Cidea (cell death-inducing DFFA-like effector a) - Rat Genome Database

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Gene: Cidea (cell death-inducing DFFA-like effector a) Rattus norvegicus
Analyze
Symbol: Cidea
Name: cell death-inducing DFFA-like effector a
RGD ID: 1305106
Description: Predicted to enable lipid transfer activity; phosphatidic acid binding activity; and protein homodimerization activity. Predicted to be involved in several processes, including lipid droplet fusion; negative regulation of metabolic process; and negative regulation of transforming growth factor beta receptor signaling pathway. Predicted to act upstream of or within lipid metabolic process. Predicted to be located in mitochondrial envelope and nucleus. Predicted to be active in lipid droplet. Human ortholog(s) of this gene implicated in obesity. Orthologous to human CIDEA (cell death inducing DFFA like effector a); INTERACTS WITH (S)-nicotine; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cell death activator CIDE-A; cell death-inducing DNA fragmentation factor, alpha subunit-like effector A; lipid transferase CIDEA; LOC291541
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81863,164,817 - 63,190,384 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1863,164,099 - 63,190,382 (+)EnsemblGRCr8
mRatBN7.21860,894,917 - 60,920,485 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1860,894,874 - 60,920,481 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1862,965,177 - 62,990,782 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01863,663,950 - 63,689,555 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01861,515,712 - 61,541,659 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01863,082,861 - 63,108,450 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1863,098,144 - 63,108,051 (+)Ensemblrn6Rnor6.0
Rnor_5.01862,268,025 - 62,292,643 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41863,871,538 - 63,896,975 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1859,001,666 - 59,027,159 (+)NCBICelera
RGSC_v3.11863,919,174 - 63,970,178 (+)NCBI
Cytogenetic Map18q12.1NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-pantothenic acid  (ISO)
(S)-nicotine  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,2-dichloroethane  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrophenol  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acetamide  (EXP)
aflatoxin B1  (EXP,ISO)
alcohol  (EXP)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
amiodarone  (ISO)
amitrole  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (EXP,ISO)
biotin  (ISO)
biphenyl-4-amine  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorohydrocarbon  (EXP)
chlorpyrifos  (ISO)
choline  (ISO)
chromium atom  (ISO)
ciguatoxin CTX1B  (ISO)
clofibrate  (ISO)
cocaine  (ISO)
Cuprizon  (EXP)
D-glucose  (ISO)
delphinidin  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dibutyl phthalate  (ISO)
dieldrin  (EXP)
diethylstilbestrol  (EXP)
dioxygen  (ISO)
diuron  (EXP)
doxorubicin  (ISO)
fipronil  (EXP)
flutamide  (EXP)
folic acid  (ISO)
fructose  (EXP)
furosemide  (EXP)
gamma-hexachlorocyclohexane  (EXP)
Geniposide  (ISO)
glucose  (ISO)
glycidol  (EXP)
graphite  (ISO)
harmine  (ISO)
imidacloprid  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
indole-3-methanol  (EXP)
inulin  (ISO)
isoflurane  (EXP)
isotretinoin  (ISO)
ketoconazole  (EXP)
L-methionine  (ISO)
Licarin A  (ISO)
mangiferin  (ISO)
methamphetamine  (EXP)
methimazole  (EXP)
methylmercury chloride  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
monosodium L-glutamate  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
nefazodone  (EXP)
nickel atom  (ISO)
nickel dichloride  (EXP)
nickel sulfate  (ISO)
nicotine  (EXP)
nicotinic acid  (ISO)
nimesulide  (EXP)
orphenadrine  (EXP)
oxazepam  (ISO)
ozone  (EXP,ISO)
p-menthan-3-ol  (ISO)
paraquat  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
permethrin  (EXP)
phenobarbital  (EXP)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
rac-lactic acid  (ISO)
resveratrol  (EXP,ISO)
rotenone  (EXP)
scopoletin  (EXP)
sodium arsenite  (ISO)
streptozocin  (EXP,ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
testosterone  (EXP)
thioacetamide  (EXP)
thyroxine  (ISO)
titanium dioxide  (ISO)
tolcapone  (ISO)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (EXP)
usnic acid  (ISO)
valproic acid  (EXP)
VX nerve agent  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (ISO)
cytosol  (IEA)
lipid droplet  (IBA,IEA,ISO)
mitochondrial envelope  (ISO)
mitochondrion  (ISO)
nucleus  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. The CIDEA gene V115F polymorphism is associated with obesity in Swedish subjects. Dahlman I, etal., Diabetes. 2005 Oct;54(10):3032-4.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Comprehensive gene review and curation RGD comprehensive gene curation
7. Cidea-deficient mice have lean phenotype and are resistant to obesity. Zhou Z, etal., Nat Genet. 2003 Sep;35(1):49-56. doi: 10.1038/ng1225. Epub 2003 Aug 10.
Additional References at PubMed
PMID:9564035   PMID:15919794   PMID:17080483   PMID:17086191   PMID:18509062   PMID:19577538   PMID:28763438   PMID:33661766  


Genomics

Comparative Map Data
Cidea
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81863,164,817 - 63,190,384 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1863,164,099 - 63,190,382 (+)EnsemblGRCr8
mRatBN7.21860,894,917 - 60,920,485 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1860,894,874 - 60,920,481 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1862,965,177 - 62,990,782 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01863,663,950 - 63,689,555 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01861,515,712 - 61,541,659 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01863,082,861 - 63,108,450 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1863,098,144 - 63,108,051 (+)Ensemblrn6Rnor6.0
Rnor_5.01862,268,025 - 62,292,643 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41863,871,538 - 63,896,975 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1859,001,666 - 59,027,159 (+)NCBICelera
RGSC_v3.11863,919,174 - 63,970,178 (+)NCBI
Cytogenetic Map18q12.1NCBI
CIDEA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381812,254,361 - 12,277,595 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1812,254,361 - 12,277,595 (+)Ensemblhg38GRCh38
GRCh371812,254,360 - 12,277,594 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361812,244,318 - 12,267,594 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341812,244,787 - 12,267,592NCBI
Celera1812,134,265 - 12,157,825 (+)NCBICelera
Cytogenetic Map18p11.21NCBI
HuRef1812,208,579 - 12,232,002 (+)NCBIHuRef
CHM1_11812,253,696 - 12,277,015 (+)NCBICHM1_1
T2T-CHM13v2.01812,417,352 - 12,440,590 (+)NCBIT2T-CHM13v2.0
Cidea
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391867,476,634 - 67,500,864 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1867,476,674 - 67,500,855 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381867,343,564 - 67,367,794 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1867,343,604 - 67,367,785 (+)Ensemblmm10GRCm38
MGSCv371867,503,218 - 67,527,448 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361867,468,974 - 67,493,147 (+)NCBIMGSCv36mm8
Celera1868,616,250 - 68,640,339 (+)NCBICelera
Cytogenetic Map18E1NCBI
cM Map1839.94NCBI
Cidea
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554021,090,518 - 1,096,569 (-)Ensembl
ChiLan1.0NW_0049554021,090,372 - 1,096,621 (-)NCBIChiLan1.0ChiLan1.0
CIDEA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21725,767,841 - 25,793,449 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11811,461,331 - 11,486,053 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0182,051,880 - 2,075,909 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11817,162,126 - 17,185,450 (-)NCBIPanPan1.1PanPan1.1panPan2
CIDEA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1777,685,383 - 77,703,320 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl777,684,863 - 77,702,934 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha777,086,385 - 77,104,317 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0777,743,846 - 77,761,779 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl777,743,898 - 77,761,770 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1777,440,425 - 77,458,243 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0777,487,476 - 77,505,403 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0777,774,353 - 77,792,294 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Cidea
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049441,002,039 - 1,028,179 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936626230,329 - 246,893 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936626230,372 - 246,893 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CIDEA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl697,253,074 - 97,267,405 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1697,253,074 - 97,268,355 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CIDEA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11870,836,188 - 70,853,917 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605045,858,688 - 45,878,472 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cidea
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477019,559,692 - 19,573,788 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462477019,559,735 - 19,573,394 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Cidea
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11563,921,804 - 63,947,613 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Cidea
210 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182507112683910656Rat
1331730Scl27Serum cholesterol level QTL 273.826blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)185449080186134022Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182349405785487725Rat
1331742Bp228Blood pressure QTL 2283.88752arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050577371277Rat
1300125Rf26Renal function QTL 263.2urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)185335052168120379Rat
631834Sach3Saccharin preference QTL 33.90.01consumption behavior trait (VT:0002069)calculated saccharin drink intake volume (CMO:0001600)183857591983575919Rat
12904668Bw188Body weight QTL 1880.03body mass (VT:0001259)body weight (CMO:0000012)182682218671822186Rat
12904669Cm125Cardiac mass QTL 1250.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)182682218671822186Rat
12904670Cm126Cardiac mass QTL 1260.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)182682218671822186Rat
6893683Bw110Body weight QTL 1102.70.002body mass (VT:0001259)body weight (CMO:0000012)184562030686134022Rat
1331727Bp237Blood pressure QTL 2373.053arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050563968306Rat
12904677Kidm72Kidney mass QTL 720.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)182682218671822186Rat
9589041Epfw12Epididymal fat weight QTL 1217.080.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)184891573786134022Rat
8694432Bw165Body weight QTL 1653.810.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)184891573786134022Rat
12904673Cm127Cardiac mass QTL 1270.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)182682218671822186Rat
12904675Am19Aortic mass QTL 190.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)182682218671822186Rat
1331774Bp226Blood pressure QTL 2264.41065arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050577371277Rat
9589816Gluco68Glucose level QTL 687.250.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)183199089176990891Rat
1331770Bp234Blood pressure QTL 2343.807arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184562030686134022Rat
2301969Bp324Blood pressure QTL 3244.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)186198220476619168Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181206648285493247Rat
2303120Mamtr8Mammary tumor resistance QTL 80.001mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)183161050585493247Rat
12880368Bw187Body weight QTL 1870.045body mass (VT:0001259)body weight (CMO:0000012)183337915878379158Rat
724542Kidm2Kidney mass QTL 22.6kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)186144685386134022Rat
61367Iddm4Insulin dependent diabetes mellitus QTL 42.330.0074blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)184046238385462383Rat
1359020Ppulsi2Prepulse inhibition QTL 22.71prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)185449080176272247Rat
2312600Bp341Blood pressure QTL 3410.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)186160038472538878Rat
9590318Scort22Serum corticosterone level QTL 227.640.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)183199089176990891Rat
1331752Bw27Body weight QTL 272.963body mass (VT:0001259)body weight (CMO:0000012)185449080168120379Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181206648285493247Rat
1331754Bp230Blood pressure QTL 2304.61609arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181564228086134022Rat
12904069Cm123Cardiac mass QTL 1230.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)183337915878379158Rat
1331798Bp224Blood pressure QTL 2243.53873arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050577371277Rat
12904070Cm124Cardiac mass QTL 1240.01heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)183337915878379158Rat
12904071Am18Aortic mass QTL 180.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)183337915878379158Rat
2303584Gluco55Glucose level QTL 552blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)185079521286134022Rat
2301413Bp318Blood pressure QTL 3180.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182682218671822186Rat
61383Bp47Blood pressure QTL 4717.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)183152278376522783Rat
12904067Cm122Cardiac mass QTL 1220.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)183337915878379158Rat
61384Bp48Blood pressure QTL 4819.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)186289225779484461Rat
2301417Bp319Blood pressure QTL 3190.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183337915878379158Rat
12904073Kidm71Kidney mass QTL 710.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)183337915878379158Rat
738008Hcar14Hepatocarcinoma resistance QTL 144.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion number (CMO:0001462)185782524385493247Rat
1331776Bp225Blood pressure QTL 2252.829arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)183161050577371277Rat
631518Bw11Body weight QTL 112.8body mass (VT:0001259)body weight (CMO:0000012)183612162681121626Rat
1641923Colcr8Colorectal carcinoma resistance QTL 83.10.0014intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)183199089176990891Rat
8694366Abfw8Abdominal fat weight QTL 86.380.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)184891573786134022Rat
631509Sald2Serum aldosterone level QTL 22.9blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)182641582171415821Rat
631274Sprol1Serum protein level QTL 15.3blood total protein amount (VT:0005567)serum total protein level (CMO:0000661)183164450879484311Rat
1598832Glom11Glomerulus QTL 112.9kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)185326667186134022Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181955353285493247Rat
8694378Bw157Body weight QTL 1573.590.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)183199089176990891Rat
2303571Bw92Body weight QTL 923body mass (VT:0001259)body weight (CMO:0000012)185079521286134022Rat
631675Iddm15Insulin dependent diabetes mellitus QTL 15urine glucose amount (VT:0001758)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)186289225779484461Rat
61429Cia17Collagen induced arthritis QTL 174.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)183161050572538878Rat
7411719Strs5Sensitivity to stroke QTL 59.4cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)185219805968120379Rat

Markers in Region
D18Got62  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21860,906,701 - 60,906,914 (+)MAPPERmRatBN7.2
Rnor_6.01863,094,612 - 63,094,824NCBIRnor6.0
Rnor_5.01862,279,280 - 62,279,492UniSTSRnor5.0
RGSC_v3.41863,883,157 - 63,883,369UniSTSRGSC3.4
RGSC_v3.41863,883,156 - 63,883,369RGDRGSC3.4
Celera1859,013,355 - 59,013,553UniSTS
RGSC_v3.11863,956,358 - 63,956,570RGD
RH 3.4 Map18618.2UniSTS
RH 3.4 Map18618.2RGD
RH 2.0 Map18296.1RGD
Cytogenetic Map18q12.1UniSTS
RH128852  
Rat AssemblyChrPosition (strand)SourceJBrowse
RGSC_v3.41863,896,776 - 63,896,974UniSTSRGSC3.4
RH 3.4 Map18625.5UniSTS
Cytogenetic Map18q12.1UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 138 89 88 57 43 57 6 303 143 11 117 79 91 31 12 12

Sequence


Ensembl Acc Id: ENSRNOT00000024968   ⟹   ENSRNOP00000024968
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1863,168,294 - 63,190,382 (+)Ensembl
mRatBN7.2 Ensembl1860,898,400 - 60,920,481 (+)Ensembl
Rnor_6.0 Ensembl1863,098,144 - 63,108,051 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000099378   ⟹   ENSRNOP00000088912
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1863,168,148 - 63,190,382 (+)Ensembl
mRatBN7.2 Ensembl1860,906,421 - 60,920,481 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000110214   ⟹   ENSRNOP00000095439
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1863,164,801 - 63,190,382 (+)Ensembl
mRatBN7.2 Ensembl1860,894,874 - 60,920,481 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000112497   ⟹   ENSRNOP00000078103
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1863,168,493 - 63,190,379 (+)Ensembl
mRatBN7.2 Ensembl1860,898,584 - 60,920,481 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000115288   ⟹   ENSRNOP00000077736
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1863,164,099 - 63,190,382 (+)Ensembl
mRatBN7.2 Ensembl1860,900,436 - 60,920,481 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000123416   ⟹   ENSRNOP00000108103
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1863,164,801 - 63,190,382 (+)Ensembl
RefSeq Acc Id: NM_001170467   ⟹   NP_001163938
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81863,164,817 - 63,190,380 (+)NCBI
mRatBN7.21860,894,917 - 60,920,481 (+)NCBI
Rnor_6.01863,082,861 - 63,108,450 (+)NCBI
Rnor_5.01862,268,025 - 62,292,643 (+)NCBI
RGSC_v3.41863,871,538 - 63,896,975 (+)RGD
Celera1859,001,666 - 59,027,159 (+)RGD
Sequence:
RefSeq Acc Id: XM_039096669   ⟹   XP_038952597
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81863,168,459 - 63,190,384 (+)NCBI
mRatBN7.21860,898,548 - 60,920,485 (+)NCBI
RefSeq Acc Id: XM_039096670   ⟹   XP_038952598
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81863,168,459 - 63,190,384 (+)NCBI
mRatBN7.21860,898,596 - 60,920,485 (+)NCBI
RefSeq Acc Id: NP_001163938   ⟸   NM_001170467
- UniProtKB: A0A8I6AJS6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000024968   ⟸   ENSRNOT00000024968
RefSeq Acc Id: XP_038952597   ⟸   XM_039096669
- Peptide Label: isoform X1
- UniProtKB: A0A8I5Y2E9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038952598   ⟸   XM_039096670
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AJS6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000095439   ⟸   ENSRNOT00000110214
Ensembl Acc Id: ENSRNOP00000077736   ⟸   ENSRNOT00000115288
Ensembl Acc Id: ENSRNOP00000088912   ⟸   ENSRNOT00000099378
Ensembl Acc Id: ENSRNOP00000078103   ⟸   ENSRNOT00000112497
Ensembl Acc Id: ENSRNOP00000108103   ⟸   ENSRNOT00000123416
Protein Domains
CIDE-N

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4ACH9-F1-model_v2 AlphaFold D4ACH9 1-182 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305106 AgrOrtholog
BioCyc Gene G2FUF-7145 BioCyc
Ensembl Genes ENSRNOG00000018505 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000024968.9 UniProtKB/TrEMBL
  ENSRNOT00000099378.2 UniProtKB/TrEMBL
  ENSRNOT00000110214 ENTREZGENE
  ENSRNOT00000110214.2 UniProtKB/TrEMBL
  ENSRNOT00000112497 ENTREZGENE
  ENSRNOT00000112497.2 UniProtKB/TrEMBL
  ENSRNOT00000115288.2 UniProtKB/TrEMBL
  ENSRNOT00000123416.1 UniProtKB/TrEMBL
Gene3D-CATH 3.10.20.10 UniProtKB/TrEMBL
InterPro CAD UniProtKB/TrEMBL
  CIDE-A UniProtKB/TrEMBL
NCBI Gene 291541 ENTREZGENE
PANTHER CELL DEATH ACTIVATOR CIDE UniProtKB/TrEMBL
  PTHR12306:SF8 UniProtKB/TrEMBL
Pfam CIDE-N UniProtKB/TrEMBL
PhenoGen Cidea PhenoGen
PROSITE CIDE_N UniProtKB/TrEMBL
RatGTEx ENSRNOG00000018505 RatGTEx
SMART CAD UniProtKB/TrEMBL
Superfamily-SCOP CAD & PB1 domains UniProtKB/TrEMBL
UniProt A0A8I5Y1I8_RAT UniProtKB/TrEMBL
  A0A8I5Y2E9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AJN5_RAT UniProtKB/TrEMBL
  A0A8I6AJS6 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LZQ3_RAT UniProtKB/TrEMBL
  D4ACH9_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-11-05 Cidea  cell death-inducing DFFA-like effector a  Cidea  cell death-inducing DNA fragmentation factor, alpha subunit-like effector A   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Cidea  cell death-inducing DNA fragmentation factor, alpha subunit-like effector A   Cidea_predicted  cell death-inducing DNA fragmentation factor, alpha subunit-like effector A (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Cidea_predicted  cell death-inducing DNA fragmentation factor, alpha subunit-like effector A (predicted)      Symbol and Name status set to approved 70820 APPROVED