Lims2 (LIM zinc finger domain containing 2) - Rat Genome Database

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Gene: Lims2 (LIM zinc finger domain containing 2) Rattus norvegicus
Analyze
Symbol: Lims2
Name: LIM zinc finger domain containing 2
RGD ID: 1305273
Description: Predicted to enable metal ion binding activity. Predicted to be involved in several processes, including cell-cell junction organization; positive regulation of integrin-mediated signaling pathway; and positive regulation of substrate adhesion-dependent cell spreading. Predicted to act upstream of or within negative regulation of apoptotic process and negative regulation of cell population proliferation. Predicted to be located in plasma membrane. Predicted to be active in cell-cell junction; cytoplasm; and focal adhesion. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy type 2W. Orthologous to human LIMS2 (LIM zinc finger domain containing 2); PARTICIPATES IN integrin mediated signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LIM and senescent cell antigen like domains 2; LIM and senescent cell antigen-like-containing domain protein 2; LIM-type zinc finger domains 2; LOC361303
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81823,828,164 - 23,866,363 (+)NCBIGRCr8
mRatBN7.21823,553,937 - 23,592,137 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1823,553,937 - 23,592,137 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1823,682,035 - 23,720,226 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01824,431,078 - 24,469,221 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01823,777,003 - 23,815,196 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01824,707,951 - 24,746,159 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1824,708,115 - 24,746,159 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01824,422,274 - 24,460,482 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41824,347,374 - 24,386,082 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11824,374,019 - 24,412,728 (+)NCBI
Celera1823,306,381 - 23,344,707 (+)NCBICelera
Cytogenetic Map18p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
amitrole  (EXP)
antirheumatic drug  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP)
bisphenol F  (ISO)
buta-1,3-diene  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
cisplatin  (EXP,ISO)
clotrimazole  (EXP)
cobalt dichloride  (ISO)
cocaine  (EXP)
copper(II) sulfate  (ISO)
cumene  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
diuron  (EXP)
endosulfan  (EXP)
epoxiconazole  (ISO)
ferric oxide  (ISO)
folic acid  (ISO)
hydrogen cyanide  (ISO)
lead diacetate  (EXP)
mercury atom  (ISO)
mercury(0)  (ISO)
methamphetamine  (ISO)
methapyrilene  (EXP,ISO)
methimazole  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
nefazodone  (EXP)
ozone  (ISO)
pentanal  (ISO)
perfluorooctanoic acid  (EXP)
pirinixic acid  (ISO)
poly(I:C)  (ISO)
potassium cyanide  (ISO)
propanal  (ISO)
rotenone  (EXP)
silicon dioxide  (ISO)
succimer  (ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (EXP,ISO)
tremolite asbestos  (ISO)
trichloroethene  (EXP)
triclosan  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ILK, PINCH and parvin: the tIPP of integrin signalling. Legate KR, etal., Nat Rev Mol Cell Biol. 2006 Jan;7(1):20-31.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:12651156   PMID:19652092   PMID:21423176   PMID:24058607   PMID:24719101  


Genomics

Comparative Map Data
Lims2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81823,828,164 - 23,866,363 (+)NCBIGRCr8
mRatBN7.21823,553,937 - 23,592,137 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1823,553,937 - 23,592,137 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1823,682,035 - 23,720,226 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01824,431,078 - 24,469,221 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01823,777,003 - 23,815,196 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01824,707,951 - 24,746,159 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1824,708,115 - 24,746,159 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01824,422,274 - 24,460,482 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41824,347,374 - 24,386,082 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11824,374,019 - 24,412,728 (+)NCBI
Celera1823,306,381 - 23,344,707 (+)NCBICelera
Cytogenetic Map18p12NCBI
LIMS2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382127,638,426 - 127,681,786 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2127,638,381 - 127,681,786 (-)EnsemblGRCh38hg38GRCh38
GRCh372128,396,001 - 128,439,360 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362128,112,471 - 128,138,590 (-)NCBINCBI36Build 36hg18NCBI36
Build 342128,112,232 - 128,138,343NCBI
Celera2121,706,938 - 121,750,307 (-)NCBICelera
Cytogenetic Map2q14.3NCBI
HuRef2120,702,371 - 120,745,600 (-)NCBIHuRef
CHM1_12128,400,424 - 128,443,742 (-)NCBICHM1_1
T2T-CHM13v2.02128,073,680 - 128,117,027 (-)NCBIT2T-CHM13v2.0
Lims2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391832,055,346 - 32,091,673 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1832,055,343 - 32,091,672 (+)EnsemblGRCm39 Ensembl
GRCm381831,922,293 - 31,958,620 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1831,922,290 - 31,958,619 (+)EnsemblGRCm38mm10GRCm38
MGSCv371832,091,161 - 32,118,273 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361832,074,517 - 32,101,629 (+)NCBIMGSCv36mm8
Celera1832,422,000 - 32,448,987 (+)NCBICelera
Cytogenetic Map18B1NCBI
cM Map1817.89NCBI
Lims2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554592,864,580 - 2,914,263 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554592,874,282 - 2,913,956 (+)NCBIChiLan1.0ChiLan1.0
LIMS2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21347,962,453 - 48,005,844 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B47,977,422 - 48,020,823 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B32,594,330 - 32,637,697 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B128,304,799 - 128,347,951 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B128,304,799 - 128,347,951 (-)Ensemblpanpan1.1panPan2
LIMS2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11922,932,251 - 22,978,437 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1922,931,779 - 22,982,765 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1923,179,486 - 23,225,586 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01924,258,143 - 24,304,404 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1924,263,562 - 24,304,401 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11922,962,031 - 23,008,263 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01923,156,801 - 23,202,782 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01924,288,646 - 24,334,679 (+)NCBIUU_Cfam_GSD_1.0
Lims2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530397,952,575 - 97,989,447 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646943,634,074 - 43,665,175 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493646943,628,280 - 43,665,145 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LIMS2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1559,672,540 - 59,709,379 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11559,672,508 - 59,709,380 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21566,435,456 - 66,458,874 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LIMS2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1102,540,383 - 2,578,117 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl102,543,091 - 2,579,332 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606120,181,687 - 20,218,054 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lims2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473214,102,543 - 14,144,722 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473214,102,543 - 14,144,479 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Lims2
179 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:134
Count of miRNA genes:99
Interacting mature miRNAs:117
Transcripts:ENSRNOT00000061054
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2301410Bp317Blood pressure QTL 3170.004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181194427326548295Rat
1358358Sradr6Stress Responsive Adrenal Weight QTL 62.49adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)181194429959330563Rat
1331735Rf44Renal function QTL 442.981urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)181823456431359530Rat
61382Bp46Blood pressure QTL 4618.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194179131393320Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182137289383213037Rat
8552968Pigfal19Plasma insulin-like growth factor 1 level QTL 1911.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)18125758124Rat
61388Bp2Blood pressure QTL 23.23arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)18135374722Rat
1331781Scl28Serum cholesterol level QTL 283.995blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)181194429924797117Rat
6903359Bp355Blood pressure QTL 3553.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194454459796478Rat
2313082Bss85Bone structure and strength QTL 850.80.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)181495133759951337Rat
1641923Colcr8Colorectal carcinoma resistance QTL 83.10.0014intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)182206624252293055Rat
2312568Glom21Glomerulus QTL 2120.005kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)18518585840503530Rat
1331766Bp236Blood pressure QTL 2363.022arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181194429931359530Rat
1358193Emca2Estrogen-induced mammary cancer QTL 21.6mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)181800759963571040Rat
631264Scl22Serum cholesterol level QTL 226.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)181194179131393320Rat
1331775Bp235Blood pressure QTL 2353.201arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181823456431359530Rat
12904680Bw189Body weight QTL 1890.019body mass (VT:0001259)body weight (CMO:0000012)181194427326548295Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181927890183218561Rat
2293708Bss46Bone structure and strength QTL 468.80.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)181179151863636873Rat
12904693Am20Aortic mass QTL 200.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)181194427326548295Rat
9589153Insul31Insulin level QTL 317.150.05blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)18142547119Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181179151883218561Rat
12904695Kidm73Kidney mass QTL 730.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)181194427326548295Rat
2312598Bp340Blood pressure QTL 3400.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)18130558703Rat
12904689Cm128Cardiac mass QTL 1280.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)181194427326548295Rat
12904690Cm129Cardiac mass QTL 1290.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)181194427326548295Rat
2300180Bmd67Bone mineral density QTL 674.80.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)18134291613Rat
12904691Cm130Cardiac mass QTL 1300.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)181194427326548295Rat
9590248Scort10Serum corticosterone level QTL 1019.710.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)18125758124Rat
2299160Iddm35Insulin dependent diabetes mellitus QTL 352.79blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)18420794160377792Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181179151883218561Rat
1331753Bp231Blood pressure QTL 2313.643arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194429952293055Rat
2293661Bss50Bone structure and strength QTL 504.640.0003lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)18134291613Rat
61375Bp41Blood pressure QTL 412.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)181194429941122201Rat

Markers in Region
BE105871  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21823,571,172 - 23,571,329 (+)MAPPERmRatBN7.2
Rnor_6.01824,725,199 - 24,725,355NCBIRnor6.0
Rnor_5.01824,439,522 - 24,439,678UniSTSRnor5.0
RGSC_v3.41824,365,122 - 24,365,278UniSTSRGSC3.4
Celera1823,323,749 - 23,323,905UniSTS
RH 3.4 Map18301.5UniSTS
Cytogenetic Map18p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 111 91 90 59 25 59 6 218 97 91 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000061054   ⟹   ENSRNOP00000057770
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1823,553,937 - 23,592,137 (+)Ensembl
Rnor_6.0 Ensembl1824,708,115 - 24,746,159 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000090923   ⟹   ENSRNOP00000075365
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1823,563,359 - 23,592,137 (+)Ensembl
Rnor_6.0 Ensembl1824,717,336 - 24,745,747 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000112249   ⟹   ENSRNOP00000092203
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1823,563,464 - 23,592,134 (+)Ensembl
RefSeq Acc Id: NM_001012163   ⟹   NP_001012163
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81823,828,164 - 23,866,363 (+)NCBI
mRatBN7.21823,553,937 - 23,592,137 (+)NCBI
Rnor_6.01824,708,115 - 24,746,159 (+)NCBI
Rnor_5.01824,422,274 - 24,460,482 (+)NCBI
RGSC_v3.41824,347,374 - 24,386,082 (+)RGD
Celera1823,306,381 - 23,344,707 (+)RGD
Sequence:
RefSeq Acc Id: NM_001415697   ⟹   NP_001402626
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81823,837,704 - 23,866,363 (+)NCBI
mRatBN7.21823,563,477 - 23,592,137 (+)NCBI
RefSeq Acc Id: NM_001415698   ⟹   NP_001402627
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81823,837,704 - 23,866,363 (+)NCBI
mRatBN7.21823,563,477 - 23,592,137 (+)NCBI
RefSeq Acc Id: NP_001012163   ⟸   NM_001012163
- Peptide Label: isoform 1
- UniProtKB: A0A8I6GK29 (UniProtKB/TrEMBL),   A6J2P7 (UniProtKB/TrEMBL),   A0A0G2KAE1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000057770   ⟸   ENSRNOT00000061054
Ensembl Acc Id: ENSRNOP00000075365   ⟸   ENSRNOT00000090923
Ensembl Acc Id: ENSRNOP00000092203   ⟸   ENSRNOT00000112249
RefSeq Acc Id: NP_001402627   ⟸   NM_001415698
- Peptide Label: isoform 1
- UniProtKB: A0A8I6GK29 (UniProtKB/TrEMBL),   A6J2P7 (UniProtKB/TrEMBL),   A0A0G2KAE1 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001402626   ⟸   NM_001415697
- Peptide Label: isoform 2
- UniProtKB: A6J2P6 (UniProtKB/TrEMBL),   A0A0G2KAE1 (UniProtKB/TrEMBL)
Protein Domains
LIM zinc-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2KAE1-F1-model_v2 AlphaFold A0A0G2KAE1 1-341 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700680
Promoter ID:EPDNEW_R11202
Type:initiation region
Name:Lims2_1
Description:LIM zinc finger domain containing 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R11203  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01824,708,103 - 24,708,163EPDNEW
RGD ID:13700679
Promoter ID:EPDNEW_R11203
Type:multiple initiation site
Name:Lims2_2
Description:LIM zinc finger domain containing 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R11202  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01824,717,512 - 24,717,572EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305273 AgrOrtholog
BioCyc Gene G2FUF-8048 BioCyc
Ensembl Genes ENSRNOG00000016021 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000061054.3 UniProtKB/TrEMBL
  ENSRNOT00000090923.2 UniProtKB/TrEMBL
  ENSRNOT00000112249.1 UniProtKB/TrEMBL
Gene3D-CATH Cysteine Rich Protein UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7193274 IMAGE-MGC_LOAD
InterPro LIMS1/2-like_LIM1 UniProtKB/TrEMBL
  PINCH-1/2-like UniProtKB/TrEMBL
  Znf_LIM UniProtKB/TrEMBL
KEGG Report rno:361303 UniProtKB/TrEMBL
MGC_CLONE MGC:94717 IMAGE-MGC_LOAD
NCBI Gene 361303 ENTREZGENE
PANTHER LIM AND SENESCENT CELL ANTIGEN-LIKE-CONTAINING DOMAIN PROTEIN 2 UniProtKB/TrEMBL
  PTHR24210 UniProtKB/TrEMBL
Pfam LIM UniProtKB/TrEMBL
PhenoGen Lims2 PhenoGen
PIRSF PINCH UniProtKB/TrEMBL
PROSITE LIM_DOMAIN_1 UniProtKB/TrEMBL
  LIM_DOMAIN_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016021 RatGTEx
SMART LIM UniProtKB/TrEMBL
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/TrEMBL
UniProt A0A0G2KAE1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GK29 ENTREZGENE, UniProtKB/TrEMBL
  A6J2P6 ENTREZGENE, UniProtKB/TrEMBL
  A6J2P7 ENTREZGENE, UniProtKB/TrEMBL
  Q5PQM7_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-17 Lims2  LIM zinc finger domain containing 2  Lims2  LIM-type zinc finger domains 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-01-13 Lims2  LIM-type zinc finger domains 2  Lims2  LIM and senescent cell antigen like domains 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Lims2  LIM and senescent cell antigen like domains 2  Lims2_predicted  LIM and senescent cell antigen like domains 2 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Lims2_predicted  LIM and senescent cell antigen like domains 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED