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Gene: Atl2 (atlastin GTPase 2) Rattus norvegicus

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Symbol:

Atl2

Name:

atlastin GTPase 2

RGD ID:

1305125

Description:

Predicted to enable GTP binding activity and GTPase-dependent fusogenic activity. Predicted to be involved in endoplasmic reticulum membrane fusion; endoplasmic reticulum tubular network membrane organization; and protein homooligomerization. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum tubular network membrane. Orthologous to human ATL2 (atlastin GTPase 2); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; acetamide.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

ADP-ribosylation factor-like 6 interacting protein 2; Arl6ip2; atlastin-2; LOC298757

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	ATL2 (atlastin GTPase 2)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Mus musculus (house mouse):	Atl2 (atlastin GTPase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Atl2 (atlastin GTPase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	ATL2 (atlastin GTPase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	ATL2 (atlastin GTPase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Atl2 (atlastin GTPase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	ATL2 (atlastin GTPase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	ATL2 (atlastin GTPase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Atl2 (atlastin GTPase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Atl2 (atlastin GTPase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	ATL2 (atlastin GTPase 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Atl2 (atlastin GTPase 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	atl2 (atlastin GTPase 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	zgc:158270	Alliance	DIOPT (OMA\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	atl	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	atl	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	atln-1	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	atln-1	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	atl2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	atl2	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	20,891,220 - 20,932,644 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	6	20,891,227 - 20,933,320 (+)	Ensembl				GRCr8
mRatBN7.2	6	15,139,071 - 15,180,421 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	15,139,044 - 15,180,421 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	6	15,437,506 - 15,478,862 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	15,759,677 - 15,801,031 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	15,255,967 - 15,297,313 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	2,568,975 - 2,610,432 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	2,568,990 - 2,610,437 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	6	2,548,610 - 2,590,125 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	6	2,728,722 - 2,771,082 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	6	14,809,037 - 14,850,517 (+)	NCBI		Celera
RGSC_v3.1	6	2,728,977 - 2,771,107 (-)	NCBI
Cytogenetic Map	6	q12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (EXP,ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4,6-tribromophenol (ISO)

3,3',4,4'-tetrachlorobiphenyl (ISO)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

acetamide (EXP)

acrylamide (EXP)

all-trans-retinoic acid (ISO)

antirheumatic drug (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenite(3-) (ISO)

asbestos (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

beta-lapachone (ISO)

beta-naphthoflavone (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

buspirone (EXP)

cadmium atom (ISO)

cadmium dichloride (ISO)

caffeine (ISO)

carbamazepine (ISO)

carbon nanotube (ISO)

clofibrate (ISO)

clofibric acid (EXP)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

Cuprizon (EXP)

cyclosporin A (ISO)

decabromodiphenyl ether (ISO)

deoxynivalenol (ISO)

Dibutyl phosphate (ISO)

dibutyl phthalate (ISO)

doxorubicin (ISO)

ethanol (ISO)

gentamycin (EXP)

glafenine (EXP)

gold atom (ISO)

gold(0) (ISO)

GSK-J4 (ISO)

hexane (EXP)

hydrogen cyanide (ISO)

inulin (ISO)

irinotecan (ISO)

ivermectin (ISO)

methotrexate (ISO)

methyl methanesulfonate (ISO)

N-nitrosodiethylamine (EXP)

nefazodone (EXP)

nimesulide (EXP)

oxaliplatin (EXP)

paracetamol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (ISO)

phenobarbital (ISO)

pirinixic acid (ISO)

potassium cyanide (ISO)

pregnenolone 16alpha-carbonitrile (ISO)

quercetin (ISO)

resveratrol (ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

temozolomide (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

topotecan (EXP)

troglitazone (ISO)

tungsten (ISO)

tunicamycin (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

endoplasmic reticulum membrane fusion (ISO)

endoplasmic reticulum organization (IBA)

endoplasmic reticulum to Golgi vesicle-mediated transport (ISO)

endoplasmic reticulum tubular network membrane organization (ISO)

protein homooligomerization (IBA)

Cellular Component

endoplasmic reticulum (ISO)

endoplasmic reticulum membrane (ISO)

endoplasmic reticulum tubular network membrane (ISO)

Molecular Function

GTP binding (IBA,IEA)

GTPase activity (IBA,IEA)

GTPase-dependent fusogenic activity (ISO)

hydrolase activity (IEA)

nucleotide binding (IEA)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:18270207	PMID:19665976	PMID:19946888	PMID:27619977

Genomics

Comparative Map Data

Atl2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	20,891,220 - 20,932,644 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	6	20,891,227 - 20,933,320 (+)	Ensembl				GRCr8
mRatBN7.2	6	15,139,071 - 15,180,421 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	15,139,044 - 15,180,421 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	6	15,437,506 - 15,478,862 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	15,759,677 - 15,801,031 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	15,255,967 - 15,297,313 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	2,568,975 - 2,610,432 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	2,568,990 - 2,610,437 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	6	2,548,610 - 2,590,125 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	6	2,728,722 - 2,771,082 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	6	14,809,037 - 14,850,517 (+)	NCBI		Celera
RGSC_v3.1	6	2,728,977 - 2,771,107 (-)	NCBI
Cytogenetic Map	6	q12	NCBI

ATL2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	38,293,954 - 38,378,584 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	38,293,949 - 38,377,438 (-)	Ensembl			hg38	GRCh38
GRCh37	2	38,521,096 - 38,605,726 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	38,376,628 - 38,457,919 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	2	38,434,774 - 38,516,066	NCBI
Celera	2	38,362,844 - 38,445,253 (-)	NCBI		Celera
Cytogenetic Map	2	p22.2-p22.1	NCBI
HuRef	2	38,262,225 - 38,345,208 (-)	NCBI		HuRef
CHM1_1	2	38,451,392 - 38,534,265 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	2	38,300,848 - 38,385,467 (-)	NCBI		T2T-CHM13v2.0

Atl2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	80,155,819 - 80,203,633 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	80,155,819 - 80,203,552 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	17	79,848,352 - 79,896,204 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	79,848,390 - 79,896,123 (-)	Ensembl			mm10	GRCm38
MGSCv37	17	80,247,732 - 80,295,463 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	17	79,756,718 - 79,764,456 (-)	NCBI		MGSCv36	mm8
Celera	17	84,160,361 - 84,207,686 (-)	NCBI		Celera
Cytogenetic Map	17	E3	NCBI
cM Map	17	50.3	NCBI

Atl2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955441	6,004,209 - 6,034,476 (-)	Ensembl
ChiLan1.0	NW_004955441	6,004,209 - 6,034,484 (-)	NCBI	ChiLan1.0	ChiLan1.0

ATL2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	12	88,101,383 - 88,188,043 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2A	88,105,351 - 88,192,017 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2A	38,318,803 - 38,405,435 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2A	39,081,933 - 39,166,310 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2A	39,083,033 - 39,164,137 (-)	Ensembl			panPan2	panpan1.1

ATL2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	17	30,437,657 - 30,493,784 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	17	30,438,777 - 30,493,749 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	17	30,254,174 - 30,310,057 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	17	31,092,659 - 31,148,778 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	17	31,092,421 - 31,148,767 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	17	30,315,959 - 30,371,989 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	17	30,385,725 - 30,441,644 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	17	30,598,360 - 30,654,735 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Atl2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024406292	41,473,955 - 41,527,739 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936663	164,266 - 193,237 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936663	139,448 - 193,231 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ATL2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	101,957,209 - 102,029,667 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	3	101,957,189 - 102,029,120 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	108,074,640 - 108,147,104 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ATL2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	14	69,020,343 - 69,099,692 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	14	69,020,944 - 69,100,885 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666045	42,882,636 - 42,963,026 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Atl2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624738	19,836,181 - 19,902,265 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624738	19,836,771 - 19,902,181 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Atl2
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	7	13,168,565 - 13,210,081 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Atl2
317 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	163
Count of miRNA genes:	111
Interacting mature miRNAs:	142
Transcripts:	ENSRNOT00000008988
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
8552962	Pigfal16	Plasma insulin-like growth factor 1 level QTL 16	9.4		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	6	1975879	46975879	Rat
7411603	Foco13	Food consumption QTL 13	5.5	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	6	1975879	46975879	Rat
1598843	Cm63	Cardiac mass QTL 63	2.6		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	6	1	44788383	Rat
7411542	Bw127	Body weight QTL 127	5.5	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	6	1975879	46975879	Rat
8693699	Alc37	Alcohol consumption QTL 37	2.6	0.224	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	6	13717169	27053860	Rat
2293706	Bmd20	Bone mineral density QTL 20	4.3	0.0002	femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	6	1	25740059	Rat
2292616	Ept15	Estrogen-induced pituitary tumorigenesis QTL 15	4.4		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	6	1	44788383	Rat
9589048	Scfw3	Subcutaneous fat weight QTL 3	4.57	0.001	subcutaneous adipose mass (VT:1000472)	abdominal subcutaneous fat pad weight (CMO:0002069)	6	1975879	46975879	Rat
10401812	Kidm54	Kidney mass QTL 54			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	6	20097635	65097635	Rat
1576309	Emca7	Estrogen-induced mammary cancer QTL 7	4		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	6	20859430	113082285	Rat
2301964	Bp323	Blood pressure QTL 323	4.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	6	1	86868070	Rat
2293709	Bss23	Bone structure and strength QTL 23	5.18	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	6	3239989	48239989	Rat
2293650	Bss31	Bone structure and strength QTL 31	5.05	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	6	3239989	48239989	Rat
1300128	Rf16	Renal function QTL 16	3.89		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	6	1	40163351	Rat
70199	Coreg1	Compensatory renal growth QTL 1	11.8		kidney mass (VT:0002707)	compensatory renal growth score (CMO:0001894)	6	14599473	63457687	Rat
10401800	Kidm49	Kidney mass QTL 49			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	6	20097635	65097635	Rat
1300164	Rf15	Renal function QTL 15	3.12		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	6	3239989	48239989	Rat
2301972	Bp325	Blood pressure QTL 325	4.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	6	16089372	61967788	Rat
1358190	Ept1	Estrogen-induced pituitary tumorigenesis QTL 1	4.4		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	6	1	44788383	Rat
2293656	Bss28	Bone structure and strength QTL 28	6.79	0.0001	femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	6	3239989	48239989	Rat
9589129	Insul24	Insulin level QTL 24	19.06	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	6	1975879	46975879	Rat
8693690	Alc35	Alcohol consumption QTL 35	2.2	0.606	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	6	13717169	27053860	Rat

Markers in Region

RH103002

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	6,176,785 - 6,176,929 (+)	MAPPER	mRatBN7.2
mRatBN7.2	6	15,180,163 - 15,180,307 (+)	MAPPER	mRatBN7.2
Rnor_6.0	6	2,610,175 - 2,610,318	NCBI	Rnor6.0
Rnor_6.0	5	5,813,285 - 5,813,428	NCBI	Rnor6.0
Rnor_5.0	6	2,589,868 - 2,590,011	UniSTS	Rnor5.0
Rnor_5.0	5	10,652,436 - 10,652,579	UniSTS	Rnor5.0
RGSC_v3.4	6	2,728,836 - 2,728,979	UniSTS	RGSC3.4
RGSC_v3.4	5	5,390,926 - 5,391,069	UniSTS	RGSC3.4
Celera	5	5,754,477 - 5,754,620	UniSTS
Celera	6	14,850,260 - 14,850,403	UniSTS
Cytogenetic Map	6	q11	UniSTS

RH131775

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	6	15,155,557 - 15,155,747 (+)	MAPPER	mRatBN7.2
Rnor_6.0	6	2,585,562 - 2,585,751	NCBI	Rnor6.0
Rnor_5.0	6	2,565,255 - 2,565,444	UniSTS	Rnor5.0
RGSC_v3.4	6	2,753,403 - 2,753,592	UniSTS	RGSC3.4
Celera	6	14,825,647 - 14,825,836	UniSTS
Cytogenetic Map	6	q11	UniSTS

G43537

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	6,176,814 - 6,176,956 (+)	MAPPER	mRatBN7.2
mRatBN7.2	6	15,180,192 - 15,180,334 (+)	MAPPER	mRatBN7.2
Rnor_6.0	6	2,610,204 - 2,610,345	NCBI	Rnor6.0
Rnor_6.0	5	5,813,314 - 5,813,455	NCBI	Rnor6.0
Rnor_5.0	6	2,589,897 - 2,590,038	UniSTS	Rnor5.0
Rnor_5.0	5	10,652,465 - 10,652,606	UniSTS	Rnor5.0
RGSC_v3.4	6	2,728,809 - 2,728,950	UniSTS	RGSC3.4
RGSC_v3.4	5	5,390,955 - 5,391,096	UniSTS	RGSC3.4
Celera	5	5,754,506 - 5,754,647	UniSTS
Celera	6	14,850,289 - 14,850,430	UniSTS
Cytogenetic Map	6	q11	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	356	192	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001100671	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006239640	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006239641	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017594067	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063261599	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063261600	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC092650	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CB580536	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473947	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CO395790	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	EV762626	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ213215	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000008988 ⟹ ENSRNOP00000008988

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	6	20,891,257 - 20,932,639 (+)	Ensembl
mRatBN7.2 Ensembl	6	15,139,044 - 15,180,421 (+)	Ensembl
Rnor_6.0 Ensembl	6	2,569,013 - 2,610,437 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000077543 ⟹ ENSRNOP00000071967

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	6	20,891,257 - 20,932,639 (+)	Ensembl
mRatBN7.2 Ensembl	6	15,139,046 - 15,179,359 (+)	Ensembl
Rnor_6.0 Ensembl	6	2,568,990 - 2,609,370 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000084673 ⟹ ENSRNOP00000071234

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	6	2,569,013 - 2,609,372 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000091063

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	6	2,569,002 - 2,594,799 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000134159 ⟹ ENSRNOP00000101185

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	6	20,891,227 - 20,933,320 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000172058 ⟹ ENSRNOP00000106218

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	6	20,891,227 - 20,933,320 (+)	Ensembl

RefSeq Acc Id:

NM_001100671 ⟹ NP_001094141

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	20,891,284 - 20,932,644 (+)	NCBI
mRatBN7.2	6	15,139,071 - 15,180,421 (+)	NCBI
Rnor_6.0	6	2,569,015 - 2,610,432 (+)	NCBI
Rnor_5.0	6	2,548,610 - 2,590,125 (+)	NCBI
RGSC_v3.4	6	2,728,722 - 2,771,082 (-)	RGD
Celera	6	14,809,037 - 14,850,517 (+)	RGD

Sequence:

show sequence

ATGGCGGAGGGGGACGAGGCAGCGCGAAGGCAGCAGCCGCAGCAGGGGCTGAGGCGCCGGCGAC
AGACTAGCGACTCGAGCGTCGGGGTTAACCACGTCTCGTCCACGACCTCCTTAGGTGAGGATTA
TGAAGATGCTGACCTAGTGAACTCAGATGAGGTCATGAGGAAACCGTGCCCAGTACAGATTGTC
CTTGCCCATGAAGACGACCATAACTTTGAGCTTGACGAAGAGGCTTTGGAGCGGATACTGCTGC
AGGAGCACATCCGGGACCTTAACATAGTCGTGGTATCTGTGGCAGGAGCTTTTCGTAAAGGGAA
ATCATTTCTCCTGGACTTCATGCTTAGATATATGTATAACAAGGATTCGCAAAGCTGGATTGGT
GGAAGCAATGAGCCGTTGACTGGCTTTACATGGCGAGGTGGTTGTGAAAGAGAAACAACAGGCA
TACAAGTTTGGAATGAAGTGTTTGTGATCGACAGACCTAATGGAACAAAAGTGGCTGTGCTGCT
AATGGATACCCAGGGTGCCTTTGATAGCCAGTCAACCATTAAAGACTGTGCGACGGTGTTTGCT
CTGAGCACCATGACCAGCTCTGTCCAGGTATATAATTTGTCTCAGAATATTCAAGAAGATGATC
TTCAACACTTACAATTATTTACAGAGTATGGGAGACTTGCAATGGAAGAGATCTACCAGAAGCC
ATTTCAGACGTTAATGTTTTTGATTCGAGATTGGAGTTATCCTTATGAGCATTCATATGGCTTG
GAAGGTGGAAAGCAGTTCCTGGAAAAGAGATTGCAGGTAAAACAAAACCAGCACGAAGAGCTAC
AGAATGTCAGGAAGCATATTCACAATTGCTTCTCAAATCTGGGCTGCTTCCTTCTACCACATCC
TGGTCTTAAAGTTGCCACGAACCCTAGTTTTGATGGACGACTGAAAGATATTGATGAAGACTTT
AAACGGGAGCTTCGGAATCTGGTTCCATTGCTGCTTGCTCCTGAGAATCTCGTTGAGAAAGAGA
TAAGTGGATCTAAAGTCACTTGTAGAGATCTTGTAGAGTATTTTAAGGCATACATTAAAATATA
TCAAGGAGAGGAACTACCACATCCAAAATCTATGCTTCAGGCAACAGCTGAGGCTAATAACCTG
GCAGCAGTAGCGGGAGCAAGGGATGCCTACTGTAGAAGTATGGAGCAGGTATGTGGTGGCGACA
AGCCGTACATTGCACCTTCAGATTTGGAGCGAAAACACCTGGATCTCAAGGAAGTGGCGCTCAA
ACAGTTTCGTTCTGTGAAAAAAATGGGTGGTGATGAATTCTGCCGCCGTTATCAGGACCAGCTT
GAAGCTGAAATCGAAGAAACCTATGCAAATTTCATAAAGCACAATGATGGCAAAAACATCTTCT
ATGCTGCTCGCACCCCCGCCACACTGTTCGCAGTCATGTTTGCTATGTACATAATCTCAGGACT
GACCGGCTTCATCGGCCTGAACTCTATAGCTGTCTTATGCAACCTTGTCATGGGGCTGGCACTG
ACCTCCCTGTGTACGTGGGCATATGTTAAGTACTCTGGGGAGTTCAGAGAAATTGGAACAATGA
TTGATCAGGTTGCTGAAACACTATGGGAACAGGTATTGAAGCCCCTGGGTGATAATTTGATGGA
GGAAAACATAAGGCAGTCTGTAACAAACTCTATCAAAGCAGGCCTGACTGACCAGGTGTCTCAT
CATGCCCGATTAAAGACAGACTGACAGCTCATCTCCTCACGGACTCCCTTGTTCATGCTTGCTG
TACAATGAGAACTCAGATAAATAAACCAAAGTTTACAATCAACTGTAGAAGTAGCTTAGTGTAA
CTGGCCTCACAGATGGCTGCCACAGAGTGTGAACATTGTTTGTTGGTTTTCAGCCTTCTTTTGA
TGTCTCCTCAGACCGGCGATTGGCTGAGGAGCGTTAGTTTATCATGCACATTTGTGCCATGTTT
AATTCTTTTCTTTCTTTTTACTGAATTTAATGTTAGTGAAATTTGTCTTATGTAAAAGGATATT
TCAGGGAAATATTTTAAGAAATCTATTTAGAGTCTCTTTAATATAGTGTCCCATTGAAATTTTA
ATTTTTAGAGAATTTATGAATCACTGTATCAAGAATCAGATCGGAATGACAATGAAGCCTTTAT
TGAGCCACTACATTAAAAGTGTATATTGCTTTACTGCCTTCAATGCCAGTATTACATAAATGCA
TGTATCAGAAACTTCACAGAAATCACATGACAACTCGTAGCTGAGAAGGTAATTCTGAGGTGTA
CATTGTCTTGCCTTTTTAAATTTGTAAACCTGCCCTGAACGGAGATGCATTATCTGGGAAACTG
AGCTGTCTTTGCAGTTTAGCCTTTCATGTACATAAAATACGCCATTAATTTTATTGGGGGAGAA
ATTCCATCCAAAAATGTTGCCTACAGCTGTGAGTTAAGAGTGTCTGTACAGTGTGTAGCTTTTA
TTTTCTAAAAATTACAGGTAGGGCATGTATATGAATTATAAATATATAAATACAATTTTGTATT
AAAAGTTTTGTAGTTTATGGCAAAATCTGGTTCTGTGGTAGGCTAATAAGTACAGTCCTGTGAA
AGGAATGTCTGTGGCTCATGTCAGTGTGTGAATGCATAGACAGTTTGAAGTTTTGATATATTTG
TGATATTTATCTTCCTTGAGCACTGCAATCTCACCCCCAAGAGAATTCAATGGGAATGTTTTAT
TGTGACTTGTCCTCTGTTGCATTTTAAAGTTATTTCCTGTAATTTATTTTCAGTACATAATTAA
AAATTTGTTGTATATATAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_063261599 ⟹ XP_063117669

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	20,891,220 - 20,932,644 (+)	NCBI

RefSeq Acc Id:

XM_063261600 ⟹ XP_063117670

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	20,891,220 - 20,932,644 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001094141	(Get FASTA)	NCBI Sequence Viewer
	XP_063117669	(Get FASTA)	NCBI Sequence Viewer
	XP_063117670	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH92650	(Get FASTA)	NCBI Sequence Viewer
	EDM02785	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000008988.5
	ENSRNOP00000071967
	ENSRNOP00000071967.2
	ENSRNOP00000101185.1
	ENSRNOP00000106218
	ENSRNOP00000106218.1

RefSeq Acc Id:

NP_001094141 ⟸ NM_001100671

- UniProtKB:

F1LQ09 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAEGDEAARRQQPQQGLRRRRQTSDSSVGVNHVSSTTSLGEDYEDADLVNSDEVMRKPCPVQIV
LAHEDDHNFELDEEALERILLQEHIRDLNIVVVSVAGAFRKGKSFLLDFMLRYMYNKDSQSWIG
GSNEPLTGFTWRGGCERETTGIQVWNEVFVIDRPNGTKVAVLLMDTQGAFDSQSTIKDCATVFA
LSTMTSSVQVYNLSQNIQEDDLQHLQLFTEYGRLAMEEIYQKPFQTLMFLIRDWSYPYEHSYGL
EGGKQFLEKRLQVKQNQHEELQNVRKHIHNCFSNLGCFLLPHPGLKVATNPSFDGRLKDIDEDF
KRELRNLVPLLLAPENLVEKEISGSKVTCRDLVEYFKAYIKIYQGEELPHPKSMLQATAEANNL
AAVAGARDAYCRSMEQVCGGDKPYIAPSDLERKHLDLKEVALKQFRSVKKMGGDEFCRRYQDQL
EAEIEETYANFIKHNDGKNIFYAARTPATLFAVMFAMYIISGLTGFIGLNSIAVLCNLVMGLAL
TSLCTWAYVKYSGEFREIGTMIDQVAETLWEQVLKPLGDNLMEENIRQSVTNSIKAGLTDQVSH
HARLKTD

hide sequence

Ensembl Acc Id:

ENSRNOP00000008988 ⟸ ENSRNOT00000008988

Ensembl Acc Id:

ENSRNOP00000071234 ⟸ ENSRNOT00000084673

Ensembl Acc Id:

ENSRNOP00000071967 ⟸ ENSRNOT00000077543

RefSeq Acc Id:	XP_063117669 ⟸ XM_063261599
- Peptide Label:	isoform X1
- UniProtKB:	F1LQ09 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063117670 ⟸ XM_063261600
- Peptide Label:	isoform X2
- UniProtKB:	F1LQ09 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000101185 ⟸ ENSRNOT00000134159

Ensembl Acc Id:

ENSRNOP00000106218 ⟸ ENSRNOT00000172058

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-F1LQ09-F1-model_v2	AlphaFold	F1LQ09	1-583	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13694381

Promoter ID:

EPDNEW_R4887

Type:

initiation region

Name:

Atl2_1

Description:

atlastin GTPase 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	6	2,569,003 - 2,569,063	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1305125	AgrOrtholog
BioCyc Gene	G2FUF-38515	BioCyc
Ensembl Genes	ENSRNOG00000006523	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000008988.6	UniProtKB/TrEMBL
	ENSRNOT00000077543	ENTREZGENE
	ENSRNOT00000077543.3	UniProtKB/TrEMBL
	ENSRNOT00000134159.1	UniProtKB/TrEMBL
	ENSRNOT00000172058	ENTREZGENE
	ENSRNOT00000172058.1	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.300	UniProtKB/TrEMBL
	AHSP	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7319396	IMAGE-MGC_LOAD
InterPro	G_GB1_RHD3_dom	UniProtKB/TrEMBL
	Guanylate-bd_C_sf	UniProtKB/TrEMBL
	Guanylate-bd_N	UniProtKB/TrEMBL
	P-loop_NTPase	UniProtKB/TrEMBL
KEGG Report	rno:298757	UniProtKB/TrEMBL
MGC_CLONE	MGC:109431	IMAGE-MGC_LOAD
NCBI Gene	298757	ENTREZGENE
PANTHER	GUANYLATE BINDING PROTEIN	UniProtKB/TrEMBL
Pfam	GBP	UniProtKB/TrEMBL
PhenoGen	Atl2	PhenoGen
PROSITE	G_GB1_RHD3	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000006523	RatGTEx
Superfamily-SCOP	GBP	UniProtKB/TrEMBL
	SSF52540	UniProtKB/TrEMBL
UniProt	A0A0G2JZY7_RAT	UniProtKB/TrEMBL
	A0ABK0L7Q4_RAT	UniProtKB/TrEMBL
	A0ABK0L9C7_RAT	UniProtKB/TrEMBL
	F1LQ09	ENTREZGENE, UniProtKB/TrEMBL
	Q562A0_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2010-04-20	Atl2	atlastin GTPase 2	Arl6ip2	ADP-ribosylation factor-like 6 interacting protein 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-12-06	Arl6ip2	ADP-ribosylation factor-like 6 interacting protein 2	Arl6ip2_predicted	ADP-ribosylation factor-like 6 interacting protein 2 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Arl6ip2_predicted	ADP-ribosylation factor-like 6 interacting protein 2 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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