Triml1 (tripartite motif family-like 1) - Rat Genome Database

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Pathways
Gene: Triml1 (tripartite motif family-like 1) Rattus norvegicus
Analyze
Symbol: Triml1
Name: tripartite motif family-like 1
RGD ID: 1305337
Description: Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in innate immune response. Predicted to be active in cytoplasm. Orthologous to human TRIML1 (tripartite motif family like 1); INTERACTS WITH bisphenol A; cyclophosphamide; paracetamol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC290767; probable E3 ubiquitin-protein ligase TRIML1; RGD1305337; similar to tripartite motif-containing 11
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81655,727,383 - 55,737,770 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1655,729,691 - 55,737,769 (+)EnsemblGRCr8
mRatBN7.21648,994,968 - 49,005,343 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1648,997,252 - 49,005,417 (+)EnsemblmRatBN7.2
Rnor_6.01652,169,426 - 52,177,548 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1652,169,450 - 52,177,586 (+)Ensemblrn6Rnor6.0
Rnor_5.01651,895,696 - 51,903,792 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41652,328,994 - 52,336,646 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1646,968,104 - 46,976,226 (+)NCBICelera
RGSC_v3.11652,329,068 - 52,336,721 (+)NCBI
Cytogenetic Map16q12.1NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA,IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:19156909  


Genomics

Comparative Map Data
Triml1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81655,727,383 - 55,737,770 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1655,729,691 - 55,737,769 (+)EnsemblGRCr8
mRatBN7.21648,994,968 - 49,005,343 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1648,997,252 - 49,005,417 (+)EnsemblmRatBN7.2
Rnor_6.01652,169,426 - 52,177,548 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1652,169,450 - 52,177,586 (+)Ensemblrn6Rnor6.0
Rnor_5.01651,895,696 - 51,903,792 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41652,328,994 - 52,336,646 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1646,968,104 - 46,976,226 (+)NCBICelera
RGSC_v3.11652,329,068 - 52,336,721 (+)NCBI
Cytogenetic Map16q12.1NCBI
TRIML1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384188,137,229 - 188,150,767 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4188,139,441 - 188,147,743 (+)Ensemblhg38GRCh38
GRCh374189,060,595 - 189,068,897 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364189,297,592 - 189,305,643 (+)NCBIBuild 36Build 36hg18NCBI36
Celera4186,370,123 - 186,378,284 (+)NCBICelera
Cytogenetic Map4q35.2NCBI
HuRef4184,797,144 - 184,805,172 (+)NCBIHuRef
CHM1_14189,037,036 - 189,045,104 (+)NCBICHM1_1
T2T-CHM13v2.04191,484,912 - 191,498,442 (+)NCBIT2T-CHM13v2.0
Triml1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39843,582,843 - 43,633,531 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl843,582,844 - 43,594,523 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm39 Ensembl843,594,712 - 43,633,333 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38843,129,806 - 43,180,494 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl843,129,807 - 43,141,486 (-)Ensemblmm10GRCm38
MGSCv37844,215,161 - 44,226,840 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36844,628,624 - 44,640,303 (-)NCBIMGSCv36mm8
Celera845,810,994 - 45,822,269 (-)NCBICelera
Cytogenetic Map8A4NCBI
cM Map823.89NCBI
Triml1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540321,041,982 - 21,050,181 (-)Ensembl
ChiLan1.0NW_00495540321,043,233 - 21,050,261 (-)NCBIChiLan1.0ChiLan1.0
TRIML1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23185,859,683 - 185,870,381 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14186,214,255 - 186,224,957 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04180,294,211 - 180,302,527 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14192,483,186 - 192,491,414 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4192,483,189 - 192,491,414 (+)EnsemblpanPan2panpan1.1
TRIML1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11642,954,353 - 42,984,128 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1642,954,012 - 42,980,309 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1643,442,909 - 43,472,680 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01645,174,211 - 45,204,062 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1645,173,861 - 45,180,528 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11643,134,589 - 43,142,611 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01643,714,818 - 43,744,586 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01643,844,318 - 43,874,160 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Triml1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494336,476,389 - 36,483,042 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365541,627,624 - 1,633,479 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365541,627,624 - 1,633,479 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TRIML1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl177,283,709 - 7,292,681 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1177,284,392 - 7,290,639 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
TRIML1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17133,998,623 - 134,009,606 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl7134,001,323 - 134,009,241 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666037114,423,366 - 114,431,773 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Triml1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476919,097,452 - 19,102,862 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462476919,095,899 - 19,103,190 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Triml1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11344,540,294 - 44,549,519 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Triml1
40 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:55
Count of miRNA genes:51
Interacting mature miRNAs:52
Transcripts:ENSRNOT00000019474
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)164445512389455123Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)163692878281928782Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)164199206486992064Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16423421266955197Rat
2302057Pia29Pristane induced arthritis QTL 293.60.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)162846870173468701Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164909919691442908Rat
1357403Slep4Serum leptin concentration QTL 43.91blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)163236104377361043Rat
631833Sach2Saccharin preference QTL 240.01consumption behavior trait (VT:0002069)calculated saccharin drink intake rate (CMO:0001613)164975766656898388Rat
8694453Bw172Body weight QTL 1728.330.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)163105803976058039Rat
1298529Arunc1Aerobic running capacity QTL 14exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)163439829479398294Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683908666195506Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683908666195506Rat
6903294Stl30Serum triglyceride level QTL 302.60.0013blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)163188527176885271Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)164445512389455123Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683908666195506Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161773081872536785Rat
2301406Kidm39Kidney mass QTL 390.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)161590580260905802Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683908666195506Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
1 2 9 10 10 3 5 3 2 13 6 1 6 1 38 7 1 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001432797 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001432798 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001432799 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001432800 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001432801 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001432804 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001432806 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017587580 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017587582 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017587583 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600368 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600369 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600370 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039094972 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039094974 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039094975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063275862 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH473995 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000019474   ⟹   ENSRNOP00000019474
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1655,729,691 - 55,737,769 (+)Ensembl
mRatBN7.2 Ensembl1648,997,252 - 49,005,417 (+)Ensembl
Rnor_6.0 Ensembl1652,169,450 - 52,177,586 (+)Ensembl
RefSeq Acc Id: XM_017600368   ⟹   XP_017455857
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81655,729,643 - 55,737,770 (+)NCBI
mRatBN7.21648,997,220 - 49,005,343 (+)NCBI
Rnor_6.01652,169,426 - 52,177,548 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017600369   ⟹   XP_017455858
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81655,729,648 - 55,737,770 (+)NCBI
mRatBN7.21648,997,224 - 49,005,343 (+)NCBI
Rnor_6.01652,169,426 - 52,177,548 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017600370   ⟹   XP_017455859
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81655,729,633 - 55,737,770 (+)NCBI
mRatBN7.21648,997,212 - 49,005,343 (+)NCBI
Rnor_6.01652,169,426 - 52,177,548 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039094972   ⟹   XP_038950900
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81655,728,228 - 55,737,770 (+)NCBI
mRatBN7.21648,995,805 - 49,005,343 (+)NCBI
RefSeq Acc Id: XM_039094974   ⟹   XP_038950902
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81655,728,228 - 55,737,770 (+)NCBI
mRatBN7.21648,995,805 - 49,005,343 (+)NCBI
RefSeq Acc Id: XM_039094975   ⟹   XP_038950903
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81655,727,383 - 55,737,770 (+)NCBI
mRatBN7.21648,994,969 - 49,005,343 (+)NCBI
RefSeq Acc Id: XM_063275862   ⟹   XP_063131932
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81655,729,638 - 55,737,770 (+)NCBI
RefSeq Acc Id: XP_017455857   ⟸   XM_017600368
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017455859   ⟸   XM_017600370
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_017455858   ⟸   XM_017600369
- Peptide Label: isoform X2
- UniProtKB: D4A221 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000019474   ⟸   ENSRNOT00000019474
RefSeq Acc Id: XP_038950903   ⟸   XM_039094975
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038950900   ⟸   XM_039094972
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038950902   ⟸   XM_039094974
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063131932   ⟸   XM_063275862
- Peptide Label: isoform X4
Protein Domains
B30.2/SPRY   RING-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A221-F1-model_v2 AlphaFold D4A221 1-470 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305337 AgrOrtholog
BioCyc Gene G2FUF-11285 BioCyc
Ensembl Genes ENSRNOG00000014502 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000019474 ENTREZGENE
  ENSRNOT00000019474.6 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.920 UniProtKB/TrEMBL
  3.30.40.10 UniProtKB/TrEMBL
InterPro B30.2/SPRY_sf UniProtKB/TrEMBL
  B302 UniProtKB/TrEMBL
  Butyrophylin UniProtKB/TrEMBL
  ConA-like_dom UniProtKB/TrEMBL
  PRY UniProtKB/TrEMBL
  SPRY_rcpt UniProtKB/TrEMBL
  TRIM/RBCC UniProtKB/TrEMBL
  Znf_RING UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
  Znf_RING_CS UniProtKB/TrEMBL
KEGG Report rno:290767 UniProtKB/TrEMBL
NCBI Gene 290767 ENTREZGENE
PANTHER E3 UBIQUITIN-PROTEIN LIGASE TRIM UniProtKB/TrEMBL
Pfam PRY UniProtKB/TrEMBL
  SPRY UniProtKB/TrEMBL
  zf-C3HC4_4 UniProtKB/TrEMBL
PhenoGen Triml1 PhenoGen
PRINTS BUTYPHLNCDUF UniProtKB/TrEMBL
PROSITE B302_SPRY UniProtKB/TrEMBL
  ZF_RING_1 UniProtKB/TrEMBL
  ZF_RING_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000014502 RatGTEx
SMART PRY UniProtKB/TrEMBL
  RING UniProtKB/TrEMBL
  SPRY UniProtKB/TrEMBL
Superfamily-SCOP ConA_like_lec_gl UniProtKB/TrEMBL
  RING/U-box UniProtKB/TrEMBL
UniProt D4A221 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-06 Triml1  tripartite motif family-like 1  RGD1305337_predicted  similar to tripartite motif-containing 11 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 RGD1305337_predicted  similar to tripartite motif-containing 11 (predicted)  LOC290767_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC290767_predicted  similar to tripartite motif-containing 11 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL