Advanced Search (OLGA)

Gene: Mxd4 (Max dimerization protein 4) Rattus norvegicus

Analyze

Symbol:

Mxd4

Name:

Max dimerization protein 4

RGD ID:

1305093

Description:

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to contribute to DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to act upstream of or within negative regulation of DNA-templated transcription. Predicted to be located in nucleus. Predicted to be part of RNA polymerase II transcription regulator complex. Orthologous to human MXD4 (MAX dimerization protein 4); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC360961

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	MXD4 (MAX dimerization protein 4)	RGD	RGD
Mus musculus (house mouse):	Mxd4 (Max dimerization protein 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Mxd4 (MAX dimerization protein 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	MXD4 (MAX dimerization protein 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	MXD4 (MAX dimerization protein 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Mxd4 (MAX dimerization protein 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	MXD4 (MAX dimerization protein 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	MXD4 (MAX dimerization protein 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Mxd4 (MAX dimerization protein 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Mxd4 (MAX dimerization protein 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	LMX1A (LIM homeobox transcription factor 1 alpha)	HGNC	OMA
Homo sapiens (human):	MAEL (maelstrom spermatogenic transposon silencer)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	MXD4 (MAX dimerization protein 4)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	MXD4 (MAX dimerization protein 4)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Mxd4 (Max dimerization protein 4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	mxd4 (MAX dimerization protein 4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	mdl-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	mdl-1	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	mxd4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	mxd4	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	80,786,768 - 80,800,790 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	14	80,786,342 - 80,800,788 (+)	Ensembl				GRCr8
mRatBN7.2	14	76,562,105 - 76,576,224 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	76,561,774 - 76,576,221 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	14	81,014,092 - 81,028,122 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	82,254,721 - 82,268,759 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	78,699,972 - 78,714,002 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd	14	81,321,676 - 81,335,685 (+)	NCBI		Dahl_SR_JrHsd
Lyon_Normotensive	14	79,946,624 - 79,960,633 (+)	NCBI		Lyon_Normotensive
Lyon_Hypertensive	14	81,469,181 - 81,483,190 (+)	NCBI		Lyon_Hypertensive
F344_StmMcwi	14	80,380,111 - 80,394,095 (+)	NCBI		F344_StmMcwi
Rnor_6.0	14	81,819,415 - 81,833,456 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	81,819,415 - 81,833,456 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	14	82,504,529 - 82,518,778 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	14	82,253,309 - 82,264,705 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	14	75,485,821 - 75,497,217 (+)	NCBI		Celera
RGSC_v3.1	14	82,255,491 - 82,266,879 (+)	NCBI
Cytogenetic Map	14	q21	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

(1->4)-beta-D-glucan (ISO)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-palmitoylglycerol (ISO)

3,3',5,5'-tetrabromobisphenol A (ISO)

3,4-methylenedioxymethamphetamine (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (ISO)

aflatoxin B1 (ISO)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol AF (ISO)

buta-1,3-diene (ISO)

butan-1-ol (ISO)

butanal (ISO)

cadmium atom (EXP)

cadmium dichloride (EXP,ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chloroprene (ISO)

cisplatin (ISO)

clofibrate (ISO)

copper(II) chloride (ISO)

copper(II) sulfate (ISO)

coumestrol (ISO)

cyclosporin A (ISO)

DDE (ISO)

dexamethasone (ISO)

diazinon (ISO)

dibutyl phthalate (ISO)

diethylstilbestrol (ISO)

dimethyl sulfoxide (ISO)

dioxygen (EXP,ISO)

doxorubicin (ISO)

endosulfan (EXP)

Enterolactone (ISO)

ethanol (ISO)

ethyl methanesulfonate (ISO)

fenthion (ISO)

folic acid (ISO)

genistein (ISO)

gentamycin (EXP)

geraniol (ISO)

GSK-J4 (ISO)

GW 7647 (EXP)

indometacin (ISO)

lead diacetate (ISO)

manganese(II) chloride (EXP)

methamphetamine (ISO)

methidathion (ISO)

N-methyl-4-phenylpyridinium (EXP)

naled (ISO)

ozone (ISO)

palbociclib (ISO)

paracetamol (EXP)

paraquat (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (EXP)

potassium chromate (ISO)

rotenone (ISO)

silicon dioxide (ISO)

silver atom (ISO)

silver(0) (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

Soman (EXP)

succimer (ISO)

sulforaphane (ISO)

testosterone enanthate (ISO)

tetrachloromethane (EXP,ISO)

thioacetamide (EXP)

thiram (ISO)

titanium dioxide (ISO)

tremolite asbestos (ISO)

tributylstannane (EXP)

triphenyl phosphate (ISO)

tris(2-butoxyethyl) phosphate (ISO)

troglitazone (ISO)

urethane (ISO)

valproic acid (ISO)

vinclozolin (EXP)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

DNA-templated transcription (IEA)

negative regulation of DNA-templated transcription (ISO)

negative regulation of transcription by RNA polymerase II (ISO)

regulation of transcription by RNA polymerase II (IBA)

Cellular Component

cytosol (ISO)

nucleus (IEA)

RNA polymerase II transcription regulator complex (ISO)

Molecular Function

DNA binding (IEA,ISO)

DNA-binding transcription factor activity, RNA polymerase II-specific (IBA)

DNA-binding transcription repressor activity, RNA polymerase II-specific (ISO)

protein binding (ISO)

protein dimerization activity (IEA)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (IBA)

RNA polymerase II transcription regulatory region sequence-specific DNA binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	GOA pipeline	RGD automated data pipeline
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:8521822

Genomics

Comparative Map Data

Mxd4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	80,786,768 - 80,800,790 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	14	80,786,342 - 80,800,788 (+)	Ensembl				GRCr8
mRatBN7.2	14	76,562,105 - 76,576,224 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	76,561,774 - 76,576,221 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	14	81,014,092 - 81,028,122 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	82,254,721 - 82,268,759 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	78,699,972 - 78,714,002 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd	14	81,321,676 - 81,335,685 (+)	NCBI		Dahl_SR_JrHsd
Lyon_Normotensive	14	79,946,624 - 79,960,633 (+)	NCBI		Lyon_Normotensive
Lyon_Hypertensive	14	81,469,181 - 81,483,190 (+)	NCBI		Lyon_Hypertensive
F344_StmMcwi	14	80,380,111 - 80,394,095 (+)	NCBI		F344_StmMcwi
Rnor_6.0	14	81,819,415 - 81,833,456 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	81,819,415 - 81,833,456 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	14	82,504,529 - 82,518,778 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	14	82,253,309 - 82,264,705 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	14	75,485,821 - 75,497,217 (+)	NCBI		Celera
RGSC_v3.1	14	82,255,491 - 82,266,879 (+)	NCBI
Cytogenetic Map	14	q21	NCBI

MXD4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	4	2,247,432 - 2,262,109 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	4	2,247,432 - 2,262,115 (-)	Ensembl			hg38	GRCh38
GRCh37	4	2,249,159 - 2,263,836 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	2,218,958 - 2,233,537 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	4	2,216,390 - 2,230,970	NCBI
Celera	4	2,161,509 - 2,176,088 (-)	NCBI		Celera
Cytogenetic Map	4	p16.3	NCBI
HuRef	4	2,190,152 - 2,204,706 (-)	NCBI		HuRef
CHM1_1	4	2,247,665 - 2,262,244 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	4	2,246,204 - 2,260,881 (-)	NCBI		T2T-CHM13v2.0

Mxd4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	34,331,231 - 34,345,076 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	34,331,227 - 34,345,064 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	5	34,176,580 - 34,187,710 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	34,173,883 - 34,187,720 (-)	Ensembl			mm10	GRCm38
MGSCv37	5	34,519,229 - 34,530,359 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	5	34,493,437 - 34,504,567 (-)	NCBI		MGSCv36	mm8
MGSCv36	5	32,887,006 - 32,898,136 (-)	NCBI		MGSCv36	mm8
Celera	5	31,647,161 - 31,658,349 (-)	NCBI		Celera
Cytogenetic Map	5	B2	NCBI
cM Map	5	17.84	NCBI

Mxd4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955514	1,345,960 - 1,358,092 (-)	Ensembl
ChiLan1.0	NW_004955514	1,348,602 - 1,358,092 (-)	NCBI	ChiLan1.0	ChiLan1.0

MXD4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	3	2,581,151 - 2,595,884 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	4	2,517,600 - 2,532,333 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	4	2,390,409 - 2,405,141 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	4	2,298,112 - 2,310,442 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2

MXD4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	3	61,927,722 - 61,941,780 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	3	61,927,816 - 61,938,638 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	3	64,445,683 - 64,459,744 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	3	62,403,021 - 62,417,086 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	3	62,403,118 - 62,414,892 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	3	61,895,895 - 61,909,954 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	3	62,099,576 - 62,113,646 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	3	62,459,495 - 62,473,558 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Mxd4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405285	67,531,339 - 67,544,510 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936477	21,235,288 - 21,246,202 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936477	21,233,026 - 21,246,202 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MXD4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	8	1,203,172 - 1,216,725 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	8	1,203,163 - 1,216,807 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	8	695,002 - 708,702 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MXD4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	27	46,502,767 - 46,517,500 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666051	2,872,601 - 2,887,443 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Mxd4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624755	25,300,712 - 25,313,243 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624755	25,300,875 - 25,313,128 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Mxd4
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	11	77,054,424 - 77,068,362 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Mxd4
36 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	112
Count of miRNA genes:	91
Interacting mature miRNAs:	96
Transcripts:	ENSRNOT00000018515
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2313089	Bss81	Bone structure and strength QTL 81	3.4	0.0001	body length (VT:0001256)	body length, nose to rump (CMO:0000079)	14	38023710	83023710	Rat
9590294	Uminl4	Urine mineral level QTL 4	5.66	0.001	urine mineral amount (VT:0015086)	urine electrolyte level (CMO:0000593)	14	59848686	104848686	Rat
1582236	Gluco22	Glucose level QTL 22	3.3	0.0164	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	14	77640071	96755654	Rat
2300197	Scl59	Serum cholesterol level QTL 59			blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	14	77914838	104348525	Rat
70214	Niddm28	Non-insulin dependent diabetes mellitus QTL 28	4.06		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	14	39009444	84009444	Rat
70153	Bp59	Blood pressure QTL 59	3.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	14	72970210	87582095	Rat
70187	Pancm5	Pancreatic morphology QTL 5	16.7		pancreas mass (VT:0010144)	pancreas weight to body weight ratio (CMO:0000630)	14	30674469	85041098	Rat
631523	Pia13	Pristane induced arthritis QTL 13	3.3		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	14	33424686	102238540	Rat
1582259	Gluco23	Glucose level QTL 23	3.1	0.0008	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	14	74255551	109089856	Rat
1582197	Gluco27	Glucose level QTL 27	3.4	0.0006	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	14	77640071	96755654	Rat
2313100	Bss82	Bone structure and strength QTL 82	3	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	14	38023710	83023710	Rat
634328	Hc5	Hypercalciuria QTL 5	2.3		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	14	62398852	107398852	Rat
1582250	Gluco26	Glucose level QTL 26	3.3	0.0009	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	14	77640071	100078267	Rat
2317879	Alcrsp27	Alcohol response QTL 27	3.3	0.63	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	14	60854936	105854936	Rat
1641900	Alcrsp11	Alcohol response QTL 11			alcohol metabolism trait (VT:0015089)	blood ethanol level (CMO:0000535)	14	74255551	109089856	Rat
631839	Niddm37	Non-insulin dependent diabetes mellitus QTL 37	3.37		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	14	11334716	100078267	Rat
1582255	Gluco29	Glucose level QTL 29	3.1	0.0025	blood glucose amount (VT:0000188)	absolute change in blood glucose level area under curve (CMO:0002034)	14	77640071	96755654	Rat
9589034	Epfw11	Epididymal fat weight QTL 11	6	0.001	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	14	59848686	104848686	Rat
1582209	Gluco20	Glucose level QTL 20	3.8	0.0005	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	14	77640071	96755654	Rat
2313048	Bss84	Bone structure and strength QTL 84	3.1	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	14	38023710	83023710	Rat
1300136	Rf22	Renal function QTL 22	3.9		renal blood flow trait (VT:2000006)	absolute change in renal vascular resistance (CMO:0001900)	14	42616258	99224555	Rat
1549834	Scl45	Serum cholesterol level QTL 45	5.8		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	14	65920283	99224555	Rat
738037	Hcas6	Hepatocarcinoma susceptibility QTL 6	2.93		liver integrity trait (VT:0010547)	liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)	14	39411170	87582095	Rat
2313084	Bss83	Bone structure and strength QTL 83	2.9	0.0001	tibia size trait (VT:0100001)	tibia midshaft endosteal cross-sectional area (CMO:0001716)	14	38023710	83023710	Rat

Markers in Region

AI059001

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	14	76,573,221 - 76,573,403 (+)	MAPPER	mRatBN7.2
Rnor_6.0	14	81,830,454 - 81,830,635	NCBI	Rnor6.0
Rnor_5.0	14	82,515,776 - 82,515,957	UniSTS	Rnor5.0
RGSC_v3.4	14	82,264,348 - 82,264,529	UniSTS	RGSC3.4
Celera	14	75,496,860 - 75,497,041	UniSTS
Cytogenetic Map	14	q21	UniSTS

BI274201

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	14	80,796,963 - 80,797,617 (+)	Marker Load Pipeline
mRatBN7.2	14	76,572,397 - 76,573,051 (+)	MAPPER	mRatBN7.2
Rnor_6.0	14	81,829,630 - 81,830,283	NCBI	Rnor6.0
Rnor_5.0	14	82,514,952 - 82,515,605	UniSTS	Rnor5.0
RGSC_v3.4	14	82,263,524 - 82,264,177	UniSTS	RGSC3.4
Celera	14	75,496,036 - 75,496,689	UniSTS
Cytogenetic Map	14	q21	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	164	91	90	59	92	59	6	356	192	11	143	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001394732	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017599316	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473963	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000014	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000018515 ⟹ ENSRNOP00000018515

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	14	81,819,415 - 81,830,811 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000075863 ⟹ ENSRNOP00000068353

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	14	81,819,459 - 81,830,780 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000076840 ⟹ ENSRNOP00000068275

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	14	81,819,799 - 81,829,639 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000077060 ⟹ ENSRNOP00000067906

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	14	76,562,312 - 76,576,221 (+)	Ensembl
Rnor_6.0 Ensembl	14	81,819,469 - 81,833,456 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000093859 ⟹ ENSRNOP00000093856

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	14	80,786,342 - 80,800,788 (+)	Ensembl
mRatBN7.2 Ensembl	14	76,561,774 - 76,576,221 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000146361 ⟹ ENSRNOP00000108444

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	14	80,786,801 - 80,798,803 (+)	Ensembl

RefSeq Acc Id:

NM_001394732 ⟹ NP_001381661

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	14	80,786,781 - 80,800,790 (+)	NCBI
mRatBN7.2	14	76,562,214 - 76,576,224 (+)	NCBI
Dahl_SR_JrHsd	14	81,321,676 - 81,335,685 (+)	NCBI
Lyon_Normotensive	14	79,946,624 - 79,960,633 (+)	NCBI
Lyon_Hypertensive	14	81,469,181 - 81,483,190 (+)	NCBI
F344_StmMcwi	14	80,380,111 - 80,394,095 (+)	NCBI

RefSeq Acc Id:

XM_017599316 ⟹ XP_017454805

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	14	80,786,768 - 80,800,790 (+)	NCBI
mRatBN7.2	14	76,562,187 - 76,576,224 (+)	NCBI
Rnor_6.0	14	81,819,420 - 81,833,456 (+)	NCBI

Sequence:

show sequence

TTGGCTGTGTCGACTGCTGCTCTACTTATGTGTCAATTTGAGGGCCTGAGGCGGAGGGTGGCGG
CCCAGCGCTGGAGTCCGCGAGTCGCGCTGGTGTGCCGCCAGGCGCGGGGCGTGCGGCGAGCAGA
GCCGGCAGGAGCGCGCCGGGCAGCCGCCGCCGCCGTCCCGTGCGCGGGCGGCAGGATGGAGCTG
AACTCTCTGCTGCTGCTGTTGGAGGCGGCCGAGTACCTGGAGCGTAGGGACCGAGAGGCCGAGC
ACGGCTACGCCTCGGTGCTGCCCTTCGACGGTGACTTCGCCAGGAAGAAAACAAAGACGGCCGG
CCTGGTGCGCAAGGCCCCGAACAACAGACGAGCTAAACTCAGGCTCTACTTGGAGCAGCTCAAG
CAGCTGGTACCCCTGGGCCCTGACAGCACGCGCCACACCACTCTGAGCCTCCTGAAGCGTGCTA
AGATGCACATCAAGAAACTGGAGGAGCAGGACCGCAGGGCACTGAGCATCAAGGAGCAGCTTCA
GCGGGAGCATCGCTTCCTAAAGAGACGTTTGGAGCAGCTATCGGTGCAGAGTGTAGAGCGAGTG
CGCACTGACAGCACTGGTTCTGCTGTGTCCACAGACGATTCAGAGCAAGAGGTGGATATAGAGG
GCATGGAGTTTGGCCCTGGGGAGCTGGACAGTGTTGGCAGCAGCAGTGATGCCGATGACCACTA
CAGCCTACAGAGCAGTGGCTGCAGCGACAGCAGCTATGGGCATCCTTGCAGGCGGCCTGGCTGC
CCCGGCCTTTCGTAGGCTCTATGTCCTTTGCTTCCTGGCCCACCTGCCTGCTCACCTAGCCAAG
CGTCTCAGCCTTCCAATCCTCCCTTGACTGAAGCCAGCCTCATCATGGGCCTACTGCTGTGCCA
TTCTCCAAGCTACAGCTGCTGCCTGGTCTGCCTGCCTCTGCCTGCCCACCCTTCGGTCAGGACT
CAAGTTGCCTGTCCCTTCTCCGCAGGGCAAGACCCCATGCAGGGAAGCAGGATCAGGCTCTCAC
ATCCTGGAGCCCAGGGTAGCCACCCACAATCTGTTCTCAGATTCCTAATCATTCCAGAAGTATT
AAATATCATTTCTACAAATCTCGGCAGGATCCGTGTAGGGGCCTTAATGACCACCATGGGGAGC
TTGAACCCCAACAACGGATCCCAGGAGAGAGGAGTGGACTGAGGAAGGAAGGAAGAAAGGAAGG
AAGGAAGGAAGGAAGGAAGGAAGGAAGGAAGGAAGGAAAAGGAAAGGAAAGGGAAGGGAGGGAG
GAAAGTGCTGCTGTCCGTCTATCCATCTATCCATCTAGCTATTGGTCCACATAATCTGAGGTGT
GGACAGAGGGATCTGTGAAGGGTAGTAACTTGAATGAGCATCCTGTGGGTGGCCTCCTTTTCCA
TGGTGTCAGGAGCCATGGGGATGTTCCTGGGGTCTGGCTGGACCACCTCAAACCAAGTTGGGTG
GCTTCTGCTCTTTTAGACCATCAGATGTATACACACATACCTAGGCTCACACCTACAAGCACAA
ATACGCATGGACGTCAGAGAATGTATATCTTGAAATAGTTGGCCTGAGGTCACTTGGAAACAGT
GGCCCTAACCTGTGCCTGACTTGTTCTCAGGCCCCGCTCACCTGGGCCAGTCCAGATGGCTCTG
CCTGGTCTGCACAGGAAGTAGATAGGGCTTTTCTTCCTGGCAGGGGACTAGGATAAGCTGGGTG
GCAAGCTGAAACCACTGGGTCCTCTGAGCTTCCTCAACTTCCTTTCTTAAGAAAAGAAAAAAAG
AAAAAAAAAGTGCAACAGGGAGCTCCCAGAAGGGGCCTCACAAGCCCTGCCCAGGGCAGCCTCA
GCTGGCCGAGGCTTTACCCAAAACACAAAACAGAAACATTTTTAAAAAGAGAAAAAACTCTGAA
GACTCGCCAGGGGACATGAGTGTGTGCGCCTCTATTTCCTGTATGAGATTTTTGTACTCTATTT
TCCTAGCCATTGTTGTGTCCTTGTTTGCTGAGGGGTGGGAGCGACCCAGCGTCTCAGGGACCCA
TCCTCTGTCACATTGTCATAGTGTGCCTTGTGTTCCCCGTCTCAGATCACCCACTGCCACCAGC
ATGCTCCTGTGGCTTATGGGATGCACCAGGCCTCTTGGTAGGTGCCCCCCTCACTGCTTTCCTA
CAGGTAGTCCTTCCCAGCAGCTGCAGCCTCCTGGGAGGGACATGTGCACGCCTGTGCGTCTCCC
ATTGCTGATTCCTGTATCCTGCAGGGCTATGACCTGGTTTCCAGTGGTGCCTCCATGGTAACTG
GCGGGGTGGCTGTGCCTGAAAGTTCGGGGACAGCAGGCCTGCTAGCATAGGGCCCTGTCTCTGG
ACCTTAAGCAAGGGCCTGGAGTGTCAGCCATGGGCAGTTTATAAGTACAGCAGTTCTGGAGTAG
GACAGGCATGACCAGGAGGCTTCTGCTGGCCTTTTAATACTAGAAGACCTTGTTTCTAGGGGCA
CCACACAGCAATATTTGGGTAGTGGCCACGGGTTGGTCCACAGCACCACCTGCCCCCTCCTCTG
GTGCATTTTAAACCATTTCCAAACTGTGGGGAAAATTCTTGTCCATCTTCAGTCATGCCAATGA
GCATCCTAGGATGGGTGGCCTACTGATAGGCAGAACGAGGTTCCTGGAAACAACTCTGGCATAG
AACCTGCTCTGTGGGCACTCAAAGTGACAGGTGGATAGCAGGCCTGGGTAGGAGTCCCTGGAGT
AGAAACATAGCCAACATCTTAGTAAGCTGGTTCTGTCTACATTTTCTGCCCAACTGGGGGCTTC
AGTGTCCGCCTAAAGCATGTCCCCCAGGCATTTGTCTTGAGCACACCCACCCTCAGCACAGAAC
GGAGCTCTGTTTAATGACTTTGCTCCAGGGCTCCTGCCGCGCCCTGAATTCTATCGTCACCTCC
CTGCTCCATCTCAGCTTCTGCTTCCACCCTGCCAGCAGCATCCACTCCTGGTGACCAGATTGGC
CCCCTTGGCTGAATTTTGTGGCAGCTCAGCCCTTTGCCTTTTCAGGCTATGGATCCCATGTAGC
CTAGGGGTTGGCCTCCTTGGTCACCCAGGGGTGTTAGCCAGCTGCCCCTCCCACTAGCAGGCAT
GCAAGGGGTGGTCCATGGGCATGGGGGCTGGTGCTAAGAGTTACATATCCATTACTCCTTCTCC
TGCTCTCTACCATTTGCACAGTGTGGACATTACTGGTAGCCGTGGGATTCAGCCAAGGCTATTG
TGTATCTGTAGAAAGAAAGCTGGACCAAAATAGCTGCTGCTATGTCCTCCACCTGCACCTGTCC
ATGTGAGCCACGTGGTGCTCCATAACAGAGTCTGCAACTCCAGGCTCAGGCTTGGGCCTCTTTC
CTAGGAGGTGGTCCAGATGTACCAGACCCACCATCCTGCTGCAGACCCAGCTTGTCTAGCAGGA
GAGGACACGGAGGTTTTGTCTCCATATGGGCCCTAGGTCTGCCTCTGTATTTCTAACCTGCAGG
TGCTTGAGCTTGCTCTTCTAGGCAGATGGAGTTGTGCACCAAACTGTGGCTGGACAGCCCCCAC
CCTTCTGTGTGCCCCAAGCCTTCCCTGCCTCTGGTGGGTCAGTTAGCCTCTCACCCCTTGTGCC
TGCACAGAGGGTCTTGATCCCAGGCCAGCAAGCAAGTTTTCAGGCCTCTAAACTAGGGCACTAG
GGCAGGTTCCGTGCCAGAGTCTGGGGCTACACAAGGGGCCTGGTGCCAGTGCAGTGGGTGAGTT
ATGAGACCTGAGCTGCAGACTGGAATGGGACCCCATCCCACCTGTCTAACAGATGGGGCTGTGC
TGTGTCATTATGTCATTGTAATATAAATACAGATTTTTATACCTCA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001381661	(Get FASTA)	NCBI Sequence Viewer
	XP_017454805	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDM00101	(Get FASTA)	NCBI Sequence Viewer
	EDM00102	(Get FASTA)	NCBI Sequence Viewer
	EDM00103	(Get FASTA)	NCBI Sequence Viewer
	EDM00104	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000093856.2
	ENSRNOP00000108444
	ENSRNOP00000108444.1

RefSeq Acc Id:	XP_017454805 ⟸ XM_017599316
- Peptide Label:	isoform X1
- UniProtKB:	A6IK39 (UniProtKB/TrEMBL)
- Sequence:	show sequence MCQFEGLRRRVAAQRWSPRVALVCRQARGVRRAEPAGARRAAAAAVPCAGGRMELNSLLLLLEA AEYLERRDREAEHGYASVLPFDGDFARKKTKTAGLVRKAPNNRRAKLRLYLEQLKQLVPLGPDS TRHTTLSLLKRAKMHIKKLEEQDRRALSIKEQLQREHRFLKRRLEQLSVQSVERVRTDSTGSAV STDDSEQEVDIEGMEFGPGELDSVGSSSDADDHYSLQSSGCSDSSYGHPCRRPGCPGLS hide sequence

Ensembl Acc Id:

ENSRNOP00000067906 ⟸ ENSRNOT00000077060

Ensembl Acc Id:

ENSRNOP00000018515 ⟸ ENSRNOT00000018515

Ensembl Acc Id:

ENSRNOP00000068353 ⟸ ENSRNOT00000075863

Ensembl Acc Id:

ENSRNOP00000068275 ⟸ ENSRNOT00000076840

Ensembl Acc Id:

ENSRNOP00000093856 ⟸ ENSRNOT00000093859

RefSeq Acc Id:	NP_001381661 ⟸ NM_001394732
- UniProtKB:	A6IK39 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000108444 ⟸ ENSRNOT00000146361

Protein Domains

bHLH

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-A0A096MIW8-F1-model_v2	AlphaFold	A0A096MIW8	1-209	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13699413

Promoter ID:

EPDNEW_R9928

Type:

initiation region

Name:

Mxd4_1

Description:

Max dimerization protein 4

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	14	81,819,487 - 81,819,547	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1305093	AgrOrtholog
BioCyc Gene	G2FUF-15283	BioCyc
Ensembl Genes	ENSRNOG00000015033	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000093859.2	UniProtKB/TrEMBL
	ENSRNOT00000146361	ENTREZGENE
	ENSRNOT00000146361.1	UniProtKB/TrEMBL
Gene3D-CATH	4.10.280.10	UniProtKB/TrEMBL
InterPro	bHLH_dom	UniProtKB/TrEMBL
	HLH_DNA-bd_sf	UniProtKB/TrEMBL
NCBI Gene	360961	ENTREZGENE
PANTHER	MAX DIMERIZATION PROTEIN 4	UniProtKB/TrEMBL
	MAX DIMERIZATION, MAD	UniProtKB/TrEMBL
Pfam	HLH	UniProtKB/TrEMBL
PhenoGen	Mxd4	PhenoGen
PROSITE	BHLH	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000015033	RatGTEx
SMART	HLH	UniProtKB/TrEMBL
Superfamily-SCOP	SSF47459	UniProtKB/TrEMBL
UniProt	A0A8I6AJN6_RAT	UniProtKB/TrEMBL
	A0ABK0LVS6_RAT	UniProtKB/TrEMBL
	A6IK39	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-04-30	Mxd4	Max dimerization protein 4	Mxd4_predicted	Max dimerization protein 4 (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Mxd4_predicted	Max dimerization protein 4 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Send us a Message