Cldn22 (claudin 22) - Rat Genome Database

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Gene: Cldn22 (claudin 22) Rattus norvegicus
Analyze
Symbol: Cldn22
Name: claudin 22
RGD ID: 1305271
Description: Predicted to enable structural molecule activity. Predicted to be involved in bicellular tight junction assembly and cell adhesion. Predicted to be located in anchoring junction and lateral plasma membrane. Predicted to be active in bicellular tight junction and plasma membrane. Orthologous to human CLDN22 (claudin 22); PARTICIPATES IN hepatitis C pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,3',5,5'-tetrabromobisphenol A; alpha-Zearalanol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: claudin-22; LOC306454
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81651,155,058 - 51,156,084 (-)NCBIGRCr8GRCr8GRCr8
mRatBN7.21644,422,344 - 44,423,370 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1644,422,345 - 44,423,354 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1649,828,702 - 49,829,711 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01653,189,273 - 53,190,282 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01648,466,312 - 48,467,321 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01647,534,349 - 47,535,358 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1647,534,349 - 47,535,358 (-)Ensemblrn6Rnor6.0
Rnor_5.01647,255,003 - 47,256,012 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41647,624,778 - 47,625,787 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1642,434,491 - 42,435,500 (-)NCBICelera
RGSC_v3.11647,625,152 - 47,625,815 (-)NCBI
Cytogenetic Map16q11NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:18036336  


Genomics

Comparative Map Data
Cldn22
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81651,155,058 - 51,156,084 (-)NCBIGRCr8GRCr8GRCr8
mRatBN7.21644,422,344 - 44,423,370 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1644,422,345 - 44,423,354 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1649,828,702 - 49,829,711 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01653,189,273 - 53,190,282 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01648,466,312 - 48,467,321 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01647,534,349 - 47,535,358 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1647,534,349 - 47,535,358 (-)Ensemblrn6Rnor6.0
Rnor_5.01647,255,003 - 47,256,012 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41647,624,778 - 47,625,787 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1642,434,491 - 42,435,500 (-)NCBICelera
RGSC_v3.11647,625,152 - 47,625,815 (-)NCBI
Cytogenetic Map16q11NCBI
CLDN22
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384183,318,100 - 183,320,276 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4183,318,100 - 183,320,276 (-)Ensemblhg38GRCh38
GRCh374184,239,253 - 184,241,429 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364184,473,564 - 184,478,921 (-)NCBIBuild 36Build 36hg18NCBI36
Build 344184,614,368 - 184,616,470NCBI
Celera4181,573,166 - 181,575,874 (-)NCBICelera
Cytogenetic Map4q35.1NCBI
HuRef4179,999,556 - 180,002,264 (-)NCBIHuRef
CHM1_14184,215,665 - 184,218,373 (-)NCBICHM1_1
T2T-CHM13v2.04186,661,555 - 186,663,732 (-)NCBIT2T-CHM13v2.0
Cldn22
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39848,277,501 - 48,278,511 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl848,277,517 - 48,278,511 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38847,824,482 - 47,825,475 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl847,824,482 - 47,825,476 (+)Ensemblmm10GRCm38
MGSCv37848,909,836 - 48,910,829 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36849,323,346 - 49,324,008 (+)NCBIMGSCv36mm8
Celera850,502,634 - 50,503,627 (+)NCBICelera
Cytogenetic Map8B1.1NCBI
cM Map826.91NCBI
Cldn22
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495540325,480,063 - 25,481,646 (+)NCBIChiLan1.0ChiLan1.0
LOC103786942
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23181,051,012 - 181,052,741 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14181,415,980 - 181,417,889 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04175,494,516 - 175,496,676 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14187,721,030 - 187,723,720 (-)NCBIPanPan1.1PanPan1.1panPan2
LOC482919
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11647,011,100 - 47,013,362 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1647,444,891 - 47,446,417 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01649,235,475 - 49,237,001 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1649,236,014 - 49,236,676 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11647,197,164 - 47,198,688 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01647,811,558 - 47,813,094 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01647,952,197 - 47,953,733 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
CLDN22
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1544,804,228 - 44,804,908 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11544,804,228 - 44,804,908 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21551,416,948 - 51,417,627 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103236594
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17129,291,766 - 129,298,689 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl7129,296,373 - 129,297,035 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666037109,505,791 - 109,509,966 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Cldn22
19 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:97
Count of miRNA genes:79
Interacting mature miRNAs:85
Transcripts:ENSRNOT00000040731
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)164445512389455123Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)163692878281928782Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)164199206486992064Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16423421266955197Rat
2302057Pia29Pristane induced arthritis QTL 293.60.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)162846870173468701Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164909919691442908Rat
1357403Slep4Serum leptin concentration QTL 43.91blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)163236104377361043Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16423421253708481Rat
631833Sach2Saccharin preference QTL 240.01consumption behavior trait (VT:0002069)calculated saccharin drink intake rate (CMO:0001613)164975766656898388Rat
8694453Bw172Body weight QTL 1728.330.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)163105803976058039Rat
1298529Arunc1Aerobic running capacity QTL 14exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)163439829479398294Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683908666195506Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683908666195506Rat
6903294Stl30Serum triglyceride level QTL 302.60.0013blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)163188527176885271Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)164445512389455123Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683908666195506Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161773081872536785Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683908652786090Rat
2301406Kidm39Kidney mass QTL 390.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)161590580260905802Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683908666195506Rat

Markers in Region
RH138522  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21644,422,354 - 44,422,538 (+)MAPPERmRatBN7.2
Rnor_6.01647,534,359 - 47,534,542NCBIRnor6.0
Rnor_5.01647,255,013 - 47,255,196UniSTSRnor5.0
RGSC_v3.41647,624,788 - 47,624,971UniSTSRGSC3.4
Celera1642,434,501 - 42,434,684UniSTS
Cytogenetic Map16q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
13 12 49 109 49 48 17 25 17 6 200 106 9 88 56 83 31 8 8

Sequence


Ensembl Acc Id: ENSRNOT00000040731   ⟹   ENSRNOP00000050527
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1644,422,345 - 44,423,354 (-)Ensembl
Rnor_6.0 Ensembl1647,534,349 - 47,535,358 (-)Ensembl
RefSeq Acc Id: NM_001110143   ⟹   NP_001103613
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81651,155,058 - 51,156,084 (-)NCBI
mRatBN7.21644,422,344 - 44,423,370 (-)NCBI
Rnor_6.01647,534,349 - 47,535,358 (-)NCBI
Rnor_5.01647,255,003 - 47,256,012 (-)NCBI
RGSC_v3.41647,624,778 - 47,625,787 (-)RGD
Celera1642,434,491 - 42,435,500 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001103613 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL78920 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001103613   ⟸   NM_001110143
- UniProtKB: D3ZEF2 (UniProtKB/TrEMBL),   A6JPK2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000050527   ⟸   ENSRNOT00000040731

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZEF2-F1-model_v2 AlphaFold D3ZEF2 1-220 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305271 AgrOrtholog
BioCyc Gene G2FUF-11418 BioCyc
Ensembl Genes ENSRNOG00000030889 Ensembl
Gene3D-CATH 1.20.140.150 UniProtKB/TrEMBL
InterPro Claudin UniProtKB/TrEMBL
  Claudin_CS UniProtKB/TrEMBL
  PMP22/EMP/MP20/Claudin UniProtKB/TrEMBL
KEGG Report rno:306454 UniProtKB/TrEMBL
NCBI Gene 306454 ENTREZGENE
PANTHER Claudin UniProtKB/TrEMBL
Pfam PMP22_Claudin UniProtKB/TrEMBL
PhenoGen Cldn22 PhenoGen
PRINTS CLAUDIN UniProtKB/TrEMBL
PROSITE CLAUDIN UniProtKB/TrEMBL
  PROKAR_LIPOPROTEIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000030889 RatGTEx
UniProt A6JPK2 ENTREZGENE, UniProtKB/TrEMBL
  D3ZEF2 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Cldn22  claudin 22   Cldn22_predicted  claudin 22 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Cldn22_predicted  claudin 22 (predicted)      Symbol and Name status set to approved 70820 APPROVED