Drc11 (dynein regulatory complex subunit 11) - Rat Genome Database

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Gene: Drc11 (dynein regulatory complex subunit 11) Rattus norvegicus
Analyze
Symbol: Drc11 (Ensembl: Iqca1)
Name: dynein regulatory complex subunit 11 (Ensembl:IQ motif containing with AAA domain 1)
RGD ID: 1305311
Description: Predicted to enable ATP binding activity and ATP hydrolysis activity. Orthologous to human IQCA1 (IQ motif containing with AAA domain 1); INTERACTS WITH bisphenol A; Cuprizon; fenvalerate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: dynein regulatory complex protein 11; IQ and AAA domain-containing protein 1; IQ motif containing with AAA domain; IQ motif containing with AAA domain 1; Iqca; Iqca1; LOC316616; RGD1305311; similar to hypothetical protein FLJ22527
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8998,074,389 - 98,190,233 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl998,073,887 - 98,190,066 (-)EnsemblGRCr8
mRatBN7.2990,626,735 - 90,742,563 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl990,626,744 - 90,742,618 (-)EnsemblmRatBN7.2
Rnor_6.0997,190,240 - 97,298,760 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl997,183,214 - 97,290,639 (-)NCBIrn6Rnor6.0
Rnor_5.0996,873,940 - 96,989,685 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4989,153,670 - 89,273,101 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera988,175,143 - 88,290,699 (-)NCBICelera
RGSC_v3.1989,335,555 - 89,537,162 (-)NCBI
Cytogenetic Map9q36NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. GOA pipeline RGD automated data pipeline
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:21873635  


Genomics

Comparative Map Data
Drc11
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8998,074,389 - 98,190,233 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl998,073,887 - 98,190,066 (-)EnsemblGRCr8
mRatBN7.2990,626,735 - 90,742,563 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl990,626,744 - 90,742,618 (-)EnsemblmRatBN7.2
Rnor_6.0997,190,240 - 97,298,760 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl997,183,214 - 97,290,639 (-)NCBIrn6Rnor6.0
Rnor_5.0996,873,940 - 96,989,685 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4989,153,670 - 89,273,101 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera988,175,143 - 88,290,699 (-)NCBICelera
RGSC_v3.1989,335,555 - 89,537,162 (-)NCBI
Cytogenetic Map9q36NCBI
DRC11
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382236,306,685 - 236,507,476 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2236,324,147 - 236,507,716 (-)Ensemblhg38GRCh38
GRCh372237,232,794 - 237,416,119 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362236,897,533 - 237,080,831 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342237,014,793 - 237,198,092NCBI
Celera2230,945,804 - 231,128,787 (-)NCBICelera
Cytogenetic Map2q37.2-q37.3NCBI
HuRef2229,027,057 - 229,210,048 (-)NCBIHuRef
CHM1_12237,238,581 - 237,421,557 (-)NCBICHM1_1
T2T-CHM13v2.02236,813,779 - 236,997,787 (-)NCBIT2T-CHM13v2.0
Iqca1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39189,969,854 - 90,081,158 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl189,969,854 - 90,081,123 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38190,042,132 - 90,153,436 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl190,042,132 - 90,153,401 (-)Ensemblmm10GRCm38
MGSCv37191,938,707 - 92,049,976 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36191,938,707 - 92,049,976 (-)NCBIMGSCv36mm8
Celera192,983,783 - 93,096,895 (-)NCBICelera
Cytogenetic Map1DNCBI
cM Map145.08NCBI
Iqca1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955453291,334 - 416,529 (+)Ensembl
ChiLan1.0NW_004955453282,601 - 416,715 (+)NCBIChiLan1.0ChiLan1.0
IQCA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213138,954,414 - 139,134,752 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B138,969,380 - 139,149,684 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B123,555,491 - 123,735,660 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B242,416,200 - 242,593,852 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B242,416,200 - 242,593,852 (-)EnsemblpanPan2panpan1.1
IQCA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12547,129,449 - 47,276,056 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2547,129,452 - 47,276,074 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2547,625,888 - 47,772,079 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02547,477,271 - 47,623,558 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2547,477,267 - 47,623,606 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12547,385,272 - 47,531,480 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02547,178,551 - 47,324,854 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02547,408,853 - 47,555,398 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Iqca1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303189,198,942 - 189,326,840 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365251,621,562 - 1,740,354 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365251,613,034 - 1,740,726 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IQCA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15136,152,982 - 136,321,605 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.115136,153,182 - 136,322,725 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215150,587,819 - 150,757,656 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DRC11
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110122,335,436 - 122,500,848 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10122,335,980 - 122,500,711 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604076,900,712 - 77,068,857 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Iqca1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248472,008,468 - 2,128,794 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248472,008,479 - 2,128,737 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Iqca1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v14162,046,198 - 162,157,569 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Drc11
628 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:236
Count of miRNA genes:96
Interacting mature miRNAs:104
Transcripts:ENSRNOT00000026491, ENSRNOT00000056724, ENSRNOT00000068539
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)956047863101047863Rat
1582203Gluco19Glucose level QTL 193.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)963376862108376862Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)965657365108376720Rat
724547Cm21Cardiac mass QTL 212.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)986720043110356905Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)94445825699506504Rat
2303178Bp334Blood pressure QTL 3343.70.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)986720043121768150Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)964220169109220169Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)964220169109220169Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)944458256121768150Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)964220169109220169Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)968875497121768150Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)983161999118999486Rat
4889852Pur26Proteinuria QTL 26150.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)985262459109044727Rat
7794784Mcs31Mammary carcinoma susceptibility QTL 312.98mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)985262459118999486Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)948718864108376862Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)964220169109220169Rat
4889943Bss90Bone structure and strength QTL 904.1tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)95450650499506504Rat

Markers in Region
D9Got111  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2990,719,946 - 90,720,113 (+)MAPPERmRatBN7.2
Rnor_6.0997,276,144 - 97,276,310NCBIRnor6.0
Rnor_5.0996,967,774 - 96,967,940UniSTSRnor5.0
RGSC_v3.4989,249,726 - 89,249,893RGDRGSC3.4
RGSC_v3.4989,249,727 - 89,249,893UniSTSRGSC3.4
Celera988,267,055 - 88,267,221UniSTS
RGSC_v3.1989,454,495 - 89,454,662RGD
RH 2.0 Map9927.4RGD
Cytogenetic Map9q35UniSTS
BE102230  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2990,689,435 - 90,689,651 (+)MAPPERmRatBN7.2
Rnor_6.0997,245,661 - 97,245,876NCBIRnor6.0
Rnor_5.0996,937,629 - 96,937,844UniSTSRnor5.0
RGSC_v3.4989,218,735 - 89,218,950UniSTSRGSC3.4
Celera988,236,574 - 88,236,789UniSTS
Cytogenetic Map9q35UniSTS
BE110326  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2990,626,787 - 90,626,946 (+)MAPPERmRatBN7.2
Rnor_6.0997,182,810 - 97,182,968NCBIRnor6.0
Rnor_5.0996,873,536 - 96,873,694UniSTSRnor5.0
RGSC_v3.4989,153,266 - 89,153,424UniSTSRGSC3.4
Celera988,175,196 - 88,175,354UniSTS
RH 3.4 Map9784.08UniSTS
Cytogenetic Map9q35UniSTS
RH140487  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2990,663,687 - 90,663,848 (+)MAPPERmRatBN7.2
Rnor_6.0997,220,053 - 97,220,213NCBIRnor6.0
Rnor_5.0996,911,877 - 96,912,037UniSTSRnor5.0
RGSC_v3.4989,191,558 - 89,191,718UniSTSRGSC3.4
Celera988,211,684 - 88,211,844UniSTS
Cytogenetic Map9q35UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
hemolymphoid system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
sensory system
visual system
1 14 29 1 34 23 8 22 10 22 8 8

Sequence


Ensembl Acc Id: ENSRNOT00000026491   ⟹   ENSRNOP00000026491
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl998,074,398 - 98,190,066 (-)Ensembl
mRatBN7.2 Ensembl990,626,744 - 90,742,618 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000056724   ⟹   ENSRNOP00000053565
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl998,073,887 - 98,190,066 (-)Ensembl
mRatBN7.2 Ensembl990,626,744 - 90,742,618 (-)Ensembl
RefSeq Acc Id: XM_017596905   ⟹   XP_017452394
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8998,074,389 - 98,190,233 (-)NCBI
mRatBN7.2990,626,735 - 90,742,562 (-)NCBI
Rnor_6.0997,190,240 - 97,298,760 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039084725   ⟹   XP_038940653
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8998,095,645 - 98,190,215 (-)NCBI
mRatBN7.2990,647,765 - 90,742,563 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001418200 (Get FASTA)   NCBI Sequence Viewer  
  XP_017452394 (Get FASTA)   NCBI Sequence Viewer  
  XP_038940653 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000026491.9
  ENSRNOP00000053565
  ENSRNOP00000053565.6
RefSeq Acc Id: XP_017452394   ⟸   XM_017596905
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_038940653   ⟸   XM_039084725
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000053565   ⟸   ENSRNOT00000056724
Ensembl Acc Id: ENSRNOP00000026491   ⟸   ENSRNOT00000026491

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M7Z2-F1-model_v2 AlphaFold F1M7Z2 1-852 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305311 AgrOrtholog
BioCyc Gene G2FUF-26756 BioCyc
Ensembl Genes ENSRNOG00000019592 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000026491.10 UniProtKB/TrEMBL
  ENSRNOT00000056724 ENTREZGENE
  ENSRNOT00000056724.7 UniProtKB/TrEMBL
Gene3D-CATH 1.10.8.60 UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/TrEMBL
InterPro AAA+_ATPase UniProtKB/TrEMBL
  ATPase_AAA_core UniProtKB/TrEMBL
  N-DRC_Component UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
NCBI Gene 316616 ENTREZGENE
PANTHER DYNEIN REGULATORY COMPLEX PROTEIN 11 UniProtKB/TrEMBL
  UNCHARACTERIZED UniProtKB/TrEMBL
Pfam AAA UniProtKB/TrEMBL
PhenoGen Drc11 PhenoGen
RatGTEx ENSRNOG00000019592 RatGTEx
SMART AAA UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
UniProt F1LX47 ENTREZGENE, UniProtKB/TrEMBL
  F1M7Z2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2025-11-13 Drc11  dynein regulatory complex subunit 11  Iqca1  IQ motif containing with AAA domain 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2022-06-02 Iqca1  IQ motif containing with AAA domain 1  Iqca  IQ motif containing with AAA domain  Data merged from RGD:15003483 737654 PROVISIONAL
2021-09-02 Iqca  IQ motif containing with AAA domain  Iqca1  IQ motif containing with AAA domain 1  Symbol and/or name change 19259462 PROVISIONAL
2021-08-09 Iqca1  IQ motif containing with AAA domain 1  Iqca  IQ motif containing with AAA domain  Symbol and/or name change 19259462 PROVISIONAL
2019-11-08 Iqca  IQ motif containing with AAA domain      Symbol and Name status set to provisional 45752 PROVISIONAL
2010-04-23 Iqca1  IQ motif containing with AAA domain 1  RGD1305311  similar to hypothetical protein FLJ22527  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1305311  similar to hypothetical protein FLJ22527   RGD1305311_predicted  similar to hypothetical protein FLJ22527 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-20 RGD1305311_predicted  similar to hypothetical protein FLJ22527 (predicted)  LOC316616_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC316616_predicted  similar to hypothetical protein FLJ22527 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL