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Gene: Clcn6 (chloride voltage-gated channel 6) Rattus norvegicus

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Symbol:

Clcn6

Name:

chloride voltage-gated channel 6

RGD ID:

1305379

Description:

Predicted to enable voltage-gated chloride channel activity. Involved in response to mechanical stimulus. Predicted to be located in late endosome membrane. Human ortholog(s) of this gene implicated in coronary artery disease. Orthologous to human CLCN6 (chloride voltage-gated channel 6); INTERACTS WITH 1-naphthyl isothiocyanate; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

chloride channel 6; chloride channel, voltage-sensitive 6; chloride transport protein 6; H(+)/Cl(-) exchange transporter 6; LOC295586

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CLCN6 (chloride voltage-gated channel 6)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther
Mus musculus (house mouse):	Clcn6 (chloride channel, voltage-sensitive 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Clcn6 (chloride voltage-gated channel 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	CLCN6 (chloride voltage-gated channel 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CLCN6 (chloride voltage-gated channel 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Clcn6 (chloride voltage-gated channel 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CLCN6 (chloride voltage-gated channel 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CLCN6 (chloride voltage-gated channel 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Clcn6 (chloride voltage-gated channel 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Clcn6 (chloride voltage-gated channel 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	CLCN6 (chloride voltage-gated channel 6)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Clcn6 (chloride channel, voltage-sensitive 6)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	clcn6 (chloride channel 6)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	clcn6	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Allele / Splice:

Clcn6^em2Mcwi

Genetic Models:

SS-Clcn6^em2Mcwi

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	163,715,593 - 163,748,301 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	5	163,717,439 - 163,748,198 (-)	Ensembl				GRCr8
mRatBN7.2	5	158,434,299 - 158,465,174 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	158,434,299 - 158,465,059 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	5	161,151,048 - 161,181,808 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	162,978,934 - 163,010,217 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	162,935,283 - 162,966,566 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	164,811,815 - 164,844,554 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	164,811,816 - 164,844,586 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	5	168,469,718 - 168,502,323 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	5	165,079,773 - 165,110,594 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	5	156,716,141 - 156,746,803 (-)	NCBI		Celera
RGSC_v3.1	5	165,090,327 - 165,120,752 (-)	NCBI
Cytogenetic Map	5	q36	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

coronary artery disease (ISO)

Developmental Disabilities (ISO)

neuronal ceroid lipofuscinosis 15 (ISO)

neuronal ceroid lipofuscinosis 3 (ISS)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,1-dichloroethene (ISO)

1,2-dimethylhydrazine (ISO)

1-naphthyl isothiocyanate (EXP)

2,2',4,4'-Tetrabromodiphenyl ether (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

2-bromohexadecanoic acid (ISO)

2-methylcholine (ISO)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (ISO)

acetamide (EXP)

acrylamide (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

amiodarone (ISO)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (ISO)

beta-lapachone (ISO)

bisphenol A (EXP,ISO)

butan-1-ol (ISO)

cadmium atom (ISO)

cadmium dichloride (EXP,ISO)

chlorpyrifos (ISO)

copper(II) chloride (ISO)

CU-O LINKAGE (ISO)

curcumin (ISO)

cyclosporin A (ISO)

DDE (ISO)

diazinon (ISO)

dibutyl phthalate (EXP)

dicrotophos (ISO)

disodium selenite (ISO)

doxorubicin (ISO)

epoxiconazole (ISO)

ethanol (ISO)

flutamide (EXP)

fulvestrant (ISO)

furan (EXP)

genistein (ISO)

gentamycin (EXP)

isobutanol (ISO)

manganese atom (ISO)

manganese(0) (ISO)

manganese(II) chloride (ISO)

methamphetamine (ISO)

ozone (ISO)

paracetamol (EXP)

phenytoin (EXP)

pravastatin (EXP,ISO)

raloxifene (ISO)

sodium arsenite (ISO)

sunitinib (ISO)

tetrachloromethane (EXP)

titanium dioxide (ISO)

trichloroethene (EXP)

triphenyl phosphate (ISO)

zaragozic acid A (EXP,ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

chloride transmembrane transport (IEA)

chloride transport (IBA,IEA,ISO)

monoatomic ion transport (IEA)

response to mechanical stimulus (IMP)

transmembrane transport (IEA)

Cellular Component

late endosome membrane (IEA)

membrane (IEA)

Molecular Function

antiporter activity (IEA)

ATP binding (IEA)

chloride channel activity (IEA)

chloride transmembrane transporter activity (IEA)

nucleotide binding (IEA)

voltage-gated chloride channel activity (IBA,IEA,ISO)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

decreased body weight (IMP)

decreased heart weight (IMP)

decreased mean systemic arterial blood pressure (IMP)

decreased systemic arterial diastolic blood pressure (IMP)

decreased urine creatinine level (IMP)

decreased urine protein level (IMP)

decreased urine sodium level (IMP)

References

References - curated

#	Reference Title	Reference Citation
1.	Identifying multiple causative genes at a single GWAS locus.	Flister MJ, etal., Genome Res. 2013 Dec;23(12):1996-2002. doi: 10.1101/gr.160283.113. Epub 2013 Sep 4.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
5.	Comprehensive gene review and curation	RGD comprehensive gene curation
6.	Chloride channels and the reactions of cells to topography.	Tobasnick G and Curtis AS, Eur Cell Mater. 2001 Dec 13;2:49-61.
7.	The rs3737964 single-nucleotide polymorphism of the chloride channel-6 gene as a risk factor for coronary heart disease.	Zhang L, etal., Mol Genet Genomic Med. 2015 Jul 14;3(6):537-42. doi: 10.1002/mgg3.163. eCollection 2015 Nov.

Additional References at PubMed

PMID:17897319	PMID:33390052	PMID:35927940

Genomics

Comparative Map Data

Clcn6
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	163,715,593 - 163,748,301 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	5	163,717,439 - 163,748,198 (-)	Ensembl				GRCr8
mRatBN7.2	5	158,434,299 - 158,465,174 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	158,434,299 - 158,465,059 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	5	161,151,048 - 161,181,808 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	162,978,934 - 163,010,217 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	162,935,283 - 162,966,566 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	164,811,815 - 164,844,554 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	164,811,816 - 164,844,586 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	5	168,469,718 - 168,502,323 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	5	165,079,773 - 165,110,594 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	5	156,716,141 - 156,746,803 (-)	NCBI		Celera
RGSC_v3.1	5	165,090,327 - 165,120,752 (-)	NCBI
Cytogenetic Map	5	q36	NCBI

CLCN6
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	11,806,191 - 11,843,130 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	11,806,096 - 11,848,079 (+)	Ensembl			hg38	GRCh38
GRCh37	1	11,866,248 - 11,903,187 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	11,788,794 - 11,825,788 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	1	10,979,829 - 11,016,824 (+)	NCBI		Celera
Cytogenetic Map	1	p36.22	NCBI
HuRef	1	11,021,210 - 11,058,258 (+)	NCBI		HuRef
CHM1_1	1	11,854,047 - 11,891,095 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	11,350,275 - 11,387,211 (+)	NCBI		T2T-CHM13v2.0

Clcn6
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	148,088,716 - 148,123,270 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	148,088,716 - 148,123,278 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	4	148,004,259 - 148,038,813 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	148,004,259 - 148,038,821 (-)	Ensembl			mm10	GRCm38
MGSCv37	4	147,380,593 - 147,412,876 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	4	146,850,284 - 146,882,567 (-)	NCBI		MGSCv36	mm8
Celera	4	150,272,852 - 150,305,364 (-)	NCBI		Celera
Cytogenetic Map	4	E1	NCBI
cM Map	4	78.67	NCBI

Clcn6
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955486	2,064,916 - 2,096,317 (-)	Ensembl
ChiLan1.0	NW_004955486	2,066,317 - 2,096,317 (-)	NCBI	ChiLan1.0	ChiLan1.0

CLCN6
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	216,380,834 - 216,418,073 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	215,026,384 - 215,063,498 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	10,568,222 - 10,605,459 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	11,785,643 - 11,822,505 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	11,785,643 - 11,822,505 (+)	Ensembl			panPan2	panpan1.1

CLCN6
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	84,410,740 - 84,443,874 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	2	84,413,612 - 84,445,033 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	80,943,970 - 80,978,766 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	2	85,075,630 - 85,110,501 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	2	85,075,631 - 85,108,811 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	2	81,824,232 - 81,859,027 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	2	82,824,152 - 82,858,937 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	2	83,886,934 - 83,921,795 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Clcn6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	34,813,213 - 34,844,601 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936474	637,978 - 669,833 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936474	637,930 - 669,383 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CLCN6
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	71,881,972 - 71,916,029 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	6	71,881,912 - 71,915,016 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	65,791,512 - 65,825,675 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CLCN6
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	119,948,442 - 119,987,553 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	119,948,448 - 119,987,419 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666054	23,816,466 - 23,855,604 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Clcn6
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624818	1,151,981 - 1,184,616 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624818	1,151,981 - 1,184,648 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Clcn6
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	1	12,739,863 - 12,772,291 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Clcn6
217 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	136
Count of miRNA genes:	103
Interacting mature miRNAs:	118
Transcripts:	ENSRNOT00000011287
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
10053720	Scort26	Serum corticosterone level QTL 26	2.06	0.0147	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	5	130249266	172190305	Rat
1354583	Despr3	Despair related QTL3	4.98	0.0002	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	5	132930505	172190305	Rat
61444	Strs2	Sensitivity to stroke QTL 2	4.7		cerebrum integrity trait (VT:0010549)	post-insult time to onset of cerebrovascular lesion (CMO:0002343)	5	141212838	172190305	Rat
1300119	Bp180	Blood pressure QTL 180	3.82		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	5	149642129	171146538	Rat
1549904	Neuinf1	Neuroinflammation QTL 1	3	0	nervous system integrity trait (VT:0010566)	blood T lymphocyte count (CMO:0000110)	5	160111176	171146538	Rat
61452	Ciaa5	CIA Autoantibody QTL 5	3.5		blood autoantibody amount (VT:0003725)	calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)	5	99905133	172190305	Rat
8552908	Pigfal4	Plasma insulin-like growth factor 1 level QTL 4	6.6		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	5	133789363	172190305	Rat
1331803	Rf32	Renal function QTL 32	2.798		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	5	134369199	172190305	Rat
61393	Bp7	Blood pressure QTL 7	4.5	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	65089051	166764498	Rat
7794791	Mcs33	Mammary carcinoma susceptibility QTL 33	1.93		mammary gland integrity trait (VT:0010552)	mammary tumor incidence/prevalence measurement (CMO:0000946)	5	136631198	172190305	Rat
1354631	Swd2	Spike wave discharge measurement QTL 2	3.64	0.0002	brain electrophysiology trait (VT:0010557)	brain total spike-and-wave discharge duration (CMO:0001740)	5	156396728	172190305	Rat
1598861	Cm64	Cardiac mass QTL 64	2.9		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	5	133081618	172190305	Rat
1578766	Tcas11	Tongue tumor susceptibility QTL 11	4.12		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	5	51657967	166600247	Rat
631505	Bp103	Blood pressure QTL 103	3.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	138002522	170842766	Rat
1581505	Rf54	Renal function QTL 54			kidney physiology trait (VT:0002136)	kidney 20-HETE level (CMO:0001854)	5	133270647	172190305	Rat
1641920	Colcs1	Colorectal carcinoma susceptibility QTL 1	2.99	0.0055	intestine integrity trait (VT:0010554)	benign colorectal tumor surface area measurement (CMO:0001799)	5	160071170	172129029	Rat
2317753	Glom24	Glomerulus QTL 24	3.1		kidney glomerulus integrity trait (VT:0010546)	kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)	5	141764300	172190305	Rat
8694169	Bw148	Body weight QTL 148	5	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	5	133789363	172190305	Rat
1331721	Bp210	Blood pressure QTL 210	3.413		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	5	148093485	172129029	Rat
1581510	Cm54	Cardiac mass QTL 54	3.4	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	5	125969677	172190305	Rat
1576312	Emca8	Estrogen-induced mammary cancer QTL 8	4.1		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	55124766	172190305	Rat
631272	Lanf1	Left ventricular atrial natriuretic factor QTL 1	12		heart left ventricle natriuretic peptide A amount (VT:0010596)	heart left ventricle natriuretic peptide A level (CMO:0002165)	5	156396728	167181764	Rat
724525	Bp147	Blood pressure QTL 147	4.3	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	131708216	172190305	Rat
2313096	Bmd78	Bone mineral density QTL 78	3.1	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	5	149661912	166600247	Rat
1298090	Bp155	Blood pressure QTL 155	3.8		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	5	156289283	171137955	Rat
1598819	Bp292	Blood pressure QTL 292	4.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	133081618	172190305	Rat

Genetic Models

This gene Clcn6 is modified in the following models/strains:

SS-Clcn6^em2Mcwi

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	163	91	90	59	92	59	6	356	192	11	142	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001106479	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006239377	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006239378	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039109375	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039109377	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_592730	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC094126	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473968	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000011287 ⟹ ENSRNOP00000011287

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	5	163,717,439 - 163,748,198 (-)	Ensembl
mRatBN7.2 Ensembl	5	158,434,299 - 158,465,059 (-)	Ensembl
Rnor_6.0 Ensembl	5	164,811,816 - 164,844,586 (-)	Ensembl

RefSeq Acc Id:

NM_001106479 ⟹ NP_001099949

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	163,717,439 - 163,748,198 (-)	NCBI
mRatBN7.2	5	158,434,299 - 158,465,059 (-)	NCBI
Rnor_6.0	5	164,813,662 - 164,844,421 (-)	NCBI
Rnor_5.0	5	168,469,718 - 168,502,323 (-)	NCBI
RGSC_v3.4	5	165,079,773 - 165,110,594 (-)	RGD
Celera	5	156,716,141 - 156,746,803 (-)	RGD

Sequence:

show sequence

GGTGGTCCGGAGTGGCAGGAAAGGAGGAAGATGGCGGGGTGCAGGGGGTCTGTGTGCTGCTGCT
GCAGGTGGTGCTGCTGCTGCGGCGAACGCGAGAGCCGCACTCCCGAGGAGCTGACCATCCTTGG
GGAGACACAGGAAGAGGAAGATGAGATCCTTCCAAGGAAAGACTATGAGAGTCTGGACTATGAC
CGCTGTATCAACGACCCTTACCTGGAGGTATTGGAGACCATGGATAATAAGAAAGGGCGAAGAC
ATGAGGCGGTGAAGTGGATGGTGGTGTTTGCCATTGGCGTCTGTACTGGGCTGGTGGGCCTCTT
CGTGGACTTTTCTGTGCGACTCTTCACCCAACTCAAGTTCGGAGTGGTTCAAACGTCGGTGGAG
GAATGCAGTCAGAAAGGCTGCCTTGCCCTGTCTCTCCTGGAACTCCTTGGCTTTAACTTGACCT
TTGTCTTCCTGGCAAGCCTTCTTGTCTTGATAGAGCCGGTGGCAGCAGGCTCTGGAATCCCAGA
GATCAAGTGCTATCTGAATGGTGTGAAAGTGCCAGGAATTGTCCGGCTCCGAACCCTGCTCTGC
AAAGTCTTTGGGGTGCTGTTCAGTGTGGCTGGAGGGCTCTTTGTGGGGAAAGAAGGCCCCATGA
TCCACAGTGGTGCCGTGGTAGGAGCTGGCCTCCCTCAGTTTCAGAGCATCTCCTTAAGGAAGAT
CCAGTTTAACTTCCCCTACTTCCGCAGCGACAGAGACAAGCGTGACTTCGTATCAGCAGGGGCG
GCTGCTGGAGTTGCTGCAGCTTTTGGGGCCCCTATAGGGGGCACCTTGTTCAGCCTGGAGGAGG
GCTCGTCCTTCTGGAACCAGGGACTCACGTGGAAAGTGCTCTTCTGTTCCATGTCTGCCACCTT
CACCCTCAACTTCTTCCGCTCTGGGATCCAGTTTGGAAGTTGGGGTGCCTTCCAGCTGCCTGGA
CTGCTGAACTTTGGTGAATTTAAGTGCTCTGACTCTGATAAAAAATGTCATCTCTGGACAGCTA
TGGATTTGGGTTTCTTCGTCGTGATGGGGGTCATTGGGGGCCTCCTGGGAGCCACATTCAACTG
TCTGAACAAGAGGCTTGCAAAGTACCGTATGCGCAACGTGCACCCGAAACCTAAGCTCGTCAGG
GTCTTAGAGAGCCTCTTGGTGTCCCTGGTGACGACTGTGGTGGTGTTTGTGGCCTCCATGGTGT
TGGGAGAATGCCGACAGATGTCTTCCACGAGTCAAACGGGTAATGGCTCATTCCAGCTCCAGGT
CACATCGGAAGATGTGAATTCAACTATCAAGACATTTTTCTGTCCCAATGACACCTACAACGAC
ATGGCCACACTCTTCTTCAACTCCCAGGAGTCTGCCATCCTGCAGCTCTTCCATCAGGATGGGA
CTTTCAGCCCCGTCACCCTGGCCTTATTCTTCGCCCTCTATTTCCTGATGGCATGCTGGACTTT
CGGCACCTCTGTCCCCAGTGGCCTCTTCGTGCCTTCCCTGCTGTGTGGAGCAGCTTTTGGACGT
TTAGTTGCCAATGTCCTGAAAAGCTACATTGGACTGGGCCACCTCTATTCTGGGACCTTCGCCC
TGATTGGTGCGGCAGCTTTCTTGGGTGGGGTTGTAAGAATGACCATCAGCCTCACAGTCATCCT
GATTGAGTCCACAAATGAGATCACCTATGGGCTTCCTATTATGGTCACTTTGATGGTGGCCAAG
TGGACTGGAGACTTTTTCAATAAGGGCATTTACGACATCCACATTGGGCTGAGAGGTGTGCCTC
TTCTGGAGTGGGAGACAGAGGTGGAGATGGACAGGCTGAGAGCCAGCGACATCATGGAGCCCAA
CTTGACGTATGTCTACCCACATACTCGTATCCAGTCTCTGGTGAGCATCCTGCGTACTACAGTC
CACCATGCCTTCCCAGTGGTCACAGAGAATCGCGGCAACGAGAAGGAGTTCATGAAAGGCAACC
AGCTCATAAGCAACAACATTAAGTTCAAGAAGTCCAGCATCCTCACCCGTGCTGGTGAGCAGCG
CAAGCGGGGCCAGTCCATGAAGTCTTACCCTTCCAGCGAGCTGCGCAACGTGTGTGATGAGCAT
GTGGCTTCTGAGGAGCCAGCAGAGAAGGAGGACCTGCTACAGCAGATGCTGGAGAGGAGATACA
CTCCCTACCCCAACCTATACCCTGACCAGTCCCCGAGTGAAGACTGGACCATGGAGGAGCGATT
CCGTCCGCTGACCTTCCATGGCCTCGTCCTGCGCTCCCAGCTCGTCACCCTGCTCGTCCGAGGC
GTGTGTTACTCGGAAAGTCAGTCCAGTGCCAGCCAACCACGCCTTTCTTATGCTGAGATGGCTG
AGGACTACCCGAGGTTTCCGGACATACATGACCTGGACCTCACACTGCTGAATCCCCGCATGAT
TGTGGACGTCACACCATATATGAATCCTTCACCATTTACTGTCTCCCCCAACACCCACGTTTCT
CAAGTTTTCAACCTGTTCAGAACCATGGGCCTGCGCCACTTGCCGGTGGTGAATGCGGTGGGCG
AGATCGTGGGGATCATTACACGACACAACCTGACGACTGAGTTCCTGCAGGCCCGGCTACGGCA
GCATTACCAGACCCTCTGACAGTTGAGCCCGGCTGCAGCCAGCCCACTGTCCCAGAGATGCCTC
TGCAGTGGCCAGCTCACTTGCTGGCCTCCACAGCCAGCACGAAGGCTCCCAGTCAACCATTTGC
TCAGATGCCTGGAGTCCTGGAAGATGGGGGTCAGAGGTTTTTGGGGATGTGCTGAGCAGGAAGT
TGGGGTTTTACTAAATTCCTCTGTAAGAATCTTCCATTCCCCAGCTCCCCTAGAGAGAGATCAG
GGTACTCTTGGGCTGGATCCTAGGTGGAACTTGGTGCCTCTTTGTTGCTGTTTCTCGGAGAGCC
CCGCTGTTGCCCAGACCTTTCCGGGAAGGAGTTGGACTGAGGCCGACACTGAGGATCTTGTTTG
TATATCAAGAATTAGGCACTAAGAACCCTTCCCCGTGTCTGGGGAGGCCTGGGATCAGAACCAG
GACCTCATATACACTCTGCCTCTTCAGTGTTCTGTTTCCTAGGAGTGAGCTCATGCTCTTGACC
CTGGGGCTTGAATGTCCTTAGAATCATTCCTGACCAGACCCCTGATGCTAACATTCCAGCTAAC
AGCCTCTAAGCATTAAATCCCACCACAGGAACCACAGCGTCTCCCCTCTGTGAACATTCAGTAG
TCCCCACTCACTGCTTACACCTGCTCTCCCAGTGACCTGCG

hide sequence

RefSeq Acc Id:

XM_006239378 ⟹ XP_006239440

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	163,715,593 - 163,747,944 (-)	NCBI
mRatBN7.2	5	158,434,804 - 158,464,826 (-)	NCBI
Rnor_6.0	5	164,811,815 - 164,844,192 (-)	NCBI
Rnor_5.0	5	168,469,718 - 168,502,323 (-)	NCBI

Sequence:

show sequence

GGGCCCGGGGACCGCTGCCTGAGCTCTGGAAGCATCCGTCTTTCTTGGCGCGCCCAAGTCAGAG
TTCTATTCTCATAACCTCTCTCTGGACTCTGAGGGAGGATCTCGGCCAGCTTGGGTTGATGCCA
TGCATAATCTATTTTATCGGAAAGGAGTTTTGAATGAAACAAGCGTTTTAGAATGAGCCCTTTC
GGAGAACTTGATGCTCAGGCAGTTGATTTAGTTTCTCCAGCCTTTTCTTATTCTACCCTTCACT
CTTTCTGGGTCACTGATGATCCAGCTTCCCCCTGCAAAGCAACCTGGGAAAACTTGAGTTGTGT
TCTCAGAGTTGATACATTTCCCTCAGATTTCATATTCAGTCTGTTGTCAAACGAAACGTGAATT
TTCTCCTTCAACTAAGTTGCTATCAGACATCTTTCAGGTGTCCCGAAGACCATCCTTGGGGAGA
CACAGGAAGAGGAAGATGAGATCCTTCCAAGGAAAGACTATGAGAGTCTGGACTATGACCGCTG
TATCAACGACCCTTACCTGGAGGTATTGGAGACCATGGATAATAAGAAAGGGCGAAGACATGAG
GCGGTGAAGTGGATGGTGGTGTTTGCCATTGGCGTCTGTACTGGGCTGGTGGGCCTCTTCGTGG
ACTTTTCTGTGCGACTCTTCACCCAACTCAAGTTCGGAGTGGTTCAAACGTCGGTGGAGGAATG
CAGTCAGAAAGGCTGCCTTGCCCTGTCTCTCCTGGAACTCCTTGGCTTTAACTTGACCTTTGTC
TTCCTGGCAAGCCTTCTTGTCTTGATAGAGCCGGTGGCAGCAGGCTCTGGAATCCCAGAGATCA
AGTGCTATCTGAATGGTGTGAAAGTGCCAGGAATTGTCCGGCTCCGAACCCTGCTCTGCAAAGT
CTTTGGGGTGCTGTTCAGTGTGGCTGGAGGGCTCTTTGTGGGGAAAGAAGGCCCCATGATCCAC
AGTGGTGCCGTGGTAGGAGCTGGCCTCCCTCAGTTTCAGAGCATCTCCTTAAGGAAGATCCAGT
TTAACTTCCCCTACTTCCGCAGCGACAGAGACAAGCGTGACTTCGTATCAGCAGGGGCGGCTGC
TGGAGTTGCTGCAGCTTTTGGGGCCCCTATAGGGGGCACCTTGTTCAGCCTGGAGGAGGGCTCG
TCCTTCTGGAACCAGGGACTCACGTGGAAAGTGCTCTTCTGTTCCATGTCTGCCACCTTCACCC
TCAACTTCTTCCGCTCTGGGATCCAGTTTGGAAGTTGGGGTGCCTTCCAGCTGCCTGGACTGCT
GAACTTTGGTGAATTTAAGTGCTCTGACTCTGATAAAAAATGTCATCTCTGGACAGCTATGGAT
TTGGGTTTCTTCGTCGTGATGGGGGTCATTGGGGGCCTCCTGGGAGCCACATTCAACTGTCTGA
ACAAGAGGCTTGCAAAGTACCGTATGCGCAACGTGCACCCGAAACCTAAGCTCGTCAGGGTCTT
AGAGAGCCTCTTGGTGTCCCTGGTGACGACTGTGGTGGTGTTTGTGGCCTCCATGGTGTTGGGA
GAATGCCGACAGATGTCTTCCACGAGTCAAACGGGTAATGGCTCATTCCAGCTCCAGGTCACAT
CGGAAGATGTGAATTCAACTATCAAGACATTTTTCTGTCCCAATGACACCTACAACGACATGGC
CACACTCTTCTTCAACTCCCAGGAGTCTGCCATCCTGCAGCTCTTCCATCAGGATGGGACTTTC
AGCCCCGTCACCCTGGCCTTATTCTTCGCCCTCTATTTCCTGATGGCATGCTGGACTTTCGGCA
CCTCTGTCCCCAGTGGCCTCTTCGTGCCTTCCCTGCTGTGTGGAGCAGCTTTTGGACGTTTAGT
TGCCAATGTCCTGAAAAGCTACATTGGACTGGGCCACCTCTATTCTGGGACCTTCGCCCTGATT
GGTGCGGCAGCTTTCTTGGGTGGGGTTGTAAGAATGACCATCAGCCTCACAGTCATCCTGATTG
AGTCCACAAATGAGATCACCTATGGGCTTCCTATTATGGTCACTTTGATGGTGGCCAAGTGGAC
TGGAGACTTTTTCAATAAGGGCATTTACGACATCCACATTGGGCTGAGAGGTGTGCCTCTTCTG
GAGTGGGAGACAGAGGTGGAGATGGACAGGCTGAGAGCCAGCGACATCATGGAGCCCAACTTGA
CGTATGTCTACCCACATACTCGTATCCAGTCTCTGGTGAGCATCCTGCGTACTACAGTCCACCA
TGCCTTCCCAGTGGTCACAGAGAATCGCGGCAACGAGAAGGAGTTCATGAAAGGCAACCAGCTC
ATAAGCAACAACATTAAGTTCAAGAAGTCCAGCATCCTCACCCGTGCTGGTGAGCAGCGCAAGC
GGGGCCAGTCCATGAAGTCTTACCCTTCCAGCGAGCTGCGCAACGTGTGTGATGAGCATGTGGC
TTCTGAGGAGCCAGCAGAGAAGGAGGACCTGCTACAGCAGATGCTGGAGAGGAGATACACTCCC
TACCCCAACCTATACCCTGACCAGTCCCCGAGTGAAGACTGGACCATGGAGGAGCGATTCCGTC
CGCTGACCTTCCATGGCCTCGTCCTGCGCTCCCAGCTCGTCACCCTGCTCGTCCGAGGCGTGTG
TTACTCGGAAAGTCAGTCCAGTGCCAGCCAACCACGCCTTTCTTATGCTGAGATGGCTGAGGAC
TACCCGAGGTTTCCGGACATACATGACCTGGACCTCACACTGCTGAATCCCCGCATGATTGTGG
ACGTCACACCATATATGAATCCTTCACCATTTACTGTCTCCCCCAACACCCACGTTTCTCAAGT
TTTCAACCTGTTCAGAACCATGGGCCTGCGCCACTTGCCGGTGGTGAATGCGGTGGGCGAGATC
GTGGGGATCATTACACGACACAACCTGACGACTGAGTTCCTGCAGGCCCGGCTACGGCAGCATT
ACCAGACCCTCTGACAGTTGAGCCCGGCTGCAGCCAGCCCACTGTCCCAGAGATGCCTCTGCAG
TGGCCAGCTCACTTGCTGGCCTCCACAGCCAGCACGAAGGCTCCCAGTCAACCATTTGCTCAGA
TGCCTGGAGTCCTGGAAGATGGGGGTCAGAGGTTTTTGGGGATGTGCTGAGCAGGAAGTTGGGG
TTTTACTAAATTCCTCTGTAAGAATCTTCCATTCCCCAGCTCCCCTAGAGAGAGATCAGGGTAC
TCTTGGGCTGGATCCTAGGTGGAACTTGGTGCCTCTTTGTTGCTGTTTCTCGGAGAGCCCCGCT
GTTGCCCAGACCTTTCCGGGAAGGAGTTGGACTGAGGCCGACACTGAGGATCTTGTTTGTATAT
CAAGAATTAGGCACTAAGAACCCTTCCCCGTGTCTGGGGAGGCCTGGGATCAGAACCAGGACCT
CATATACACTCTGCCTCTTCAGTGTTCTGTTTCCTAGGAGTGAGCTCATGCTCTTGACCCTGGG
GCTTGAATGTCCTTAGAATCATTCCTGACCAGACCCCTGATGCTAACATTCCAGCTAACAGCCT
CTAAGCATTAAATCCCACCACAGGAACCACAGCGTCTCCCCTCTGTGAACATTCAGTAGTCCCC
ACTCACTGCTTACACCTGCTCTCCCAGTGACCTGCGCTCTCCCAGTGTCATTCCTTTCCTCTCC
ACAACCACTCTACTTTCTAAGCCTTCATCTCTCTTCCTAGTGGGGCAGCCGCAACTTATCTTGG
ATTCATTCCCAAAGTTAGGCAAAATTGAGGAACCCCTAGACAGAGCCACTGCCCAGAGCTCTAG
CAAATTTGGGATTGCTCTAAAAGCTGGCAAGCAAGCTACCCTGAGCCAGGGCCAATCAAGGTTC
GACCTTAGCAGAAAGCCAGCAGCTCCTGTCGTGGTCACTGCTCACGCTCAGCTTCCCCTCCACT
CCCCACTCAGCCCTCTTCTGAGGACTTGGCGAGGAACCTGTCTGTGCAGCTGCTGGTCCCAGGG
CTGGGGAGGGAGGGGATGCTCTTGCCCTTGTGCCTCACCACATCATGGCTTCTTTCTCTCCTGG
TCCTCTCTGAGTCAGCACCTCAGTGAACATCTGGGTAGGACATTGCATTCATCTTCCTGCAACC
CAGGGCCCCTGTGGCAGCTGCTCTTGGGTACAGGTGGCATTCATTTGTGTTGGATACTTTTTAA
ATCATGGAACTTGCTGGAGGGCATCTGTGCTAAGCCTGGCTTCTAGCGGTGAGACCGCCAGGCC
TGGCAGAGTCCTCTGACCAGCACTTGGGAAGTTGTTCCACAGCCTTGGTTGGGGGCTACCTTGG
ATCTTTAGGTCTGACAGTGACCCTGGCCCTCTGTTTTCCCCATTTGATTATCTTTTTACCAGAA
TGAGCGTGACTTACTCTGTTTTCAGCTTCTAACTTGGGGTGGGAGTGGGAGTGTGGGAGGGGGA
GGGGGTTGAAACCTCCCCACAAGTACTTGGAAAAATAGCTAAGCAGGGTTGTGTTTGGCCTGCT
GCCAGCTTCATTTTATGGCTGATTTCAATGCCTGCCCTGCTTTGTGCTCCACCAAGAAGGAAAC
CAGTTGCCCACACTAAGCAAAGCATGACACACCACAGAATTATCCTCCAGCCTAGTGGGTTTGC
AGAGTTGTAGCCTGTGGAGGAAGGGCCTCAGTCCACAGCTTCCTCTGTGTGTGTGTGTGTGTGT
GTGTGTGTGTGTGTGCGCGCGCGCGCACACGTGCGCACATGTACAGTCACCATTAGTTTAACCC
CAGAATGGACAGGGTCCGCACATCCCCACCCTGGAACTCATGTTCCTCTAGGACACTCAGTTTT
CTGTGTCCCTCCCTGCTGAACCTGCCTCTCCAGAAAAGCCCAAAGACGACAGCTTTTTCACCTG
TGAACTATAAGTGTAAGCCCTGGACCTCTCCTCCCATGGCAGTCCCTTGGAACTAGTGACTTAG
TCTCTTAACCTGTTGCAGCTCTGTTCCCCCACCCCCAGTGCCACAGCACCTTGTCAAACACAGC
TCCTTGGAGGGACACCGAAATTGGCTTGAGGCAGTTTTCCTGGCATTTGTGTGGCTCCCTGGTA
CTGCTGTGGGAGTTTGGTATTTTATGAGATGTCTGCATGTGACCTTGTTAAGCAGTTCCAGCTG
GAACGGACATTAGCTTGACTCAGCTAGCCATGTGACATTTTGATGCGGACCTTGGTGACAAGAA
AGCTTCCGGAGAAGCCAGCACAGCCCTCCTGGCCCAGCCGTGTGGATGTGGAGTGTTGCCCTCA
GCTCCTGTGGACCTCAGTGACTGTCTGTCCAGCTGCAGCTTCTTCCTTTCTGTTTGTTCATACT
GTCTGTTTGTATGGTAGCATTAGCTGATGTCACTGTGTACATAAATGGTACCTTTTTTTAATTT
GTAAAGGTCTATTTTTATTTGGCCCTTTGGAAGGTGGACGTTCTTGTGGTCACTCTTAAGTCAG
AATAAAATGTCTGCACCTTCTCTGTAG

hide sequence

RefSeq Acc Id:

XM_039109375 ⟹ XP_038965303

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	163,722,509 - 163,748,301 (-)	NCBI
mRatBN7.2	5	158,439,370 - 158,465,174 (-)	NCBI

RefSeq Acc Id:

XM_039109377 ⟹ XP_038965305

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	163,715,593 - 163,729,510 (-)	NCBI
mRatBN7.2	5	158,434,804 - 158,446,373 (-)	NCBI

RefSeq Acc Id:

XR_592730

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	163,720,409 - 163,748,293 (-)	NCBI
mRatBN7.2	5	158,437,269 - 158,465,168 (-)	NCBI
Rnor_6.0	5	164,816,648 - 164,844,554 (-)	NCBI

Sequence:

show sequence

TGTGACGCGAGCTCTCGCCCCACCCGTCTGCAGCCACTCCCTGTCTCCGGACCCAAAGCTCGAG
AGGGCCACGTGACCCTCCCGGGGCCAGTCACGTGAGGCGCAGATCCTGGGTGGGAGGGGGGTTG
GCCTAGGTGGTCCGGAGTGGCAGGAAAGGAGGAAGATGGCGGGGTGCAGGGGGTCTGTGTGCTG
CTGCTGCAGGTGGTGCTGCTGCTGCGGCGAACGCGAGAGCCGCACTCCCGAGGAGCTGACCATC
CTTGGGGAGACACAGGAAGAGGAAGATGAGATCCTTCCAAGGAAAGACTATGAGAGTCTGGACT
ATGACCGCTGTATCAACGACCCTTACCTGGAGGTATTGGAGACCATGGATAATAAGAAAGGGCG
AAGACATGAGGCGGTGAAGTGGATGGTGGTGTTTGCCATTGGCGTCTGTACTGGGCTGGTGGGC
CTCTTCGTGGACTTTTCTGTGCGACTCTTCACCCAACTCAAGTTCGGAGTGGTTCAAACGTCGG
TGGAGGAATGCAGTCAGAAAGGCTGCCTTGCCCTGTCTCTCCTGGAACTCCTTGGCTTTAACTT
GACCTTTGTCTTCCTGGCAAGCCTTCTTGTCTTGATAGAGCCGGTGGCAGCAGGCTCTGGAATC
CCAGAGATCAAGTGCTATCTGAATGGTGTGAAAGTGCCAGGAATTGTCCGGCTCCGAACCCTGC
TCTGCAAAGTCTTTGGGGTGCTGTTCAGTGTGGCTGGAGGGCTCTTTGTGGGGAAAGAAGGCCC
CATGATCCACAGTGGTGCCGTGGTAGGAGCTGGCCTCCCTCAGTTTCAGAGCATCTCCTTAAGG
AAGATCCAGTTTAACTTCCCCTACTTCCGCAGCGACAGAGACAAGCGTGACTTCGTATCAGCAG
GGGCGGCTGCTGGAGTTGCTGCAGCTTTTGGGGCCCCTATAGGGGGCACCTTGTTCAGCCTGGA
GGAGGGCTCGTCCTTCTGGAACCAGGGACTCACGTGGAAAGTGCTCTTCTGTTCCATGTCTGCC
ACCTTCACCCTCAACTTCTTCCGCTCTGGGATCCAGTTTGGAAGTTGGGGTGCCTTCCAGCTGC
CTGGACTGCTGAACTTTGGTGAATTTAAGTGCTCTGACTCTGATAAAAAATGTCATCTCTGGAC
AGCTATGGATTTGGGTTTCTTCGTCGTGATGGGGGTCATTGGGGGCCTCCTGGGAGCCACATTC
AACTGTCTGAACAAGAGGCTTGCAAAGTACCGTATGCGCAACGTGCACCCGAAACCTAAGCTCG
TCAGGGTCTTAGAGAGCCTCTTGGTGTCCCTGGTGACGACTGTGGTGGTGTTTGTGGCCTCCAT
GGTGTTGGGAGAATGCCGACAGATGTCTTCCACGAGTCAAACGGGTAATGGCTCATTCCAGCTC
CAGGTCACATCGGAAGATGTGAATTCAACTATCAAGACATTTTTCTGTCCCAATGACACCTACA
ACGACATGGCCACACTCTTCTTCAACTCCCAGGAGTCTGCCATCCTGCAGCTCTTCCATCAGGA
TGGGACTTTCAGCCCCGTCACCCTGGCCTTATTCTTCGCCCTCTATTTCCTGATGGCATGCTGG
ACTTTCGGCACCTCTGTCCCCAGTGGCCTCTTCGTGCCTTCCCTGCTGTGTGGAGCAGCTTTTG
