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Gene: Tm2d1 (TM2 domain containing 1) Rattus norvegicus

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Symbol:

Tm2d1

Name:

TM2 domain containing 1

RGD ID:

1305442

Description:

Predicted to enable G protein-coupled receptor activity and amyloid-beta binding activity. Predicted to be involved in apoptotic signaling pathway. Predicted to be located in plasma membrane. Orthologous to human TM2D1 (TM2 domain containing 1); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,6-dinitrotoluene; 6-propyl-2-thiouracil.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

Bbp; beta-amyloid binding protein; beta-amyloid binding protein precursor; hypothetical protein LOC685326; LOC362545; LOC685326; TM2 domain-containing protein 1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	TM2D1 (TM2 domain containing 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Tm2d1 (TM2 domain containing 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Tm2d1 (TM2 domain containing 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	TM2D1 (TM2 domain containing 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	TM2D1 (TM2 domain containing 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Tm2d1 (TM2 domain containing 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	TM2D1 (TM2 domain containing 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	TM2D1 (TM2 domain containing 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Tm2d1 (TM2 domain containing 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Tm2d1 (TM2 domain containing 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	TM2D1 (TM2 domain containing 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	tm2d1 (TM2 domain containing 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG10795	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	Y66D12A.21	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	tm2d1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	118,136,299 - 118,177,639 (-)	NCBI		GRCr8
mRatBN7.2	5	113,020,793 - 113,062,134 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	113,020,760 - 113,050,933 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	115,599,177 - 115,629,306 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	117,324,531 - 117,354,658 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	117,387,059 - 117,417,182 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	116,992,405 - 117,038,882 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	116,996,652 - 117,038,882 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	120,935,312 - 120,981,789 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	118,765,552 - 118,806,996 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	118,770,816 - 118,823,630 (-)	NCBI
Celera	5	111,592,564 - 111,633,451 (-)	NCBI		Celera
Cytogenetic Map	5	q33	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

congenital disorder of glycosylation It (ISO)

intellectual disability (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (EXP)

2,3',4,4',5-Pentachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,6-dinitrotoluene (EXP)

2-hydroxypropanoic acid (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (ISO)

5-aza-2'-deoxycytidine (ISO)

6-propyl-2-thiouracil (EXP)

amitrole (EXP)

Aroclor 1254 (ISO)

arsane (ISO)

arsenic atom (ISO)

beta-lapachone (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

chlorpyrifos (ISO)

choline (ISO)

cisplatin (ISO)

clofibrate (ISO)

clofibric acid (EXP)

decabromodiphenyl ether (EXP)

dexamethasone (ISO)

dicrotophos (ISO)

diethylstilbestrol (ISO)

elemental selenium (ISO)

epoxiconazole (ISO)

finasteride (EXP)

flutamide (EXP)

folic acid (ISO)

hydrogen cyanide (ISO)

indometacin (ISO)

L-methionine (ISO)

leflunomide (EXP)

mercury atom (ISO)

mercury(0) (ISO)

methimazole (EXP)

methylmercury chloride (ISO)

N-nitrosodiethylamine (EXP)

nefazodone (EXP)

nimesulide (EXP)

potassium cyanide (ISO)

rac-lactic acid (ISO)

sarin (ISO)

selenium atom (ISO)

sodium arsenate (ISO)

sulfadimethoxine (EXP)

sulindac (EXP)

titanium dioxide (ISO)

tolcapone (EXP)

valproic acid (ISO)

vincristine (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

apoptotic signaling pathway (IBA,ISO)

G protein-coupled receptor signaling pathway (IEA)

Cellular Component

plasma membrane (ISO)

Molecular Function

amyloid-beta binding (IBA,ISO)

G protein-coupled receptor activity (IBA,ISO)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:11278849	PMID:12477932

Genomics

Comparative Map Data

Tm2d1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	118,136,299 - 118,177,639 (-)	NCBI		GRCr8
mRatBN7.2	5	113,020,793 - 113,062,134 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	113,020,760 - 113,050,933 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	115,599,177 - 115,629,306 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	117,324,531 - 117,354,658 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	117,387,059 - 117,417,182 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	116,992,405 - 117,038,882 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	116,996,652 - 117,038,882 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	120,935,312 - 120,981,789 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	118,765,552 - 118,806,996 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	118,770,816 - 118,823,630 (-)	NCBI
Celera	5	111,592,564 - 111,633,451 (-)	NCBI		Celera
Cytogenetic Map	5	q33	NCBI

TM2D1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	61,681,046 - 61,725,141 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	61,681,046 - 61,725,423 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	62,146,718 - 62,190,813 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	61,919,307 - 61,963,683 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	1	60,435,134 - 60,479,720 (-)	NCBI		Celera
Cytogenetic Map	1	p31.3	NCBI
HuRef	1	60,259,222 - 60,303,842 (-)	NCBI		HuRef
CHM1_1	1	62,262,184 - 62,306,567 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	61,559,915 - 61,604,028 (-)	NCBI		T2T-CHM13v2.0

Tm2d1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	98,243,607 - 98,271,523 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	98,243,607 - 98,271,543 (-)	Ensembl		GRCm39 Ensembl
GRCm38	4	98,355,370 - 98,383,265 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	98,355,370 - 98,383,306 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	98,022,061 - 98,049,956 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	97,847,388 - 97,875,283 (-)	NCBI		MGSCv36	mm8
Celera	4	96,717,093 - 96,747,029 (-)	NCBI		Celera
Cytogenetic Map	4	C6	NCBI
cM Map	4	45.6	NCBI

Tm2d1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955423	27,638,387 - 27,669,574 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955423	27,639,192 - 27,669,907 (+)	NCBI	ChiLan1.0	ChiLan1.0

TM2D1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	165,134,296 - 165,178,805 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	164,283,508 - 164,327,984 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	60,931,583 - 60,976,340 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	62,749,990 - 62,793,981 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	62,749,990 - 62,793,981 (-)	Ensembl	panpan1.1		panPan2

TM2D1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	48,274,876 - 48,315,480 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	5	48,268,186 - 48,313,634 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	48,341,597 - 48,382,071 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	5	48,458,896 - 48,499,370 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	5	48,458,912 - 48,500,980 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	5	48,412,554 - 48,453,045 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	5	48,358,573 - 48,399,207 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	5	48,623,148 - 48,663,793 (+)	NCBI		UU_Cfam_GSD_1.0

Tm2d1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	74,841,581 - 75,047,465 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936522	368,824 - 404,400 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936522	368,824 - 403,871 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TM2D1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	150,615,350 - 150,654,742 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	150,615,311 - 150,654,931 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	138,598,526 - 138,622,445 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TM2D1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	71,309,070 - 71,355,098 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666033	46,047,255 - 46,086,773 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Tm2d1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624742	31,731,422 - 31,756,425 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Tm2d1
125 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	46
Count of miRNA genes:	40
Interacting mature miRNAs:	45
Transcripts:	ENSRNOT00000009897
Prediction methods:	Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1549845	Scl44	Serum cholesterol level QTL 44	6		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	40128307	148607290	Rat
8552960	Pigfal15	Plasma insulin-like growth factor 1 level QTL 15			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	5	111416838	156416838	Rat
1298070	Scl18	Serum cholesterol level QTL 18	3.7		blood LDL cholesterol amount (VT:0000181)	calculated plasma low density lipoprotein cholesterol level (CMO:0001245)	5	79584860	124584860	Rat
61452	Ciaa5	CIA Autoantibody QTL 5	3.5		blood autoantibody amount (VT:0003725)	calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)	5	94858972	143070159	Rat
7411582	Foco3	Food consumption QTL 3	7.5	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	5	87468046	132468046	Rat
1598859	Cm66	Cardiac mass QTL 66	2		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	5	79584860	124584860	Rat
1302790	Scl20	Serum cholesterol level QTL 20	6.4	0.0001	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	82394392	166664054	Rat
1578766	Tcas11	Tongue tumor susceptibility QTL 11	4.12		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	5	46711509	161317411	Rat
1549838	Bss4	Bone structure and strength QTL 4	9.2		femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	5	106906205	151906205	Rat
2317753	Glom24	Glomerulus QTL 24	3.1		kidney glomerulus integrity trait (VT:0010546)	kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)	5	97570330	136479578	Rat
1582212	Livw2	Liver weight QTL 2	3.5	0.0004	liver mass (VT:0003402)	liver weight to body weight ratio (CMO:0000633)	5	99016066	119085810	Rat
7411564	Bw135	Body weight QTL 135		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	5	87468046	132468046	Rat
8657050	Bw146	Body weight QTL 146	19.84	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	5	108938288	153938288	Rat
1641912	Alcrsp18	Alcohol response QTL 18			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	5	35189153	141643988	Rat
2317056	Wbc3	White blood cell count QTL 3	2.51	0.01	leukocyte quantity (VT:0000217)	white blood cell count (CMO:0000027)	5	105999803	150999803	Rat
1358909	Kidm25	Kidney mass QTL 25	1.87		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	5	90067849	128034027	Rat
1578673	Bmd13	Bone mineral density QTL 13	4.9		femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	5	103689353	148689353	Rat
70189	Mcs5	Mammary carcinoma susceptibility QTL 5	10.51		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	55805606	132207589	Rat
7207488	Bss110	Bone structure and strength QTL 1	8.4		femur strength trait (VT:0010010)	femur stiffness (CMO:0001674)	5	106906205	151906205	Rat
8694441	Bw169	Body weight QTL 169	17.61	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	5	111416838	156416838	Rat
7207491	Bss112	Bone structure and strength QTL 112	7		femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	5	106906205	151906205	Rat
2290448	Scl54	Serum cholesterol level QTL 54	2.93		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	31663789	131345958	Rat
8694198	Abfw3	Abdominal fat weight QTL 3	16.13	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	5	111416838	156416838	Rat
1298086	Bp156	Blood pressure QTL 156			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	84132602	129132602	Rat
2306971	Anxrr21	Anxiety related response QTL 21	9.47		fear/anxiety-related behavior trait (VT:1000241)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	5	66174080	124160948	Rat
1298089	Scl14	Serum cholesterol level QTL 14	5.8	0.0004	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	108845856	153845856	Rat
1358895	Bp254	Blood pressure QTL 254	3.6	0.0003	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	5	58829236	128034027	Rat
2316959	Gluco59	Glucose level QTL 59	4.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	5	34944474	113558310	Rat
1358889	Bp261	Blood pressure QTL 261	2.86		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	5	90067849	128034027	Rat
2316957	Pur21	Proteinuria QTL 21	6.2		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	5	59793528	113558156	Rat
1331796	Thshl2	Thyroid stimulating hormone level QTL 2	2.3		blood thyroid-stimulating hormone amount (VT:0005119)	serum thyroid stimulating hormone level (CMO:0001248)	5	97059760	147465714	Rat
7794743	Bp373	Blood pressure QTL 373		0.0058	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	112175546	116047089	Rat
70212	Niddm25	Non-insulin dependent diabetes mellitus QTL 25	3.54		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	5	1	131345958	Rat
634305	Mamtr1	Mammary tumor resistance QTL 1		0.0001	mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	12789751	113558310	Rat
1331801	Rf33	Renal function QTL 33	4.149		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	5	43726656	129132602	Rat
61393	Bp7	Blood pressure QTL 7	4.5	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	60293434	161481680	Rat
7207486	Bss109	Bone structure and strength QTL 109			femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	5	106906205	151906205	Rat
7207481	Bss106	Bone structure and strength QTL 106	7.9		femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	5	106906205	151906205	Rat
1576312	Emca8	Estrogen-induced mammary cancer QTL 8	4.1		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	50328551	141643988	Rat
7411601	Foco12	Food consumption QTL 12	19.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	5	87468046	132468046	Rat
1576314	Eutr1	Estrogen induced uterine response QTL 1			uterus integrity trait (VT:0010575)	pyometritis severity score (CMO:0002009)	5	2138965	166875058	Rat
7394708	Emca11	Estrogen-induced mammary cancer QTL 11			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	99753548	113061097	Rat
1598846	Bp293	Blood pressure QTL 293	3.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	79584860	124584860	Rat
1598847	Cm62	Cardiac mass QTL 62	3.4		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	5	108845856	153845856	Rat
631527	Tls1	T-lymphoma susceptibility QTL 1	0	0.001	thymus integrity trait (VT:0010555)	post-insult time to onset of T-cell lymphoma (CMO:0001907)	5	90450144	135450144	Rat
8694389	Bw160	Body weight QTL 160	6.17	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	5	111416838	156416838	Rat
61426	Scl2	Serum cholesterol level QTL 2	7.3	0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	59793399	143070159	Rat
1354598	Srn6	Serum renin concentration QTL 6	3.8		blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	5	69540295	151018848	Rat
6903316	Bw113	Body weight QTL 113	2	0.0103	body mass (VT:0001259)	body weight (CMO:0000012)	5	87765973	132765973	Rat
1358187	Emca1	Estrogen-induced mammary cancer QTL 1	4.4		mammary gland integrity trait (VT:0010552)	post-insult time to mammary tumor formation (CMO:0000345)	5	99216724	148607142	Rat

Markers in Region

D5Rat25

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	5	118,176,414 - 118,176,602 (+)	Marker Load Pipeline
mRatBN7.2	5	113,060,909 - 113,061,097 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	117,037,089 - 117,037,276	NCBI	Rnor6.0
Rnor_5.0	5	120,979,996 - 120,980,183	UniSTS	Rnor5.0
RGSC_v3.4	5	118,805,536 - 118,805,723	UniSTS	RGSC3.4
RGSC_v3.4	5	118,805,535 - 118,805,723	RGD	RGSC3.4
RGSC_v3.1	5	118,810,762 - 118,810,949	RGD
Celera	5	111,631,991 - 111,632,178	UniSTS
RH 3.4 Map	5	789.6	UniSTS
RH 3.4 Map	5	789.6	RGD
SHRSP x BN Map	5	61.5499	RGD
SHRSP x BN Map	5	61.5499	UniSTS
Cytogenetic Map	5	q33	UniSTS

RH142851

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	113,046,670 - 113,046,914 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	117,022,849 - 117,023,092	NCBI	Rnor6.0
Rnor_5.0	5	120,965,756 - 120,965,999	UniSTS	Rnor5.0
RGSC_v3.4	5	118,791,294 - 118,791,537	UniSTS	RGSC3.4
RH 3.4 Map	5	793.0	UniSTS
Cytogenetic Map	5	q33	UniSTS

RH132157

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	113,020,904 - 113,021,091 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	116,996,797 - 116,996,983	NCBI	Rnor6.0
Rnor_5.0	5	120,939,704 - 120,939,890	UniSTS	Rnor5.0
RGSC_v3.4	5	118,765,697 - 118,765,883	UniSTS	RGSC3.4
Celera	5	111,592,709 - 111,592,895	UniSTS
RH 3.4 Map	5	791.3	UniSTS
Cytogenetic Map	5	q33	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001108670	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006238417	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063287944	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063287945	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063287946	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063287947	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC168758	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC168763	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473998	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000009897 ⟹ ENSRNOP00000009897

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	113,020,760 - 113,050,933 (-)	Ensembl
Rnor_6.0 Ensembl	5	116,996,652 - 117,038,882 (-)	Ensembl

RefSeq Acc Id:

NM_001108670 ⟹ NP_001102140

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	118,136,299 - 118,166,476 (-)	NCBI
mRatBN7.2	5	113,020,793 - 113,050,971 (-)	NCBI
Rnor_6.0	5	116,996,652 - 117,038,882 (-)	NCBI
Rnor_5.0	5	120,935,312 - 120,981,789 (-)	NCBI
RGSC_v3.4	5	118,765,552 - 118,806,996 (-)	RGD
Celera	5	111,592,564 - 111,633,451 (-)	RGD

Sequence:

show sequence

AGATCCCCGAGCACGCGCGATCGCTGAGCTCGCAGGCCGGGTGGGCCTGGAAGTTCGAGCGGGG
CTGATTGGCCTGGTCGCCGGCCGCCGCCAAGGCCTGCGAGCTGCCCAGCGCACCCTCCGCGGGC
TCGGGACACGGCTTCCGCGCGGCCCCCGCACAGTGCGCCGCGAGCGTTACCTGATCAGGCGACA
GCCGGGTGGGAGCCCCGAGGCTGCGATCACGGCCTCCTCACCTGGCGGAAGTACAGCTGCTGCC
CTCACCTGGACGGAAGTGTGGCGGCCTCCTCACCTGGGCGTCTCTCCACCTCGCCAGAGGCTGG
GCGGGGCGAGCGGGGCTCTAGCCCCTGGGCGTCTGCGCGCCTGTAAAAGTTCCGGGGGTGAGTG
GGGCTACCAATCCTGGTGAGGCGGCCTGAGGCCTTGCGGCCAGATGGCGGCCGCCTGGCCCGCG
GGTCGGGCTTCTCCAGCGGCGGGGCCTCCGGCCCTCCTCCGCACTCTGTGGCTCGTGACGGTCG
CCGCGGGACATTGTGGGGCTGCTGCCTCTGGCGCTGTCGGAGGCGAGGAGACGCCCAAGTGTGA
GGACCTCAGAGTGGGACAATATATTTGTAAAGAACCAAAAATAAATGATGCTACGCAAGAACCA
GTTAATTGTACAAACTACACAGCTCATGTTCAATGTTTTCCAGCACCCAACATAACTTGTAAGG
ATTTGAGTGGTAATGAAACACATTTTACTGGAAGTGAAGTTGGTTTTCTCAAGCCCATATCTTG
CCGAAATGTGAATGGCTATTCATACAAAGTGGCAGTTGCACTATCTCTTTTTTTGGGATGGCTG
GGAGCAGATCGATTTTACCTCGGATATCCTGCCTTAGGCTTGTTAAAGTTTTGCACTGTGGGAT
TTTGCGGAATTGGGAGCCTAATTGATTTCGTCCTTATTTCAATGCAGATCGTCGGCCCTTCGGA
TGGGAGTAGTTACATTATAGACTATTATGGAACCAGACTCACGAGACTCAGCGTTACTAATGAG
ACATTTAGAAAAACACAGTTGTATCCATGAGTGTTTGAAAGAGGAACAGATTTGAGCCTCCCTG
ATTTCAATCAAGAGCCCTGTGTGTGGAATTCCAGATTTCCTTTTCCTTTAGTATCACTTTATGG
GTTCTAGATGATGTTTGACATGTGCTCAACCTTGATTTGTTGATTTAGTTAGAGTATACTATTC
CTAGATTTATTTAATAGTCTTTCTTAAAATCAGTATACTATGTTTCGAGGGCTTCTGTCTCTAT
GAGACAGCTAGTCTATCACTTTGTTACTATTGTATTACTGTCATGTCCTTTACACGTCACTTGT
CATTTTTATTTGTGAAAAATAAAAAGATAACTTATTCACATTTGACTGACTGTCATTAAGAAGA
CCTTTATTACTGAA

hide sequence

RefSeq Acc Id:

XM_063287944 ⟹ XP_063144014

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	118,136,304 - 118,177,639 (-)	NCBI

RefSeq Acc Id:

XM_063287945 ⟹ XP_063144015

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	118,136,304 - 118,177,634 (-)	NCBI

RefSeq Acc Id:

XM_063287946 ⟹ XP_063144016

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	118,136,304 - 118,177,639 (-)	NCBI

RefSeq Acc Id:

XM_063287947 ⟹ XP_063144017

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	118,139,000 - 118,170,289 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001102140	(Get FASTA)	NCBI Sequence Viewer
	XP_063144014	(Get FASTA)	NCBI Sequence Viewer
	XP_063144015	(Get FASTA)	NCBI Sequence Viewer
	XP_063144016	(Get FASTA)	NCBI Sequence Viewer
	XP_063144017	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL97796	(Get FASTA)	NCBI Sequence Viewer
	EDL97797	(Get FASTA)	NCBI Sequence Viewer
	EDL97798	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000009897.5

RefSeq Acc Id:	NP_001102140 ⟸ NM_001108670
- Peptide Label:	precursor
- UniProtKB:	D3ZYF8 (UniProtKB/TrEMBL), A6JRK6 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAAAWPAGRASPAAGPPALLRTLWLVTVAAGHCGAAASGAVGGEETPKCEDLRVGQYICKEPKI NDATQEPVNCTNYTAHVQCFPAPNITCKDLSGNETHFTGSEVGFLKPISCRNVNGYSYKVAVAL SLFLGWLGADRFYLGYPALGLLKFCTVGFCGIGSLIDFVLISMQIVGPSDGSSYIIDYYGTRLT RLSVTNETFRKTQLYP hide sequence

Ensembl Acc Id:

ENSRNOP00000009897 ⟸ ENSRNOT00000009897

RefSeq Acc Id:	XP_063144016 ⟸ XM_063287946
- Peptide Label:	isoform X1
- UniProtKB:	A6JRK6 (UniProtKB/TrEMBL), D3ZYF8 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063144014 ⟸ XM_063287944
- Peptide Label:	isoform X1
- UniProtKB:	A6JRK6 (UniProtKB/TrEMBL), D3ZYF8 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063144015 ⟸ XM_063287945
- Peptide Label:	isoform X1
- UniProtKB:	A6JRK6 (UniProtKB/TrEMBL), D3ZYF8 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063144017 ⟸ XM_063287947
- Peptide Label:	isoform X2

Protein Domains

TM2

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZYF8-F1-model_v2	AlphaFold	D3ZYF8	1-208	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13693850

Promoter ID:

EPDNEW_R4375

Type:

single initiation site

Name:

Tm2d1_1

Description:

TM2 domain containing 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	5	117,038,866 - 117,038,926	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1305442	AgrOrtholog
BioCyc Gene	G2FUF-40589	BioCyc
Ensembl Genes	ENSRNOG00000007527	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000009897.7	UniProtKB/TrEMBL
InterPro	TM2	UniProtKB/TrEMBL
	TM2_domain	UniProtKB/TrEMBL
KEGG Report	rno:362545	UniProtKB/TrEMBL
NCBI Gene	362545	ENTREZGENE
PANTHER	BETA-AMYLOID BINDING PROTEIN-RELATED	UniProtKB/TrEMBL
	TM2 DOMAIN-CONTAINING PROTEIN 1	UniProtKB/TrEMBL
Pfam	TM2	UniProtKB/TrEMBL
PhenoGen	Tm2d1	PhenoGen
RatGTEx	ENSRNOG00000007527	RatGTEx
UniProt	A6JRK6	ENTREZGENE, UniProtKB/TrEMBL
	D3ZYF8	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-07-29	Tm2d1	TM2 domain containing 1	LOC685326	hypothetical protein LOC685326	Data merged from RGD:1595122	737654	PROVISIONAL
2008-04-30	Tm2d1	TM2 domain containing 1	Tm2d1_predicted	TM2 domain containing 1 (predicted)	'predicted' is removed	2292626	APPROVED
2008-01-09	LOC685326	hypothetical protein LOC685326	LOC682077	hypothetical protein LOC682077	Data merged from RGD:1588090	1643240	APPROVED
2006-11-20	LOC685326	hypothetical protein LOC685326			Symbol and Name status set to provisional	70820	PROVISIONAL
2006-11-19	LOC682077	hypothetical protein LOC682077			Symbol and Name status set to provisional	70820	PROVISIONAL
2006-03-30	Tm2d1_predicted	TM2 domain containing 1 (predicted)	Bbp_predicted	beta-amyloid binding protein precursor (predicted)	Symbol and Name updated	1299863	APPROVED
2005-01-12	Bbp_predicted	beta-amyloid binding protein precursor (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar