Zkscan7 (zinc finger with KRAB and SCAN domains 7) - Rat Genome Database

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Gene: Zkscan7 (zinc finger with KRAB and SCAN domains 7) Rattus norvegicus
Analyze
Symbol: Zkscan7
Name: zinc finger with KRAB and SCAN domains 7
RGD ID: 1305242
Description: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to several human genes including ZKSCAN7 (zinc finger with KRAB and SCAN domains 7); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC363170; MGC189403; Zfp167; zinc finger protein 167; zinc finger protein with KRAB and SCAN domains 7; Znf167
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88131,379,514 - 131,397,065 (+)NCBIGRCr8
mRatBN7.28122,501,938 - 122,519,600 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8122,502,218 - 122,519,600 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8128,096,432 - 128,122,490 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08126,295,377 - 126,321,435 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08124,121,492 - 124,143,490 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08131,932,753 - 131,968,550 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8131,933,387 - 131,950,776 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08131,088,282 - 131,105,818 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48127,591,874 - 127,625,629 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18127,611,607 - 127,631,186 (+)NCBI
Celera8121,619,370 - 121,636,751 (+)NCBICelera
Cytogenetic Map8q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleus  (IBA)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932  


Genomics

Comparative Map Data
Zkscan7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88131,379,514 - 131,397,065 (+)NCBIGRCr8
mRatBN7.28122,501,938 - 122,519,600 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8122,502,218 - 122,519,600 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8128,096,432 - 128,122,490 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08126,295,377 - 126,321,435 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08124,121,492 - 124,143,490 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08131,932,753 - 131,968,550 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8131,933,387 - 131,950,776 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08131,088,282 - 131,105,818 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48127,591,874 - 127,625,629 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18127,611,607 - 127,631,186 (+)NCBI
Celera8121,619,370 - 121,636,751 (+)NCBICelera
Cytogenetic Map8q32NCBI
ZKSCAN7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38344,555,193 - 44,583,483 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl344,555,193 - 44,594,173 (+)EnsemblGRCh38hg38GRCh38
GRCh37344,596,685 - 44,624,975 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36344,571,717 - 44,599,979 (+)NCBINCBI36Build 36hg18NCBI36
Celera344,534,728 - 44,562,986 (+)NCBICelera
Cytogenetic Map3p21.31NCBI
HuRef344,640,894 - 44,669,146 (+)NCBIHuRef
CHM1_1344,546,810 - 44,575,076 (+)NCBICHM1_1
T2T-CHM13v2.0344,570,938 - 44,599,205 (+)NCBIT2T-CHM13v2.0
Zkscan7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399122,715,883 - 122,727,684 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9122,714,750 - 122,727,683 (+)EnsemblGRCm39 Ensembl
GRCm389122,886,818 - 122,898,619 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9122,903,246 - 122,914,154 (+)EnsemblGRCm38mm10GRCm38
GRCm38.p6 Ensembl9122,885,685 - 122,898,618 (+)EnsemblGRCm38mm10GRCm38
MGSCv379122,797,589 - 122,805,242 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369122,737,240 - 122,745,073 (+)NCBIMGSCv36mm8
Celera9123,337,974 - 123,345,620 (+)NCBICelera
Cytogenetic Map9F4NCBI
cM Map973.21NCBI
ZKSCAN7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2244,502,298 - 44,530,656 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1344,507,065 - 44,535,422 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0344,445,127 - 44,467,642 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1345,503,507 - 45,531,854 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl345,505,381 - 45,542,991 (+)Ensemblpanpan1.1panPan2
ZKSCAN7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1231,820,468 - 1,830,056 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha231,849,190 - 1,862,730 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0232,060,134 - 2,073,671 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1231,900,916 - 1,914,453 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0232,025,579 - 2,039,109 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0231,993,371 - 2,006,908 (-)NCBIUU_Cfam_GSD_1.0
LOC101959868
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118198,651,116 - 198,678,399 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366951,019,307 - 1,030,742 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366951,003,162 - 1,030,719 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ZKSCAN7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1327,839,208 - 27,855,361 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11327,839,195 - 27,856,745 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21330,515,163 - 30,530,266 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ZKSCAN7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1226,035,412 - 6,052,396 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl226,035,812 - 6,052,465 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041161,113,971 - 161,139,348 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Zkscan7
300 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:269
Count of miRNA genes:176
Interacting mature miRNAs:220
Transcripts:ENSRNOT00000043784
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)882460758122812818Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)893535351123900184Rat
1358893Bp263Blood pressure QTL 2635.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
1358903Bp252Blood pressure QTL 25270.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
738014Anxrr15Anxiety related response QTL 153.60.005locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)895718998123900184Rat
2300182Bmd56Bone mineral density QTL 565.4femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)895718998123900184Rat

Markers in Region
BE117635  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28122,517,189 - 122,517,368 (+)MAPPERmRatBN7.2
Rnor_6.08131,948,367 - 131,948,545NCBIRnor6.0
Rnor_5.08131,103,409 - 131,103,587UniSTSRnor5.0
RGSC_v3.48127,606,785 - 127,606,963UniSTSRGSC3.4
Celera8121,634,342 - 121,634,520UniSTS
RH 3.4 Map81258.5UniSTS
Cytogenetic Map8q32UniSTS
RH139140  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28122,525,915 - 122,526,053 (+)MAPPERmRatBN7.2
Rnor_6.08131,957,092 - 131,957,229NCBIRnor6.0
Rnor_5.08131,112,134 - 131,112,271UniSTSRnor5.0
RGSC_v3.48127,615,510 - 127,615,647UniSTSRGSC3.4
Celera8121,643,067 - 121,643,204UniSTS
RH 3.4 Map81260.09UniSTS
Cytogenetic Map8q32UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 3 43 57 41 19 41 8 11 74 35 41 11 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000043784   ⟹   ENSRNOP00000051121
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8122,502,218 - 122,519,600 (+)Ensembl
Rnor_6.0 Ensembl8131,933,387 - 131,950,776 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000114699   ⟹   ENSRNOP00000084377
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8122,502,218 - 122,519,600 (+)Ensembl
RefSeq Acc Id: NM_001170577   ⟹   NP_001164048
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88131,379,684 - 131,397,065 (+)NCBI
mRatBN7.28122,502,218 - 122,519,600 (+)NCBI
Rnor_6.08131,933,387 - 131,950,776 (+)NCBI
Rnor_5.08131,088,282 - 131,105,818 (+)NCBI
Celera8121,619,370 - 121,636,751 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006244199   ⟹   XP_006244261
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88131,379,517 - 131,397,065 (+)NCBI
mRatBN7.28122,501,939 - 122,519,600 (+)NCBI
Rnor_6.08131,933,370 - 131,950,776 (+)NCBI
Rnor_5.08131,088,282 - 131,105,818 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017595774   ⟹   XP_017451263
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88131,379,514 - 131,397,065 (+)NCBI
mRatBN7.28122,501,938 - 122,519,600 (+)NCBI
Rnor_6.08131,932,755 - 131,950,776 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039081822   ⟹   XP_038937750
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88131,384,438 - 131,397,065 (+)NCBI
mRatBN7.28122,506,972 - 122,519,600 (+)NCBI
RefSeq Acc Id: XM_063265857   ⟹   XP_063121927
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88131,379,538 - 131,397,065 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001164048   ⟸   NM_001170577
- UniProtKB: E9PTG0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006244261   ⟸   XM_006244199
- Peptide Label: isoform X2
- UniProtKB: E9PTG0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017451263   ⟸   XM_017595774
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000051121   ⟸   ENSRNOT00000043784
RefSeq Acc Id: XP_038937750   ⟸   XM_039081822
- Peptide Label: isoform X3
RefSeq Acc Id: ENSRNOP00000084377   ⟸   ENSRNOT00000114699
RefSeq Acc Id: XP_063121927   ⟸   XM_063265857
- Peptide Label: isoform X4
Protein Domains
C2H2-type   SCAN box

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-E9PTG0-F1-model_v2 AlphaFold E9PTG0 1-723 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696398
Promoter ID:EPDNEW_R6923
Type:multiple initiation site
Name:Zkscan7_1
Description:zinc finger with KRAB and SCAN domains 7
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.08131,933,406 - 131,933,466EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305242 AgrOrtholog
BioCyc Gene G2FUF-28632 BioCyc
Ensembl Genes ENSRNOG00000004104 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000043784 ENTREZGENE
  ENSRNOT00000043784.5 UniProtKB/TrEMBL
  ENSRNOT00000114699.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.4020.10 UniProtKB/TrEMBL
  Classic Zinc Finger UniProtKB/TrEMBL
InterPro SCAN_sf UniProtKB/TrEMBL
  Tscrpt_reg_SCAN UniProtKB/TrEMBL
  Znf_C2H2/integrase_DNA-bd UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
KEGG Report rno:363170 UniProtKB/TrEMBL
NCBI Gene 363170 ENTREZGENE
PANTHER IP01015P-RELATED UniProtKB/TrEMBL
  ZINC FINGER PROTEIN UniProtKB/TrEMBL
  ZINC FINGER PROTEIN 382 UniProtKB/TrEMBL
  ZINC FINGER PROTEIN WITH KRAB AND SCAN DOMAINS 7 UniProtKB/TrEMBL
Pfam SCAN UniProtKB/TrEMBL
  zf-C2H2 UniProtKB/TrEMBL
PhenoGen Zkscan7 PhenoGen
PROSITE SCAN_BOX UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000004104 RatGTEx
SMART SCAN UniProtKB/TrEMBL
  ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP Retrovirus capsid dimerization domain-like UniProtKB/TrEMBL
  SSF57667 UniProtKB/TrEMBL
UniProt A0A8I5ZXY7_RAT UniProtKB/TrEMBL
  E9PTG0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-06-28 Zkscan7  zinc finger with KRAB and SCAN domains 7  Zfp167  zinc finger protein 167  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-03 Zfp167  zinc finger protein 167  Znf167_predicted  zinc finger protein 167 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-12 Znf167_predicted  zinc finger protein 167 (predicted)      Symbol and Name status set to approved 70820 APPROVED