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Gene: Abraxas1 (abraxas 1, BRCA1 A complex subunit) Rattus norvegicus

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Symbol:

Abraxas1

Name:

abraxas 1, BRCA1 A complex subunit

RGD ID:

1305287

Description:

Predicted to enable microtubule binding activity and polyubiquitin modification-dependent protein binding activity. Predicted to be involved in several processes, including mitotic G2 DNA damage checkpoint signaling; nuclear chromosome segregation; and positive regulation of DNA repair. Predicted to be located in nuclear body. Predicted to be part of BRCA1-A complex. Predicted to be active in nucleus. Orthologous to human ABRAXAS1 (abraxas 1, BRCA1 A complex subunit); INTERACTS WITH bisphenol A; Cuprizon; ochratoxin A.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

BRCA1-A complex subunit Abraxas; BRCA1-A complex subunit Abraxas 1; Ccdc98; coiled-coil domain containing 98; coiled-coil domain-containing protein 98; Fam175a; family with sequence similarity 175, member A; LOC289468; MGC94265; RGD1305287; similar to RIKEN cDNA 3830405G04

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	ABRAXAS1 (abraxas 1, BRCA1 A complex subunit)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Abraxas1 (BRCA1 A complex subunit)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Abraxas1 (abraxas 1, BRCA1 A complex subunit)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	ABRAXAS1 (abraxas 1, BRCA1 A complex subunit)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	ABRAXAS1 (abraxas 1, BRCA1 A complex subunit)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Abraxas1 (abraxas 1, BRCA1 A complex subunit)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	ABRAXAS1 (abraxas 1, BRCA1 A complex subunit)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	ABRAXAS1 (abraxas 1, BRCA1 A complex subunit)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Abraxas1 (abraxas 1, BRCA1 A complex subunit)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Abraxas1 (BRCA1 A complex subunit)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	ABRAXAS1 (abraxas 1, BRCA1 A complex subunit)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	abraxas1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	abraxas1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	9,100,650 - 9,115,012 (+)	NCBI		GRCr8
mRatBN7.2	14	8,796,281 - 8,810,625 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	8,796,266 - 8,810,622 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	14	8,764,210 - 8,778,527 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	10,064,061 - 10,078,375 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	8,760,668 - 8,774,988 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	10,424,674 - 10,439,010 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	10,424,674 - 10,439,003 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	10,372,640 - 10,386,976 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	10,080,191 - 10,094,528 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	14	10,080,190 - 10,094,521 (+)	NCBI
Celera	14	8,905,322 - 8,919,658 (+)	NCBI		Celera
Cytogenetic Map	14	p22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

breast cancer (ISO)

chromosome 4q21 deletion syndrome (ISO)

genetic disease (ISO)

hereditary breast ovarian cancer syndrome (ISO)

Hereditary Neoplastic Syndromes (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

4,4'-diaminodiphenylmethane (ISO)

all-trans-retinoic acid (ISO)

antirheumatic drug (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

caffeine (ISO)

coumestrol (ISO)

Cuprizon (EXP)

cyclosporin A (ISO)

dicrotophos (ISO)

dorsomorphin (ISO)

folic acid (ISO)

FR900359 (ISO)

melphalan (ISO)

methylmercury chloride (ISO)

monocrotaline (ISO)

nickel sulfate (ISO)

ochratoxin A (EXP)

paracetamol (EXP)

perfluorooctane-1-sulfonic acid (ISO)

phenylmercury acetate (ISO)

potassium chromate (ISO)

quercetin (ISO)

rotenone (ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

Soman (EXP)

sunitinib (ISO)

temozolomide (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

trichostatin A (ISO)

triphenyl phosphate (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

attachment of spindle microtubules to kinetochore (IBA)

chromatin organization (IEA)

DNA repair (IEA)

double-strand break repair (IEA,ISO,ISS)

mitotic G2 DNA damage checkpoint signaling (IEA,ISO,ISS)

mitotic spindle assembly (IBA)

positive regulation of DNA repair (IEA,ISO,ISS)

response to ionizing radiation (IEA,ISO,ISS)

Cellular Component

BRCA1-A complex (IEA,ISO,ISS)

nuclear body (IEA,ISO)

nucleus (IBA,IEA,ISO,ISS)

Molecular Function

microtubule binding (IBA)

polyubiquitin modification-dependent protein binding (IBA,IEA,ISO,ISS)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:15489334	PMID:17525340	PMID:17643121	PMID:19261746	PMID:19261748	PMID:19261749

Genomics

Comparative Map Data

Abraxas1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	9,100,650 - 9,115,012 (+)	NCBI		GRCr8
mRatBN7.2	14	8,796,281 - 8,810,625 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	8,796,266 - 8,810,622 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	14	8,764,210 - 8,778,527 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	10,064,061 - 10,078,375 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	8,760,668 - 8,774,988 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	10,424,674 - 10,439,010 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	10,424,674 - 10,439,003 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	10,372,640 - 10,386,976 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	10,080,191 - 10,094,528 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	14	10,080,190 - 10,094,521 (+)	NCBI
Celera	14	8,905,322 - 8,919,658 (+)	NCBI		Celera
Cytogenetic Map	14	p22	NCBI

ABRAXAS1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	4	83,459,517 - 83,485,100 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	4	83,459,517 - 83,523,348 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	4	84,380,670 - 84,406,253 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	84,601,116 - 84,625,314 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	4	81,672,544 - 81,696,745 (-)	NCBI		Celera
Cytogenetic Map	4	q21.23	NCBI
HuRef	4	80,124,868 - 80,149,059 (-)	NCBI		HuRef
CHM1_1	4	84,358,666 - 84,382,863 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	4	86,789,585 - 86,815,160 (-)	NCBI		T2T-CHM13v2.0

Abraxas1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	100,952,668 - 100,968,816 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	100,953,058 - 100,968,831 (-)	Ensembl		GRCm39 Ensembl
GRCm38	5	100,804,802 - 100,845,864 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	100,805,192 - 100,820,965 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	101,233,821 - 101,249,954 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	101,045,104 - 101,061,237 (-)	NCBI		MGSCv36	mm8
Celera	5	98,132,877 - 98,148,983 (-)	NCBI		Celera
Cytogenetic Map	5	E4	NCBI
cM Map	5	48.52	NCBI

Abraxas1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955474	6,252,321 - 6,265,286 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955474	6,252,321 - 6,265,518 (+)	NCBI	ChiLan1.0	ChiLan1.0

ABRAXAS1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	3	46,578,145 - 46,602,631 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	4	46,767,746 - 46,792,008 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	4	40,711,139 - 40,736,763 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	4	46,557,655 - 46,581,579 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	46,556,892 - 46,581,573 (+)	Ensembl	panpan1.1		panPan2

ABRAXAS1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	32	7,298,789 - 7,316,665 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	32	7,298,790 - 7,317,001 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	32	34,568,904 - 34,586,771 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	32	7,320,316 - 7,338,440 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	32	7,320,321 - 7,338,373 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	32	7,385,865 - 7,408,418 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	32	7,255,339 - 7,277,886 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	32	32,683,802 - 32,706,375 (+)	NCBI		UU_Cfam_GSD_1.0

Abraxas1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405285	5,040,804 - 5,058,384 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936738	1,202,608 - 1,221,321 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936738	1,202,668 - 1,217,825 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ABRAXAS1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	8	135,002,321 - 135,023,335 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	8	135,002,297 - 135,021,205 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	8	144,298,595 - 144,315,429 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ABRAXAS1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	7	31,852,411 - 31,875,968 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	7	31,853,490 - 31,875,189 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666037	10,447,568 - 10,470,855 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Abraxas1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624900	434,576 - 447,518 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624900	431,969 - 447,535 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Abraxas1
99 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	13
Count of miRNA genes:	11
Interacting mature miRNAs:	12
Transcripts:	ENSRNOT00000002956
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1300114	Srn2	Serum renin concentration QTL 2	3.27		blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	14	3813074	21217635	Rat
2293089	Iddm31	Insulin dependent diabetes mellitus QTL 31	4.7		blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	14	3813074	18274691	Rat
1581500	Renag1	Renal agenesis QTL 1			kidney development trait (VT:0000527)	percentage of study population developing unilateral renal agenesis during a period of time (CMO:0000940)	14	8170668	68298175	Rat
1331740	Bw26	Body weight QTL 26	3.028		body mass (VT:0001259)	body weight (CMO:0000012)	14	3813074	30767156	Rat
619619	Rf4	Renal disease susceptibility QTL 4	4.1	0.002	urine total protein amount (VT:0000032)	urine protein excretion rate to body weight ratio (CMO:0001099)	14	1	32754612	Rat
71115	Niddm15	Non-insulin dependent diabetes mellitus QTL 15	4.8		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	14	1217606	11030812	Rat
1358296	Ael3	Aortic elastin QTL 3	3.7	0.00051	aorta elastin amount (VT:0003905)	aortic elastin	14	8267090	53267090	Rat
70195	Mcs8	Mammary carcinoma susceptibility QTL 8	4.28		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	14	3813074	24531477	Rat
2300183	Bmd60	Bone mineral density QTL 60	5.7	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	14	1	26541967	Rat
724541	Niddm53	Non-insulin dependent diabetes mellitus QTL 53		0.001	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	14	3813074	9088978	Rat
634352	Apr6	Acute phase response QTL 6	3.7		blood interleukin-6 amount (VT:0008595)	plasma interleukin-6 level (CMO:0001927)	14	1	41131407	Rat
2300159	Bmd61	Bone mineral density QTL 61	5.3	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	14	1	26541967	Rat
70204	Niddm20	Non-insulin dependent diabetes mellitus QTL 20	5.1	0.000008	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	14	1217606	16960180	Rat
2302045	Pia39	Pristane induced arthritis QTL 39	4.9	0.001	blood immunoglobulin amount (VT:0002460)	serum immunoglobulin G2a level (CMO:0002116)	14	8267090	53267090	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001009633	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039091664	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039091665	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039091666	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC088408	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474022	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000014	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000002956 ⟹ ENSRNOP00000002956

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	14	8,796,266 - 8,810,620 (+)	Ensembl
Rnor_6.0 Ensembl	14	10,424,674 - 10,439,003 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000117431 ⟹ ENSRNOP00000078807

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	14	8,796,277 - 8,810,622 (+)	Ensembl

RefSeq Acc Id:

NM_001009633 ⟹ NP_001009633

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	14	9,100,670 - 9,115,007 (+)	NCBI
mRatBN7.2	14	8,796,283 - 8,810,620 (+)	NCBI
Rnor_6.0	14	10,424,674 - 10,439,010 (+)	NCBI
Rnor_5.0	14	10,372,640 - 10,386,976 (+)	NCBI
RGSC_v3.4	14	10,080,191 - 10,094,528 (+)	RGD
Celera	14	8,905,322 - 8,919,658 (+)	RGD

Sequence:

show sequence

CGTCGGGCGCCGCGATAGTGGCTGTGGCGGTAGCGACTGAGGCGGCAGTATGGAGGGCGAGAGC
ACGTTGGGGGTGTTGTCTGGCTTCGTGCTTGGCGCGCTCACCTTCCAGCATCTCAACACTGACT
CAGATACGGAGGGTCTTCTCCTCGGTGAAATGAAAGGTGAAGCCAAGAATAGCATCACTGACTC
ACAGATGGACAGCGTTAAAGTCGTCTACACAATTGACATTCAGAAATATATTCCATGCTACCGG
CTTTTTAGCTTTTATAATTCTTTAGGTGAAGTAAATGAACACGCACTGAAGAAAATTCTTTCAA
ATGTCAAAAAGACTGTGGTGGGTTGGTATAAATTCCGTCGTCACTCGGATCAGATAATGACATT
TAGAGAGCAGTTGCTCCACAGAAACTTACAGACGCATCTTTCAAGCCCAGAGCTTGTTTTTCTG
TTGTTAACACCAAGTATAACAACAGAGAGCTGCTGCACTCACTGCCTGGAACACGGCCTGTACA
AACCTCAAAGTGGGCTTTTTCATAAGGTACCTTTGGTGGTTACCAATCTGGGAATGTCTGATCA
ACTGGGTTATAAAACAGAGTCTGTTTCCTGTACGTCCACTGTCTTTAGCAGAGCTGTGAGGACA
TACAGTTCTCAATTTTTTAATGAAGATGGATCATTAAAGGAAGTACGTAAGATAAATGAAATGT
ATGCTGCTATACAAGAAGAATTAAAGACTATATGCCAAAAAGTTGAACAAAGTGAACGAGAAGT
AGAGAAACTATTGATGGATGTAAACCGATTAAAAGAAGTTAGAAAAAAACAGCAAGCACAGGCT
AAAGGAGCAGGAGAGAAGAGCCAAAACCATCCCCAGGAGAACATTCTCCTCTGCCAAGCTTTAC
GAACATTCTTTCCAGAGTCTCGAGTTCTTCACTCTTGCGTTATTTCTTTGAAAAATAGACATAT
TTCTCACAGTGGGTGTAACACTGACCACCATCTTGATGTGGTGGATAAGCTAACCTTAATGGTG
GAGTACGTTTACAGCCCTGAAGCTAGTCCAGCACCTGCAGCCCCACTGAGCAAACGTAAAGCTC
TAGACACACAAGATCAGTGGCCTGCGAAGAGACCACGGCTGCTAGAGTCAGAAAGCAGACCTGG
GCCAGCATTTCGAGGCAGTCACCAGGACAAAGCCTCCTCAAGCAGCCTCGATATAGACACAGAG
GTGGGGAGCCCGGAAGATGATACTGACTACCCTCGCTCTCCCACATTTTGATTCTTTGTAGAGG
ACATTTTTTACTAGACTGGAGTTTAGGGCACTTATTTTTACTCTTTGCTTCCTGGAGTAATAGA
GTTCATGCTTTTACTCTATTCAGCTGTTTGTAATACATGGATATTTTTACTGTTCAACTGCTTA
TAATATATAGGTAAGTTAATATTTTATAAAGTATCTTAAAAATTAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039091664 ⟹ XP_038947592

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	14	9,103,405 - 9,115,012 (+)	NCBI
mRatBN7.2	14	8,799,012 - 8,810,625 (+)	NCBI

RefSeq Acc Id:

XM_039091665 ⟹ XP_038947593

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	14	9,100,650 - 9,109,577 (+)	NCBI
mRatBN7.2	14	8,796,281 - 8,805,183 (+)	NCBI

RefSeq Acc Id:

XM_039091666 ⟹ XP_038947594

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	14	9,100,650 - 9,111,920 (+)	NCBI
mRatBN7.2	14	8,796,281 - 8,807,533 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001009633	(Get FASTA)	NCBI Sequence Viewer
	XP_038947592	(Get FASTA)	NCBI Sequence Viewer
	XP_038947593	(Get FASTA)	NCBI Sequence Viewer
	XP_038947594	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH88408	(Get FASTA)	NCBI Sequence Viewer
	EDL99546	(Get FASTA)	NCBI Sequence Viewer
	EDL99547	(Get FASTA)	NCBI Sequence Viewer
	EDL99548	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000002956.5
	ENSRNOP00000078807.1
GenBank Protein	Q5I0F1	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001009633 ⟸ NM_001009633

- UniProtKB:

Q5I0F1 (UniProtKB/Swiss-Prot), A6K5X6 (UniProtKB/TrEMBL), G3V696 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MEGESTLGVLSGFVLGALTFQHLNTDSDTEGLLLGEMKGEAKNSITDSQMDSVKVVYTIDIQKY
IPCYRLFSFYNSLGEVNEHALKKILSNVKKTVVGWYKFRRHSDQIMTFREQLLHRNLQTHLSSP
ELVFLLLTPSITTESCCTHCLEHGLYKPQSGLFHKVPLVVTNLGMSDQLGYKTESVSCTSTVFS
RAVRTYSSQFFNEDGSLKEVRKINEMYAAIQEELKTICQKVEQSEREVEKLLMDVNRLKEVRKK
QQAQAKGAGEKSQNHPQENILLCQALRTFFPESRVLHSCVISLKNRHISHSGCNTDHHLDVVDK
LTLMVEYVYSPEASPAPAAPLSKRKALDTQDQWPAKRPRLLESESRPGPAFRGSHQDKASSSSL
DIDTEVGSPEDDTDYPRSPTF

hide sequence

Ensembl Acc Id:

ENSRNOP00000002956 ⟸ ENSRNOT00000002956

RefSeq Acc Id:	XP_038947594 ⟸ XM_039091666
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_038947593 ⟸ XM_039091665
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038947592 ⟸ XM_039091664
- Peptide Label:	isoform X1
- UniProtKB:	A6K5X8 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000078807 ⟸ ENSRNOT00000117431

Protein Domains

MPN

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q5I0F1-F1-model_v2	AlphaFold	Q5I0F1	1-405	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13699189

Promoter ID:

EPDNEW_R9713

Type:

initiation region

Name:

Abraxas1_1

Description:

abraxas 1, BRCA1 A complex subunit

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	14	10,424,690 - 10,424,750	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1305287	AgrOrtholog
BioCyc Gene	G2FUF-16419	BioCyc
Ensembl Genes	ENSRNOG00000002165	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000002956.8	UniProtKB/TrEMBL
	ENSRNOT00000117431.1	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7131771	IMAGE-MGC_LOAD
InterPro	FAM175	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	FAM175_Abraxas1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	MPN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:289468	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:94265	IMAGE-MGC_LOAD
NCBI Gene	289468	ENTREZGENE
PANTHER	BRCA1-A COMPLEX SUBUNIT ABRAXAS 1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR31728	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	MPN_2A_DUB_like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Abraxas1	PhenoGen
PRINTS	ABRAXAS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PROTEINF175	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	MPN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000002165	RatGTEx
UniProt	A0A8I5ZLL6_RAT	UniProtKB/TrEMBL
	A6K5X6	ENTREZGENE, UniProtKB/TrEMBL
	A6K5X8	ENTREZGENE, UniProtKB/TrEMBL
	ABRX1_RAT	UniProtKB/Swiss-Prot
	G3V696	ENTREZGENE, UniProtKB/TrEMBL
	Q5I0F1	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2017-05-05	Abraxas1	abraxas 1, BRCA1 A complex subunit	Fam175a	family with sequence similarity 175, member A	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2009-03-24	Fam175a	family with sequence similarity 175, member A	Ccdc98	coiled-coil domain containing 98	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-06	Ccdc98	coiled-coil domain containing 98	RGD1305287	similar to RIKEN cDNA 3830405G04	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-12-06	RGD1305287	similar to RIKEN cDNA 3830405G04	RGD1305287_predicted	similar to RIKEN cDNA 3830405G04 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-20	RGD1305287_predicted	similar to RIKEN cDNA 3830405G04 (predicted)	LOC289468_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC289468_predicted	similar to RIKEN cDNA 3830405G04 (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar