Psmg1 (proteasome assembly chaperone 1) - Rat Genome Database

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Gene: Psmg1 (proteasome assembly chaperone 1) Rattus norvegicus
Analyze
Symbol: Psmg1
Name: proteasome assembly chaperone 1
RGD ID: 1305454
Description: Predicted to enable molecular adaptor activity and proteasome binding activity. Predicted to be involved in chaperone-mediated protein complex assembly and proteasome core complex assembly. Predicted to act upstream of or within cerebellar granule cell precursor proliferation. Predicted to be located in cytoplasm. Predicted to be part of protein folding chaperone complex. Predicted to be active in endoplasmic reticulum. Orthologous to human PSMG1 (proteasome assembly chaperone 1); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Down syndrome critical region gene 2; Down syndrome critical region homolog 2; Down syndrome critical region homolog 2 (human); Dscr2; LOC288236; proteasome (prosome, macropain) assembly chaperone 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81148,745,581 - 48,755,040 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1148,745,581 - 48,755,040 (-)EnsemblGRCr8
mRatBN7.21135,276,080 - 35,285,541 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1135,276,011 - 35,285,622 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1143,933,336 - 43,942,793 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01136,604,713 - 36,614,170 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01135,750,492 - 35,759,951 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01136,327,798 - 36,337,289 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1136,327,800 - 36,337,256 (-)Ensemblrn6Rnor6.0
Rnor_5.01139,858,073 - 39,867,561 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41136,283,570 - 36,291,750 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1133,185,477 - 33,193,657 (+)NCBICelera
RGSC_v3.11136,340,284 - 36,349,713 (-)NCBI
Cytogenetic Map11q11NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA,ISO)
cytosol  (IEA,ISO)
endoplasmic reticulum  (IBA,IEA,ISO)
Golgi apparatus  (IEA,ISO)
nucleoplasm  (IEA,ISO)
protein folding chaperone complex  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15590417   PMID:15670775   PMID:16251969   PMID:17189198   PMID:20498273   PMID:21630459  


Genomics

Comparative Map Data
Psmg1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81148,745,581 - 48,755,040 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1148,745,581 - 48,755,040 (-)EnsemblGRCr8
mRatBN7.21135,276,080 - 35,285,541 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1135,276,011 - 35,285,622 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1143,933,336 - 43,942,793 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01136,604,713 - 36,614,170 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01135,750,492 - 35,759,951 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01136,327,798 - 36,337,289 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1136,327,800 - 36,337,256 (-)Ensemblrn6Rnor6.0
Rnor_5.01139,858,073 - 39,867,561 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41136,283,570 - 36,291,750 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1133,185,477 - 33,193,657 (+)NCBICelera
RGSC_v3.11136,340,284 - 36,349,713 (-)NCBI
Cytogenetic Map11q11NCBI
PSMG1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382139,174,769 - 39,183,514 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2139,174,769 - 39,183,503 (-)Ensemblhg38GRCh38
GRCh372140,546,695 - 40,555,440 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362139,469,254 - 39,477,310 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342139,469,257 - 39,477,310NCBI
Celera2125,745,057 - 25,753,109 (-)NCBICelera
Cytogenetic Map21q22.2NCBI
HuRef2126,017,701 - 26,025,770 (-)NCBIHuRef
CHM1_12140,108,716 - 40,116,785 (-)NCBICHM1_1
T2T-CHM13v2.02137,559,338 - 37,568,084 (-)NCBIT2T-CHM13v2.0
Psmg1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391695,781,133 - 95,792,160 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1695,781,133 - 95,792,160 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381695,979,933 - 95,990,960 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1695,979,933 - 95,990,960 (-)Ensemblmm10GRCm38
MGSCv371696,201,542 - 96,212,510 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361696,084,845 - 96,095,813 (-)NCBIMGSCv36mm8
Celera1697,054,046 - 97,065,015 (-)NCBICelera
Cytogenetic Map16C4NCBI
cM Map1656.76NCBI
Psmg1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540737,993,657 - 38,002,985 (-)Ensembl
ChiLan1.0NW_00495540737,993,657 - 38,002,986 (-)NCBIChiLan1.0ChiLan1.0
PSMG1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22235,128,560 - 35,297,511 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12130,135,188 - 30,143,255 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02125,526,270 - 25,535,005 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12138,876,026 - 38,884,027 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2138,876,026 - 38,884,027 (-)EnsemblpanPan2panpan1.1
PSMG1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13133,914,640 - 33,925,925 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3133,914,668 - 33,925,883 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3133,221,739 - 33,233,022 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03133,455,703 - 33,466,983 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3133,455,704 - 33,587,841 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13133,328,745 - 33,340,221 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03133,333,051 - 33,344,336 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03133,823,473 - 33,834,757 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Psmg1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440497133,461,429 - 33,470,393 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365003,997,379 - 4,006,418 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365003,997,415 - 4,006,394 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PSMG1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13202,762,512 - 202,775,642 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.113202,762,509 - 202,775,601 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213212,903,272 - 212,916,125 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PSMG1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1283,105,263 - 83,113,289 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl283,102,363 - 83,113,229 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605410,963,244 - 10,971,573 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Psmg1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474524,850,366 - 24,859,663 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474524,850,386 - 24,859,669 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Psmg1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1448,682,576 - 48,692,317 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Psmg1
35 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:158
Count of miRNA genes:134
Interacting mature miRNAs:141
Transcripts:ENSRNOT00000002242
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)112252474682951192Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)114644316891443168Rat
1598841Memor7Memory QTL 7exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)113330600878306008Rat
1598842Glom10Glomerulus QTL 103.4kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)11381815448818154Rat
1598811Bp291Blood pressure QTL 2911.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)113330600878306008Rat
634339Niddm50Non-insulin dependent diabetes mellitus QTL 503.32blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)111080612555806125Rat
634341Bw121Body weight QTL 1213.56abdominal fat pad mass (VT:1000711)abdominal fat pad weight (CMO:0000088)113532319955805892Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)113674945981749459Rat
10755497Bp388Blood pressure QTL 3882.76arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)113294306789836615Rat
724517Uae18Urinary albumin excretion QTL 183.7urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)112995899657754989Rat
1300130Rf20Renal function QTL 204.44kidney glomerulus integrity trait (VT:0010546)kidney glomerulus diameter (CMO:0001166)113191546976915469Rat
2290451Scl58Serum cholesterol level QTL 583.48blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)112631803155806125Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)113642841681428416Rat
1600394Edcs1Endometrial carcinoma susceptibility QTL12.90.04uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)111282315257823152Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)113461876079618760Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112019354996351019Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)113674945981749459Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)113674945981749459Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)113674945981749459Rat
631510Spl2Serum phospholipid level QTL 24.1blood phospholipid amount (VT:0006084)serum phospholipid level (CMO:0001171)112755668572556685Rat

Markers in Region
AW552102  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21135,278,555 - 35,278,666 (+)MAPPERmRatBN7.2
Rnor_6.01136,330,272 - 36,330,382NCBIRnor6.0
Rnor_5.01139,860,547 - 39,860,657UniSTSRnor5.0
RGSC_v3.41136,286,044 - 36,286,154UniSTSRGSC3.4
Cytogenetic Map11q11UniSTS
RH139029  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21135,283,882 - 35,285,516 (+)MAPPERmRatBN7.2
Rnor_6.01136,335,599 - 36,337,232NCBIRnor6.0
Rnor_5.01139,865,874 - 39,867,507UniSTSRnor5.0
RGSC_v3.41136,291,371 - 36,293,004UniSTSRGSC3.4
Celera1133,184,223 - 33,185,856UniSTS
Cytogenetic Map11q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000002242   ⟹   ENSRNOP00000002242
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1148,745,581 - 48,755,040 (-)Ensembl
mRatBN7.2 Ensembl1135,276,086 - 35,285,596 (-)Ensembl
Rnor_6.0 Ensembl1136,327,800 - 36,337,256 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000105649   ⟹   ENSRNOP00000085876
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1148,745,581 - 48,754,785 (-)Ensembl
mRatBN7.2 Ensembl1135,276,011 - 35,285,622 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000121972   ⟹   ENSRNOP00000100896
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1148,745,581 - 48,755,040 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000160345   ⟹   ENSRNOP00000099724
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1148,747,372 - 48,755,040 (-)Ensembl
RefSeq Acc Id: NM_001399237   ⟹   NP_001386166
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81148,745,581 - 48,755,040 (-)NCBI
mRatBN7.21135,276,080 - 35,285,541 (-)NCBI
Ensembl Acc Id: ENSRNOP00000002242   ⟸   ENSRNOT00000002242
Ensembl Acc Id: ENSRNOP00000085876   ⟸   ENSRNOT00000105649
RefSeq Acc Id: NP_001386166   ⟸   NM_001399237
- UniProtKB: A6KPT1 (UniProtKB/TrEMBL),   D4AAH6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000100896   ⟸   ENSRNOT00000121972
Ensembl Acc Id: ENSRNOP00000099724   ⟸   ENSRNOT00000160345

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4AAH6-F1-model_v2 AlphaFold D4AAH6 1-289 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698084
Promoter ID:EPDNEW_R8609
Type:multiple initiation site
Name:Psmg1_1
Description:proteasome assembly chaperone 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01136,337,253 - 36,337,313EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305454 AgrOrtholog
BioCyc Gene G2FUF-21718 BioCyc
Ensembl Genes ENSRNOG00000001643 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000002242.9 UniProtKB/TrEMBL
  ENSRNOT00000105649.2 UniProtKB/TrEMBL
  ENSRNOT00000121972 ENTREZGENE
  ENSRNOT00000121972.1 UniProtKB/TrEMBL
  ENSRNOT00000160345.1 UniProtKB/TrEMBL
InterPro Proteasome_assmbl_chp_1 UniProtKB/TrEMBL
NCBI Gene 288236 ENTREZGENE
PANTHER PROTEASOME ASSEMBLY CHAPERONE 1 UniProtKB/TrEMBL
  PTHR15069 UniProtKB/TrEMBL
Pfam PAC1 UniProtKB/TrEMBL
PhenoGen Psmg1 PhenoGen
RatGTEx ENSRNOG00000001643 RatGTEx
UniProt A0A8I6A4K6_RAT UniProtKB/TrEMBL
  A0ABK0L9H5_RAT UniProtKB/TrEMBL
  A0ABK0LCE3_RAT UniProtKB/TrEMBL
  A6KPT1 ENTREZGENE, UniProtKB/TrEMBL
  D4AAH6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-12 Psmg1  proteasome assembly chaperone 1  Psmg1  proteasome (prosome, macropain) assembly chaperone 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-25 Psmg1  proteasome (prosome, macropain) assembly chaperone 1  Dscr2_predicted  Down syndrome critical region homolog 2 (human) (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Dscr2_predicted  Down syndrome critical region homolog 2 (human) (predicted)    Down syndrome critical region gene 2 (predicted)  Name updated 1299863 APPROVED
2005-01-12 Dscr2_predicted  Down syndrome critical region gene 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED