Mcm8 (minichromosome maintenance 8 homologous recombination repair factor) - Rat Genome Database

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Gene: Mcm8 (minichromosome maintenance 8 homologous recombination repair factor) Rattus norvegicus
Analyze
Symbol: Mcm8
Name: minichromosome maintenance 8 homologous recombination repair factor
RGD ID: 1305218
Description: Predicted to enable several functions, including chromatin binding activity; mismatch repair complex binding activity; and single-stranded DNA binding activity. Predicted to contribute to single-stranded DNA helicase activity. Predicted to be involved in several processes, including protein localization to chromatin; protein stabilization; and recombinational repair. Predicted to be located in chromosome. Predicted to be part of MCM8-MCM9 complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in primary ovarian insufficiency 10. Orthologous to human MCM8 (minichromosome maintenance 8 homologous recombination repair factor); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acetamide; aflatoxin B1.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: DNA helicase MCM8; DNA replication licensing factor MCM8; LOC296178; minichromosome maintenance 8; minichromosome maintenance complex component 8; minichromosome maintenance deficient 8; minichromosome maintenance deficient 8 (S. cerevisiae)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83140,539,590 - 140,569,891 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3140,539,647 - 140,569,891 (+)EnsemblGRCr8
mRatBN7.23120,086,741 - 120,117,008 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3120,086,763 - 120,117,008 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3123,981,812 - 124,012,084 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03132,585,444 - 132,615,628 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03130,237,946 - 130,268,218 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03125,470,499 - 125,500,795 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3125,470,551 - 125,500,795 (+)Ensemblrn6Rnor6.0
Rnor_5.03131,954,303 - 131,984,573 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43120,614,429 - 120,644,673 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3118,872,729 - 118,902,973 (+)NCBICelera
RGSC_v3.13120,520,853 - 120,549,803 (+)NCBI
Cytogenetic Map3q36NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
2,2'-Methylenebis(4-methyl-6-tert-butylphenol)  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-methylcholine  (ISO)
acetamide  (EXP)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-lapachone  (ISO)
biphenyl-4-amine  (ISO)
bisphenol A  (EXP,ISO)
butan-1-ol  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
cefaloridine  (EXP)
CGP 52608  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP)
copper(II) chloride  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cryptolepine  (ISO)
cyclosporin A  (ISO)
dioxygen  (ISO)
Enterolactone  (ISO)
etoposide  (ISO)
furan  (EXP)
hydrogen peroxide  (ISO)
hydroquinone O-beta-D-glucopyranoside  (ISO)
inulin  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
lucanthone  (ISO)
methamphetamine  (EXP)
methyl methanesulfonate  (ISO)
N-acetyl-L-cysteine  (ISO)
nickel sulfate  (ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
PhIP  (ISO)
pirinixic acid  (ISO)
resveratrol  (ISO)
SCH 23390  (EXP)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sunitinib  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
topotecan  (EXP)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
trovafloxacin  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
chromosome  (IEA)
MCM complex  (IBA)
MCM8-MCM9 complex  (IEA,ISO,ISS)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:22771115   PMID:22771120   PMID:23401855   PMID:26215093   PMID:26300262  


Genomics

Comparative Map Data
Mcm8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83140,539,590 - 140,569,891 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3140,539,647 - 140,569,891 (+)EnsemblGRCr8
mRatBN7.23120,086,741 - 120,117,008 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3120,086,763 - 120,117,008 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3123,981,812 - 124,012,084 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03132,585,444 - 132,615,628 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03130,237,946 - 130,268,218 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03125,470,499 - 125,500,795 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3125,470,551 - 125,500,795 (+)Ensemblrn6Rnor6.0
Rnor_5.03131,954,303 - 131,984,573 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43120,614,429 - 120,644,673 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3118,872,729 - 118,902,973 (+)NCBICelera
RGSC_v3.13120,520,853 - 120,549,803 (+)NCBI
Cytogenetic Map3q36NCBI
MCM8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38205,950,652 - 5,998,977 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl205,949,767 - 5,998,977 (+)Ensemblhg38GRCh38
GRCh37205,931,298 - 5,979,623 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36205,879,298 - 5,923,833 (+)NCBIBuild 36Build 36hg18NCBI36
Celera206,002,910 - 6,047,121 (+)NCBICelera
Cytogenetic Map20p12.3NCBI
HuRef205,887,832 - 5,932,254 (+)NCBIHuRef
CHM1_1205,931,687 - 5,975,911 (+)NCBICHM1_1
T2T-CHM13v2.0205,990,987 - 6,039,282 (+)NCBIT2T-CHM13v2.0
Mcm8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392132,658,061 - 132,686,117 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2132,658,061 - 132,686,117 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm382132,816,137 - 132,844,197 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2132,816,141 - 132,844,197 (+)Ensemblmm10GRCm38
MGSCv372132,642,071 - 132,669,933 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv362132,507,776 - 132,535,638 (+)NCBIMGSCv36mm8
Celera2134,043,779 - 134,071,682 (+)NCBICelera
Cytogenetic Map2F2NCBI
cM Map264.75NCBI
Mcm8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541516,346,253 - 16,379,021 (+)Ensembl
ChiLan1.0NW_00495541516,345,472 - 16,379,922 (+)NCBIChiLan1.0ChiLan1.0
MCM8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2216,872,653 - 6,918,874 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1206,869,479 - 6,920,372 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0205,945,034 - 5,993,725 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1205,727,789 - 5,775,133 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl205,729,174 - 5,775,133 (+)EnsemblpanPan2panpan1.1
MCM8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12415,850,602 - 15,893,452 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2415,814,770 - 15,893,458 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2415,672,843 - 15,715,552 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02416,253,280 - 16,296,002 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2416,217,448 - 16,295,816 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12415,860,050 - 15,902,521 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02415,968,188 - 16,010,880 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02416,299,900 - 16,342,388 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Mcm8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640164,641,384 - 164,677,033 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648513,072,600 - 13,108,411 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648513,072,791 - 13,108,392 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MCM8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1714,790,396 - 14,837,416 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11714,790,398 - 14,837,420 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21715,896,975 - 15,943,939 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MCM8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1232,137,983 - 32,181,187 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl232,138,173 - 32,181,179 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607112,360,094 - 12,404,612 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mcm8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247416,787,578 - 6,827,188 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247416,787,555 - 6,826,033 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Mcm8
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v15112,522,930 - 112,553,358 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Mcm8
111 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:222
Count of miRNA genes:152
Interacting mature miRNAs:170
Transcripts:ENSRNOT00000028898
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582233Insul10Insulin level QTL 105.40.0015blood insulin amount (VT:0001560)serum insulin level times blood glucose level (CMO:0002040)3133259579178259579Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)396509147141509147Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)3129154923182114333Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)358601291153936591Rat
7387306Bw124Body weight QTL 1243.20.0003body mass (VT:0001259)body weight (CMO:0000012)3104545086149545086Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3133134628178134628Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)381425008141509147Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)3112250810157250810Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)396509147141509147Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)3117537367162537367Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3125116475170116475Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3110225882155225882Rat
1358204Insglur1Insulin/glucose ratio QTL 13.8blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)3136091420155634702Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3139299381184299381Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)390755164141509147Rat
5686842Rf59Renal function QTL 59urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)3122395989167395989Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)3131036586176036586Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3137114333182114333Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)3131036586176036586Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)398651826167012663Rat
1331758Bp207Blood pressure QTL 2072.848arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3110634702155634702Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)3116188400161188400Rat

Markers in Region
BF389667  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23120,087,684 - 120,087,896 (+)MAPPERmRatBN7.2
Rnor_6.03125,471,473 - 125,471,684NCBIRnor6.0
Rnor_5.03131,955,251 - 131,955,462UniSTSRnor5.0
RGSC_v3.43120,615,351 - 120,615,562UniSTSRGSC3.4
Celera3118,873,651 - 118,873,862UniSTS
RH 3.4 Map31030.61UniSTS
Cytogenetic Map3q36UniSTS
BF412056  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23120,116,496 - 120,116,598 (+)MAPPERmRatBN7.2
Rnor_6.03125,500,284 - 125,500,385NCBIRnor6.0
Rnor_5.03131,984,062 - 131,984,163UniSTSRnor5.0
RGSC_v3.43120,644,162 - 120,644,263UniSTSRGSC3.4
Celera3118,902,462 - 118,902,563UniSTS
RH 3.4 Map31033.41UniSTS
Cytogenetic Map3q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
23 12 66 169 91 90 59 93 59 6 367 193 12 148 84 109 31 23 23

Sequence


Ensembl Acc Id: ENSRNOT00000028898   ⟹   ENSRNOP00000028898
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3140,539,647 - 140,569,891 (+)Ensembl
mRatBN7.2 Ensembl3120,086,763 - 120,117,008 (+)Ensembl
Rnor_6.0 Ensembl3125,470,551 - 125,500,795 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000106451   ⟹   ENSRNOP00000076589
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3140,540,499 - 140,569,891 (+)Ensembl
mRatBN7.2 Ensembl3120,087,615 - 120,117,008 (+)Ensembl
RefSeq Acc Id: NM_001106514   ⟹   NP_001099984
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83140,539,647 - 140,569,891 (+)NCBI
mRatBN7.23120,086,763 - 120,117,008 (+)NCBI
Rnor_6.03125,470,551 - 125,500,795 (+)NCBI
Rnor_5.03131,954,303 - 131,984,573 (+)NCBI
RGSC_v3.43120,614,429 - 120,644,673 (+)RGD
Celera3118,872,729 - 118,902,973 (+)RGD
Sequence:
RefSeq Acc Id: XM_006235074   ⟹   XP_006235136
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83140,539,592 - 140,569,770 (+)NCBI
mRatBN7.23120,086,742 - 120,116,890 (+)NCBI
Rnor_6.03125,470,499 - 125,500,674 (+)NCBI
Rnor_5.03131,954,303 - 131,984,573 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039104589   ⟹   XP_038960517
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83140,539,590 - 140,569,770 (+)NCBI
mRatBN7.23120,086,741 - 120,116,890 (+)NCBI
RefSeq Acc Id: XM_039104590   ⟹   XP_038960518
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83140,548,315 - 140,569,770 (+)NCBI
mRatBN7.23120,095,436 - 120,116,890 (+)NCBI
RefSeq Acc Id: NP_001099984   ⟸   NM_001106514
- UniProtKB: D3ZVK1 (UniProtKB/Swiss-Prot),   A0A8I5XV71 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006235136   ⟸   XM_006235074
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000028898   ⟸   ENSRNOT00000028898
RefSeq Acc Id: XP_038960517   ⟸   XM_039104589
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038960518   ⟸   XM_039104590
- Peptide Label: isoform X3
Ensembl Acc Id: ENSRNOP00000076589   ⟸   ENSRNOT00000106451
Protein Domains
MCM

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZVK1-F1-model_v2 AlphaFold D3ZVK1 1-830 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305218 AgrOrtholog
BioCyc Gene G2FUF-47763 BioCyc
Ensembl Genes ENSRNOG00000021272 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000028898 ENTREZGENE
  ENSRNOT00000028898.6 UniProtKB/Swiss-Prot
Gene3D-CATH 2.20.28.10 UniProtKB/Swiss-Prot
  2.40.50.140 UniProtKB/Swiss-Prot
  3.40.50.300 UniProtKB/Swiss-Prot
InterPro AAA+_ATPase UniProtKB/Swiss-Prot
  MCM UniProtKB/Swiss-Prot
  MCM8/REC_WHD UniProtKB/Swiss-Prot
  MCM_dom UniProtKB/Swiss-Prot
  MCM_lid UniProtKB/Swiss-Prot
  MCM_OB UniProtKB/Swiss-Prot
  NA-bd_OB-fold UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
KEGG Report rno:296178 UniProtKB/Swiss-Prot
NCBI Gene 296178 ENTREZGENE
PANTHER DNA HELICASE MCM8 UniProtKB/Swiss-Prot
  PTHR11630 UniProtKB/Swiss-Prot
Pfam MCM UniProtKB/Swiss-Prot
  MCM_lid UniProtKB/Swiss-Prot
  MCM_OB UniProtKB/Swiss-Prot
  WHD_MCM8 UniProtKB/Swiss-Prot
PhenoGen Mcm8 PhenoGen
PRINTS MCMFAMILY UniProtKB/Swiss-Prot
PROSITE MCM_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000021272 RatGTEx
SMART AAA UniProtKB/Swiss-Prot
  MCM UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50249 UniProtKB/Swiss-Prot
  SSF52540 UniProtKB/Swiss-Prot
UniProt A0A8I5XV71 ENTREZGENE, UniProtKB/TrEMBL
  D3ZVK1 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-09-16 Mcm8  minichromosome maintenance 8 homologous recombination repair factor  Mcm8  minichromosome maintenance complex component 8  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-24 Mcm8  minichromosome maintenance complex component 8  Mcm8  minichromosome maintenance deficient 8 (S. cerevisiae)   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Mcm8  minichromosome maintenance deficient 8 (S. cerevisiae)   Mcm8_predicted  minichromosome maintenance deficient 8 (S. cerevisiae) (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Mcm8_predicted  minichromosome maintenance deficient 8 (S. cerevisiae) (predicted)      Symbol and Name status set to approved 70820 APPROVED