Imported Disease Annotations - MGIObject Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Tp53bp2 | Rat | chromosome 1q41-q42 deletion syndrome | | ISS | Trp53bp2 (Mus musculus) | 13592920 | OMIM:612530 | MouseDO | | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Imported Disease Annotations - MGIObject Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Tp53bp2 | Rat | chromosome 1q41-q42 deletion syndrome | | ISS | Trp53bp2 (Mus musculus) | 13592920 | OMIM:612530 | MouseDO | | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| # | Reference Title | Reference Citation |
| 1. | Transcriptional regulation by p53. | Beckerman R and Prives C, Cold Spring Harb Perspect Biol. 2010 Aug;2(8):a000935. doi: 10.1101/cshperspect.a000935. Epub 2010 Apr 28. |
| 2. | Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. | Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27. |
| 3. | Rat ISS GO annotations from GOA human gene data--August 2006 | GOA data from the GO Consortium |
| 4. | Rat ISS GO annotations from MGI mouse gene data--August 2006 | MGD data from the GO Consortium |
| 5. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
| 6. | Comprehensive gene review and curation | RGD comprehensive gene curation |
| 7. | ASPP1/2 regulate p53-dependent death of retinal ganglion cells through PUMA and Fas/CD95 activation in vivo. | Wilson AM, etal., J Neurosci. 2013 Jan 30;33(5):2205-16. doi: 10.1523/JNEUROSCI.2635-12.2013. |
| PMID:10498867 | PMID:10646860 | PMID:11684014 | PMID:14985081 | PMID:16702401 | PMID:18448430 | PMID:19377511 |
| Tp53bp2 (Rattus norvegicus - Norway rat) |
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| TP53BP2 (Homo sapiens - human) |
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| Trp53bp2 (Mus musculus - house mouse) |
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| Tp53bp2 (Chinchilla lanigera - long-tailed chinchilla) |
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| TP53BP2 (Pan paniscus - bonobo/pygmy chimpanzee) |
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| TP53BP2 (Canis lupus familiaris - dog) |
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| Tp53bp2 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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| TP53BP2 (Sus scrofa - pig) |
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| TP53BP2 (Chlorocebus sabaeus - green monkey) |
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| Tp53bp2 (Heterocephalus glaber - naked mole-rat) |
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| Tp53bp2 (Rattus rattus - black rat) |
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Variants in Tp53bp2
690 total Variants
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| The detailed report is available here: | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer |
miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/). For more information about miRGate, see PMID:25858286 or access the full paper here. |
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| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
| BF390313 |
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| BE102377 |
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alimentary part of gastrointestinal system
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appendage
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circulatory system
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ectoderm
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endocrine system
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endoderm
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exocrine system
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hemolymphoid system
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hepatobiliary system
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integumental system
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mesenchyme
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mesoderm
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musculoskeletal system
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nervous system
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renal system
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reproductive system
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respiratory system
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sensory system
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visual system
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| 16 | 12 | 67 | 162 | 91 | 90 | 59 | 92 | 59 | 6 | 356 | 192 | 11 | 141 | 81 | 92 | 31 | 17 | 17 |
| RefSeq Transcripts | NM_001427417 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
| XM_001063503 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_039091490 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| GenBank Nucleotide | CH473985 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
| JAXUCZ010000013 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
| Ensembl Acc Id: | ENSRNOT00000004330 ⟹ ENSRNOP00000004330 | ||||||||||||||||
| Type: | CODING | ||||||||||||||||
| Position: |
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| Ensembl Acc Id: | ENSRNOT00000105977 ⟹ ENSRNOP00000095274 | ||||||||||||
| Type: | CODING | ||||||||||||
| Position: |
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| Ensembl Acc Id: | ENSRNOT00000106232 ⟹ ENSRNOP00000086362 | ||||||||||||
| Type: | CODING | ||||||||||||
| Position: |
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| Ensembl Acc Id: | ENSRNOT00000112631 ⟹ ENSRNOP00000094906 | ||||||||||||
| Type: | CODING | ||||||||||||
| Position: |
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| Ensembl Acc Id: | ENSRNOT00000148005 ⟹ ENSRNOP00000101381 | ||||||||
| Type: | CODING | ||||||||
| Position: |
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| RefSeq Acc Id: | NM_001427417 ⟹ NP_001414346 | ||||||||
| RefSeq Status: | VALIDATED | ||||||||
| Type: | CODING | ||||||||
| Position: |
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| RefSeq Acc Id: | XM_039091490 ⟹ XP_038947418 | ||||||||||||
| Type: | CODING | ||||||||||||
| Position: |
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| Protein RefSeqs | NP_001414346 | (Get FASTA) | NCBI Sequence Viewer |
| XP_038947418 | (Get FASTA) | NCBI Sequence Viewer | |
| GenBank Protein | EDL94874 | (Get FASTA) | NCBI Sequence Viewer |
| Ensembl Protein | ENSRNOP00000004330 | ||
| ENSRNOP00000004330.6 | |||
| ENSRNOP00000086362.2 | |||
| ENSRNOP00000094906.2 | |||
| ENSRNOP00000095274.1 | |||
| ENSRNOP00000101381.1 |
| Ensembl Acc Id: | ENSRNOP00000004330 ⟸ ENSRNOT00000004330 |
| RefSeq Acc Id: | XP_038947418 ⟸ XM_039091490 |
| - Peptide Label: | isoform X1 |
| - UniProtKB: | A0A8I6ANU5 (UniProtKB/TrEMBL), A6JGL8 (UniProtKB/TrEMBL) |
| Ensembl Acc Id: | ENSRNOP00000086362 ⟸ ENSRNOT00000106232 |
| Ensembl Acc Id: | ENSRNOP00000095274 ⟸ ENSRNOT00000105977 |
| Ensembl Acc Id: | ENSRNOP00000094906 ⟸ ENSRNOT00000112631 |
| RefSeq Acc Id: | NP_001414346 ⟸ NM_001427417 |
| - UniProtKB: | F1M5H6 (UniProtKB/TrEMBL), A0A8I6ANU5 (UniProtKB/TrEMBL), A6JGL8 (UniProtKB/TrEMBL) |
| Ensembl Acc Id: | ENSRNOP00000101381 ⟸ ENSRNOT00000148005 |
| Name | Modeler | Protein Id | AA Range | Protein Structure |
| AF-F1M5H6-F1-model_v2 | AlphaFold | F1M5H6 | 1-1128 | view protein structure |
| eQTL | View at Phenogen | |
| WGCNA | View at Phenogen | |
| Tissue/Strain Expression | View at Phenogen |
| Database | Acc Id | Source(s) |
| AGR Gene | RGD:1305461 | AgrOrtholog |
| BioCyc Gene | G2FUF-17075 | BioCyc |
| Ensembl Genes | ENSRNOG00000003237 | Ensembl, ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Transcript | ENSRNOT00000004330 | ENTREZGENE |
| ENSRNOT00000004330.9 | UniProtKB/TrEMBL | |
| ENSRNOT00000105977.2 | UniProtKB/TrEMBL | |
| ENSRNOT00000106232.2 | UniProtKB/TrEMBL | |
| ENSRNOT00000112631.2 | UniProtKB/TrEMBL | |
| ENSRNOT00000148005.1 | UniProtKB/TrEMBL | |
| Gene3D-CATH | 1.25.40.20 | UniProtKB/TrEMBL |
| Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1 | UniProtKB/TrEMBL | |
| InterPro | Ankyrin_rpt | UniProtKB/TrEMBL |
| Ankyrin_rpt-contain_sf | UniProtKB/TrEMBL | |
| ASPP1/2 | UniProtKB/TrEMBL | |
| ASPP2-like_RA | UniProtKB/TrEMBL | |
| RA_ASPP2 | UniProtKB/TrEMBL | |
| SH3-like_dom | UniProtKB/TrEMBL | |
| SH3_domain | UniProtKB/TrEMBL | |
| Ubiquitin-rel_dom | UniProtKB/TrEMBL | |
| NCBI Gene | 305025 | ENTREZGENE |
| PANTHER | APOPTOSIS-STIMULATING OF P53 PROTEIN | UniProtKB/TrEMBL |
| APOPTOSIS-STIMULATING OF P53 PROTEIN 2 | UniProtKB/TrEMBL | |
| Pfam | Ank_2 | UniProtKB/TrEMBL |
| ASPP2-like_RA | UniProtKB/TrEMBL | |
| SH3_1 | UniProtKB/TrEMBL | |
| PhenoGen | Tp53bp2 | PhenoGen |
| PROSITE | ANK_REP_REGION | UniProtKB/TrEMBL |
| ANK_REPEAT | UniProtKB/TrEMBL | |
| SH3 | UniProtKB/TrEMBL | |
| RatGTEx | ENSRNOG00000003237 | RatGTEx |
| SMART | ANK | UniProtKB/TrEMBL |
| SH3 | UniProtKB/TrEMBL | |
| Superfamily-SCOP | ANK | UniProtKB/TrEMBL |
| SH3 | UniProtKB/TrEMBL | |
| SSF54236 | UniProtKB/TrEMBL | |
| UniProt | A0A8I6A5P5_RAT | UniProtKB/TrEMBL |
| A0A8I6AMB5_RAT | UniProtKB/TrEMBL | |
| A0A8I6ANU5 | ENTREZGENE, UniProtKB/TrEMBL | |
| A0ABK0L0D2_RAT | UniProtKB/TrEMBL | |
| A6JGL8 | ENTREZGENE, UniProtKB/TrEMBL | |
| F1M5H6 | ENTREZGENE, UniProtKB/TrEMBL |
| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2008-10-23 | Tp53bp2 | tumor protein p53 binding protein, 2 | Trp53bp2 | transformation related protein 53 binding protein 2 | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
| 2008-04-30 | Trp53bp2 | transformation related protein 53 binding protein 2 | Trp53bp2_predicted | transformation related protein 53 binding protein 2 (predicted) | 'predicted' is removed | 2292626 | APPROVED |
| 2005-01-12 | Trp53bp2_predicted | transformation related protein 53 binding protein 2 (predicted) | Symbol and Name status set to approved | 70820 | APPROVED |