Acss2 (acyl-CoA synthetase short-chain family member 2) - Rat Genome Database

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Gene: Acss2 (acyl-CoA synthetase short-chain family member 2) Rattus norvegicus
Analyze
Symbol: Acss2
Name: acyl-CoA synthetase short-chain family member 2
RGD ID: 1305489
Description: Enables acetate-CoA ligase activity. Involved in acetate biosynthetic process and propionate biosynthetic process. Predicted to be located in cytosol and nucleus. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in orofacial cleft. Orthologous to human ACSS2 (acyl-CoA synthetase short chain family member 2); PARTICIPATES IN disulfiram pharmacodynamics pathway; fatty acid beta degradation pathway; Leigh disease pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Acas2; acetyl-Coenzyme A synthetase 2 (ADP forming); acetyl-coenzyme A synthetase, cytoplasmic; LOC311569
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83164,464,124 - 164,507,607 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3164,464,055 - 164,519,830 (+)EnsemblGRCr8
mRatBN7.23144,003,808 - 144,047,452 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3144,004,336 - 144,059,675 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3147,870,984 - 147,913,977 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03156,488,259 - 156,531,254 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03154,227,791 - 154,270,788 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03151,032,925 - 151,075,856 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3151,032,952 - 151,075,856 (+)Ensemblrn6Rnor6.0
Rnor_5.03157,400,353 - 157,443,341 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43146,013,995 - 146,057,119 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3142,729,140 - 142,772,009 (+)NCBICelera
RGSC_v3.13145,919,548 - 145,962,044 (+)NCBI
Cytogenetic Map3q42NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-alpha-phellandrene  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
3,4-dichloroaniline  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrolein  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (ISO)
aldrin  (ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (EXP)
alpha-phellandrene  (ISO)
alpha-pinene  (ISO)
alpha-Zearalanol  (EXP)
amiodarone  (EXP,ISO)
amitrole  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
avobenzone  (ISO)
Azoxymethane  (ISO)
benzo[a]pyrene  (ISO)
beta-D-glucosamine  (ISO)
beta-lapachone  (ISO)
bezafibrate  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bromobenzene  (EXP)
caffeine  (ISO)
carbon nanotube  (ISO)
carnosic acid  (ISO)
CGP 52608  (ISO)
chloroethene  (ISO)
chloroprene  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
cyclosporin A  (EXP,ISO)
D-glucose  (ISO)
DDE  (ISO)
DDT  (EXP)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dimethylarsinous acid  (ISO)
dioxygen  (ISO)
disulfiram  (ISO)
diuron  (EXP)
doxorubicin  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
Evodiamine  (ISO)
fenofibrate  (ISO)
ferric oxide  (ISO)
fluoxetine  (ISO)
folic acid  (ISO)
FR900359  (ISO)
Ganoderic acid A  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
glucose  (ISO)
glycidyl methacrylate  (ISO)
indometacin  (EXP,ISO)
inulin  (ISO)
isobutanol  (ISO)
ivermectin  (ISO)
lipopolysaccharide  (ISO)
lovastatin  (ISO)
manganese(II) chloride  (EXP)
methotrexate  (ISO)
methylparaben  (ISO)
miconazole  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
nefazodone  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
O-methyleugenol  (ISO)
ochratoxin A  (EXP,ISO)
okadaic acid  (ISO)
oxybenzone  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
ritonavir  (EXP)
rotenone  (EXP,ISO)
silicon dioxide  (ISO)
sodium acetate trihydrate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
tolcapone  (EXP)
trichloroethene  (EXP)
triphenyl phosphate  (EXP,ISO)
Triptolide  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
Yessotoxin  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,ISO)
cytosol  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Using Whole Exome Sequencing to Identify Candidate Genes With Rare Variants In Nonsyndromic Cleft Lip and Palate. Aylward A, etal., Genet Epidemiol. 2016 Jul;40(5):432-41. doi: 10.1002/gepi.21972. Epub 2016 May 27.
2. The subcellular distribution of short-chain fatty acyl-CoA synthetase activity in rat tissues. Barth C, etal., Biochim Biophys Acta. 1971 Oct 5;248(1):24-33.
3. ACSS2 gene variant associated with cleft lip and palate in two independent Hispanic populations. Dodhia S, etal., Laryngoscope. 2017 Oct;127(10):E336-E339. doi: 10.1002/lary.26637. Epub 2017 May 23.
4. De novo lipogenesis in adipose tissue is associated with course of morbid obesity after bariatric surgery. Garrido-Sánchez L, etal., PLoS One. 2012;7(2):e31280. doi: 10.1371/journal.pone.0031280. Epub 2012 Feb 23.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. In situ analysis of mTORC1/2 and cellular metabolism-related proteins in human Lymphangioleiomyomatosis. Krencz I, etal., Hum Pathol. 2018 Sep;79:199-207. doi: 10.1016/j.humpath.2018.05.018. Epub 2018 Jun 6.
8. Glucose-independent Acetate Metabolism Promotes Melanoma Cell Survival and Tumor Growth. Lakhter AJ, etal., J Biol Chem. 2016 Oct 14;291(42):21869-21879. doi: 10.1074/jbc.M115.712166. Epub 2016 Aug 18.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Ketone body production is differentially altered in steatosis and non-alcoholic steatohepatitis in obese humans. Männistö VT, etal., Liver Int. 2015 Jul;35(7):1853-61. doi: 10.1111/liv.12769. Epub 2015 Jan 20.
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
13. GOA pipeline RGD automated data pipeline
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome. Watkins PA, etal., J Lipid Res. 2007 Dec;48(12):2736-50. Epub 2007 Aug 30.
Additional References at PubMed
PMID:10843999   PMID:11150295   PMID:12477932   PMID:16790548   PMID:28003429   PMID:31505169   PMID:35902549  


Genomics

Comparative Map Data
Acss2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83164,464,124 - 164,507,607 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3164,464,055 - 164,519,830 (+)EnsemblGRCr8
mRatBN7.23144,003,808 - 144,047,452 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3144,004,336 - 144,059,675 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3147,870,984 - 147,913,977 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03156,488,259 - 156,531,254 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03154,227,791 - 154,270,788 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03151,032,925 - 151,075,856 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3151,032,952 - 151,075,856 (+)Ensemblrn6Rnor6.0
Rnor_5.03157,400,353 - 157,443,341 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43146,013,995 - 146,057,119 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3142,729,140 - 142,772,009 (+)NCBICelera
RGSC_v3.13145,919,548 - 145,962,044 (+)NCBI
Cytogenetic Map3q42NCBI
ACSS2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382034,874,989 - 34,927,959 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2034,872,146 - 34,927,962 (+)Ensemblhg38GRCh38
GRCh372033,462,792 - 33,515,762 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362032,926,406 - 32,979,423 (+)NCBIBuild 36Build 36hg18NCBI36
Build 342032,926,501 - 32,979,423NCBI
Celera2030,211,860 - 30,264,862 (+)NCBICelera
Cytogenetic Map20q11.22NCBI
HuRef2030,241,182 - 30,294,089 (+)NCBIHuRef
CHM1_12033,364,136 - 33,416,989 (+)NCBICHM1_1
T2T-CHM13v2.02036,595,583 - 36,648,613 (+)NCBIT2T-CHM13v2.0
Acss2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392155,359,963 - 155,404,663 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2155,359,868 - 155,427,644 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm382155,518,043 - 155,562,743 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2155,517,948 - 155,585,724 (+)Ensemblmm10GRCm38
MGSCv372155,343,779 - 155,388,479 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv362155,209,484 - 155,254,184 (+)NCBIMGSCv36mm8
Celera2161,450,232 - 161,494,992 (+)NCBICelera
Cytogenetic Map2H1NCBI
cM Map277.26NCBI
Acss2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542226,451,598 - 26,500,546 (-)Ensembl
ChiLan1.0NW_00495542226,450,899 - 26,500,336 (-)NCBIChiLan1.0ChiLan1.0
ACSS2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22140,609,437 - 40,660,734 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12040,602,540 - 40,653,837 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02031,205,104 - 31,256,263 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12032,329,706 - 32,381,274 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2032,329,721 - 32,380,526 (+)EnsemblpanPan2panpan1.1
ACSS2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12423,928,800 - 23,973,383 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2423,928,838 - 23,972,651 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2423,575,057 - 23,619,550 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02424,620,738 - 24,665,236 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2424,620,678 - 24,668,479 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12423,908,064 - 23,952,517 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02424,003,357 - 24,047,830 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02424,442,065 - 24,486,750 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Acss2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640172,906,912 - 172,955,145 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365615,795,077 - 5,842,676 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365615,794,685 - 5,842,619 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACSS2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1738,260,147 - 38,315,757 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11738,260,152 - 38,315,764 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21743,455,051 - 43,510,660 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ACSS2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1239,181,446 - 39,230,164 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl239,181,468 - 39,229,444 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605087,582,705 - 87,633,586 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Acss2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248424,471,360 - 4,522,849 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248424,470,551 - 4,523,174 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Acss2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v15134,852,118 - 134,894,795 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Acss2
537 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:107
Count of miRNA genes:75
Interacting mature miRNAs:96
Transcripts:ENSRNOT00000064013
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12879876Bw182Body weight QTL 1820.003body mass (VT:0001259)body weight (CMO:0000012)3141555229186555229Rat
2301411Bp320Blood pressure QTL 3200.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3141555229186555229Rat
1582233Insul10Insulin level QTL 105.40.0015blood insulin amount (VT:0001560)serum insulin level times blood glucose level (CMO:0002040)3133259579178259579Rat
12879872Cm97Cardiac mass QTL 970.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3141555229186555229Rat
12879873Cm96Cardiac mass QTL 960.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)3141555229186555229Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3151075912189428310Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)3129154923182114333Rat
12879874Cm98Cardiac mass QTL 980.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)3141555229186555229Rat
12879875Kidm64Kidney mass QTL 640.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3141555229186555229Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3161492708189428310Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
61335Bp20Blood pressure QTL 203arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3161799493176036425Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3133134628178134628Rat
1331726Bp208Blood pressure QTL 2083.129arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3161799270187311134Rat
1582213Insul6Insulin level QTL 63.70.0009blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
1300173Rf11Renal function QTL 113.38renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)3141508991166376254Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3152055202189428310Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3142898802187898802Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)3145335553189428310Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3125116475170116475Rat
1582256Insul9Insulin level QTL 94.40.0016blood insulin amount (VT:0001560)absolute change in serum insulin level (CMO:0002038)3155759447189428310Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3139299381184299381Rat
5686842Rf59Renal function QTL 59urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)3122395989167395989Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3141508991177728348Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)3131036586176036586Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3137114333182114333Rat
1582248Insul7Insulin level QTL 73.90.0041blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)3131036586176036586Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)398651826167012663Rat
1578666Vnigr1Vascular neointimal growth QTL 14.6artery morphology trait (VT:0002191)artery lumen area (CMO:0001409)3151075912189428310Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3151075912189428310Rat
12879871Am7Aortic mass QTL 70.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)3141555229186555229Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3144575244189428310Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)3160357340167835660Rat

Markers in Region
D3Got111  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23144,006,941 - 144,007,067 (+)MAPPERmRatBN7.2
Rnor_6.03151,035,348 - 151,035,473NCBIRnor6.0
Rnor_5.03157,402,817 - 157,402,942UniSTSRnor5.0
RGSC_v3.43146,016,390 - 146,016,515RGDRGSC3.4
RGSC_v3.43146,016,391 - 146,016,516UniSTSRGSC3.4
Celera3142,731,536 - 142,731,661UniSTS
RGSC_v3.13145,922,012 - 145,922,137RGD
RH 3.4 Map31301.8UniSTS
RH 3.4 Map31301.8RGD
RH 2.0 Map3871.5RGD
Cytogenetic Map3q42UniSTS
RH129720  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23144,047,206 - 144,047,387 (+)MAPPERmRatBN7.2
Rnor_6.03151,075,611 - 151,075,791NCBIRnor6.0
Rnor_5.03157,443,096 - 157,443,276UniSTSRnor5.0
RGSC_v3.43146,056,874 - 146,057,054UniSTSRGSC3.4
Celera3142,771,764 - 142,771,944UniSTS
RH 3.4 Map31304.8UniSTS
Cytogenetic Map3q42UniSTS
AU046887  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23144,024,138 - 144,024,340 (+)MAPPERmRatBN7.2
Rnor_6.03151,052,544 - 151,052,745NCBIRnor6.0
Rnor_5.03157,420,066 - 157,420,267UniSTSRnor5.0
RGSC_v3.43146,033,807 - 146,034,008UniSTSRGSC3.4
Celera3142,748,699 - 142,748,900UniSTS
Cytogenetic Map3q42UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000064013   ⟹   ENSRNOP00000059987
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3164,464,055 - 164,507,607 (+)Ensembl
mRatBN7.2 Ensembl3144,004,336 - 144,047,452 (+)Ensembl
Rnor_6.0 Ensembl3151,032,952 - 151,075,856 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000098802   ⟹   ENSRNOP00000090034
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3164,464,616 - 164,519,830 (+)Ensembl
mRatBN7.2 Ensembl3144,004,543 - 144,059,675 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000107324   ⟹   ENSRNOP00000090627
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3164,464,055 - 164,507,598 (+)Ensembl
mRatBN7.2 Ensembl3144,004,336 - 144,047,442 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000173298   ⟹   ENSRNOP00000109329
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3164,464,616 - 164,519,830 (+)Ensembl
RefSeq Acc Id: NM_001107793   ⟹   NP_001101263
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83164,464,703 - 164,507,607 (+)NCBI
mRatBN7.23144,004,543 - 144,047,452 (+)NCBI
Rnor_6.03151,032,952 - 151,075,856 (+)NCBI
Rnor_5.03157,400,353 - 157,443,341 (+)NCBI
RGSC_v3.43146,013,995 - 146,057,119 (+)RGD
Celera3142,729,140 - 142,772,009 (+)RGD
Sequence:
RefSeq Acc Id: XM_006235321   ⟹   XP_006235383
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83164,464,635 - 164,507,600 (+)NCBI
mRatBN7.23144,004,215 - 144,047,450 (+)NCBI
Rnor_6.03151,032,925 - 151,075,854 (+)NCBI
Rnor_5.03157,400,353 - 157,443,341 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039105076   ⟹   XP_038961004
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83164,464,124 - 164,507,600 (+)NCBI
mRatBN7.23144,003,809 - 144,047,450 (+)NCBI
RefSeq Acc Id: NP_001101263   ⟸   NM_001107793
- UniProtKB: A6KI41 (UniProtKB/TrEMBL),   B1WC11 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006235383   ⟸   XM_006235321
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GJ11 (UniProtKB/TrEMBL),   G3V9U0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000059987   ⟸   ENSRNOT00000064013
RefSeq Acc Id: XP_038961004   ⟸   XM_039105076
- Peptide Label: isoform X2
- UniProtKB: B1WC11 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000090034   ⟸   ENSRNOT00000098802
Ensembl Acc Id: ENSRNOP00000090627   ⟸   ENSRNOT00000107324
Ensembl Acc Id: ENSRNOP00000109329   ⟸   ENSRNOT00000173298
Protein Domains
Acetyl-coenzyme A synthetase N-terminal   AMP-binding enzyme C-terminal   AMP-dependent synthetase/ligase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V9U0-F1-model_v2 AlphaFold G3V9U0 1-701 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692584
Promoter ID:EPDNEW_R3109
Type:initiation region
Name:Acss2_1
Description:acyl-CoA synthetase short-chain family member 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03151,032,976 - 151,033,036EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305489 AgrOrtholog
BioCyc Gene G2FUF-47130 BioCyc
BioCyc Pathway PWY0-1313 [acetate conversion to acetyl-CoA] BioCyc
  PWY66-162 [ethanol degradation IV] BioCyc
  PWY66-21 [ethanol degradation II] BioCyc
BioCyc Pathway Image PWY0-1313 BioCyc
  PWY66-162 BioCyc
  PWY66-21 BioCyc
Ensembl Genes ENSRNOG00000018755 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000064013 ENTREZGENE
  ENSRNOT00000064013.3 UniProtKB/TrEMBL
  ENSRNOT00000098802.2 UniProtKB/TrEMBL
  ENSRNOT00000107324 ENTREZGENE
  ENSRNOT00000107324.2 UniProtKB/TrEMBL
  ENSRNOT00000173298.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.300.30 UniProtKB/TrEMBL
  3.40.50.12780 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:9028172 IMAGE-MGC_LOAD
InterPro ACAS_N UniProtKB/TrEMBL
  AMP-bd_C_sf UniProtKB/TrEMBL
  AMP-binding_CS UniProtKB/TrEMBL
  AMP-dep_Synth/Lig UniProtKB/TrEMBL
  AMP-dep_Synthh-like_sf UniProtKB/TrEMBL
  DUF4009 UniProtKB/TrEMBL
KEGG Report rno:311569 UniProtKB/TrEMBL
MGC_CLONE MGC:187768 IMAGE-MGC_LOAD
NCBI Gene 311569 ENTREZGENE
PANTHER ACETYL-COENZYME A SYNTHETASE UniProtKB/TrEMBL
  ACETYL-COENZYME A SYNTHETASE, CYTOPLASMIC UniProtKB/TrEMBL
Pfam ACAS_N UniProtKB/TrEMBL
  AMP-binding UniProtKB/TrEMBL
  DUF4009 UniProtKB/TrEMBL
PhenoGen Acss2 PhenoGen
PROSITE AMP_BINDING UniProtKB/TrEMBL
RatGTEx ENSRNOG00000018755 RatGTEx
Superfamily-SCOP Acetyl-CoA synthetase-like UniProtKB/TrEMBL
UniProt A0A8I6AD12_RAT UniProtKB/TrEMBL
  A0A8I6GJ11 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0M3M9_RAT UniProtKB/TrEMBL
  A6KI41 ENTREZGENE, UniProtKB/TrEMBL
  B1WC11 ENTREZGENE, UniProtKB/TrEMBL
  G3V9U0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Acss2  acyl-CoA synthetase short-chain family member 2   Acss2_predicted  acyl-CoA synthetase short-chain family member 2 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Acss2_predicted  acyl-CoA synthetase short-chain family member 2 (predicted)  Acas2_predicted  acetyl-Coenzyme A synthetase 2 (ADP forming) (predicted)  Symbol and Name updated 1299863 APPROVED
2005-01-12 Acas2_predicted  acetyl-Coenzyme A synthetase 2 (ADP forming) (predicted)      Symbol and Name status set to approved 70820 APPROVED