Fto (FTO, alpha-ketoglutarate dependent dioxygenase) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Fto (FTO, alpha-ketoglutarate dependent dioxygenase) Rattus norvegicus
Analyze
Symbol: Fto
Name: FTO, alpha-ketoglutarate dependent dioxygenase
RGD ID: 1305121
Description: Predicted to enable 2-oxoglutarate-dependent dioxygenase activity and ferrous iron binding activity. Involved in several processes, including negative regulation of eating behavior; positive regulation of insulin secretion involved in cellular response to glucose stimulus; and response to bisphenol A. Predicted to be located in cytoplasm and nuclear speck. Predicted to be active in nucleus. Used to study sciatic neuropathy. Biomarker of metabolic dysfunction-associated steatotic liver disease; obesity; transient cerebral ischemia; traumatic brain injury; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); diabetic neuropathy; nuclear senile cataract; renal cell carcinoma (multiple); and type 2 diabetes mellitus. Orthologous to human FTO (FTO alpha-ketoglutarate dependent dioxygenase); INTERACTS WITH acetamide; aconitine; arsenite(3-).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: alpha-ketoglutarate-dependent dioxygenase FTO; fat mass and obesity associated; fat mass and obesity-associated protein; LOC291905; m6A(m)-demethylase FTO; mRNA (2'-O-methyladenosine-N(6)-)-demethylase FTO; mRNA N(6)-methyladenosine demethylase FTO; RGD1305121; similar to fatso; similar to FTO; tRNA N1-methyl adenine demethylase FTO; U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylase FTO; U6 small nuclear RNA N(6)-methyladenosine-demethylase FTO
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81931,456,749 - 31,865,011 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1931,522,293 - 31,864,957 (-)EnsemblGRCr8
mRatBN7.21915,284,898 - 15,692,142 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1915,349,696 - 15,692,083 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1917,040,780 - 17,381,004 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01922,235,585 - 22,575,539 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01925,181,005 - 25,521,665 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01916,774,549 - 17,115,098 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1916,772,744 - 17,115,113 (-)Ensemblrn6Rnor6.0
Rnor_5.01927,803,098 - 28,182,268 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41916,514,746 - 16,858,800 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1915,258,617 - 15,598,740 (-)NCBICelera
RGSC_v3.11916,517,774 - 16,845,431 (-)NCBI
Cytogenetic Map19p11NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,4-benzoquinone  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-tribromophenol  (ISO)
2,4,6-trichlorophenol  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
acetamide  (EXP)
aconitine  (EXP)
acrolein  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (EXP,ISO)
Benoxacor  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cadmium sulfate  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
cobalt atom  (ISO)
coumarin  (ISO)
dexamethasone  (ISO)
dicrotophos  (ISO)
dihydroartemisinin  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
formaldehyde  (ISO)
fumonisin B1  (ISO)
indometacin  (ISO)
irinotecan  (ISO)
isoflurane  (ISO)
ivermectin  (ISO)
lead(0)  (EXP,ISO)
methapyrilene  (ISO)
methoxychlor  (EXP)
ML-792  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N(6)-methyladenosine  (ISO)
N-acetyl-L-cysteine  (ISO)
nafamostat  (ISO)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paraquat  (ISO)
pentanal  (ISO)
rotenone  (ISO)
sevoflurane  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
Soman  (EXP)
temozolomide  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
triphenyl phosphate  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cellular_component  (ND)
cytoplasm  (IEA,ISO,ISS)
cytosol  (ISO)
nuclear speck  (IEA,ISO,ISS)
nucleus  (IBA,IEA,ISO,ISS)

References

References - curated
# Reference Title Reference Citation
1. Fat mass and obesity-associated gene rs9939609 polymorphism is a potential biomarker of recurrent venous thromboembolism in male but not in female patients. Ahmad A, etal., Gene. 2018 Mar 20;647:136-142. doi: 10.1016/j.gene.2018.01.013. Epub 2018 Jan 9.
2. The fat mass and obesity-associated (FTO) gene variant rs9939609 predicts long-term incidence of cardiovascular disease and related death independent of the traditional risk factors. Aijala M, etal., Ann Med. 2015;47(8):655-63. doi: 10.3109/07853890.2015.1091088. Epub 2015 Nov 11.
3. The obesity associated FTO gene variant and the risk of adverse pregnancy outcomes: Evidence from the SCOPE study. Andraweera PH, etal., Obesity (Silver Spring). 2016 Dec;24(12):2600-2607. doi: 10.1002/oby.21662. Epub 2016 Oct 21.
4. Down-Regulation of m6A mRNA Methylation Is Involved in Dopaminergic Neuronal Death. Chen X, etal., ACS Chem Neurosci. 2019 May 15;10(5):2355-2363. doi: 10.1021/acschemneuro.8b00657. Epub 2019 Mar 14.
5. Perinatal exposure to environmental endocrine disruptor bisphenol A aggravates the onset of non-alcoholic fatty liver disease (NAFLD) in weanling F1 offspring of obese rats. Dabeer S and Raisuddin S, Environ Sci Pollut Res Int. 2023 Jan;30(2):3146-3165. doi: 10.1007/s11356-022-22246-y. Epub 2022 Aug 9.
6. The FTO gene is associated with an atherogenic lipid profile and myocardial infarction in patients with type 2 diabetes: a Genetics of Diabetes Audit and Research Study in Tayside Scotland (Go-DARTS) study. Doney AS, etal., Circ Cardiovasc Genet. 2009 Jun;2(3):255-9. doi: 10.1161/CIRCGENETICS.108.822320. Epub 2009 Mar 30.
7. Involvement of fat mass and obesity gene (FTO) in the anti-obesity action of Annona muricata Annonaceae: in silico and in vivo studies. Elekofehinti OO, etal., J Diabetes Metab Disord. 2020 Mar 12;19(1):197-204. doi: 10.1007/s40200-020-00491-7. eCollection 2020 Jun.
8. FTO (Fat-Mass and Obesity-Associated Protein) Participates in Hemorrhage-Induced Thalamic Pain by Stabilizing Toll-Like Receptor 4 Expression in Thalamic Neurons. Fu G, etal., Stroke. 2021 Jul;52(7):2393-2403. doi: 10.1161/STROKEAHA.121.034173. Epub 2021 Jun 9.
9. Fat mass and obesity-associated gene (FTO) hypermethylation induced by decabromodiphenyl ethane causing cardiac dysfunction via glucolipid metabolism disorder. Gao L, etal., Ecotoxicol Environ Saf. 2022 Jun 1;237:113534. doi: 10.1016/j.ecoenv.2022.113534. Epub 2022 Apr 21.
10. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
11. Fat mass and obesity-associated gene enhances oxidative stress and lipogenesis in nonalcoholic fatty liver disease. Guo J, etal., Dig Dis Sci. 2013 Apr;58(4):1004-9. doi: 10.1007/s10620-012-2516-6. Epub 2013 Jan 18.
12. FTO genotype, physical activity, and coronary heart disease risk in Swedish men and women. Gustavsson J, etal., Circ Cardiovasc Genet. 2014 Apr;7(2):171-7. doi: 10.1161/CIRCGENETICS.111.000007. Epub 2014 Mar 12.
13. Increased m6A methylation level is associated with the progression of human abdominal aortic aneurysm. He Y, etal., Ann Transl Med. 2019 Dec;7(24):797. doi: 10.21037/atm.2019.12.65.
14. Association of variations in the FTO, SCG3 and MTMR9 genes with metabolic syndrome in a Japanese population. Hotta K, etal., J Hum Genet. 2011 Sep;56(9):647-51. doi: 10.1038/jhg.2011.74. Epub 2011 Jul 28.
15. A FTO variant and risk of acute coronary syndrome. Hubacek JA, etal., Clin Chim Acta. 2010 Aug 5;411(15-16):1069-72. doi: 10.1016/j.cca.2010.03.037. Epub 2010 Apr 1.
16. Gene variants at FTO, 9p21, and 2q36.3 are age-independently associated with myocardial infarction in Czech men. Hubacek JA, etal., Clin Chim Acta. 2016 Feb 15;454:119-23. doi: 10.1016/j.cca.2016.01.005. Epub 2016 Jan 7.
17. The fat mass and obesity related gene polymorphism influences the risk of rejection in heart transplant patients. Hubacek JA, etal., Clin Transplant. 2018 Dec;32(12):e13443. doi: 10.1111/ctr.13443. Epub 2018 Nov 22.
18. The FTO variant is associated with chronic complications of diabetes mellitus in Czech population. Hubacek JA, etal., Gene. 2018 Feb 5;642:220-224. doi: 10.1016/j.gene.2017.11.040. Epub 2017 Nov 14.
19. Higher prevalence of FTO gene risk genotypes AA rs9939609, CC rs1421085, and GG rs17817449 and saliva containing Staphylococcus aureus in obese women in Croatia. Huđek A, etal., Nutr Res. 2017 Dec 18;50:94-103. doi: 10.1016/j.nutres.2017.12.005.
20. Obesity as a causal risk factor for deep venous thrombosis: a Mendelian randomization study. Klovaite J, etal., J Intern Med. 2015 May;277(5):573-84. doi: 10.1111/joim.12299. Epub 2014 Sep 15.
21. Loss of Endothelial FTO Antagonizes Obesity-Induced Metabolic and Vascular Dysfunction. Krüger N, etal., Circ Res. 2020 Jan 17;126(2):232-242. doi: 10.1161/CIRCRESAHA.119.315531. Epub 2019 Dec 5.
22. Interactions between the FTO and GNB3 genes contribute to varied clinical phenotypes in hypertension. Kumar R, etal., PLoS One. 2013 May 14;8(5):e63934. doi: 10.1371/journal.pone.0063934. Print 2013.
23. Association of the FTO gene variant (rs9939609) with cardiovascular disease in men with abnormal glucose metabolism--the Finnish Diabetes Prevention Study. Lappalainen T, etal., Nutr Metab Cardiovasc Dis. 2011 Sep;21(9):691-8. doi: 10.1016/j.numecd.2010.01.006. Epub 2010 Apr 18.
24. Intrathecal administration of the fat-mass and obesity-associated protein inhibitor mitigates neuropathic pain in female rats. Li X and Tao YX, Transl Perioper Pain Med. 2022;9(4):478-487. doi: 10.31480/2330-4871/163. Epub 2022 Nov 30.
25. Diagnosis, clustering, and immune cell infiltration analysis of m6A-related genes in patients with acute myocardial infarction-a bioinformatics analysis. Liang C, etal., J Thorac Dis. 2022 May;14(5):1607-1619. doi: 10.21037/jtd-22-569.
26. Relation of age-related cataract with obesity and obesity genes in an Asian population. Lim LS, etal., Am J Epidemiol. 2009 May 15;169(10):1267-74. doi: 10.1093/aje/kwp045. Epub 2009 Mar 27.
27. Assessing the causal relationship between obesity and venous thromboembolism through a Mendelian Randomization study. Lindström S, etal., Hum Genet. 2017 Jul;136(7):897-902. doi: 10.1007/s00439-017-1811-x. Epub 2017 May 20.
28. Exercise training ameliorates myocardial phenotypes in heart failure with preserved ejection fraction by changing N6-methyladenosine modification in mice model. Liu K, etal., Front Cell Dev Biol. 2022 Sep 2;10:954769. doi: 10.3389/fcell.2022.954769. eCollection 2022.
29. Relationship between the FTO Genotype and Early Chronic Kidney Disease in Type 2 Diabetes: The Mediating Role of Central Obesity, Hypertension, and High Albuminuria. Marchetti J, etal., Lifestyle Genom. 2021;14(3):73-80. doi: 10.1159/000516118. Epub 2021 Jun 16.
30. FTO-Dependent N6-Methyladenosine Regulates Cardiac Function During Remodeling and Repair. Mathiyalagan P, etal., Circulation. 2019 Jan 22;139(4):518-532. doi: 10.1161/CIRCULATIONAHA.118.033794.
31. Placental expression of the obesity-associated gene FTO is reduced by fetal growth restriction but not by macrosomia in rats and humans. Mayeur S, etal., J Dev Orig Health Dis. 2013 Apr;4(2):134-8. doi: 10.1017/S2040174412000748.
32. Fat mass and obesity-associated protein attenuates lipid accumulation in macrophage foam cells and alleviates atherosclerosis in apolipoprotein E-deficient mice. Mo C, etal., J Hypertens. 2017 Apr;35(4):810-821. doi: 10.1097/HJH.0000000000001255.
33. Genes associated with Type 2 Diabetes and vascular complications. Montesanto A, etal., Aging (Albany NY). 2018 Feb 4;10(2):178-196. doi: 10.18632/aging.101375.
34. Nutrition modulates Fto and Irx3 gene transcript levels, but does not alter their DNA methylation profiles in rat white adipose tissues. Nowacka-Woszuk J, etal., Gene. 2017 Apr 30;610:44-48. doi: 10.1016/j.gene.2017.02.002. Epub 2017 Feb 5.
35. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
36. Clinical correlations and genetic associations of metabolic syndrome in the United Arab Emirates. Osman WM, etal., Gene. 2020 May 15;738:144476. doi: 10.1016/j.gene.2020.144476. Epub 2020 Feb 18.
37. A common variant of the FTO gene is associated with not only increased adiposity but also elevated blood pressure in French Canadians. Pausova Z, etal., Circ Cardiovasc Genet. 2009 Jun;2(3):260-9. doi: 10.1161/CIRCGENETICS.109.857359. Epub 2009 Mar 31.
38. Association of FTO rs17817449 SNP with obesity and associated physiological parameters in a north Indian population. Prakash J, etal., Ann Hum Biol. 2011 Nov;38(6):760-3. doi: 10.3109/03014460.2011.614278. Epub 2011 Sep 15.
39. The Alteration of M6A-Tagged Transcript Profiles in the Retina of Rats After Traumatic Optic Neuropathy. Qu X, etal., Front Genet. 2021 Feb 16;12:628841. doi: 10.3389/fgene.2021.628841. eCollection 2021.
40. The contribution of FTO and UCP-1 SNPs to extreme obesity, diabetes and cardiovascular risk in Brazilian individuals. Ramos AV, etal., BMC Med Genet. 2012 Nov 7;13:101. doi: 10.1186/1471-2350-13-101.
41. Association between ACE (rs4646994), FABP2 (rs1799883), MTHFR (rs1801133), FTO (rs9939609) Genes Polymorphism and Type 2 Diabetes with Dyslipidemia. Raza ST, etal., Int J Mol Cell Med. 2017 Spring;6(2):121-130. doi: 10.22088/acadpub.BUMS.6.2.6. Epub 2017 Jul 4.
42. An FTO variant is associated with Type 2 diabetes in South Asian populations after accounting for body mass index and waist circumference. Rees SD, etal., Diabet Med. 2011 Jun;28(6):673-80. doi: 10.1111/j.1464-5491.2011.03257.x.
43. GOA pipeline RGD automated data pipeline
44. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
45. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
46. The FTO rs9939609 "A" allele is associated with impaired fasting glucose and insulin resistance in Emirati population. Saber-Ayad M, etal., Gene. 2019 Jan 10;681:93-98. doi: 10.1016/j.gene.2018.09.053. Epub 2018 Sep 29.
47. Myocardial m6A regulators in postnatal development: effect of sex. Semenovykh D, etal., Physiol Res. 2022 Dec 16;71(6):877-882. doi: 10.33549/physiolres.934970. Epub 2022 Nov 25.
48. Genetic risk analysis of coronary artery disease in Pakistani subjects using a genetic risk score of 21 variants. Shahid SU, etal., Atherosclerosis. 2017 Mar;258:1-7. doi: 10.1016/j.atherosclerosis.2017.01.024. Epub 2017 Jan 22.
49. N6-methyladenosine-modified lncRNA and mRNA modification profiles in cerebral ischemia-reperfusion injury. Shao L, etal., Front Genet. 2022 Nov 21;13:973979. doi: 10.3389/fgene.2022.973979. eCollection 2022.
50. Decreased N(6)-methyladenosine in peripheral blood RNA from diabetic patients is associated with FTO expression rather than ALKBH5. Shen F, etal., J Clin Endocrinol Metab. 2015 Jan;100(1):E148-54. doi: 10.1210/jc.2014-1893.
51. Association of gene polymorphism of the fat-mass and obesity-associated gene with insulin resistance in Japanese. Shimaoka I, etal., Hypertens Res. 2010 Mar;33(3):214-8. doi: 10.1038/hr.2009.215. Epub 2010 Jan 15.
52. IDH2 contributes to tumorigenesis and poor prognosis by regulating m6A RNA methylation in multiple myeloma. Song S, etal., Oncogene. 2021 Sep;40(35):5393-5402. doi: 10.1038/s41388-021-01939-7. Epub 2021 Jul 17.
53. Aging-Associated Differences in Epitranscriptomic m6A Regulation in Response to Acute Cardiac Ischemia/Reperfusion Injury in Female Mice. Su X, etal., Front Pharmacol. 2021 Aug 3;12:654316. doi: 10.3389/fphar.2021.654316. eCollection 2021.
54. Demethylase FTO promotes mechanical stress induced osteogenic differentiation of BMSCs with up-regulation of HIF-1α. Sun R, etal., Mol Biol Rep. 2022 Apr;49(4):2777-2784. doi: 10.1007/s11033-021-07089-z. Epub 2022 Jan 10.
55. Silencing of the FTO gene inhibits insulin secretion: An in vitro study using GRINCH cells. Taneera J, etal., Mol Cell Endocrinol. 2018 Sep 5;472:10-17. doi: 10.1016/j.mce.2018.06.003. Epub 2018 Jun 8.
56. FTO Is Associated with Aortic Valve Stenosis in a Gender Specific Manner of Heterozygote Advantage: A Population-Based Case-Control Study. Thron C, etal., PLoS One. 2015 Oct 2;10(10):e0139419. doi: 10.1371/journal.pone.0139419. eCollection 2015.
57. Hypothalamic-specific manipulation of Fto, the ortholog of the human obesity gene FTO, affects food intake in rats. Tung YC, etal., PLoS One. 2010 Jan 19;5(1):e8771. doi: 10.1371/journal.pone.0008771.
58. Four pairs of gene-gene interactions associated with increased risk for type 2 diabetes (CDKN2BAS-KCNJ11), obesity (SLC2A9-IGF2BP2, FTO-APOA5), and hypertension (MC4R-IGF2BP2) in Chinese women. Wang MH, etal., Meta Gene. 2014 May 21;2:384-91. doi: 10.1016/j.mgene.2014.04.010. eCollection 2014 Dec.
59. Associations of genetic markers of diabetes mellitus with carotid atherosclerosis: a community-based case-control study. Wu TW, etal., Cardiovasc Diabetol. 2023 Mar 9;22(1):51. doi: 10.1186/s12933-023-01787-7.
60. The common SNP (rs9939609) in the FTO gene modifies the association between obesity and high blood pressure in Chinese children. Xi B, etal., Mol Biol Rep. 2013 Feb;40(2):773-8. doi: 10.1007/s11033-012-2113-y. Epub 2012 Oct 31.
61. The m6A RNA demethylase FTO is a HIF-independent synthetic lethal partner with the VHL tumor suppressor. Xiao Y, etal., Proc Natl Acad Sci U S A. 2020 Sep 1;117(35):21441-21449. doi: 10.1073/pnas.2000516117. Epub 2020 Aug 19.
62. N6-methyladenosine demethylases Alkbh5/Fto regulate cerebral ischemia-reperfusion injury. Xu K, etal., Ther Adv Chronic Dis. 2020 Apr 29;11:2040622320916024. doi: 10.1177/2040622320916024. eCollection 2020.
63. Epitranscriptomic profiling of N6-methyladenosine-related RNA methylation in rat cerebral cortex following traumatic brain injury. Yu J, etal., Mol Brain. 2020 Jan 28;13(1):11. doi: 10.1186/s13041-020-0554-0.
64. Integrated analysis of m6A mRNA methylation in rats with monocrotaline-induced pulmonary arterial hypertension. Zeng Y, etal., Aging (Albany NY). 2021 Jul 26;13(14):18238-18256. doi: 10.18632/aging.203230. Epub 2021 Jul 26.
65. Alteration of m6A RNA Methylation in Heart Failure With Preserved Ejection Fraction. Zhang B, etal., Front Cardiovasc Med. 2021 Mar 5;8:647806. doi: 10.3389/fcvm.2021.647806. eCollection 2021.
66. m6A demethylase FTO attenuates cardiac dysfunction by regulating glucose uptake and glycolysis in mice with pressure overload-induced heart failure. Zhang B, etal., Signal Transduct Target Ther. 2021 Nov 2;6(1):377. doi: 10.1038/s41392-021-00699-w.
67. Increased m6A RNA modification is related to the inhibition of the Nrf2-mediated antioxidant response in di-(2-ethylhexyl) phthalate-induced prepubertal testicular injury. Zhao TX, etal., Environ Pollut. 2020 Apr;259:113911. doi: 10.1016/j.envpol.2020.113911. Epub 2020 Jan 6.
68. Effect of Pharmacological Inhibition of Fat-Mass and Obesity-Associated Protein on Nerve Trauma-Induced Pain Hypersensitivities. Zheng BX, etal., Neurotherapeutics. 2021 Jul;18(3):1995-2007. doi: 10.1007/s13311-021-01053-2. Epub 2021 Apr 7.
69. N6-methyladenosine demethylase FTO suppresses clear cell renal cell carcinoma through a novel FTO-PGC-1α signalling axis. Zhuang C, etal., J Cell Mol Med. 2019 Mar;23(3):2163-2173. doi: 10.1111/jcmm.14128. Epub 2019 Jan 16.
70. The Impact of Physical Activity and Dietary Measures on the Biochemical and Anthropometric Parameters in Obese Children. Is There Any Genetic Predisposition? Zlatohlavek L, etal., Cent Eur J Public Health. 2015 Nov;23 Suppl:S62-6.
Additional References at PubMed
PMID:12477932   PMID:17991826   PMID:18218688   PMID:18775698   PMID:19234441   PMID:20376003   PMID:21267512   PMID:21779089   PMID:21980407   PMID:22002720   PMID:23671692   PMID:24019958  
PMID:25452335   PMID:26287746   PMID:26457839   PMID:26458103   PMID:28002401   PMID:28914170   PMID:30197295   PMID:35803057   PMID:36327034   PMID:36538851   PMID:37074506   PMID:37199660  
PMID:37437797   PMID:37506852   PMID:37931646   PMID:38092760   PMID:38129517   PMID:38165230   PMID:38340205   PMID:38376496  


Genomics

Comparative Map Data
Fto
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81931,456,749 - 31,865,011 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1931,522,293 - 31,864,957 (-)EnsemblGRCr8
mRatBN7.21915,284,898 - 15,692,142 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1915,349,696 - 15,692,083 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1917,040,780 - 17,381,004 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01922,235,585 - 22,575,539 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01925,181,005 - 25,521,665 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01916,774,549 - 17,115,098 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1916,772,744 - 17,115,113 (-)Ensemblrn6Rnor6.0
Rnor_5.01927,803,098 - 28,182,268 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41916,514,746 - 16,858,800 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1915,258,617 - 15,598,740 (-)NCBICelera
RGSC_v3.11916,517,774 - 16,845,431 (-)NCBI
Cytogenetic Map19p11NCBI
FTO
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381653,703,963 - 54,121,941 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1653,701,692 - 54,158,512 (+)Ensemblhg38GRCh38
GRCh371653,737,875 - 54,155,853 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361652,295,376 - 52,705,882 (+)NCBIBuild 36Build 36hg18NCBI36
Celera1638,252,466 - 38,662,847 (+)NCBICelera
Cytogenetic Map16q12.2NCBI
HuRef1639,624,702 - 40,035,200 (+)NCBIHuRef
CHM1_11655,145,011 - 55,555,415 (+)NCBICHM1_1
T2T-CHM13v2.01659,501,796 - 59,919,950 (+)NCBIT2T-CHM13v2.0
Fto
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39892,039,995 - 92,395,061 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl892,040,153 - 92,395,067 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38891,313,367 - 91,668,433 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl891,313,525 - 91,668,439 (+)Ensemblmm10GRCm38
MGSCv37893,837,424 - 94,192,332 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36894,203,644 - 94,558,535 (+)NCBIMGSCv36mm8
Celera895,629,636 - 95,973,782 (+)NCBICelera
Cytogenetic Map8C5NCBI
cM Map844.34NCBI
Fto
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543311,424,176 - 11,813,771 (+)Ensembl
ChiLan1.0NW_00495543311,424,069 - 11,834,955 (+)NCBIChiLan1.0ChiLan1.0
FTO
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21863,133,875 - 63,537,984 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11669,052,529 - 69,456,636 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01633,939,300 - 34,343,419 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11653,023,203 - 53,451,708 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1653,023,425 - 53,490,231 (+)EnsemblpanPan2panpan1.1
FTO
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1261,699,864 - 62,080,199 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl261,652,236 - 62,080,059 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha258,284,508 - 58,713,282 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0262,193,054 - 62,621,914 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl262,226,376 - 62,622,690 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1259,017,676 - 59,445,579 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0260,044,508 - 60,472,356 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0260,919,844 - 61,348,533 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Fto
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934952,899,665 - 53,267,356 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364756,321,711 - 6,689,588 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364756,321,725 - 6,689,410 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FTO
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl631,174,569 - 31,564,718 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1631,177,112 - 31,564,674 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
FTO
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1539,487,304 - 39,900,238 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl539,487,418 - 39,725,747 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604736,477,673 - 36,894,149 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fto
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247572,675,671 - 3,080,480 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247572,675,810 - 3,081,751 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Fto
2362 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:526
Count of miRNA genes:235
Interacting mature miRNAs:302
Transcripts:ENSRNOT00000015718
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549847Bss8Bone structure and strength QTL 84lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)19131969901Rat
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19799775052997750Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)191922068964220689Rat
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19799775052997750Rat
631840Niddm38Non-insulin dependent diabetes mellitus QTL 383.86blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)191032907674246245Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)19574806450748064Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)193628974246245Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)192409397369093973Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191083361874246245Rat
2303628Vencon9Ventilatory control QTL 90.005respiration trait (VT:0001943)minute ventilation (CMO:0000132)192318858668188586Rat
1558656Prcs1Prostate cancer susceptibility QTL 15prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)193128753251431640Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19799775052997750Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19799775052997750Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)193177788874246245Rat
1554318Bmd5Bone mineral density QTL 512.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)192318858668188586Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)192010930665109306Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19219431774246245Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19219431774246245Rat
61407Scl12Serum cholesterol level QTL 120.001blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)193009938347207961Rat

Markers in Region
D19Mit4  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81931,777,888 - 31,778,130 (+)Marker Load Pipeline
mRatBN7.21915,605,023 - 15,605,265 (+)MAPPERmRatBN7.2
Rnor_6.01917,028,003 - 17,028,244NCBIRnor6.0
Rnor_5.01928,094,796 - 28,095,037UniSTSRnor5.0
RGSC_v3.41916,770,857 - 16,771,099RGDRGSC3.4
RGSC_v3.41916,770,858 - 16,771,099UniSTSRGSC3.4
Celera1915,511,806 - 15,512,046UniSTS
RGSC_v3.11916,775,647 - 16,775,997RGD
RH 2.0 Map19284.5RGD
Cytogenetic Map19p11UniSTS
D19Got6  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21915,353,235 - 15,353,448 (+)MAPPERmRatBN7.2
Rnor_6.01916,776,583 - 16,776,799NCBIRnor6.0
Rnor_5.01927,844,089 - 27,844,305UniSTSRnor5.0
RGSC_v3.41916,516,779 - 16,516,992RGDRGSC3.4
RGSC_v3.41916,516,780 - 16,516,992UniSTSRGSC3.4
Celera1915,260,651 - 15,260,863UniSTS
RGSC_v3.11916,521,605 - 16,521,818RGD
RH 2.0 Map19266.6RGD
Cytogenetic Map19p11UniSTS
RH134051  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81931,524,043 - 31,524,232 (+)Marker Load Pipeline
mRatBN7.21915,351,152 - 15,351,341 (+)MAPPERmRatBN7.2
Rnor_6.01916,774,500 - 16,774,688NCBIRnor6.0
Rnor_5.01927,842,006 - 27,842,194UniSTSRnor5.0
RGSC_v3.41916,514,697 - 16,514,885UniSTSRGSC3.4
Celera1915,258,568 - 15,258,756UniSTS
Cytogenetic Map19p11UniSTS
RH129525  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21915,349,421 - 15,349,620 (+)MAPPERmRatBN7.2
Rnor_6.01916,772,769 - 16,772,967NCBIRnor6.0
Rnor_5.01927,840,275 - 27,840,473UniSTSRnor5.0
RGSC_v3.41916,512,966 - 16,513,164UniSTSRGSC3.4
Celera1915,256,837 - 15,257,035UniSTS
Cytogenetic Map19p11UniSTS
BE110336  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21915,687,899 - 15,688,113 (+)MAPPERmRatBN7.2
Rnor_6.01917,110,942 - 17,111,155NCBIRnor6.0
Rnor_5.01928,178,032 - 28,178,245UniSTSRnor5.0
RGSC_v3.41916,854,644 - 16,854,857UniSTSRGSC3.4
Celera1915,594,576 - 15,594,789UniSTS
Cytogenetic Map19p11UniSTS
BF396845  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21915,568,100 - 15,568,223 (+)MAPPERmRatBN7.2
Rnor_6.01916,991,093 - 16,991,215NCBIRnor6.0
Rnor_5.01928,058,288 - 28,058,410UniSTSRnor5.0
RGSC_v3.41916,733,843 - 16,733,965UniSTSRGSC3.4
Celera1915,474,907 - 15,475,029UniSTS
Cytogenetic Map19p11UniSTS
BI295974  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21915,646,245 - 15,646,402 (+)MAPPERmRatBN7.2
Rnor_6.01917,069,014 - 17,069,170NCBIRnor6.0
Rnor_5.01928,135,813 - 28,135,969UniSTSRnor5.0
RGSC_v3.41916,812,620 - 16,812,776UniSTSRGSC3.4
Celera1915,552,922 - 15,553,078UniSTS
Cytogenetic Map19p11UniSTS
BE120169  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21915,531,489 - 15,531,656 (+)MAPPERmRatBN7.2
Rnor_6.01916,954,524 - 16,954,690NCBIRnor6.0
Rnor_5.01928,021,688 - 28,021,854UniSTSRnor5.0
RGSC_v3.41916,695,715 - 16,695,881UniSTSRGSC3.4
Celera1915,438,362 - 15,438,528UniSTS
Cytogenetic Map19p11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000015718   ⟹   ENSRNOP00000015718
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1931,522,293 - 31,864,957 (-)Ensembl
mRatBN7.2 Ensembl1915,349,696 - 15,692,083 (-)Ensembl
Rnor_6.0 Ensembl1916,772,754 - 17,115,113 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000086829   ⟹   ENSRNOP00000073704
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1931,522,293 - 31,795,228 (-)Ensembl
mRatBN7.2 Ensembl1915,349,696 - 15,622,364 (-)Ensembl
Rnor_6.0 Ensembl1916,772,744 - 17,045,349 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000160451   ⟹   ENSRNOP00000112504
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1931,522,293 - 31,803,914 (-)Ensembl
RefSeq Acc Id: NM_001039713   ⟹   NP_001034802
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81931,524,093 - 31,864,917 (-)NCBI
mRatBN7.21915,351,202 - 15,692,056 (-)NCBI
Rnor_6.01916,774,549 - 17,115,098 (-)NCBI
Rnor_5.01927,803,098 - 28,182,268 (-)NCBI
RGSC_v3.41916,514,746 - 16,858,800 (-)RGD
Celera1915,258,617 - 15,598,740 (-)RGD
Sequence:
RefSeq Acc Id: XM_039097564   ⟹   XP_038953492
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81931,484,721 - 31,865,011 (-)NCBI
mRatBN7.21915,311,827 - 15,692,142 (-)NCBI
RefSeq Acc Id: XM_039097565   ⟹   XP_038953493
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81931,456,749 - 31,865,011 (-)NCBI
mRatBN7.21915,284,898 - 15,692,142 (-)NCBI
RefSeq Acc Id: XM_039097566   ⟹   XP_038953494
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81931,522,290 - 31,864,937 (-)NCBI
mRatBN7.21915,349,399 - 15,692,088 (-)NCBI
RefSeq Acc Id: XM_039097567   ⟹   XP_038953495
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81931,522,290 - 31,802,691 (-)NCBI
mRatBN7.21915,349,399 - 15,627,851 (-)NCBI
RefSeq Acc Id: XM_039097568   ⟹   XP_038953496
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81931,522,290 - 31,804,329 (-)NCBI
mRatBN7.21915,349,399 - 15,631,429 (-)NCBI
RefSeq Acc Id: XM_063277861   ⟹   XP_063133931
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81931,522,290 - 31,804,498 (-)NCBI
RefSeq Acc Id: NP_001034802   ⟸   NM_001039713
- UniProtKB: Q2A121 (UniProtKB/Swiss-Prot),   B4F7E0 (UniProtKB/TrEMBL),   A0A0G2K675 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000073704   ⟸   ENSRNOT00000086829
Ensembl Acc Id: ENSRNOP00000015718   ⟸   ENSRNOT00000015718
RefSeq Acc Id: XP_038953493   ⟸   XM_039097565
- Peptide Label: isoform X2
- UniProtKB: A0A0G2K675 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038953492   ⟸   XM_039097564
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K675 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038953494   ⟸   XM_039097566
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038953496   ⟸   XM_039097568
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038953495   ⟸   XM_039097567
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063133931   ⟸   XM_063277861
- Peptide Label: isoform X3
Ensembl Acc Id: ENSRNOP00000112504   ⟸   ENSRNOT00000160451
Protein Domains
Alpha-ketoglutarate-dependent dioxygenase FTO

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q2A121-F1-model_v2 AlphaFold Q2A121 1-502 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700971
Promoter ID:EPDNEW_R11494
Type:multiple initiation site
Name:Fto_1
Description:FTO, alpha-ketoglutarate dependent dioxygenase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01917,115,125 - 17,115,185EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305121 AgrOrtholog
BioCyc Gene G2FUF-6365 BioCyc
Ensembl Genes ENSRNOG00000011728 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000015718 ENTREZGENE
  ENSRNOT00000015718.7 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.58.1470 UniProtKB/Swiss-Prot
  2.60.120.590 UniProtKB/Swiss-Prot
InterPro AlkB-like_sf UniProtKB/Swiss-Prot
  FTO UniProtKB/Swiss-Prot
  FTO_C UniProtKB/Swiss-Prot
  FTO_C_sf UniProtKB/Swiss-Prot
  FTO_cat_dom UniProtKB/Swiss-Prot
KEGG Report rno:291905 UniProtKB/Swiss-Prot
NCBI Gene 291905 ENTREZGENE
PANTHER ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE FTO UniProtKB/Swiss-Prot
  PTHR31291 UniProtKB/Swiss-Prot
Pfam FTO_CTD UniProtKB/Swiss-Prot
  FTO_NTD UniProtKB/Swiss-Prot
PhenoGen Fto PhenoGen
RatGTEx ENSRNOG00000011728 RatGTEx
SMART FTO_NTD UniProtKB/Swiss-Prot
UniProt A0A0G2K675 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LND2_RAT UniProtKB/TrEMBL
  B4F7E0 ENTREZGENE, UniProtKB/TrEMBL
  FTO_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-09-21 Fto  FTO, alpha-ketoglutarate dependent dioxygenase  Fto  fat mass and obesity associated  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-06 Fto  fat mass and obesity associated  RGD1305121_predicted  similar to FTO (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-04-06   similar to FTO (predicted)  RGD1305121_predicted  similar to fatso (predicted)  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2005-01-20 RGD1305121_predicted  similar to fatso (predicted)  LOC291905_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC291905_predicted  similar to fatso (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL