Tmt1b (thiol methyltransferase 1B) - Rat Genome Database

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Gene: Tmt1b (thiol methyltransferase 1B) Rattus norvegicus
Analyze
Symbol: Tmt1b
Name: thiol methyltransferase 1B
RGD ID: 1305205
Description: Predicted to enable thiol S-methyltransferase activity. Predicted to be involved in methylation. Predicted to be located in cytosol; endoplasmic reticulum membrane; and lipid droplet. Orthologous to human TMT1B (thiol methyltransferase 1B); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ALDI; associated with lipid droplet protein 1; LOC366792; methyltransferase like 7B; methyltransferase-like protein 7B; Mettl7b; MGC109041; RGD1305205; similar to RIKEN cDNA 0610006F02; thiol S-methyltransferase METTL7B; thiol S-methyltransferase TMT1B
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr871,973,334 - 1,975,980 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl71,973,337 - 1,975,980 (-)EnsemblGRCr8
mRatBN7.271,388,876 - 1,391,526 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl71,388,879 - 1,391,526 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx74,151,023 - 4,153,672 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.076,026,665 - 6,029,318 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.076,327,899 - 6,330,519 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.073,383,876 - 3,386,522 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl73,383,879 - 3,386,522 (-)Ensemblrn6Rnor6.0
Rnor_5.073,354,348 - 3,356,994 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.472,269,393 - 2,272,039 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera71,259,451 - 1,262,093 (-)NCBICelera
RGSC_v3.172,269,395 - 2,272,039 (-)NCBI
Cytogenetic Map7q11NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-nitrophenol  (ISO)
aflatoxin B1  (ISO)
aristolochic acid A  (EXP)
Aroclor 1254  (EXP)
azoxystrobin  (EXP)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buta-1,3-diene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
chlorpyrifos  (EXP)
chromium(6+)  (ISO)
cisplatin  (ISO)
clofibric acid  (EXP)
cyclosporin A  (ISO)
deoxynivalenol  (ISO)
dextran sulfate  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
erianin  (ISO)
ethanol  (EXP)
flutamide  (EXP)
gentamycin  (EXP)
glyphosate  (EXP)
GW 4064  (ISO)
hexadecanoic acid  (ISO)
hydroquinone  (ISO)
imidacloprid  (EXP)
irinotecan  (EXP)
iron dichloride  (ISO)
leflunomide  (EXP,ISO)
levetiracetam  (EXP)
lipopolysaccharide  (ISO)
Muraglitazar  (EXP)
Nivalenol  (ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
quercetin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
tamoxifen  (ISO)
temozolomide  (ISO)
Tesaglitazar  (EXP)
tetrachloromethane  (EXP)
thiabendazole  (EXP)
thioacetamide  (EXP)
triclosan  (ISO)
troglitazone  (EXP)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
methylation  (IEA)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:15489334   PMID:17004324  


Genomics

Comparative Map Data
Tmt1b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr871,973,334 - 1,975,980 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl71,973,337 - 1,975,980 (-)EnsemblGRCr8
mRatBN7.271,388,876 - 1,391,526 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl71,388,879 - 1,391,526 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx74,151,023 - 4,153,672 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.076,026,665 - 6,029,318 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.076,327,899 - 6,330,519 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.073,383,876 - 3,386,522 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl73,383,879 - 3,386,522 (-)Ensemblrn6Rnor6.0
Rnor_5.073,354,348 - 3,356,994 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.472,269,393 - 2,272,039 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera71,259,451 - 1,262,093 (-)NCBICelera
RGSC_v3.172,269,395 - 2,272,039 (-)NCBI
Cytogenetic Map7q11NCBI
TMT1B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381255,681,736 - 55,684,611 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1255,681,736 - 55,684,611 (+)Ensemblhg38GRCh38
GRCh371256,075,520 - 56,078,395 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361254,361,686 - 54,364,662 (+)NCBIBuild 36Build 36hg18NCBI36
Celera1255,727,803 - 55,730,867 (+)NCBICelera
Cytogenetic Map12q13.2NCBI
HuRef1253,114,151 - 53,117,213 (+)NCBIHuRef
CHM1_11256,042,118 - 56,045,181 (+)NCBICHM1_1
T2T-CHM13v2.01255,648,368 - 55,651,240 (+)NCBIT2T-CHM13v2.0
Tmt1b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910128,794,146 - 128,796,857 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10128,794,143 - 128,796,857 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm3810128,958,277 - 128,960,988 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10128,958,274 - 128,960,988 (-)Ensemblmm10GRCm38
MGSCv3710128,395,333 - 128,398,044 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3610128,361,226 - 128,363,937 (-)NCBIMGSCv36mm8
Celera10131,351,025 - 131,353,732 (-)NCBICelera
Cytogenetic Map10D3NCBI
cM Map1077.2NCBI
Tmt1b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554583,319,840 - 3,322,777 (+)Ensembl
ChiLan1.0NW_0049554583,319,840 - 3,322,777 (+)NCBIChiLan1.0ChiLan1.0
TMT1B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21038,643,431 - 38,646,536 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11238,640,200 - 38,643,251 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01233,226,753 - 33,229,843 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11233,950,849 - 33,953,903 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1233,950,849 - 33,953,903 (-)EnsemblpanPan2panpan1.1
TMT1B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11089,319 - 91,610 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1089,497 - 91,301 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha10151,676 - 154,219 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01096,545 - 99,089 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1096,761 - 98,566 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11074,261 - 76,804 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.010317,139 - 319,683 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.010441,241 - 443,784 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Tmt1b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494558,711,673 - 58,713,911 (-)NCBIHiC_Itri_2
SpeTri2.0NW_004936646156,318 - 158,507 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TMT1B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl521,123,543 - 21,126,607 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1521,123,548 - 21,126,295 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
TMT1B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11151,631,341 - 51,634,061 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1151,631,307 - 51,637,919 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666037194,360,265 - 194,363,330 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tmt1b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480212,330,870 - 12,335,531 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462480212,332,989 - 12,335,521 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Tmt1b
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11156,435,799 - 156,438,542 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Tmt1b
8 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:81
Count of miRNA genes:57
Interacting mature miRNAs:71
Transcripts:ENSRNOT00000010760
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7166965846669658Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)7123748937Rat
2290372Gluco33Glucose level QTL 332.71blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)7131777942Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)71104117804Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7170952746709527Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7132612984Rat
1582260Bw72Body weight QTL 723.20.0043body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582261Bw69Body weight QTL 693.20.0048body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582262Bw75Body weight QTL 7530.0038body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7129716167Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134650782Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7132612984Rat

Markers in Region
RH128213  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.271,388,522 - 1,388,731 (+)MAPPERmRatBN7.2
Rnor_6.073,383,523 - 3,383,731NCBIRnor6.0
Rnor_5.073,353,995 - 3,354,203UniSTSRnor5.0
RGSC_v3.472,269,040 - 2,269,248UniSTSRGSC3.4
Celera71,259,098 - 1,259,306UniSTS
Cytogenetic Map7q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
16 11 21 55 64 60 33 21 33 6 200 66 2 39 77 74 27

Sequence


Ensembl Acc Id: ENSRNOT00000010760   ⟹   ENSRNOP00000010760
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl71,973,337 - 1,975,980 (-)Ensembl
mRatBN7.2 Ensembl71,388,879 - 1,391,526 (-)Ensembl
Rnor_6.0 Ensembl73,383,879 - 3,386,522 (-)Ensembl
RefSeq Acc Id: NM_001024276   ⟹   NP_001019447
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr871,973,334 - 1,975,980 (-)NCBI
mRatBN7.271,388,876 - 1,391,526 (-)NCBI
Rnor_6.073,383,876 - 3,386,522 (-)NCBI
Rnor_5.073,354,348 - 3,356,994 (-)NCBI
RGSC_v3.472,269,393 - 2,272,039 (-)RGD
Celera71,259,451 - 1,262,093 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001019447 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH92587 (Get FASTA)   NCBI Sequence Viewer  
  AAH92590 (Get FASTA)   NCBI Sequence Viewer  
  EDL84781 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000010760
  ENSRNOP00000010760.4
GenBank Protein Q562C4 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001019447   ⟸   NM_001024276
- Peptide Label: precursor
- UniProtKB: Q562C4 (UniProtKB/Swiss-Prot),   A6KSL1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000010760   ⟸   ENSRNOT00000010760
Protein Domains
Methyltransferase type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q562C4-F1-model_v2 AlphaFold Q562C4 1-244 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694961
Promoter ID:EPDNEW_R5486
Type:initiation region
Name:Mettl7b_1
Description:methyltransferase like 7B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.073,386,536 - 3,386,596EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305205 AgrOrtholog
BioCyc Gene G2FUF-35317 BioCyc
Ensembl Genes ENSRNOG00000007927 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000010760 ENTREZGENE
  ENSRNOT00000010760.5 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.150 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7368213 IMAGE-MGC_LOAD
  IMAGE:7371843 IMAGE-MGC_LOAD
InterPro Methyltransf_11 UniProtKB/Swiss-Prot
  SAM-dependent_MTases UniProtKB/Swiss-Prot
  Thiol_S-MT UniProtKB/Swiss-Prot
KEGG Report rno:366792 UniProtKB/Swiss-Prot
MGC_CLONE MGC:109041 IMAGE-MGC_LOAD
  MGC:109058 IMAGE-MGC_LOAD
NCBI Gene 366792 ENTREZGENE
PANTHER METHYLTRANSFERASE LIKE 7B UniProtKB/Swiss-Prot
  METHYLTRANSFERASE-LIKE PROTEIN 7B UniProtKB/Swiss-Prot
Pfam Methyltransf_11 UniProtKB/Swiss-Prot
PhenoGen Tmt1b PhenoGen
RatGTEx ENSRNOG00000007927 RatGTEx
Superfamily-SCOP SSF53335 UniProtKB/Swiss-Prot
UniProt A6KSL1 ENTREZGENE, UniProtKB/TrEMBL
  MET7B_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-03-25 Tmt1b  thiol methyltransferase 1B  Mettl7b  methyltransferase like 7B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Mettl7b  methyltransferase like 7B  RGD1305205  similar to RIKEN cDNA 0610006F02  Symbol and Name updated 1299863 APPROVED
2005-12-06 RGD1305205  similar to RIKEN cDNA 0610006F02  RGD1305205_predicted  similar to RIKEN cDNA 0610006F02 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1305205_predicted  similar to RIKEN cDNA 0610006F02 (predicted)  LOC366792_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC366792_predicted  similar to RIKEN cDNA 0610006F02 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL