Topors (TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase) - Rat Genome Database

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Gene: Topors (TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase) Rattus norvegicus
Analyze
Symbol: Topors
Name: TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase
RGD ID: 1305270
Description: Predicted to enable several functions, including DNA topoisomerase binding activity; antigen binding activity; and ubiquitin-like protein transferase activity. Predicted to be involved in several processes, including intrinsic apoptotic signaling pathway in response to DNA damage; maintenance of protein location in nucleus; and protein modification by small protein conjugation. Predicted to act upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; positive regulation of DNA-templated transcription; and regulation of cell population proliferation. Predicted to be located in PML body; centriole; and spindle pole. Predicted to be part of gamma-tubulin complex and ubiquitin ligase complex. Predicted to be active in ciliary basal body; nuclear speck; and photoreceptor connecting cilium. Human ortholog(s) of this gene implicated in retinitis pigmentosa 31. Orthologous to human TOPORS (TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; cadmium dichloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: E3 ubiquitin-protein ligase Topors; LOC362501; TOP1 binding arginine/serine rich protein; topoisomerase I binding, arginine/serine-rich; topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8560,184,076 - 60,195,979 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl560,182,035 - 60,194,706 (-)EnsemblGRCr8
mRatBN7.2555,388,033 - 55,399,937 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl555,387,632 - 55,399,937 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx557,354,241 - 57,365,824 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0559,173,382 - 59,184,966 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0559,145,077 - 59,156,688 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0556,554,956 - 56,566,503 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl556,554,969 - 56,567,320 (-)Ensemblrn6Rnor6.0
Rnor_5.0561,098,846 - 61,110,393 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4557,663,121 - 57,676,619 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera554,004,376 - 54,015,952 (-)NCBICelera
RGSC_v3.1557,663,337 - 57,676,660 (-)NCBI
Cytogenetic Map5q22NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
centriole  (IEA,ISO)
ciliary basal body  (IEA,ISO)
gamma-tubulin complex  (IEA,ISO)
nuclear speck  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IEA,ISO)
photoreceptor connecting cilium  (IEA,ISO)
PML body  (IEA,ISO)
spindle pole  (IEA,ISO)
ubiquitin ligase complex  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10352183   PMID:10415337   PMID:11278651   PMID:14516784   PMID:15247280   PMID:15735665   PMID:17803295   PMID:18077445   PMID:19473992   PMID:20188669   PMID:21159800   PMID:26872363  


Genomics

Comparative Map Data
Topors
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8560,184,076 - 60,195,979 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl560,182,035 - 60,194,706 (-)EnsemblGRCr8
mRatBN7.2555,388,033 - 55,399,937 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl555,387,632 - 55,399,937 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx557,354,241 - 57,365,824 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0559,173,382 - 59,184,966 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0559,145,077 - 59,156,688 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0556,554,956 - 56,566,503 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl556,554,969 - 56,567,320 (-)Ensemblrn6Rnor6.0
Rnor_5.0561,098,846 - 61,110,393 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4557,663,121 - 57,676,619 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera554,004,376 - 54,015,952 (-)NCBICelera
RGSC_v3.1557,663,337 - 57,676,660 (-)NCBI
Cytogenetic Map5q22NCBI
TOPORS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38932,540,544 - 32,552,586 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl932,540,544 - 32,552,603 (-)Ensemblhg38GRCh38
GRCh37932,540,542 - 32,552,584 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36932,530,542 - 32,542,601 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34932,530,542 - 32,542,601NCBI
Celera932,471,749 - 32,483,828 (-)NCBICelera
Cytogenetic Map9p21.1NCBI
HuRef932,496,996 - 32,509,408 (-)NCBIHuRef
CHM1_1932,540,543 - 32,552,661 (-)NCBICHM1_1
T2T-CHM13v2.0932,556,707 - 32,568,751 (-)NCBIT2T-CHM13v2.0
Topors
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39440,259,606 - 40,269,841 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl440,259,601 - 40,269,850 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38440,259,606 - 40,269,841 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl440,259,601 - 40,269,850 (-)Ensemblmm10GRCm38
MGSCv37440,206,639 - 40,216,874 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36440,443,970 - 40,458,496 (-)NCBIMGSCv36mm8
Celera439,922,611 - 39,932,846 (-)NCBICelera
Cytogenetic Map4A5NCBI
cM Map420.24NCBI
Topors
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554723,073,090 - 3,076,607 (+)NCBIChiLan1.0ChiLan1.0
TOPORS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21192,062,236 - 92,074,228 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1992,068,174 - 92,091,206 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0932,314,850 - 32,327,067 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1933,124,730 - 33,136,923 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl933,124,730 - 33,135,129 (-)EnsemblpanPan2panpan1.1
TOPORS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11149,809,156 - 49,821,224 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1149,809,465 - 49,821,075 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1148,431,713 - 48,443,289 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01150,750,269 - 50,761,842 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1150,750,578 - 50,761,831 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11149,413,336 - 49,424,903 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01149,279,886 - 49,291,445 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01150,038,557 - 50,050,130 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Topors
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947164,671,640 - 164,682,295 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365241,219,907 - 1,229,723 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365241,219,101 - 1,229,937 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TOPORS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1033,865,959 - 33,879,070 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11033,865,967 - 33,878,135 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21038,119,298 - 38,131,555 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TOPORS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11247,702,638 - 47,714,309 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1247,702,995 - 47,714,338 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603844,594,963 - 44,606,860 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Topors
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473637,210,291 - 37,221,747 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473637,209,709 - 37,221,921 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Topors
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11117,933,170 - 117,944,533 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Topors
29 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:63
Count of miRNA genes:50
Interacting mature miRNAs:60
Transcripts:ENSRNOT00000066081
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578776Stresp18Stress response QTL 182.9thymus mass (VT:0004954)thymus wet weight (CMO:0000855)53275164977751649Rat
1298067Scl15Serum cholesterol level QTL 154.80.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53801167083011670Rat
1300115Hrtrt7Heart rate QTL 72.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)55266537294894052Rat
6907115Mcs29Mammary carcinoma susceptibility QTL 29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)53800433183004331Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)544924861153890773Rat
1358353Srcrtb2Stress Responsive Cort Basal QTL 23.480.003blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)52367149379046465Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)538207390136631402Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)51757663362576633Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)548523123134369373Rat
1578774Tcas8Tongue tumor susceptibility QTL 83.47tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)51570745160707451Rat
1598807Glom12Glomerulus QTL 122.7kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)53801167083011670Rat
1302786Kidm8Kidney mass QTL 828.15kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)53801167083011670Rat
1331782Rf36Renal function QTL 363.296kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)539019942102105896Rat
6903292Stl28Serum triglyceride level QTL 282.60.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)53331167378311673Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)551657967166600247Rat
1578767Stresp17Stress response QTL 174.30.01blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)53275164977751649Rat
1641922Alcrsp8Alcohol response QTL 8alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)51748608062486080Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)53998594884985948Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)5692228281330203Rat
6903306Scl35Serum cholesterol QTL 352.60.0073blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53331167378311673Rat
1576317Eutr2Estrogen induced uterine response QTL 20.01uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)53952692484526924Rat
1331773Scl26Serum cholesterol level QTL 263.065blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)54852312391770353Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)51001906491770353Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5706553574335773Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)536460764136631402Rat
1641903Alcrsp3Alcohol response QTL 3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)51748608062486080Rat
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)51001906487027358Rat
8552954Pigfal14Plasma insulin-like growth factor 1 level QTL 149blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)52602321171023211Rat
2303577Gluco47Glucose level QTL 473blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51652001961520019Rat
2316959Gluco59Glucose level QTL 594.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)556546393101546393Rat
1600358Mamtr5Mammary tumor resistance QTL 5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)52367149368671493Rat

Markers in Region
AW105885  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2555,388,138 - 55,388,251 (+)MAPPERmRatBN7.2
Rnor_6.0556,555,062 - 56,555,174NCBIRnor6.0
Rnor_5.0561,098,952 - 61,099,064UniSTSRnor5.0
RGSC_v3.4557,663,227 - 57,663,339UniSTSRGSC3.4
Celera554,004,482 - 54,004,594UniSTS
Cytogenetic Map5q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000066081   ⟹   ENSRNOP00000063561
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl560,182,035 - 60,194,706 (-)Ensembl
mRatBN7.2 Ensembl555,388,041 - 55,398,684 (-)Ensembl
Rnor_6.0 Ensembl556,554,969 - 56,567,320 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000116027   ⟹   ENSRNOP00000095797
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl555,388,049 - 55,399,937 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000119019   ⟹   ENSRNOP00000077956
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl560,182,035 - 60,187,587 (-)Ensembl
mRatBN7.2 Ensembl555,387,632 - 55,398,560 (-)Ensembl
RefSeq Acc Id: NM_001108658   ⟹   NP_001102128
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8560,184,076 - 60,195,979 (-)NCBI
mRatBN7.2555,388,033 - 55,399,937 (-)NCBI
Rnor_6.0556,554,956 - 56,566,503 (-)NCBI
Rnor_5.0561,098,846 - 61,110,393 (-)NCBI
RGSC_v3.4557,663,121 - 57,676,619 (-)RGD
Celera554,004,376 - 54,015,952 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001102128 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL98629 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000063561.3
  ENSRNOP00000077956.1
RefSeq Acc Id: NP_001102128   ⟸   NM_001108658
- UniProtKB: D3ZZE0 (UniProtKB/TrEMBL),   A0A8I6ANV8 (UniProtKB/TrEMBL),   A6IIQ9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000063561   ⟸   ENSRNOT00000066081
Ensembl Acc Id: ENSRNOP00000077956   ⟸   ENSRNOT00000119019
Ensembl Acc Id: ENSRNOP00000095797   ⟸   ENSRNOT00000116027
Protein Domains
RING-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZZE0-F1-model_v2 AlphaFold D3ZZE0 1-1042 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693629
Promoter ID:EPDNEW_R4154
Type:initiation region
Name:Topors_1
Description:TOP1 binding arginine/serine rich protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0556,566,461 - 56,566,521EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305270 AgrOrtholog
BioCyc Gene G2FUF-41603 BioCyc
Ensembl Genes ENSRNOG00000006485 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000066081.4 UniProtKB/TrEMBL
  ENSRNOT00000119019.2 UniProtKB/TrEMBL
Gene3D-CATH 3.30.40.10 UniProtKB/TrEMBL
InterPro Znf_C3HC4_RING-type UniProtKB/TrEMBL
  Znf_RING UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
  Znf_RING_CS UniProtKB/TrEMBL
KEGG Report rno:362501 UniProtKB/TrEMBL
NCBI Gene 362501 ENTREZGENE
PANTHER E3 UBIQUITIN-PROTEIN LIGASE TOPORS UniProtKB/TrEMBL
  E3 UBIQUITIN-PROTEIN LIGASE TOPORS UniProtKB/TrEMBL
Pfam zf-C3HC4 UniProtKB/TrEMBL
PhenoGen Topors PhenoGen
PROSITE ZF_RING_1 UniProtKB/TrEMBL
  ZF_RING_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000006485 RatGTEx
SMART RING UniProtKB/TrEMBL
Superfamily-SCOP RING/U-box UniProtKB/TrEMBL
UniProt A0A8I6ANV8 ENTREZGENE
  A6IIQ9 ENTREZGENE, UniProtKB/TrEMBL
  D3ZZE0 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A0A8I5Y285 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-04-28 Topors  TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase  Topors  TOP1 binding arginine/serine rich protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-04-27 Topors  TOP1 binding arginine/serine rich protein  Topors  topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-08-01 Topors  topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase  Topors  topoisomerase I binding, arginine/serine-rich  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Topors  topoisomerase I binding, arginine/serine-rich   Topors_predicted  topoisomerase I binding, arginine/serine-rich (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Topors_predicted  topoisomerase I binding, arginine/serine-rich (predicted)      Symbol and Name status set to approved 70820 APPROVED