GACGTTTAGTTGCCAATGTCCTGAAAAGCTACATTGGACTGGGCCACCTCTATTCTGGGACCTT
CGCCCTGATTGGTGCGGCAGCTTTCTTGGGTGGGGTTGTAAGAATGACCATCAGCCTCACAGTC
ATCCTGATTGAGTCCACAAATGAGATCACCTATGGGCTTCCTATTATGGTCACTTTGATGGTGG
CCAAGTGGACTGGAGACTTTTTCAATAAGGGCATTTACGACATCCACATTGGGCTGAGAGGTGT
GCCTCTTCTGGAGTGGGAGACAGAGGTGGAGATGGACAGGCTGAGAGCCAGCGACATCATGGAG
CCCAACTTGACGTATGTCTACCCACATACTCGTATCCAGTCTCTGGTGAGCATCCTGCGTACTA
CAGTCCACCATGCCTTCCCAGTGGTCACAGAGAATCGCGGCAACGAGAAGGAGTTCATGAAAGG
CAACCAGCTCATAAGCAACAACATTAAGTTCAAGAAGTCCAGCATCCTCACCCGTGCTGGTGAG
CAGCGCAAGCGGGGCCAGTCCATGAAGTCTTACCCTTCCAGCGAGCTGCGCAACGTGTGTGATG
AGCATGTGGCTTCTGAGGAGCCAGCAGAGAAGGAGGACCTGCTACAGCAGATGCTGGAGAGGAG
TCCCCGAGTGAAGACTGGACCATGGAGGAGCGATTCCGTCCGCTGACCTTCCATGGCCTCGTCC
TGCGCTCCCAGCTCGTCACCCTGCTCGTCCGAGGCGTGTGTTACTCGGAAAGTCAGTCCAGTGC
CAGCCAACCACGCCTTTCTTATGCTGAGATGGCTGAGGACTACCCGAGGTTTCCGGACATACAT
GACCTGGACCTCACACTGCTGAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001099949	(Get FASTA)	NCBI Sequence Viewer
	XP_006239440	(Get FASTA)	NCBI Sequence Viewer
	XP_038965303	(Get FASTA)	NCBI Sequence Viewer
	XP_038965305	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL81090	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000011287
	ENSRNOP00000011287.6

RefSeq Acc Id:

NP_001099949 ⟸ NM_001106479

- UniProtKB:

D4A3H5 (UniProtKB/TrEMBL), A6IU39 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAGCRGSVCCCCRWCCCCGERESRTPEELTILGETQEEEDEILPRKDYESLDYDRCINDPYLEV
LETMDNKKGRRHEAVKWMVVFAIGVCTGLVGLFVDFSVRLFTQLKFGVVQTSVEECSQKGCLAL
SLLELLGFNLTFVFLASLLVLIEPVAAGSGIPEIKCYLNGVKVPGIVRLRTLLCKVFGVLFSVA
GGLFVGKEGPMIHSGAVVGAGLPQFQSISLRKIQFNFPYFRSDRDKRDFVSAGAAAGVAAAFGA
PIGGTLFSLEEGSSFWNQGLTWKVLFCSMSATFTLNFFRSGIQFGSWGAFQLPGLLNFGEFKCS
DSDKKCHLWTAMDLGFFVVMGVIGGLLGATFNCLNKRLAKYRMRNVHPKPKLVRVLESLLVSLV
TTVVVFVASMVLGECRQMSSTSQTGNGSFQLQVTSEDVNSTIKTFFCPNDTYNDMATLFFNSQE
SAILQLFHQDGTFSPVTLALFFALYFLMACWTFGTSVPSGLFVPSLLCGAAFGRLVANVLKSYI
GLGHLYSGTFALIGAAAFLGGVVRMTISLTVILIESTNEITYGLPIMVTLMVAKWTGDFFNKGI
YDIHIGLRGVPLLEWETEVEMDRLRASDIMEPNLTYVYPHTRIQSLVSILRTTVHHAFPVVTEN
RGNEKEFMKGNQLISNNIKFKKSSILTRAGEQRKRGQSMKSYPSSELRNVCDEHVASEEPAEKE
DLLQQMLERRYTPYPNLYPDQSPSEDWTMEERFRPLTFHGLVLRSQLVTLLVRGVCYSESQSSA
SQPRLSYAEMAEDYPRFPDIHDLDLTLLNPRMIVDVTPYMNPSPFTVSPNTHVSQVFNLFRTMG
LRHLPVVNAVGEIVGIITRHNLTTEFLQARLRQHYQTL

hide sequence

RefSeq Acc Id:	XP_006239440 ⟸ XM_006239378
- Peptide Label:	isoform X1
- UniProtKB:	D4A3H5 (UniProtKB/TrEMBL)
- Sequence:	show sequence MDNKKGRRHEAVKWMVVFAIGVCTGLVGLFVDFSVRLFTQLKFGVVQTSVEECSQKGCLALSLL ELLGFNLTFVFLASLLVLIEPVAAGSGIPEIKCYLNGVKVPGIVRLRTLLCKVFGVLFSVAGGL FVGKEGPMIHSGAVVGAGLPQFQSISLRKIQFNFPYFRSDRDKRDFVSAGAAAGVAAAFGAPIG GTLFSLEEGSSFWNQGLTWKVLFCSMSATFTLNFFRSGIQFGSWGAFQLPGLLNFGEFKCSDSD KKCHLWTAMDLGFFVVMGVIGGLLGATFNCLNKRLAKYRMRNVHPKPKLVRVLESLLVSLVTTV VVFVASMVLGECRQMSSTSQTGNGSFQLQVTSEDVNSTIKTFFCPNDTYNDMATLFFNSQESAI LQLFHQDGTFSPVTLALFFALYFLMACWTFGTSVPSGLFVPSLLCGAAFGRLVANVLKSYIGLG HLYSGTFALIGAAAFLGGVVRMTISLTVILIESTNEITYGLPIMVTLMVAKWTGDFFNKGIYDI HIGLRGVPLLEWETEVEMDRLRASDIMEPNLTYVYPHTRIQSLVSILRTTVHHAFPVVTENRGN EKEFMKGNQLISNNIKFKKSSILTRAGEQRKRGQSMKSYPSSELRNVCDEHVASEEPAEKEDLL QQMLERRYTPYPNLYPDQSPSEDWTMEERFRPLTFHGLVLRSQLVTLLVRGVCYSESQSSASQP RLSYAEMAEDYPRFPDIHDLDLTLLNPRMIVDVTPYMNPSPFTVSPNTHVSQVFNLFRTMGLRH LPVVNAVGEIVGIITRHNLTTEFLQARLRQHYQTL hide sequence

Ensembl Acc Id:

ENSRNOP00000011287 ⟸ ENSRNOT00000011287

RefSeq Acc Id:	XP_038965305 ⟸ XM_039109377
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_038965303 ⟸ XM_039109375
- Peptide Label:	isoform X2

Protein Domains

CBS

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D4A3H5-F1-model_v2	AlphaFold	D4A3H5	1-870	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1305379	AgrOrtholog
BioCyc Gene	G2FUF-39200	BioCyc
Ensembl Genes	ENSRNOG00000008345	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000011287	ENTREZGENE
	ENSRNOT00000011287.8	UniProtKB/TrEMBL
Gene3D-CATH	3.10.580.10	UniProtKB/TrEMBL
	Clc chloride channel	UniProtKB/TrEMBL
InterPro	CBS_dom_sf	UniProtKB/TrEMBL
	Cl-channel/antiporter	UniProtKB/TrEMBL
	Cl-channel_core	UniProtKB/TrEMBL
	Cl-channel_volt-gated	UniProtKB/TrEMBL
	Cl_channel-6	UniProtKB/TrEMBL
	Cysta_beta_synth_core	UniProtKB/TrEMBL
KEGG Report	rno:295586	UniProtKB/TrEMBL
NCBI Gene	295586	ENTREZGENE
PANTHER	CHLORIDE CHANNEL PROTEIN CLC FAMILY MEMBER	UniProtKB/TrEMBL
	H(+)_CL(-) EXCHANGE TRANSPORTER 6	UniProtKB/TrEMBL
Pfam	CBS	UniProtKB/TrEMBL
	Voltage_CLC	UniProtKB/TrEMBL
PhenoGen	Clcn6	PhenoGen
PRINTS	CLCHANNEL	UniProtKB/TrEMBL
	CLCHANNEL6	UniProtKB/TrEMBL
PROSITE	CBS	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000008345	RatGTEx
SMART	CBS	UniProtKB/TrEMBL
Superfamily-SCOP	Cl-channel_core	UniProtKB/TrEMBL
	SSF54631	UniProtKB/TrEMBL
UniProt	A6IU39	ENTREZGENE, UniProtKB/TrEMBL
	D4A3H5	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2013-05-24	Clcn6	chloride channel, voltage-sensitive 6	LOC680079	similar to Chloride channel protein 6 (ClC-6)	Data merged from RGD:1596809	1643240	APPROVED
2012-07-05	LOC680079	similar to Chloride channel protein 6 (ClC-6)	LOC680079	similar to Chloride channel protein 6 (ClC-6)	Gene reactivated at release of RGSC5.0 assembly	2298974	REACTIVATED
2008-04-30	Clcn6	chloride channel 6	Clcn6_predicted	chloride channel 6 (predicted)	'predicted' is removed	2292626	APPROVED
2006-11-20	LOC680079	similar to Chloride channel protein 6 (ClC-6)			Symbol and Name status set to provisional	70820	PROVISIONAL
2005-01-12	Clcn6_predicted	chloride channel 6 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

Mammalian Phenotype

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