Trem3 (triggering receptor expressed on myeloid cells 3) - Rat Genome Database

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Gene: Trem3 (triggering receptor expressed on myeloid cells 3) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Trem3
Name: triggering receptor expressed on myeloid cells 3
RGD ID: 1305477
Description: Predicted to enable transmembrane signaling receptor activity. Predicted to be involved in immune response; neutrophil chemotaxis; and neutrophil-mediated killing of gram-negative bacterium. Predicted to be located in plasma membrane. Predicted to be active in cell surface; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC367215; RGD1305477; similar to TREM-3
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8920,247,453 - 20,259,071 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl920,247,453 - 20,257,918 (-)EnsemblGRCr8
mRatBN7.2912,749,821 - 12,762,547 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl912,749,852 - 12,760,779 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx921,263,259 - 21,273,385 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0926,329,483 - 26,339,611 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0924,718,701 - 24,728,829 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0914,713,935 - 14,725,945 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl914,713,935 - 14,724,093 (-)Ensemblrn6Rnor6.0
Rnor_5.0913,635,294 - 13,645,628 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.498,161,126 - 8,171,287 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera910,521,565 - 10,531,696 (-)NCBICelera
RGSC_v3.198,107,707 - 8,169,815 (-)NCBI
Cytogenetic Map9q12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in Trem3
102 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:38
Count of miRNA genes:36
Interacting mature miRNAs:37
Transcripts:ENSRNOT00000018500
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)9671488884474983Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9534647950346479Rat
10054141Gmadr4Adrenal mass QTL 42.450.0074adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)9121707400Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9875049253750492Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)9131250552Rat
1578675Bss17Bone structure and strength QTL 173.8femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)9360535521031556Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)949664545496645Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9621499551214995Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9875049253750492Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9141763315Rat
61425Cia15Collagen induced arthritis QTL 154.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)9534647950416711Rat
631643Bp120Blood pressure QTL 12030.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)9671488829567695Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)949664545496645Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)949664545496645Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9621499551214995Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
15 9 42 88 88 88 57 92 57 6 314 165 11 65 70 69 31 9 9

Sequence


Ensembl Acc Id: ENSRNOT00000018500   ⟹   ENSRNOP00000018500
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl920,247,453 - 20,257,918 (-)Ensembl
mRatBN7.2 Ensembl912,749,852 - 12,760,779 (-)Ensembl
Rnor_6.0 Ensembl914,713,935 - 14,724,093 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000167795   ⟹   ENSRNOP00000112011
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl920,247,861 - 20,256,303 (-)Ensembl
RefSeq Acc Id: NM_001191581   ⟹   NP_001178510
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8920,247,453 - 20,257,614 (-)NCBI
mRatBN7.2912,749,852 - 12,760,025 (-)NCBI
Rnor_6.0914,713,935 - 14,724,093 (-)NCBI
Rnor_5.0913,635,294 - 13,645,628 (-)NCBI
Celera910,521,565 - 10,531,696 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017596546   ⟹   XP_017452035
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8920,251,754 - 20,259,071 (-)NCBI
mRatBN7.2912,755,258 - 12,762,547 (-)NCBI
Rnor_6.0914,721,847 - 14,725,945 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039083952   ⟹   XP_038939880
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8920,251,754 - 20,259,071 (-)NCBI
mRatBN7.2912,754,215 - 12,762,547 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001178510 (Get FASTA)   NCBI Sequence Viewer  
  XP_017452035 (Get FASTA)   NCBI Sequence Viewer  
  XP_038939880 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM18918 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000018500.5
  ENSRNOP00000112011.1
RefSeq Acc Id: NP_001178510   ⟸   NM_001191581
- Peptide Label: precursor
- UniProtKB: A6JIG4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017452035   ⟸   XM_017596546
- Peptide Label: isoform X2
- Sequence:
Ensembl Acc Id: ENSRNOP00000018500   ⟸   ENSRNOT00000018500
RefSeq Acc Id: XP_038939880   ⟸   XM_039083952
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000112011   ⟸   ENSRNOT00000167795
Protein Domains
Immunoglobulin V-set

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZJA7-F1-model_v2 AlphaFold D3ZJA7 1-185 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305477 AgrOrtholog
BioCyc Gene G2FUF-28297 BioCyc
Ensembl Genes ENSRNOG00000013748 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000018500.6 UniProtKB/TrEMBL
  ENSRNOT00000167795.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
InterPro Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_V-set UniProtKB/TrEMBL
KEGG Report rno:367215 UniProtKB/TrEMBL
NCBI Gene 367215 ENTREZGENE
PANTHER TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 1 UniProtKB/TrEMBL
  TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 3 UniProtKB/TrEMBL
Pfam V-set UniProtKB/TrEMBL
PhenoGen Trem3 PhenoGen
RatGTEx ENSRNOG00000013748 RatGTEx
Superfamily-SCOP SSF48726 UniProtKB/TrEMBL
UniProt A0ABK0LLY6_RAT UniProtKB/TrEMBL
  A6JIG4 ENTREZGENE, UniProtKB/TrEMBL
  D3ZJA7_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-06 Trem3  triggering receptor expressed on myeloid cells 3  RGD1305477_predicted  similar to TREM-3 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 RGD1305477_predicted  similar to TREM-3 (predicted)  LOC367215_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC367215_predicted  similar to TREM-3 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL