Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Ro60 | Rat | 1,2-dimethylhydrazine | decreases expression | ISO | Ro60 (Mus musculus) | 6480464 | 1,2-Dimethylhydrazine results in decreased expression of TROVE2 mRNA | CTD | PMID:22206623 | Ro60 | Rat | 17alpha-ethynylestradiol | increases expression | EXP | | 6480464 | Ethinyl Estradiol results in increased expression of RO60 mRNA | CTD | PMID:29097150 | Ro60 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Ro60 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of RO60 mRNA | CTD | PMID:21570461 | Ro60 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of RO60 mRNA; Tetrachlorodibenzodioxin results in decreased expression of TROVE2 more ... | CTD | PMID:32109520|PMID:33387578 | Ro60 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Ro60 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of RO60 mRNA | CTD | PMID:19465110 | Ro60 | Rat | 2,3,7,8-Tetrachlorodibenzofuran | decreases expression | EXP | | 6480464 | 2,3,7,8-tetrachlorodibenzofuran results in decreased expression of RO60 mRNA | CTD | PMID:32109520 | Ro60 | Rat | 2-methylcholine | affects expression | ISO | RO60 (Homo sapiens) | 6480464 | beta-methylcholine affects the expression of RO60 mRNA | CTD | PMID:21179406 | Ro60 | Rat | 4,4'-sulfonyldiphenol | decreases expression | ISO | Ro60 (Mus musculus) | 6480464 | bisphenol S results in decreased expression of RO60 mRNA | CTD | PMID:39298647 | Ro60 | Rat | acetamide | decreases expression | EXP | | 6480464 | acetamide results in decreased expression of RO60 mRNA | CTD | PMID:31881176 | Ro60 | Rat | acrolein | multiple interactions | ISO | RO60 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of more ... | CTD | PMID:32699268 | Ro60 | Rat | acrylamide | decreases expression | EXP | | 6480464 | Acrylamide results in decreased expression of RO60 mRNA | CTD | PMID:28959563 | Ro60 | Rat | actinomycin D | multiple interactions | ISO | RO60 (Homo sapiens) | 6480464 | [Dactinomycin co-treated with nutlin 3] results in increased expression of RO60 protein | CTD | PMID:38460933 | Ro60 | Rat | aflatoxin B1 | decreases methylation | ISO | RO60 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased methylation of RO60 gene | CTD | PMID:27153756 | Ro60 | