-gamma domain containing 3) - Rat Genome Database

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Gene: Crybg3 (crystallin beta-gamma domain containing 3) Rattus norvegicus
Analyze
Symbol: Crybg3
Name: crystallin beta-gamma domain containing 3
RGD ID: 1305628
Description: Predicted to enable protein kinase A binding activity. Predicted to be a structural constituent of eye lens. Predicted to be involved in lens development in camera-type eye and visual perception. Predicted to be part of protein-containing complex. Orthologous to human CRYBG3 (crystallin beta-gamma domain containing 3); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: AABR07033887.1; beta-gamma crystallin domain containing 3; beta/gamma crystallin domain-containing protein 3; LOC288204; RGD1305628; similar to Hypothetical protein 5031404N19
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81154,218,399 - 54,330,962 (+)NCBIGRCr8
mRatBN7.21140,749,198 - 40,861,753 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1140,749,214 - 40,861,752 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01142,895,610 - 43,006,568 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1142,945,084 - 43,005,097 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01146,086,217 - 46,195,875 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41141,563,759 - 41,625,885 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11141,568,746 - 41,682,825 (+)NCBI
Celera1140,591,247 - 40,703,634 (+)NCBICelera
Cytogenetic Map11q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:25097019  


Genomics

Comparative Map Data
Crybg3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81154,218,399 - 54,330,962 (+)NCBIGRCr8
mRatBN7.21140,749,198 - 40,861,753 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1140,749,214 - 40,861,752 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01142,895,610 - 43,006,568 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1142,945,084 - 43,005,097 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01146,086,217 - 46,195,875 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41141,563,759 - 41,625,885 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11141,568,746 - 41,682,825 (+)NCBI
Celera1140,591,247 - 40,703,634 (+)NCBICelera
Cytogenetic Map11q12NCBI
CRYBG3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38397,822,011 - 97,944,984 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl397,822,011 - 97,944,984 (+)EnsemblGRCh38hg38GRCh38
GRCh37397,540,855 - 97,663,828 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36399,078,509 - 99,146,500 (+)NCBINCBI36Build 36hg18NCBI36
Celera395,930,143 - 96,053,398 (+)NCBICelera
Cytogenetic Map3q11.2NCBI
HuRef394,910,774 - 95,033,728 (+)NCBIHuRef
CHM1_1397,503,917 - 97,626,863 (+)NCBICHM1_1
T2T-CHM13v2.03100,525,753 - 100,648,725 (+)NCBIT2T-CHM13v2.0
Crybg3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391659,312,451 - 59,421,410 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1659,311,138 - 59,421,342 (-)EnsemblGRCm39 Ensembl
GRCm381659,492,088 - 59,601,047 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1659,490,775 - 59,600,979 (-)EnsemblGRCm38mm10GRCm38
MGSCv371659,490,601 - 59,555,578 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361659,434,352 - 59,498,008 (-)NCBIMGSCv36mm8
Celera1659,842,911 - 59,907,993 (-)NCBICelera
Cytogenetic Map16C1.3NCBI
cM Map1634.83NCBI
Crybg3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955407205,010 - 298,664 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955407203,315 - 329,017 (-)NCBIChiLan1.0ChiLan1.0
CRYBG3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2295,731,832 - 95,858,282 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1395,736,621 - 95,863,089 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0394,891,281 - 95,017,694 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13101,577,148 - 101,702,418 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3101,577,148 - 101,702,418 (+)Ensemblpanpan1.1panPan2
CRYBG3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1334,864,458 - 4,967,707 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl334,864,458 - 4,966,440 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha335,046,281 - 5,148,274 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0334,975,125 - 5,077,246 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl334,974,992 - 5,077,248 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1334,851,593 - 4,953,682 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0334,911,930 - 5,014,053 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0335,186,317 - 5,288,372 (+)NCBIUU_Cfam_GSD_1.0
Crybg3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602152,276,840 - 152,388,522 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366663,127,135 - 3,239,324 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366663,127,109 - 3,237,636 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CRYBG3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13162,355,472 - 162,478,720 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113162,354,343 - 162,478,771 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213172,665,064 - 172,743,604 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CRYBG3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12282,756,653 - 82,885,465 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2282,758,339 - 82,885,431 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604183,700,498 - 83,825,139 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Crybg3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478910,273,429 - 10,391,131 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478910,273,386 - 10,392,694 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Crybg3
824 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:657
Count of miRNA genes:274
Interacting mature miRNAs:343
Transcripts:ENSRNOT00000002292
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11169446234Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)11104193166113562Rat
1641927Alcrsp10Alcohol response QTL 10alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)11843667453436674Rat
724517Uae18Urinary albumin excretion QTL 183.7urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)111647204744285911Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)112295940367959403Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)112328045668280456Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)112328045668280456Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
1300130Rf20Renal function QTL 204.44kidney glomerulus integrity trait (VT:0010546)kidney glomerulus diameter (CMO:0001166)112952841860324829Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)113123913478851519Rat
70180BpQTLcluster10Blood pressure QTL cluster 103.19arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)113491804179918041Rat

Markers in Region
BI290110  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21140,860,282 - 40,860,393 (+)MAPPERmRatBN7.2
Rnor_6.01143,005,098 - 43,005,208NCBIRnor6.0
Rnor_5.01146,194,597 - 46,194,707UniSTSRnor5.0
RGSC_v3.41141,625,229 - 41,625,339UniSTSRGSC3.4
Celera1140,702,164 - 40,702,274UniSTS
RH 3.4 Map11301.1UniSTS
Cytogenetic Map11q12UniSTS
AU047431  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21140,819,804 - 40,819,928 (+)MAPPERmRatBN7.2
Rnor_6.01142,964,262 - 42,964,392NCBIRnor6.0
Rnor_5.01146,153,761 - 46,153,891UniSTSRnor5.0
RGSC_v3.41141,583,555 - 41,583,678UniSTSRGSC3.4
Celera1140,661,685 - 40,661,808UniSTS
Cytogenetic Map11q12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 42 10 13 7 7 3 18 19 11 7
Low 3 1 47 41 6 41 1 4 71 17 22 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000002292   ⟹   ENSRNOP00000002292
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1140,800,015 - 40,861,752 (+)Ensembl
Rnor_6.0 Ensembl1142,945,084 - 43,005,097 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000074653   ⟹   ENSRNOP00000067850
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1140,749,214 - 40,861,752 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000095286   ⟹   ENSRNOP00000087519
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1140,749,348 - 40,861,193 (+)Ensembl
RefSeq Acc Id: XM_213639   ⟹   XP_213639
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81154,218,399 - 54,330,962 (+)NCBI
mRatBN7.21140,749,198 - 40,861,753 (+)NCBI
Rnor_6.01142,895,610 - 43,006,568 (+)NCBI
Rnor_5.01146,086,217 - 46,195,875 (+)NCBI
RGSC_v3.41141,563,759 - 41,625,885 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs XP_213639 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM10989 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000002292.7
  ENSRNOP00000067850
  ENSRNOP00000067850.3
  ENSRNOP00000087519.1
Reference Protein Sequences
RefSeq Acc Id: XP_213639   ⟸   XM_213639
- UniProtKB: M0RDY6 (UniProtKB/TrEMBL),   A0A8I6A3B0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000002292   ⟸   ENSRNOT00000002292
RefSeq Acc Id: ENSRNOP00000087519   ⟸   ENSRNOT00000095286
RefSeq Acc Id: ENSRNOP00000067850   ⟸   ENSRNOT00000074653
Protein Domains
Beta/gamma crystallin 'Greek key'

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M8T4-F1-model_v2 AlphaFold F1M8T4 1-1241 view protein structure
AF-M0RDY6-F1-model_v2 AlphaFold M0RDY6 1-1594 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305628 AgrOrtholog
BioCyc Gene G2FUF-21619 BioCyc
Ensembl Genes ENSRNOG00000001687 Ensembl
  ENSRNOG00000045728 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000002292.8 UniProtKB/TrEMBL
  ENSRNOT00000074653.3 UniProtKB/TrEMBL
  ENSRNOT00000095286.1 UniProtKB/TrEMBL
Gene3D-CATH 2.80.10.50 UniProtKB/TrEMBL
  Crystallins UniProtKB/TrEMBL
InterPro Beta/gamma_crystallin UniProtKB/TrEMBL
  G_crystallin-like UniProtKB/TrEMBL
  Ricin_B-like_lectins UniProtKB/TrEMBL
  Ricin_B_lectin UniProtKB/TrEMBL
KEGG Report rno:288204 UniProtKB/TrEMBL
NCBI Gene 288204 ENTREZGENE
PANTHER BETA/GAMMA CRYSTALLIN UniProtKB/TrEMBL
  GAMMA-CRYSTALLIN B UniProtKB/TrEMBL
  VERY LARGE A-KINASE ANCHOR PROTEIN UniProtKB/TrEMBL
Pfam Crystall UniProtKB/TrEMBL
  Ricin_B_lectin UniProtKB/TrEMBL
PhenoGen Crybg3 PhenoGen
PRINTS BGCRYSTALLIN UniProtKB/TrEMBL
PROSITE CRYSTALLIN_BETA_GAMMA UniProtKB/TrEMBL
  RICIN_B_LECTIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000001687 RatGTEx
  ENSRNOG00000045728 RatGTEx
SMART RICIN UniProtKB/TrEMBL
  XTALbg UniProtKB/TrEMBL
Superfamily-SCOP SSF49695 UniProtKB/TrEMBL
  SSF50370 UniProtKB/TrEMBL
UniProt A0A8I6A3B0 ENTREZGENE, UniProtKB/TrEMBL
  F1M8T4_RAT UniProtKB/TrEMBL
  M0RDY6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-02 Crybg3  crystallin beta-gamma domain containing 3  AABR07033887.1    Data merged from RGD:15004879 737654 PROVISIONAL
2021-09-02 AABR07033887.1    Crybg3  crystallin beta-gamma domain containing 3  Symbol and/or name change 19259462 PROVISIONAL
2021-08-09 Crybg3  crystallin beta-gamma domain containing 3  AABR07033887.1    Symbol and/or name change 19259462 PROVISIONAL
2019-11-08 AABR07033887.1        Symbol and Name status set to provisional 45752 PROVISIONAL
2015-12-09 Crybg3  crystallin beta-gamma domain containing 3  Crybg3  beta-gamma crystallin domain containing 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-04-23 Crybg3  beta-gamma crystallin domain containing 3  RGD1305628  similar to Hypothetical protein 5031404N19  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1305628  similar to Hypothetical protein 5031404N19   RGD1305628_predicted  similar to Hypothetical protein 5031404N19 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-20 RGD1305628_predicted  similar to Hypothetical protein 5031404N19 (predicted)  LOC288204_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC288204_predicted  similar to Hypothetical protein 5031404N19 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL