Amotl1 (angiomotin-like 1) - Rat Genome Database

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Gene: Amotl1 (angiomotin-like 1) Rattus norvegicus
Analyze
Symbol: Amotl1
Name: angiomotin-like 1
RGD ID: 1305268
Description: Predicted to enable identical protein binding activity. Predicted to act upstream of or within establishment of cell polarity involved in ameboidal cell migration; establishment of epithelial cell polarity; and positive regulation of blood vessel endothelial cell migration. Predicted to be located in several cellular components, including apical plasma membrane; bicellular tight junction; and lamellipodium. Predicted to be part of COP9 signalosome. Orthologous to human AMOTL1 (angiomotin like 1); INTERACTS WITH 17beta-estradiol; bisphenol A; glyphosate.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: angiomotin-like protein 1; LOC315430
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8819,630,139 - 19,749,027 (-)NCBIGRCr8
mRatBN7.2811,348,651 - 11,467,564 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl811,353,674 - 11,467,573 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0813,037,265 - 13,157,701 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl813,042,641 - 13,109,487 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0812,982,311 - 13,099,471 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4811,296,503 - 11,392,970 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1811,296,994 - 11,394,851 (-)NCBI
Celera812,842,189 - 12,874,526 (-)NCBICelera
Cytogenetic Map8q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11733531   PMID:16019084   PMID:17397395   PMID:18850735   PMID:19590046  


Genomics

Comparative Map Data
Amotl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8819,630,139 - 19,749,027 (-)NCBIGRCr8
mRatBN7.2811,348,651 - 11,467,564 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl811,353,674 - 11,467,573 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0813,037,265 - 13,157,701 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl813,042,641 - 13,109,487 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0812,982,311 - 13,099,471 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4811,296,503 - 11,392,970 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1811,296,994 - 11,394,851 (-)NCBI
Celera812,842,189 - 12,874,526 (-)NCBICelera
Cytogenetic Map8q12NCBI
AMOTL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381194,706,460 - 94,876,748 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1194,706,431 - 94,876,748 (+)EnsemblGRCh38hg38GRCh38
GRCh371194,501,522 - 94,609,913 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361194,141,156 - 94,249,566 (+)NCBINCBI36Build 36hg18NCBI36
Build 341194,141,184 - 94,251,003NCBI
Celera1191,789,295 - 91,897,678 (+)NCBICelera
Cytogenetic Map11q21NCBI
HuRef1190,566,554 - 90,674,939 (+)NCBIHuRef
CHM1_11194,384,453 - 94,492,924 (+)NCBICHM1_1
T2T-CHM13v2.01194,713,440 - 94,883,739 (+)NCBIT2T-CHM13v2.0
Amotl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39914,453,262 - 14,574,408 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl914,453,262 - 14,556,352 (-)EnsemblGRCm39 Ensembl
GRCm38914,541,966 - 14,662,974 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl914,541,966 - 14,645,056 (-)EnsemblGRCm38mm10GRCm38
MGSCv37914,346,410 - 14,419,444 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36914,292,363 - 14,365,393 (-)NCBIMGSCv36mm8
Celera911,822,704 - 11,895,738 (-)NCBICelera
Cytogenetic Map9A2NCBI
cM Map94.12NCBI
Amotl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955605113,570 - 245,932 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955605113,570 - 275,921 (-)NCBIChiLan1.0ChiLan1.0
AMOTL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2995,584,025 - 95,730,714 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11196,686,982 - 96,822,188 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01189,743,625 - 89,890,334 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11193,268,860 - 93,413,197 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1193,278,464 - 93,413,197 (+)Ensemblpanpan1.1panPan2
AMOTL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1216,109,600 - 6,280,025 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl216,109,683 - 6,256,060 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha216,120,727 - 6,290,996 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0216,295,578 - 6,460,498 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl216,291,262 - 6,437,052 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1216,077,936 - 6,202,162 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0216,140,874 - 6,310,947 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0216,188,761 - 6,359,356 (-)NCBIUU_Cfam_GSD_1.0
Amotl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494779,605,892 - 79,727,013 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936674156,552 - 223,685 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936674163,889 - 285,523 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AMOTL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl926,864,312 - 26,973,552 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1926,811,872 - 26,978,107 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2930,564,601 - 30,732,223 (+)NCBISscrofa10.2Sscrofa10.2susScr3
AMOTL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1185,927,458 - 86,080,239 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl185,996,908 - 86,079,857 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604339,700,123 - 39,839,962 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Amotl1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473539,435,338 - 39,539,826 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473539,393,567 - 39,544,266 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Amotl1
880 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:31
Count of miRNA genes:31
Interacting mature miRNAs:31
Transcripts:ENSRNOT00000061616
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2302367Slep5Serum leptin concentration QTL 53.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)8971246341866876Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
2317882Alcrsp24Alcohol response QTL 243.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)8125902202Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)8971222053356647Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)8767057852670578Rat
1357398Slep3Serum leptin concentration QTL 33.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)8971246341866876Rat
1354595Despr4Despair related QTL 42.160.0036locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)8768895552688955Rat
1354627Despr14Despair related QTL 140.0056locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)8768895552688955Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)8873663553736635Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)8470581049705810Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)8470581049705810Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)8470581049705810Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)8873663553736635Rat
9590084Insglur5Insulin/glucose ratio QTL 518.540.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)8124597739Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)8209764047097640Rat
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)8209764047097640Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)8209764047097640Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)8209764047097640Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 34 8 6 6 6 8 11 55 22 31 11 8
Low 3 9 49 35 13 35 19 13 10
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000061616   ⟹   ENSRNOP00000058333
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl811,353,674 - 11,400,683 (-)Ensembl
Rnor_6.0 Ensembl813,042,641 - 13,109,487 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000097452   ⟹   ENSRNOP00000077333
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl811,353,674 - 11,467,573 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000103850   ⟹   ENSRNOP00000084828
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl811,353,674 - 11,419,590 (-)Ensembl
RefSeq Acc Id: XM_039082230   ⟹   XP_038938158
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8819,630,139 - 19,749,026 (-)NCBI
mRatBN7.2811,348,651 - 11,467,563 (-)NCBI
RefSeq Acc Id: XM_039082231   ⟹   XP_038938159
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8819,630,139 - 19,749,027 (-)NCBI
mRatBN7.2811,348,651 - 11,467,564 (-)NCBI
RefSeq Acc Id: XM_039082232   ⟹   XP_038938160
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8819,630,139 - 19,749,026 (-)NCBI
mRatBN7.2811,348,651 - 11,467,563 (-)NCBI
RefSeq Acc Id: XM_039082233   ⟹   XP_038938161
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8819,630,139 - 19,701,118 (-)NCBI
mRatBN7.2811,348,651 - 11,419,581 (-)NCBI
RefSeq Acc Id: XM_039082234   ⟹   XP_038938162
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8819,630,139 - 19,701,563 (-)NCBI
mRatBN7.2811,348,651 - 11,420,094 (-)NCBI
RefSeq Acc Id: XM_063266287   ⟹   XP_063122357
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8819,630,139 - 19,701,052 (-)NCBI
RefSeq Acc Id: ENSRNOP00000058333   ⟸   ENSRNOT00000061616
RefSeq Acc Id: XP_038938159   ⟸   XM_039082231
- Peptide Label: isoform X2
- UniProtKB: F1LZQ6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038938160   ⟸   XM_039082232
- Peptide Label: isoform X3
- UniProtKB: A0A8I5Y7F3 (UniProtKB/TrEMBL),   F1LZQ6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038938158   ⟸   XM_039082230
- Peptide Label: isoform X1
- UniProtKB: F1LZQ6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038938162   ⟸   XM_039082234
- Peptide Label: isoform X6
- UniProtKB: F1LZQ6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038938161   ⟸   XM_039082233
- Peptide Label: isoform X4
- UniProtKB: A0A8I6A227 (UniProtKB/TrEMBL),   F1LZQ6 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000084828   ⟸   ENSRNOT00000103850
RefSeq Acc Id: ENSRNOP00000077333   ⟸   ENSRNOT00000097452
RefSeq Acc Id: XP_063122357   ⟸   XM_063266287
- Peptide Label: isoform X5
Protein Domains
Angiomotin C-terminal

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305268 AgrOrtholog
BioCyc Gene G2FUF-31690 BioCyc
Ensembl Genes ENSRNOG00000008990 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000061616.5 UniProtKB/TrEMBL
  ENSRNOT00000097452.1 UniProtKB/TrEMBL
  ENSRNOT00000103850.1 UniProtKB/TrEMBL
InterPro Angiomotin UniProtKB/TrEMBL
  Angiomotin_C UniProtKB/TrEMBL
NCBI Gene 315430 ENTREZGENE
PANTHER ANGIOMOTIN UniProtKB/TrEMBL
  ANGIOMOTIN-LIKE PROTEIN 1 UniProtKB/TrEMBL
Pfam Angiomotin_C UniProtKB/TrEMBL
PhenoGen Amotl1 PhenoGen
PRINTS ANGIOMOTIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000008990 RatGTEx
UniProt A0A8I5Y7F3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A227 ENTREZGENE, UniProtKB/TrEMBL
  F1LZQ6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Amotl1  angiomotin-like 1   Amotl1_predicted  angiomotin-like 1 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Amotl1_predicted  angiomotin-like 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED