Ttll12 (tubulin tyrosine ligase like 12)

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Gene: Ttll12 (tubulin tyrosine ligase like 12) Rattus norvegicus

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Symbol:

Ttll12

Name:

tubulin tyrosine ligase like 12

RGD ID:

1305319

Description:

Predicted to enable H4K20me3 modified histone binding activity and tubulin binding activity. Predicted to be involved in negative regulation of type I interferon-mediated signaling pathway and regulation of mitotic cell cycle. Predicted to be located in cytosol and plasma membrane. Predicted to be active in cytoplasm. Orthologous to human TTLL12 (tubulin tyrosine ligase like 12); INTERACTS WITH 2,4-dinitrotoluene; 4-amino-2,6-dinitrotoluene; alpha-Zearalanol.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC300105; RGD1305319; similar to KIAA0153 protein; tubulin tyrosine ligase-like family, member 12; tubulin--tyrosine ligase-like protein 12

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	TTLL12 (tubulin tyrosine ligase like 12)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Ttll12 (tubulin tyrosine ligase-like family, member 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Ttll12 (tubulin tyrosine ligase like 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	TTLL12 (tubulin tyrosine ligase like 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	TTLL12 (tubulin tyrosine ligase like 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Ttll12 (tubulin tyrosine ligase like 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	TTLL12 (tubulin tyrosine ligase like 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	TTLL12 (tubulin tyrosine ligase like 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Ttll12 (tubulin tyrosine ligase like 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Ttll12 (tubulin tyrosine ligase-like family, member 12)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	TTLL12 (tubulin tyrosine ligase like 12)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	ttll12 (tubulin tyrosine ligase-like family, member 12)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	TTLL12	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	ttll-12	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	ttll12	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	116,612,609 - 116,631,244 (-)	NCBI		GRCr8
mRatBN7.2	7	114,731,890 - 114,751,237 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	114,731,892 - 114,751,356 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	116,479,632 - 116,498,238 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	118,705,346 - 118,723,851 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	118,674,816 - 118,693,321 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	124,472,758 - 124,491,004 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	124,472,758 - 124,491,004 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	124,461,238 - 124,479,484 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	121,601,492 - 121,620,937 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	121,634,544 - 121,655,280 (-)	NCBI
Celera	7	111,043,936 - 111,062,464 (-)	NCBI		Celera
Cytogenetic Map	7	q34	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Developmental Delay with Variable Intellectual Impairment and Behavioral Abnormalities (ISO)

intellectual disability (ISO)

Phelan-McDermid syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4-dinitrotoluene (EXP)

2-butoxyethanol (ISO)

3,3',5,5'-tetrabromobisphenol A (ISO)

4,4'-sulfonyldiphenol (ISO)

4-amino-2,6-dinitrotoluene (EXP)

all-trans-retinoic acid (ISO)

alpha-Zearalanol (EXP)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

butan-1-ol (ISO)

cadmium dichloride (ISO)

carbon nanotube (ISO)

chromium(6+) (ISO)

clobetasol (ISO)

cobalt dichloride (ISO)

copper atom (ISO)

copper(0) (ISO)

decabromodiphenyl ether (ISO)

diazinon (ISO)

Dibutyl phosphate (ISO)

dibutyl phthalate (EXP)

dicrotophos (ISO)

enzyme inhibitor (ISO)

ethanol (ISO)

ethyl methanesulfonate (ISO)

fenthion (ISO)

folic acid (ISO)

formaldehyde (ISO)

genistein (ISO)

glafenine (EXP)

glyphosate (ISO)

ivermectin (ISO)

lead(0) (ISO)

methamphetamine (EXP)

methidathion (ISO)

methyl methanesulfonate (ISO)

ozone (EXP,ISO)

paracetamol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (EXP)

phenobarbital (ISO)

progesterone (ISO)

rotenone (ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

temozolomide (ISO)

thioacetamide (EXP)

thiram (ISO)

trimellitic anhydride (ISO)

tunicamycin (ISO)

urethane (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

negative regulation of type I interferon-mediated signaling pathway (ISO)

protein modification process (IEA)

regulation of mitotic cell cycle (ISO)

Cellular Component

cytoplasm (IBA,ISO)

cytosol (IEA,ISO)

plasma membrane (IEA,ISO)

Molecular Function

H4K20me3 modified histone binding (ISO)

histone H4K20 trimethyltransferase activity (ISO)

protein binding (ISO)

tubulin binding (ISO)

tubulin-tyrosine ligase activity (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:23251473	PMID:28011935

Genomics

Comparative Map Data

Ttll12
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	116,612,609 - 116,631,244 (-)	NCBI		GRCr8
mRatBN7.2	7	114,731,890 - 114,751,237 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	114,731,892 - 114,751,356 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	116,479,632 - 116,498,238 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	118,705,346 - 118,723,851 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	118,674,816 - 118,693,321 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	124,472,758 - 124,491,004 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	124,472,758 - 124,491,004 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	124,461,238 - 124,479,484 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	121,601,492 - 121,620,937 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	121,634,544 - 121,655,280 (-)	NCBI
Celera	7	111,043,936 - 111,062,464 (-)	NCBI		Celera
Cytogenetic Map	7	q34	NCBI

TTLL12
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	22	43,166,622 - 43,187,134 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	22	43,166,622 - 43,187,134 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	22	43,562,628 - 43,583,140 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	22	41,892,572 - 41,913,051 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	22	27,473,015 - 27,493,525 (-)	NCBI		Celera
Cytogenetic Map	22	q13.2	NCBI
HuRef	22	26,520,840 - 26,541,320 (-)	NCBI		HuRef
CHM1_1	22	43,521,891 - 43,542,376 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	22	43,647,474 - 43,667,938 (-)	NCBI		T2T-CHM13v2.0

Ttll12
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	15	83,459,295 - 83,479,358 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	15	83,459,291 - 83,479,358 (-)	Ensembl		GRCm39 Ensembl
GRCm38	15	83,575,094 - 83,595,157 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	15	83,575,090 - 83,595,157 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	15	83,405,524 - 83,425,587 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	15	83,403,576 - 83,422,878 (-)	NCBI		MGSCv36	mm8
Celera	15	85,701,912 - 85,721,975 (-)	NCBI		Celera
Cytogenetic Map	15	E1	NCBI
cM Map	15	39.4	NCBI

Ttll12
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955413	28,316,936 - 28,333,508 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955413	28,316,936 - 28,333,423 (-)	NCBI	ChiLan1.0	ChiLan1.0

TTLL12
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	23	52,977,557 - 53,009,632 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	22	55,669,517 - 55,702,553 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	22	24,038,128 - 24,070,135 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	22	42,248,276 - 42,270,232 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	22	42,249,660 - 42,271,318 (-)	Ensembl	panpan1.1		panPan2

TTLL12
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	10	22,367,590 - 22,385,167 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	10	22,367,367 - 22,386,617 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	10	22,304,290 - 22,321,864 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	10	23,112,096 - 23,129,643 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	10	23,111,562 - 23,129,625 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	10	22,831,432 - 22,848,971 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	10	23,150,355 - 23,167,934 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	10	23,326,241 - 23,343,803 (+)	NCBI		UU_Cfam_GSD_1.0

Ttll12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	5,966,837 - 5,983,407 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936718	996,000 - 1,010,342 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936718	996,758 - 1,013,372 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TTLL12
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	5,701,583 - 5,720,724 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	5	5,687,895 - 5,719,003 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	3,124,019 - 3,141,730 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TTLL12
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	19	25,693,844 - 25,714,386 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	19	25,692,610 - 25,714,342 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666045	99,724,252 - 99,744,802 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ttll12
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624752	5,796,958 - 5,813,075 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624752	5,796,935 - 5,813,078 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Ttll12
142 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	275
Count of miRNA genes:	167
Interacting mature miRNAs:	184
Transcripts:	ENSRNOT00000037710
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1300179	Kidm5	Kidney mass QTL 5	3.51		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	7	43747012	135012528	Rat
1300112	Bp183	Blood pressure QTL 183	3.51		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	7	111182207	135012528	Rat
1331728	Bp214	Blood pressure QTL 214	2.825		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	80221299	124373579	Rat
1331731	Bp216	Blood pressure QTL 216	2.851		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	102297359	133492884	Rat
2298475	Eau6	Experimental allergic uveoretinitis QTL 6		0.0029	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	7	84257275	129257275	Rat
71114	Niddm14	Non-insulin dependent diabetes mellitus QTL 14	4.5		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	7	84257275	129257275	Rat
1357336	Gluco6	Glucose level QTL 6	3.4		blood glucose amount (VT:0000188)	serum glucose level (CMO:0000543)	7	94811326	116294265	Rat
70159	Bp61	Blood pressure QTL 61		0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	103146217	116738842	Rat
631687	Hcas1	Hepatocarcinoma susceptibility QTL 1	3.9	0.001	liver integrity trait (VT:0010547)	liver tumorous lesion volume to total liver volume ratio (CMO:0001082)	7	91412594	129807172	Rat
1357339	Stl14	Serum triglyceride level QTL 14	3.45	0.0001	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	7	112729683	133492707	Rat
634331	Pia17	Pristane induced arthritis QTL 17	4.7		joint integrity trait (VT:0010548)	arthritic paw count (CMO:0001460)	7	73829340	130221005	Rat
1358914	Bp266	Blood pressure QTL 266			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	83591953	134666232	Rat
631504	Cm27	Cardiac mass QTL 27	3.45		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	7	44421311	118198041	Rat
634322	Bw12	Body weight QTL 12	0		body mass (VT:0001259)	body weight (CMO:0000012)	7	83153392	128153392	Rat
70173	Niddm19	Non-insulin dependent diabetes mellitus QTL 19	4.33	0.00005	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	7	64002457	135012528	Rat
1549899	Stresp8	Stress response QTL 8	4.37	0.0008	stress-related behavior trait (VT:0010451)	defensive burying duration (CMO:0001961)	7	90482196	135012528	Rat
2317052	Aia17	Adjuvant induced arthritis QTL 17	2.13		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	7	81737938	126737938	Rat
731176	Glom5	Glomerulus QTL 5	2.5	0.0035	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)	7	96670164	135012528	Rat
631663	Bw6	Body weight QTL 6	3.4		body mass (VT:0001259)	body weight (CMO:0000012)	7	111075573	134976056	Rat
2306821	Bp335	Blood pressure QTL 335		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	106571501	135012528	Rat
7411607	Foco15	Food consumption QTL 15		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	7	75918751	120918751	Rat
1558655	Swd4	Spike wave discharge measurement QTL 4	3.68	0.0002	brain electrophysiology trait (VT:0010557)	brain spike-and-wave discharge severity grade (CMO:0001988)	7	86983365	131983365	Rat
634336	Anxrr17	Anxiety related response QTL 17	3.66		locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	7	924703	115097879	Rat
1331768	Kidm10	Kidney mass QTL 10	4.62096		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	7	80221299	125221299	Rat
731174	Uae23	Urinary albumin excretion QTL 23	2.4	0.0042	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	7	104603555	135012528	Rat
2313102	Bmd79	Bone mineral density QTL 79	2.3	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	7	94811085	116738842	Rat
61357	Bp38	Blood pressure QTL 38	1.6	0.052	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	41333674	119109060	Rat
1331748	Bp215	Blood pressure QTL 215	4.043		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	112308254	133492884	Rat
7411654	Foco25	Food consumption QTL 25	9.3	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	7	75918751	120918751	Rat
2299163	Iddm34	Insulin dependent diabetes mellitus QTL 34	2.71		blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	7	91281130	135012528	Rat
631540	Bw9	Body weight QTL 9	4.5		body mass (VT:0001259)	body weight (CMO:0000012)	7	69736226	117455174	Rat
1358891	Bp265	Blood pressure QTL 265	2.21		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	83591953	134666232	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001135922	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473950	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000007	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000037710 ⟹ ENSRNOP00000038639

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	114,731,892 - 114,751,356 (-)	Ensembl
Rnor_6.0 Ensembl	7	124,472,758 - 124,491,004 (-)	Ensembl

RefSeq Acc Id:

NM_001135922 ⟹ NP_001129394

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	116,612,609 - 116,631,244 (-)	NCBI
mRatBN7.2	7	114,732,598 - 114,751,237 (-)	NCBI
Rnor_6.0	7	124,472,758 - 124,491,004 (-)	NCBI
Rnor_5.0	7	124,461,238 - 124,479,484 (-)	NCBI
RGSC_v3.4	7	121,601,492 - 121,620,937 (-)	RGD
Celera	7	111,043,936 - 111,062,464 (-)	RGD

Sequence:

show sequence

GCATCCGAGCACCATGGAGGGCGAACCCCGGTCGCAGCCTGGCAGCCCGGGCCGCGCCGAGAGG
CTGAACGCGCGGCTGCTGGACGAGTTCGTGTCGCTACACGGACCCGCGCTACGCGCCTCAGGCG
TCCCAGAGCGACTATGGGGCAGCCTCCTGCACAAGCTGGAGCACGAGGTTTTCGATGCTGGGGA
GATGTTTGGGATAATGCAAGTGGAGGAGGTGGAGGAGGCTGAGGACGAGGCCGCCAGGGAGGCT
CAGAGAAAGCAGCCGAATCCTGGGGGCGAGCTGTGCTACAAGGTCATTGTGACCAGTGAGAACG
GCGTCCGGGCTGATGACCCCAACAGCATCTTCCTCATCGACCATGCCTGGACGTGCCGTGTGGA
GCATGCACGCAAACAGCTGCAGCAGGTGCCTGGACTCCTACACCGGATGGCCAACCTCATGGGC
ATCGAGTTCCATGGCGAAGTGCCCAGTCCAGAGGTTGTGGCCCTAGTGCTGGAGGAGATGTGGA
AATTCAACCAGACCTATCAGCTGGCCCATGGGACAGCCGAAGAGAAGGTGCCAGTGTGGTACAT
CATGGACGAGTTTGGCTCAAGGATCCAGCATGCAGACATGCCCAGCTTCGCCACTGCTCCCTTC
TTCTACATGCCCCAGCAGGTGGCATACACGCTGCTGTGGCCCCTAAGGGACCTAGACACAGGCG
AGGAGGTGACCCGGGACTATGCCTACGGAGAGGCAGACCCTCTGATCCGGAAATGCATGCTGCT
GCCCTGGGCCCCCGCCGACATGCTGGACCTCAGCTCCTCTACGCCTGAGCCTCCCGCCAAGTAC
TACCAGGCCATTTTGGAGGAAAACAAGGAGAAACTGCCACTCACCATTAGCCCGGTGGCACGTC
CCCAGGGCCACATCTTCAGAGTCCACTGCGATGTGCAACAGGTGCTCAGCCACCTCACGCACCC
TCGCTTCACCTTCACTGACAGCGAGGCCGACGCCGACGTCTACTTCCATTTCTCGCACTTCAAG
GACTACACGAAACTCAGCCAAGAGAGCCCACAGGTACTACTCAACCAGTTCCCCTGTGAGAACC
TGCTGACTGTTAAGGACTGTCTGGCCTCCATCGCTCGCCGGGCTGGAGGTCCTGAGGGTCCCCC
CTGGCTACCCCGAACCTTCAACCTGCGCACCGAGCTGCCCCAGTTCGTCAGCTATTTCCAGCAC
CGAGAGAGGCGGGGTGAAGACAACCACTGGATCTGCAAGCCTTGGAACCTGGCCCGCAGCCTGG
ACACTCACGTCACCAACAATCTCCACAGCATCATCCGACACCGAGAGAGCACCCCCAAGGTTGT
GTCAAAATACATTGAAAGTCCCGTCTTGTTCTTCCGAGAAGACGTGGGGAACGTCAAGTTTGAC
ATCCGCTACATTGTGCTGCTGCGCTCAGTGAGGCCGCTGAGGTTGTTTGTGTATGATGTGTTCT
GGCTACGCTTCTCCAATCGGCCTTTCGCCCTCAATGACCTAGACGACTATGAGAAGCATTTCAC
CGTCATGAACTATGACCCGGATGTGGTGCTAAAGCAGGTGCACTATAATGAGTTCATCCCCCAG
TTTGAGAAGCAGAACCCAGAGTTTCCTTGGAGTGGTGTCCAGGCTGAGATCTTCAAGGCCTTCA
CGGAGCTGTTTGAAGTGGCATGTGCCAAGCCACCCCCCATGGGTCTCTGCGACTACCCCTCATC
TCGGGCCATATATGCTATTGACCTCATGCTCAAGTGGGACAGCCATCCAGATGGAAAGCGGGTG
ATGCAGCCCCAGATCCTGGAGGTGAACTTCAACCCTGACTGCGAGCGAGCCTGCAAGTACCACC
CCTCGTTCTTCAACGATGTCTTCAGCACCTTGTTTCTGGACGAGACCGACGACTGCCATGTCAC
CCGCATCATCTAGGTGCCCAGAGTTCTGCCCGTGCTCGTAGCTGGTTCCAGCCTCTGCTCATGG
AACTGCCTCTGCAGCCCCAGCCATCTCCTTCCCTCCCTTCCCCACTTCCTGAGCCGTGTTCCTG
CTTCGTATGTGGGATGTCAGGTCCATGTGTGGCAGAGCTGGACAGGGAGTGGTGTCCCAAGGGC
TGGGCTCTGCCCCGGCACTCTCCATACCCCTTAACCCTCTCTTCTCTGAGGAGTCTGCAGCTCA
GCTCTTCTGGCATCCAGAGAGTTCGCAGACAAAGAGGTGTTCTGCAGAAACAGGGTTCCACGTG
AAGCCTTTGGGAACCCCATATCCACCAGGGCCAAGGAGTGCTCTCTCAGAACCTCTGCCCTCCT
GTGCCGTGGCTGCTGTAAGCAGGGTACAGGAACCCTGTGTTACACCCGAGACCCCAGAACAGCC
CAGGGGAAACAAACATTTGCCAACCCAGCCTTATGCCTTGGCTC

hide sequence

Protein Sequences


Protein RefSeqs	NP_001129394	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDM15621	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000038639.5

RefSeq Acc Id:

NP_001129394 ⟸ NM_001135922

- UniProtKB:

D4A1Q9 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MEGEPRSQPGSPGRAERLNARLLDEFVSLHGPALRASGVPERLWGSLLHKLEHEVFDAGEMFGI
MQVEEVEEAEDEAAREAQRKQPNPGGELCYKVIVTSENGVRADDPNSIFLIDHAWTCRVEHARK
QLQQVPGLLHRMANLMGIEFHGEVPSPEVVALVLEEMWKFNQTYQLAHGTAEEKVPVWYIMDEF
GSRIQHADMPSFATAPFFYMPQQVAYTLLWPLRDLDTGEEVTRDYAYGEADPLIRKCMLLPWAP
ADMLDLSSSTPEPPAKYYQAILEENKEKLPLTISPVARPQGHIFRVHCDVQQVLSHLTHPRFTF
TDSEADADVYFHFSHFKDYTKLSQESPQVLLNQFPCENLLTVKDCLASIARRAGGPEGPPWLPR
TFNLRTELPQFVSYFQHRERRGEDNHWICKPWNLARSLDTHVTNNLHSIIRHRESTPKVVSKYI
ESPVLFFREDVGNVKFDIRYIVLLRSVRPLRLFVYDVFWLRFSNRPFALNDLDDYEKHFTVMNY
DPDVVLKQVHYNEFIPQFEKQNPEFPWSGVQAEIFKAFTELFEVACAKPPPMGLCDYPSSRAIY
AIDLMLKWDSHPDGKRVMQPQILEVNFNPDCERACKYHPSFFNDVFSTLFLDETDDCHVTRII

hide sequence

Ensembl Acc Id:

ENSRNOP00000038639 ⟸ ENSRNOT00000037710

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D4A1Q9-F1-model_v2	AlphaFold	D4A1Q9	1-639	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13695551

Promoter ID:

EPDNEW_R6076

Type:

multiple initiation site

Name:

Ttll12_1

Description:

tubulin tyrosine ligase like 12

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	7	124,491,002 - 124,491,062	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1305319	AgrOrtholog
BioCyc Gene	G2FUF-32597	BioCyc
Ensembl Genes	ENSRNOG00000022623	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000037710.5	UniProtKB/TrEMBL
Gene3D-CATH	ATP-grasp fold, B domain	UniProtKB/TrEMBL
InterPro	TTLL12	UniProtKB/TrEMBL
	Tub_tyr_ligase	UniProtKB/TrEMBL
NCBI Gene	300105	ENTREZGENE
PANTHER	PTHR46088	UniProtKB/TrEMBL
	TUBULIN--TYROSINE LIGASE-LIKE PROTEIN 12	UniProtKB/TrEMBL
Pfam	TTL	UniProtKB/TrEMBL
PhenoGen	Ttll12	PhenoGen
PROSITE	TTL	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000022623	RatGTEx
UniProt	D4A1Q9	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-11-25	Ttll12	tubulin tyrosine ligase like 12	Ttll12	tubulin tyrosine ligase-like family, member 12	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Ttll12	tubulin tyrosine ligase-like family, member 12	Ttll12_predicted	tubulin tyrosine ligase-like family, member 12 (predicted)	'predicted' is removed	2292626	APPROVED
2006-03-30	Ttll12_predicted	tubulin tyrosine ligase-like family, member 12 (predicted)	RGD1305319_predicted	similar to KIAA0153 protein (predicted)	Symbol and Name updated	1299863	APPROVED
2005-01-20	RGD1305319_predicted	similar to KIAA0153 protein (predicted)	LOC300105_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC300105_predicted	similar to KIAA0153 protein (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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