Emilin2 (elastin microfibril interfacer 2) - Rat Genome Database

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Gene: Emilin2 (elastin microfibril interfacer 2) Rattus norvegicus
Analyze
Symbol: Emilin2
Name: elastin microfibril interfacer 2
RGD ID: 1305343
Description: Predicted to be involved in several processes, including positive regulation of angiogenesis; positive regulation of blood coagulation; and positive regulation of platelet aggregation. Predicted to be located in extracellular region. Predicted to be part of collagen trimer. Orthologous to human EMILIN2 (elastin microfibril interfacer 2); INTERACTS WITH alpha-Zearalanol; amphetamine; DDT.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: EMILIN-2; LOC316736
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr89118,607,312 - 118,667,087 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl9118,606,891 - 118,666,957 (-)EnsemblGRCr8
mRatBN7.29111,160,708 - 111,220,463 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl9111,160,712 - 111,220,352 (-)EnsemblmRatBN7.2
Rnor_6.09119,594,049 - 119,653,675 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl9119,594,629 - 119,653,255 (-)Ensemblrn6Rnor6.0
Rnor_5.09119,047,568 - 119,106,639 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.49110,458,062 - 110,488,722 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera9108,289,680 - 108,349,263 (-)NCBICelera
RGSC_v3.19110,668,124 - 110,751,827 (-)NCBI
Cytogenetic Map9q38NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
aflatoxin B1  (ISO)
alpha-Zearalanol  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
chloroprene  (ISO)
choline  (ISO)
cisplatin  (ISO)
copper(II) sulfate  (ISO)
DDT  (EXP)
dexamethasone  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
folic acid  (ISO)
gentamycin  (EXP)
glyphosate  (ISO)
GSK-J4  (ISO)
Heliotrine  (EXP)
indole-3-methanol  (EXP)
L-methionine  (ISO)
lead(0)  (ISO)
methapyrilene  (ISO)
methylmercury chloride  (ISO)
N-acetyl-L-cysteine  (EXP)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
okadaic acid  (ISO)
paracetamol  (EXP)
pentanal  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenylmercury acetate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
senecionine  (EXP)
Senkirkine  (EXP)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
temozolomide  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trimellitic anhydride  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11278945   PMID:23658023   PMID:24006456  


Genomics

Comparative Map Data
Emilin2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr89118,607,312 - 118,667,087 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl9118,606,891 - 118,666,957 (-)EnsemblGRCr8
mRatBN7.29111,160,708 - 111,220,463 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl9111,160,712 - 111,220,352 (-)EnsemblmRatBN7.2
Rnor_6.09119,594,049 - 119,653,675 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl9119,594,629 - 119,653,255 (-)Ensemblrn6Rnor6.0
Rnor_5.09119,047,568 - 119,106,639 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.49110,458,062 - 110,488,722 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera9108,289,680 - 108,349,263 (-)NCBICelera
RGSC_v3.19110,668,124 - 110,751,827 (-)NCBI
Cytogenetic Map9q38NCBI
EMILIN2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38182,846,232 - 2,916,003 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl182,846,930 - 2,916,003 (+)Ensemblhg38GRCh38
GRCh37182,847,004 - 2,916,001 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36182,837,028 - 2,904,090 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34182,837,027 - 2,904,088NCBI
Celera182,722,463 - 2,789,538 (+)NCBICelera
Cytogenetic Map18p11.32-p11.31NCBI
HuRef182,808,350 - 2,875,373 (+)NCBIHuRef
CHM1_1182,846,395 - 2,913,454 (+)NCBICHM1_1
T2T-CHM13v2.0183,001,875 - 3,071,504 (+)NCBIT2T-CHM13v2.0
Emilin2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391771,559,167 - 71,618,551 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1771,559,167 - 71,618,973 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381771,252,172 - 71,311,556 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1771,252,172 - 71,311,978 (-)Ensemblmm10GRCm38
MGSCv371771,601,516 - 71,660,305 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361771,154,355 - 71,216,323 (-)NCBIMGSCv36mm8
Celera1775,520,092 - 75,581,836 (-)NCBICelera
Cytogenetic Map17E1.3NCBI
cM Map1741.87NCBI
Emilin2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554027,508,159 - 7,519,977 (-)Ensembl
ChiLan1.0NW_0049554027,507,674 - 7,519,978 (-)NCBIChiLan1.0ChiLan1.0
EMILIN2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21735,533,333 - 35,599,301 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11821,225,935 - 21,291,535 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01811,368,328 - 11,435,808 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11813,678,090 - 13,743,075 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1813,678,772 - 13,743,346 (-)EnsemblpanPan2panpan1.1
EMILIN2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1769,521,430 - 69,580,963 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha768,976,680 - 69,036,232 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0769,583,656 - 69,642,665 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl769,584,913 - 69,643,162 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1769,266,531 - 69,325,009 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0769,286,034 - 69,345,061 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0769,583,984 - 69,642,505 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Emilin2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494465,880,202 - 65,931,886 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366721,609,193 - 1,661,528 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366721,607,914 - 1,661,531 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EMILIN2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6103,730,626 - 103,786,927 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.16103,730,618 - 103,786,921 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2696,739,144 - 96,792,557 (-)NCBISscrofa10.2Sscrofa10.2susScr3
EMILIN2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11862,110,324 - 62,171,066 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1862,110,616 - 62,170,384 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605036,965,893 - 37,026,280 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Emilin2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462477013,133,319 - 13,156,420 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Emilin2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v14180,721,646 - 180,780,184 (-)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:50
Count of miRNA genes:45
Interacting mature miRNAs:50
Transcripts:ENSRNOT00000056272
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)944458256121768150Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)968875497121768150Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)983161999118999486Rat
7794784Mcs31Mammary carcinoma susceptibility QTL 312.98mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)985262459118999486Rat
2303178Bp334Blood pressure QTL 3343.70.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)986720043121768150Rat

Markers in Region
RH130840  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.29111,160,755 - 111,160,952 (+)MAPPERmRatBN7.2
Rnor_6.09119,594,096 - 119,594,292NCBIRnor6.0
Rnor_5.09119,047,615 - 119,047,811UniSTSRnor5.0
RGSC_v3.49110,458,112 - 110,458,308UniSTSRGSC3.4
Celera9108,289,727 - 108,289,923UniSTS
RH 3.4 Map9868.3UniSTS
Cytogenetic Map9q38UniSTS
RH139954  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.29111,243,577 - 111,243,758 (+)MAPPERmRatBN7.2
Rnor_6.09119,675,883 - 119,676,063NCBIRnor6.0
Rnor_5.09119,129,078 - 119,129,258UniSTSRnor5.0
RGSC_v3.49110,536,120 - 110,536,300UniSTSRGSC3.4
Celera9108,372,104 - 108,372,284UniSTS
RH 3.4 Map9869.3UniSTS
Cytogenetic Map9q38UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 160 91 90 59 92 59 6 354 192 11 139 79 92 31 16 16

Sequence


Ensembl Acc Id: ENSRNOT00000056272   ⟹   ENSRNOP00000053111
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl9118,606,891 - 118,666,957 (-)Ensembl
mRatBN7.2 Ensembl9111,160,712 - 111,220,352 (-)Ensembl
Rnor_6.0 Ensembl9119,594,629 - 119,653,255 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000174149   ⟹   ENSRNOP00000107148
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl9118,607,050 - 118,654,140 (-)Ensembl
RefSeq Acc Id: XM_017596881   ⟹   XP_017452370
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89118,607,312 - 118,667,073 (-)NCBI
mRatBN7.29111,160,708 - 111,220,445 (-)NCBI
Rnor_6.09119,594,879 - 119,653,675 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039084817   ⟹   XP_038940745
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89118,607,312 - 118,667,087 (-)NCBI
mRatBN7.29111,160,708 - 111,220,463 (-)NCBI
RefSeq Acc Id: XM_039084818   ⟹   XP_038940746
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89118,607,312 - 118,659,719 (-)NCBI
mRatBN7.29111,160,708 - 111,213,088 (-)NCBI
RefSeq Acc Id: XP_017452370   ⟸   XM_017596881
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000053111   ⟸   ENSRNOT00000056272
RefSeq Acc Id: XP_038940745   ⟸   XM_039084817
- Peptide Label: isoform X2
- UniProtKB: A6KFA0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038940746   ⟸   XM_039084818
- Peptide Label: isoform X3
- UniProtKB: A6KFA0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000107148   ⟸   ENSRNOT00000174149
Protein Domains
C1q   EMI

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LXD8-F1-model_v2 AlphaFold F1LXD8 1-1075 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696915
Promoter ID:EPDNEW_R7438
Type:single initiation site
Name:Emilin2_1
Description:elastin microfibril interfacer 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.09119,653,329 - 119,653,389EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305343 AgrOrtholog
BioCyc Gene G2FUF-26328 BioCyc
Ensembl Genes ENSRNOG00000014837 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000056272 ENTREZGENE
  ENSRNOT00000056272.6 UniProtKB/TrEMBL
  ENSRNOT00000174149 ENTREZGENE
  ENSRNOT00000174149.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.1490 UniProtKB/TrEMBL
  2.60.120.40 UniProtKB/TrEMBL
InterPro C1q UniProtKB/TrEMBL
  Collagen/C1q_domain UniProtKB/TrEMBL
  EMI_domain UniProtKB/TrEMBL
  Tumour_necrosis_fac-like_dom UniProtKB/TrEMBL
NCBI Gene 316736 ENTREZGENE
PANTHER EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER UniProtKB/TrEMBL
  EMILIN-2 UniProtKB/TrEMBL
Pfam C1q UniProtKB/TrEMBL
  EMI UniProtKB/TrEMBL
PhenoGen Emilin2 PhenoGen
PROSITE C1Q UniProtKB/TrEMBL
  EMI UniProtKB/TrEMBL
RatGTEx ENSRNOG00000014837 RatGTEx
SMART C1Q UniProtKB/TrEMBL
Superfamily-SCOP TNF_like UniProtKB/TrEMBL
UniProt A0ABK0LT10_RAT UniProtKB/TrEMBL
  A6KFA0 ENTREZGENE, UniProtKB/TrEMBL
  F1LXD8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Emilin2  elastin microfibril interfacer 2   Emilin2_predicted  elastin microfibril interfacer 2 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Emilin2_predicted  elastin microfibril interfacer 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED