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Gene: Tpst2 (tyrosylprotein sulfotransferase 2) Rattus norvegicus

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Symbol:

Tpst2

Name:

tyrosylprotein sulfotransferase 2

RGD ID:

1305331

Description:

Predicted to enable protein homodimerization activity and protein-tyrosine sulfotransferase activity. Predicted to be involved in peptidyl-tyrosine sulfation. Predicted to act upstream of or within fusion of sperm to egg plasma membrane involved in single fertilization and prevention of polyspermy. Predicted to be located in Golgi membrane. Predicted to be active in Golgi lumen and trans-Golgi network. Orthologous to human TPST2 (tyrosylprotein sulfotransferase 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3H-1,2-dithiole-3-thione; 6-propyl-2-thiouracil.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC288719; MGC105657; protein-tyrosine sulfotransferase 2; TPST-2; tyrosylprotein sulfotransferase-2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	TPST2 (tyrosylprotein sulfotransferase 2)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Tpst2 (protein-tyrosine sulfotransferase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Tpst2 (tyrosylprotein sulfotransferase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	TPST2 (tyrosylprotein sulfotransferase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	TPST2 (tyrosylprotein sulfotransferase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Tpst2 (tyrosylprotein sulfotransferase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	TPST2 (tyrosylprotein sulfotransferase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	TPST2 (tyrosylprotein sulfotransferase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Tpst2 (tyrosylprotein sulfotransferase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Tpst2 (tyrosylprotein sulfotransferase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	TPST2 (tyrosylprotein sulfotransferase 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Tpst2 (protein-tyrosine sulfotransferase 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Tpst2 (protein-tyrosine sulfotransferase 2)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	tpst2 (tyrosylprotein sulfotransferase 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PANTHER\|PhylomeDB)
Danio rerio (zebrafish):	tpst2 (tyrosylprotein sulfotransferase 2)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	Tango13	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	tpst-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	tpst2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	tpst-2	Alliance	DIOPT (OrthoFinder\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	tpst-2	Alliance	DIOPT (OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	49,982,281 - 50,024,489 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	12	49,982,281 - 50,023,058 (-)	Ensembl				GRCr8
mRatBN7.2	12	44,321,875 - 44,363,892 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	44,321,875 - 44,362,329 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	12	45,490,785 - 45,531,171 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	46,101,129 - 46,141,600 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	45,161,667 - 45,202,131 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	50,343,076 - 50,383,534 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	50,343,086 - 50,383,496 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	12	52,099,677 - 52,141,423 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	19	14,283,684 - 14,297,517 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	12	45,904,930 - 45,945,380 (-)	NCBI		Celera
RGSC_v3.1	19	14,290,594 - 14,302,342 (+)	NCBI
Cytogenetic Map	12	q16	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autism spectrum disorder (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-methylcholine (ISO)

3H-1,2-dithiole-3-thione (EXP)

4,4'-sulfonyldiphenol (ISO)

5-fluorouracil (ISO)

6-propyl-2-thiouracil (EXP)

aflatoxin B1 (ISO)

amitrole (EXP)

aristolochic acid A (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

Butylbenzyl phthalate (EXP)

C60 fullerene (EXP)

chlorpyrifos (ISO)

cyclosporin A (ISO)

Dibutyl phosphate (ISO)

diuron (ISO)

dorsomorphin (ISO)

endosulfan (EXP)

flutamide (EXP)

folic acid (ISO)

glafenine (EXP)

kojic acid (ISO)

lipopolysaccharide (ISO)

methimazole (EXP)

methoxychlor (EXP)

methylmercury chloride (ISO)

mono(2-ethylhexyl) phthalate (ISO)

monobenzyl phthalate (ISO)

Monobutylphthalate (ISO)

monoethyl phthalate (ISO)

N-nitrosodiethylamine (ISO)

nimesulide (EXP)

nitrates (ISO)

ozone (ISO)

paracetamol (EXP,ISO)

phenobarbital (EXP)

pirinixic acid (EXP)

potassium chromate (ISO)

quercetin (ISO)

SB 431542 (ISO)

sodium fluoride (ISO)

sulfadimethoxine (EXP)

tamoxifen (ISO)

temozolomide (ISO)

tert-butyl hydroperoxide (ISO)

testosterone (ISO)

titanium dioxide (ISO)

trichostatin A (ISO)

triphenyl phosphate (EXP,ISO)

urethane (ISO)

valproic acid (ISO)

vinclozolin (EXP)

zinc atom (ISO)

zinc(0) (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

fusion of sperm to egg plasma membrane involved in single fertilization (ISO)

peptidyl-tyrosine sulfation (ISO,ISS)

prevention of polyspermy (ISO)

Cellular Component

endoplasmic reticulum (ISO)

Golgi apparatus (IBA,IEA)

Golgi lumen (IEA,ISO)

Golgi membrane (IEA)

trans-Golgi network (IEA,ISO)

Molecular Function

protein homodimerization activity (ISO)

protein-tyrosine sulfotransferase activity (IBA,IEA,ISO,ISS)

transferase activity (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	GOA pipeline	RGD automated data pipeline
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:9733778	PMID:12477932	PMID:15489334	PMID:17046811	PMID:21339297	PMID:23376485	PMID:23481380

Genomics

Comparative Map Data

Tpst2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	49,982,281 - 50,024,489 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	12	49,982,281 - 50,023,058 (-)	Ensembl				GRCr8
mRatBN7.2	12	44,321,875 - 44,363,892 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	44,321,875 - 44,362,329 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	12	45,490,785 - 45,531,171 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	46,101,129 - 46,141,600 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	45,161,667 - 45,202,131 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	50,343,076 - 50,383,534 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	50,343,086 - 50,383,496 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	12	52,099,677 - 52,141,423 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	19	14,283,684 - 14,297,517 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	12	45,904,930 - 45,945,380 (-)	NCBI		Celera
RGSC_v3.1	19	14,290,594 - 14,302,342 (+)	NCBI
Cytogenetic Map	12	q16	NCBI

TPST2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	22	26,521,996 - 26,590,132 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	22	26,521,996 - 26,596,717 (-)	Ensembl			hg38	GRCh38
GRCh37	22	26,917,962 - 26,986,096 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	22	25,251,714 - 25,316,089 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	22	25,246,269 - 25,310,643	NCBI
Celera	22	10,725,568 - 10,789,890 (-)	NCBI		Celera
Cytogenetic Map	22	q12.1	NCBI
HuRef	22	9,869,106 - 9,933,721 (-)	NCBI		HuRef
CHM1_1	22	26,880,965 - 26,945,609 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	22	26,984,404 - 27,052,464 (-)	NCBI		T2T-CHM13v2.0

Tpst2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	112,424,548 - 112,463,222 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	112,424,557 - 112,463,227 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	5	112,276,682 - 112,315,356 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	112,276,691 - 112,315,361 (+)	Ensembl			mm10	GRCm38
MGSCv37	5	112,705,727 - 112,744,376 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	5	112,517,029 - 112,555,659 (+)	NCBI		MGSCv36	mm8
Celera	5	109,396,281 - 109,435,190 (+)	NCBI		Celera
Cytogenetic Map	5	F	NCBI
cM Map	5	54.65	NCBI

Tpst2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955455	1,106,294 - 1,129,196 (-)	Ensembl
ChiLan1.0	NW_004955455	1,106,403 - 1,128,455 (-)	NCBI	ChiLan1.0	ChiLan1.0

TPST2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	23	36,531,196 - 36,595,395 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	22	39,229,633 - 39,293,863 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	22	7,587,446 - 7,651,645 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	22	25,309,254 - 25,334,638 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	22	25,309,254 - 25,334,638 (-)	Ensembl			panPan2	panpan1.1

TPST2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	26	20,199,731 - 20,240,084 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	26	20,199,754 - 20,212,869 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	26	20,063,735 - 20,115,947 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	26	20,563,110 - 20,615,356 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	26	20,563,112 - 20,615,982 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	26	20,296,215 - 20,336,928 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	26	20,535,592 - 20,587,560 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	26	20,605,612 - 20,657,891 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Tpst2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	114,713,206 - 114,726,168 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936657	1,144,292 - 1,157,507 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936657	1,144,526 - 1,157,501 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TPST2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	44,122,159 - 44,145,822 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	14	44,122,156 - 44,140,654 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	47,001,956 - 47,066,378 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TPST2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	19	9,427,529 - 9,490,992 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	19	9,426,162 - 9,446,863 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666045	116,611,623 - 116,675,737 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Tpst2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624747	3,065,098 - 3,083,279 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624747	3,065,217 - 3,118,526 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Tpst2
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	16	41,659,065 - 41,699,170 (-)	NCBI		Rrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	279
Count of miRNA genes:	168
Interacting mature miRNAs:	183
Transcripts:	ENSRNOT00000000831
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
631560	Apr1	Acute phase response QTL 1	6.1		orosomucoid 1 amount (VT:0010541)	plasma orosomucoid 1 level (CMO:0001467)	12	24805022	52308831	Rat
2293699	Bss49	Bone structure and strength QTL 49	5.61	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra trabecular cross-sectional area (CMO:0001692)	12	16135029	52308831	Rat
70213	Niddm27	Non-insulin dependent diabetes mellitus QTL 27	3.72		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	11200494	52308831	Rat
1331761	Bp218	Blood pressure QTL 218	2.973		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	12	16187438	51213550	Rat
8552964	Pigfal17	Plasma insulin-like growth factor 1 level QTL 17	3.5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200494	52308831	Rat
1331763	Wbc2	White blood cell count QTL 2	3.162		leukocyte quantity (VT:0000217)	total white blood cell count (CMO:0000365)	12	11200494	52308831	Rat
8693635	Alc28	Alcohol consumption QTL 28	2.7	0.439	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	12	28717718	50386405	Rat
7411641	Foco19	Food consumption QTL 19	27.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat
7411547	Bw129	Body weight QTL 129		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	6	11200494	52308831	Rat
7411643	Foco20	Food consumption QTL 20		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	25989355	52308831	Rat
1300162	Bp188	Blood pressure QTL 188	3.19		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	12	37764145	51558799	Rat
1641928	Alcrsp5	Alcohol response QTL 5			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	12	18473041	52308831	Rat
2303569	Gluco44	Glucose level QTL 44	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	18473041	52308831	Rat
1549829	Scl48	Serum cholesterol level QTL 48	5		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	12	15264248	52308831	Rat
8552912	Pigfal6	Plasma insulin-like growth factor 1 level QTL 6	5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200497	52308831	Rat
10059594	Kidm46	Kidney mass QTL 46	3.79	0.025	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	12	11743528	52308831	Rat
8552918	Pigfal7	Plasma insulin-like growth factor 1 level QTL 7			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200494	52308831	Rat
7411588	Foco6	Food consumption QTL 6		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat
7243862	Mcs30	Mammary carcinoma susceptibility QTL 30	8.62		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	12	5633306	50633306	Rat
2300186	Bmd59	Bone mineral density QTL 59	7.1	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	12	16135029	52308831	Rat
1300175	Cm5	Cardiac mass QTL 5	3.78		heart mass (VT:0007028)	heart left ventricle weight to body weight ratio (CMO:0000530)	12	33700432	51558799	Rat
7411597	Foco10	Food consumption QTL 10		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat
1331786	Kidm11	Kidney mass QTL 11	3.571		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	12	16187438	52308831	Rat
631543	Bp83	Blood pressure QTL 83	5.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	12	44139558	52308831	Rat

Markers in Region

AA894309

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	12	44,321,996 - 44,322,172 (+)	MAPPER	mRatBN7.2
Rnor_6.0	12	50,343,198 - 50,343,373	NCBI	Rnor6.0
Rnor_5.0	12	52,099,799 - 52,099,974	UniSTS	Rnor5.0
RGSC_v3.4	19	14,297,229 - 14,297,404	UniSTS	RGSC3.4
Celera	12	45,905,052 - 45,905,227	UniSTS
Cytogenetic Map	19	p11	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	164	91	90	59	92	59	6	356	192	11	143	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001008508	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039089270	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039089272	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063271217	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063271218	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063271219	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063271220	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005491621	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010056380	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC123358	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC086518	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000012	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000000831 ⟹ ENSRNOP00000000831

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	49,982,281 - 50,001,090 (-)	Ensembl
mRatBN7.2 Ensembl	12	44,321,875 - 44,362,329 (-)	Ensembl
Rnor_6.0 Ensembl	12	50,343,086 - 50,383,496 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000117196 ⟹ ENSRNOP00000091231

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	49,982,281 - 50,006,592 (-)	Ensembl
mRatBN7.2 Ensembl	12	44,321,893 - 44,362,304 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000127254 ⟹ ENSRNOP00000110204

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	49,982,281 - 50,000,691 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000140812 ⟹ ENSRNOP00000103238

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	49,982,281 - 50,023,058 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000159288 ⟹ ENSRNOP00000100087

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	49,982,281 - 50,023,058 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000168469 ⟹ ENSRNOP00000103330

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	49,982,281 - 49,995,444 (-)	Ensembl

RefSeq Acc Id:

NM_001008508 ⟹ NP_001008508

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	49,982,281 - 50,022,741 (-)	NCBI
mRatBN7.2	12	44,321,875 - 44,362,329 (-)	NCBI
Rnor_6.0	12	50,343,076 - 50,383,534 (-)	NCBI
Rnor_5.0	12	52,099,677 - 52,141,423 (-)	NCBI
RGSC_v3.4	19	14,283,684 - 14,297,517 (+)	RGD
Celera	12	45,904,930 - 45,945,380 (-)	NCBI

Sequence:

show sequence

CCCTGGCGGCCGGCAGGGAGCCGGAGTCTGCGCGGGCGCGGATTCGGGCACGGACTGTCAGGGC
AGGAAGCTGTGGTGACCAGGCTCGAGGACTGGTGCTTGGAAATGAGAGCCTCCAGGGGAGATGT
ATACCAGGTGGGCCTGCTGACCCGTCCATGAGGCGGGCCCCCTGGCTGGGCCTGCGACCCTGGC
TGGGCATGCGCCTGTCGGTGCGTAAGGTGCTGCTGGCCGTGGGCTGCGCTCTGGCCCTGGTGCT
CGCTGTGCAGCTTGGGCAGCAAGTACTGGAGTGCCGGGCGGTGCTCGGGGGCGTGCGGAGCCCA
CGGAGGATGCAACCGGAGCAGGAGGAACTGGTGATGCTCGGCGCCGACCACGTGGAGTACCGTT
ACGGCAAGACCATGCCGCTCATCTTTGTGGGCGGCGTGCCACGCAGTGGCACCACCCTCATGCG
CGCCATGTTGGACGCGCACCCTGAGGTGCGCTGTGGGGAGGAGACGCGCATCATCCCTCGCGTG
CTGGCCATGCGGCAGGCCTGGACCAAGTCAGGCCGCGAGAAGCTGCGACTGGACGAGGCAGGTG
TGACAGATGAGGTGCTGGACGCGGCCATGCAGGCCTTCATCCTGGAGGTGATCGCCAAGCACGG
CGAGCCGGCACGCGTGCTATGTAACAAGGACCCCTTCACACTCAAGTCGTCCGTCTACCTGGCA
CGCCTGTTCCCCAACTCCAAATTCCTGCTAATGGTGCGTGATGGCCGGGCGTCCGTGCACTCCA
TGATCACACGCAAGGTCACCATCGCGGGCTTTGACCTCAGCAGCTACCGAGACTGCCTCACCAA
GTGGAACAAGGCCATCGAGGTGATGTACGCACAGTGCATGGAGGTGGGCAGGGACAAGTGCCTG
CCTGTGTACTATGAGCAGTTGGTGCTGCATCCCCGGCGCTCACTCAAACGCATCCTGGACTTCC
TGGGCATCGCCTGGAGTGACACAGTCCTGCACCACGAGGACCTCATTGGCAAGCCTGGGGGCGT
CTCCTTGTCCAAGATTGAGCGGTCCACGGACCAGGTCATCAAACCCGTGAACCTGGAAGCTCTC
TCCAAGTGGACTGGCCACATCCCCAGAGACGTGGTGAGGGACATGGCCCAGATTGCCCCCATGC
TGGCCCGGCTTGGCTATGATCCGTACGCAAATCCACCCAACTATGGGAACCCCGACCCCATTGT
CATCAACAACACACACCGGGTCTTGAAAGGAGACTATAAAACGCCAGCCAATCTGAAAGGATAT
TTTCAGGTGAACCAGAACAGTACCTCCCCACACCTGGGAAGTTCGTGATTTCCAGTCTCCACAG
GGCTCAGATGCCTGAGTCCTCGACCTGCACACGGAAGCTGGACTAACCCAAGCACATGGCTCTC
GGTCATGCCAGGATGGAGCAGTCATACATCTCGGCAGAAGCTAGCTCAGAACCTCTGTTCTGGG
CAACACCGAGGAGGGAGAGACTACTTCGGTTTCAGAGACTTGGGGATTTTCTATTTTTTTTTTC
TCCTTGAGAACTTTTTTTAAAAGAATTGAATTTGCTATCTTCCCTAATGGACAGGCTCCTTGGT
GACCTCATCTCCTGGGATAAGACCTGTGACCCGTGCCTCTCCTTGACTGGACGCTGAACTCAAA
GGATCTATTTAAGAGTTTAATATATGGGCTCTCCTCTCTTTAGTCCTACTCAGTTTCACAGAGA
AAAGAAATTAATTATTTGAATAAAGTAGACAGGCTGCTGTCTGTGCCTTACTTCACACAGTGAA

hide sequence

RefSeq Acc Id:

XM_039089270 ⟹ XP_038945198

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	49,982,290 - 50,024,489 (-)	NCBI
mRatBN7.2	12	44,321,879 - 44,363,892 (-)	NCBI

RefSeq Acc Id:

XM_039089272 ⟹ XP_038945200

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	49,982,290 - 50,009,567 (-)	NCBI
mRatBN7.2	12	44,321,879 - 44,348,162 (-)	NCBI

RefSeq Acc Id:

XM_063271217 ⟹ XP_063127287

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	49,984,188 - 50,022,737 (-)	NCBI

RefSeq Acc Id:

XM_063271218 ⟹ XP_063127288

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	49,984,188 - 50,024,306 (-)	NCBI

RefSeq Acc Id:

XM_063271219 ⟹ XP_063127289

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	49,982,290 - 50,022,769 (-)	NCBI

RefSeq Acc Id:

XM_063271220 ⟹ XP_063127290

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	49,984,188 - 50,008,570 (-)	NCBI

RefSeq Acc Id:

XR_005491621

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	49,988,065 - 50,022,778 (-)	NCBI
mRatBN7.2	12	44,327,664 - 44,362,368 (-)	NCBI

RefSeq Acc Id:

XR_010056380

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	49,982,290 - 50,022,777 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001008508	(Get FASTA)	NCBI Sequence Viewer
	XP_038945198	(Get FASTA)	NCBI Sequence Viewer
	XP_038945200	(Get FASTA)	NCBI Sequence Viewer
	XP_063127287	(Get FASTA)	NCBI Sequence Viewer
	XP_063127288	(Get FASTA)	NCBI Sequence Viewer
	XP_063127289	(Get FASTA)	NCBI Sequence Viewer
	XP_063127290	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH86518	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000000831
GenBank Protein	Q5RJS8	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001008508 ⟸ NM_001008508

- UniProtKB:

Q5RJS8 (UniProtKB/Swiss-Prot), A0A8L2PYI1 (UniProtKB/TrEMBL), A6J265 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MRRAPWLGLRPWLGMRLSVRKVLLAVGCALALVLAVQLGQQVLECRAVLGGVRSPRRMQPEQEE
LVMLGADHVEYRYGKTMPLIFVGGVPRSGTTLMRAMLDAHPEVRCGEETRIIPRVLAMRQAWTK
SGREKLRLDEAGVTDEVLDAAMQAFILEVIAKHGEPARVLCNKDPFTLKSSVYLARLFPNSKFL
LMVRDGRASVHSMITRKVTIAGFDLSSYRDCLTKWNKAIEVMYAQCMEVGRDKCLPVYYEQLVL
HPRRSLKRILDFLGIAWSDTVLHHEDLIGKPGGVSLSKIERSTDQVIKPVNLEALSKWTGHIPR
DVVRDMAQIAPMLARLGYDPYANPPNYGNPDPIVINNTHRVLKGDYKTPANLKGYFQVNQNSTS
PHLGSS

hide sequence

Ensembl Acc Id:

ENSRNOP00000000831 ⟸ ENSRNOT00000000831

RefSeq Acc Id:	XP_038945198 ⟸ XM_039089270
- Peptide Label:	isoform X4
- UniProtKB:	Q5RJS8 (UniProtKB/Swiss-Prot)

RefSeq Acc Id:	XP_038945200 ⟸ XM_039089272
- Peptide Label:	isoform X3
- UniProtKB:	Q5RJS8 (UniProtKB/Swiss-Prot), A0A8L2PYI1 (UniProtKB/TrEMBL), A6J265 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000091231 ⟸ ENSRNOT00000117196

RefSeq Acc Id:	XP_063127289 ⟸ XM_063271219
- Peptide Label:	isoform X3
- UniProtKB:	Q5RJS8 (UniProtKB/Swiss-Prot), A0A8L2PYI1 (UniProtKB/TrEMBL), A6J265 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063127288 ⟸ XM_063271218
- Peptide Label:	isoform X2
- UniProtKB:	A0A8I6AQ08 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063127287 ⟸ XM_063271217
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I6AQ08 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063127290 ⟸ XM_063271220
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I6AQ08 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000103238 ⟸ ENSRNOT00000140812

Ensembl Acc Id:

ENSRNOP00000103330 ⟸ ENSRNOT00000168469

Ensembl Acc Id:

ENSRNOP00000100087 ⟸ ENSRNOT00000159288

Ensembl Acc Id:

ENSRNOP00000110204 ⟸ ENSRNOT00000127254

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q5RJS8-F1-model_v2	AlphaFold	Q5RJS8	1-376	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13698729

Promoter ID:

EPDNEW_R9254

Type:

initiation region

Name:

Tpst2_1

Description:

tyrosylprotein sulfotransferase 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	12	50,383,507 - 50,383,567	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1305331	AgrOrtholog
BioCyc Gene	G2FUF-18865	BioCyc
Ensembl Genes	ENSRNOG00000000664	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000000831	ENTREZGENE
	ENSRNOT00000159288	ENTREZGENE
Gene3D-CATH	3.40.50.300	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7302513	IMAGE-MGC_LOAD
InterPro	P-loop_NTPase	UniProtKB/Swiss-Prot
	TPST	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:105657	IMAGE-MGC_LOAD
NCBI Gene	288719	ENTREZGENE
PANTHER	PROTEIN-TYROSINE SULFOTRANSFERASE 2	UniProtKB/Swiss-Prot
	PTHR12788	UniProtKB/Swiss-Prot
Pfam	Sulfotransfer_3	UniProtKB/Swiss-Prot
PhenoGen	Tpst2	PhenoGen
RatGTEx	ENSRNOG00000000664	RatGTEx
Superfamily-SCOP	SSF52540	UniProtKB/Swiss-Prot
UniProt	A0A8I6AQ08	ENTREZGENE, UniProtKB/TrEMBL
	A0A8L2PYI1	ENTREZGENE, UniProtKB/TrEMBL
	A0ABK0L2X9_RAT	UniProtKB/TrEMBL
	A0ABK0L2Z9_RAT	UniProtKB/TrEMBL
	A0ABK0LH88_RAT	UniProtKB/TrEMBL
	A0ABK0LIM6_RAT	UniProtKB/TrEMBL
	A6J265	ENTREZGENE, UniProtKB/TrEMBL
	Q5RJS8	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2006-03-30	Tpst2	tyrosylprotein sulfotransferase 2		protein-tyrosine sulfotransferase 2	Name updated	1299863	APPROVED
2005-12-06	Tpst2	protein-tyrosine sulfotransferase 2	Tpst2_predicted	protein-tyrosine sulfotransferase 2 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Tpst2_predicted	protein-tyrosine sulfotransferase 2 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD