Tmt1b (thiol methyltransferase 1B)

Gene: Tmt1b (thiol methyltransferase 1B) Rattus norvegicus

Analyze

Symbol:

Tmt1b (Ensembl: Mettl7b)

Name:

thiol methyltransferase 1B (Ensembl:methyltransferase like 7B)

RGD ID:

1305205

Description:

Predicted to enable thiol S-methyltransferase activity. Predicted to be involved in methylation. Predicted to be located in cytosol; endoplasmic reticulum membrane; and lipid droplet. Orthologous to human TMT1B (thiol methyltransferase 1B); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,2',4,4'-Tetrabromodiphenyl ether.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

ALDI; associated with lipid droplet protein 1; LOC366792; methyltransferase like 7B; methyltransferase-like protein 7B; Mettl7b; MGC109041; RGD1305205; similar to RIKEN cDNA 0610006F02; thiol S-methyltransferase METTL7B; thiol S-methyltransferase TMT1B

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	TMT1B (thiol methyltransferase 1B)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Tmt1b (thiol methyltransferase 1B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Tmt1b (thiol methyltransferase 1B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	TMT1B (thiol methyltransferase 1B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	TMT1B (thiol methyltransferase 1B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Tmt1b (thiol methyltransferase 1B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	TMT1B (thiol methyltransferase 1B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	TMT1B (thiol methyltransferase 1B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Tmt1b (thiol methyltransferase 1B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	TMT1A (thiol methyltransferase 1A)	HGNC	OrthoDB
Alliance orthologs ³
Mus musculus (house mouse):	Tmt1b (thiol methyltransferase 1B)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	TMT1B (thiol methyltransferase 1B)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	si:ch211-173n18.4	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	mettl7a (methyltransferase like 7A)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	si:ch211-173n18.3	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	CRG1	Alliance	DIOPT (Ensembl Compara\|OrthoInspector)
Caenorhabditis elegans (roundworm):	pmt-2	Alliance	DIOPT (Ensembl Compara\|PANTHER)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	1,973,334 - 1,975,980 (-)	NCBI		GRCr8
mRatBN7.2	7	1,388,876 - 1,391,526 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	1,388,879 - 1,391,526 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	4,151,023 - 4,153,672 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	6,026,665 - 6,029,318 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	6,327,899 - 6,330,519 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	3,383,876 - 3,386,522 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	3,383,879 - 3,386,522 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	3,354,348 - 3,356,994 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	2,269,393 - 2,272,039 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	2,269,395 - 2,272,039 (-)	NCBI
Celera	7	1,259,451 - 1,262,093 (-)	NCBI		Celera
Cytogenetic Map	7	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

congenital muscular dystrophy due to integrin alpha-7 deficiency (ISO)

genetic disease (ISO)

ovarian carcinoma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

(1->4)-beta-D-glucan (ISO)

17beta-estradiol (EXP,ISO)

2,2',4,4'-Tetrabromodiphenyl ether (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

3,3',4,4',5-pentachlorobiphenyl (EXP)

3,3',5,5'-tetrabromobisphenol A (ISO)

3H-1,2-dithiole-3-thione (EXP)

4-nitrophenol (ISO)

aflatoxin B1 (ISO)

aristolochic acid A (EXP)

Aroclor 1254 (EXP)

azoxystrobin (EXP)

belinostat (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

buta-1,3-diene (ISO)

cadmium dichloride (EXP)

chlorpyrifos (EXP)

chromium(6+) (ISO)

cisplatin (ISO)

clofibric acid (EXP)

cyclosporin A (ISO)

dextran sulfate (ISO)

diuron (EXP)

dorsomorphin (ISO)

endosulfan (EXP)

entinostat (ISO)

ethanol (EXP)

flutamide (EXP)

gentamycin (EXP)

glyphosate (EXP)

GW 4064 (ISO)

hydroquinone (ISO)

imidacloprid (EXP)

irinotecan (EXP)

iron dichloride (ISO)

leflunomide (EXP,ISO)

levetiracetam (EXP)

lipopolysaccharide (ISO)

Muraglitazar (EXP)

p-chloromercuribenzoic acid (ISO)

paracetamol (EXP,ISO)

perfluorooctane-1-sulfonic acid (EXP,ISO)

pirinixic acid (ISO)

pregnenolone 16alpha-carbonitrile (ISO)

quercetin (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

sodium dichromate (EXP)

tamoxifen (ISO)

temozolomide (ISO)

Tesaglitazar (EXP)

tetrachloromethane (EXP)

thiabendazole (EXP)

thioacetamide (EXP)

triclosan (ISO)

troglitazone (EXP)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

methylation (IEA)

Cellular Component

cytosol (IEA)

endoplasmic reticulum membrane (IEA)

lipid droplet (IEA)

Molecular Function

methyltransferase activity (IBA)

S-adenosylmethionine-dependent methyltransferase activity (ISO,ISS)

thiol S-methyltransferase activity (ISO,ISS)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	GOA pipeline	RGD automated data pipeline
4.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:15489334	PMID:17004324

Genomics

Comparative Map Data

Tmt1b
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	1,973,334 - 1,975,980 (-)	NCBI		GRCr8
mRatBN7.2	7	1,388,876 - 1,391,526 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	1,388,879 - 1,391,526 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	4,151,023 - 4,153,672 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	6,026,665 - 6,029,318 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	6,327,899 - 6,330,519 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	3,383,876 - 3,386,522 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	3,383,879 - 3,386,522 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	3,354,348 - 3,356,994 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	2,269,393 - 2,272,039 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	2,269,395 - 2,272,039 (-)	NCBI
Celera	7	1,259,451 - 1,262,093 (-)	NCBI		Celera
Cytogenetic Map	7	q11	NCBI

TMT1B
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	55,681,736 - 55,684,611 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	55,681,736 - 55,684,611 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	12	56,075,520 - 56,078,395 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	54,361,686 - 54,364,662 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	12	55,727,803 - 55,730,867 (+)	NCBI		Celera
Cytogenetic Map	12	q13.2	NCBI
HuRef	12	53,114,151 - 53,117,213 (+)	NCBI		HuRef
CHM1_1	12	56,042,118 - 56,045,181 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	12	55,648,368 - 55,651,240 (+)	NCBI		T2T-CHM13v2.0

Tmt1b
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	128,794,146 - 128,796,857 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	128,794,143 - 128,796,857 (-)	Ensembl		GRCm39 Ensembl
GRCm38	10	128,958,277 - 128,960,988 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	128,958,274 - 128,960,988 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	10	128,395,333 - 128,398,044 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	10	128,361,226 - 128,363,937 (-)	NCBI		MGSCv36	mm8
Celera	10	131,351,025 - 131,353,732 (-)	NCBI		Celera
Cytogenetic Map	10	D3	NCBI
cM Map	10	77.2	NCBI

Tmt1b
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955458	3,319,840 - 3,322,777 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955458	3,319,840 - 3,322,777 (+)	NCBI	ChiLan1.0	ChiLan1.0

TMT1B
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	38,643,431 - 38,646,536 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	38,640,200 - 38,643,251 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	33,226,753 - 33,229,843 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	33,950,849 - 33,953,903 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	33,950,849 - 33,953,903 (-)	Ensembl	panpan1.1		panPan2

TMT1B
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	10	89,319 - 91,610 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	10	89,497 - 91,301 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	10	151,676 - 154,219 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	10	96,545 - 99,089 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	10	96,761 - 98,566 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	10	74,261 - 76,804 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	10	317,139 - 319,683 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	10	441,241 - 443,784 (+)	NCBI		UU_Cfam_GSD_1.0

Tmt1b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	58,711,673 - 58,713,911 (-)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936646	156,318 - 158,507 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TMT1B
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	21,123,543 - 21,126,607 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	5	21,123,548 - 21,126,295 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

TMT1B
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	51,631,341 - 51,634,061 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	51,631,307 - 51,637,919 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666037	194,360,265 - 194,363,330 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Tmt1b
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624802	12,330,870 - 12,335,531 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624802	12,332,989 - 12,335,521 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Tmt1b
23 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	81
Count of miRNA genes:	57
Interacting mature miRNAs:	71
Transcripts:	ENSRNOT00000010760
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2298550	Neuinf6	Neuroinflammation QTL 6	3.3		nervous system integrity trait (VT:0010566)	spinal cord RT1-B protein level (CMO:0002132)	7	1	27829089	Rat
7411566	Bw136	Body weight QTL 136	10.4	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	7	1	31962314	Rat
9590142	Scort5	Serum corticosterone level QTL 5	24.4	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	7	1	31962314	Rat
724560	Plsm3	Polydactyly-luxate syndrome (PLS) morphotypes QTL 3		0.0003	tibia length (VT:0004357)	tibia length (CMO:0000450)	7	1	34000259	Rat
2317047	Wbc4	White blood cell count QTL 4		0.01	leukocyte quantity (VT:0000217)	white blood cell count (CMO:0000027)	7	1	35342956	Rat
61410	Bw19	Body weight QTL 19	6.2	0.001	body mass (VT:0001259)	body weight (CMO:0000012)	7	1	44782185	Rat
631503	Bp102	Blood pressure QTL 102	1.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	1	44822433	Rat
1300176	Hrtrt10	Heart rate QTL 10	3.19		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	7	664270	26029351	Rat
634336	Anxrr17	Anxiety related response QTL 17	3.66		locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	7	924703	115097879	Rat

Markers in Region

RH128213

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	7	1,388,522 - 1,388,731 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	3,383,523 - 3,383,731	NCBI	Rnor6.0
Rnor_5.0	7	3,353,995 - 3,354,203	UniSTS	Rnor5.0
RGSC_v3.4	7	2,269,040 - 2,269,248	UniSTS	RGSC3.4
Celera	7	1,259,098 - 1,259,306	UniSTS
Cytogenetic Map	7	q11	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3		13	13		13				27
Low			2				1	1		4	7	1	1
Below cutoff		12	15	2	14	2	7	9	15		22	7	7

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001024276	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC097931	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC092587	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC092590	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474104	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ209514	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ218969	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000007	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000010760 ⟹ ENSRNOP00000010760

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	1,388,879 - 1,391,526 (-)	Ensembl
Rnor_6.0 Ensembl	7	3,383,879 - 3,386,522 (-)	Ensembl

RefSeq Acc Id:

NM_001024276 ⟹ NP_001019447

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	1,973,334 - 1,975,980 (-)	NCBI
mRatBN7.2	7	1,388,876 - 1,391,526 (-)	NCBI
Rnor_6.0	7	3,383,876 - 3,386,522 (-)	NCBI
Rnor_5.0	7	3,354,348 - 3,356,994 (-)	NCBI
RGSC_v3.4	7	2,269,393 - 2,272,039 (-)	RGD
Celera	7	1,259,451 - 1,262,093 (-)	RGD

Sequence:

show sequence

CGCGCCATCAGAAGCTAACGCCATGGATGTCCTGGTTCCATTGCTGCAGCTGCTGGTGCTGCTC
CTGACTCTGCCTTTACACCTGCTGGCTCTGCTGGGCTGCTGGCAGCCCATATGCAAAACCTACT
TCCCCTACCTAATGGCCACACTAACAGCCAGGTCCTACAAAAAGATGGAGAGCAAGAAGCGAGA
ACTATTTAGCCAGATAAAAGATCTTAAGGGGACCTCCAACGAAGTGACCCTGCTGGAGCTGGGC
TGTGGCACCGGTGCCAACTTCCAGTTCTACCCGCCTGGCTGCAAGGTCACCTGTGTGGACCCAA
ACCCCAACTTTGAGAAGTTTCTGACCAAGAGCATGGCTGAGAACAGGCACCTCCAATATGAGCG
CTTCATTGTGGCATACGGAGAAAACATGAAACAGCTGGCTGACAGTTCCATGGATGTGGTGGTC
TGTACCCTGGTGCTGTGTTCTGTGCAGAGCCCCAGAAAAGTCCTTCAGGAAGTCCAGAGAGTCC
TGAAGCCGGGAGGCCTGCTGTTCTTCTGGGAGCATGTGTCTGAGCCTCAGGGAAGCCAGGCCCT
CCTGTGGCAGCGAGTTTTAGAACCTACCTGGAAACACATCGGAGATGGCTGCCACCTCACCAGA
GAGACCTGGAAAGACATTGAGAAGGCACAGTTCTCTGAAGTCCAACTGGAATGGCAGCCCCCTC
CCTTCAAGTGGTTACCTGTTGGGCCCCACATCATGGGGAAAGCTGTGAAATAACTCTCCCCCAA
GAAGGCCATCTGATCTCCCCATCTGCAGCCAGAAGCCACCCCAGTACTTCTAAGGAGGGGTCAG
GTAAAGCAGAGACTCTCAGCACCGCTGCCACGGCCGGGGTGATCATTAATCAGCTTCAGCCTTT
CTCCACAGTGAGGCTTTCTTCCTGCTCTCTTGAGGCAGAAAACTAGACTGCAAGGCCCTGGACT
TACCCAACCCAACCCTTCTAGGACCCCTATTCATTCATTTATTCATTCTCTCTCTCTCTCTCTC
TCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCGCCCTTGTGTGTCCTTCCAGCCATGCCC
CGTGTCTCACAGCATTGTAACGTTCTCCCTGGTGCCCCCTTGGCATGTATCCCTTGCTTGGCCA
CCTCAGCCTCCCTCCCCACCATACACTCTATCCTGAACTACAGAGGAACAGAGAGCAGACAAAC
GTCAGAATGAGAGCAGCACTCAATAAAGCAGCCAGAGTTCTTATTGTCAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

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Protein Sequences


Protein RefSeqs	NP_001019447	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH92587	(Get FASTA)	NCBI Sequence Viewer
	AAH92590	(Get FASTA)	NCBI Sequence Viewer
	EDL84781	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000010760
	ENSRNOP00000010760.4
	ENSRNOP00055019666
	ENSRNOP00060040123
	ENSRNOP00065016557
GenBank Protein	Q562C4	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_001019447 ⟸ NM_001024276
- Peptide Label:	precursor
- UniProtKB:	Q562C4 (UniProtKB/Swiss-Prot), A6KSL1 (UniProtKB/TrEMBL)
- Sequence:	show sequence MDVLVPLLQLLVLLLTLPLHLLALLGCWQPICKTYFPYLMATLTARSYKKMESKKRELFSQIKD LKGTSNEVTLLELGCGTGANFQFYPPGCKVTCVDPNPNFEKFLTKSMAENRHLQYERFIVAYGE NMKQLADSSMDVVVCTLVLCSVQSPRKVLQEVQRVLKPGGLLFFWEHVSEPQGSQALLWQRVLE PTWKHIGDGCHLTRETWKDIEKAQFSEVQLEWQPPPFKWLPVGPHIMGKAVK hide sequence

RefSeq Acc Id:

ENSRNOP00000010760 ⟸ ENSRNOT00000010760

Protein Domains

Methyltransferase type

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q562C4-F1-model_v2	AlphaFold	Q562C4	1-244	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13694961

Promoter ID:

EPDNEW_R5486

Type:

initiation region

Name:

Mettl7b_1

Description:

methyltransferase like 7B

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	7	3,386,536 - 3,386,596	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1305205	AgrOrtholog
BioCyc Gene	G2FUF-35317	BioCyc
Ensembl Genes	ENSRNOG00000007927	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
	ENSRNOG00055014028	UniProtKB/Swiss-Prot
	ENSRNOG00060027792	UniProtKB/Swiss-Prot
	ENSRNOG00065013051	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000010760	ENTREZGENE
	ENSRNOT00000010760.5	UniProtKB/Swiss-Prot
	ENSRNOT00055024104	UniProtKB/Swiss-Prot
	ENSRNOT00060048207	UniProtKB/Swiss-Prot
	ENSRNOT00065021399	UniProtKB/Swiss-Prot
Gene3D-CATH	3.40.50.150	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7368213	IMAGE-MGC_LOAD
	IMAGE:7371843	IMAGE-MGC_LOAD
InterPro	Methyltransf_11	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SAM-dependent_MTases	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:366792	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE	MGC:109041	IMAGE-MGC_LOAD
	MGC:109058	IMAGE-MGC_LOAD
NCBI Gene	366792	ENTREZGENE
PANTHER	METHYLTRANSFERASE LIKE 7B	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	METHYLTRANSFERASE-LIKE PROTEIN 7B	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Methyltransf_11	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Tmt1b	PhenoGen
RatGTEx	ENSRNOG00000007927	RatGTEx
	ENSRNOG00055014028	RatGTEx
	ENSRNOG00060027792	RatGTEx
	ENSRNOG00065013051	RatGTEx
Superfamily-SCOP	S-adenosyl-L-methionine-dependent methyltransferases	UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
UniProt	A6KSL1	ENTREZGENE, UniProtKB/TrEMBL
	MET7B_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2024-03-25	Tmt1b	thiol methyltransferase 1B	Mettl7b	methyltransferase like 7B	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-30	Mettl7b	methyltransferase like 7B	RGD1305205	similar to RIKEN cDNA 0610006F02	Symbol and Name updated	1299863	APPROVED
2005-12-06	RGD1305205	similar to RIKEN cDNA 0610006F02	RGD1305205_predicted	similar to RIKEN cDNA 0610006F02 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-20	RGD1305205_predicted	similar to RIKEN cDNA 0610006F02 (predicted)	LOC366792_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC366792_predicted	similar to RIKEN cDNA 0610006F02 (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

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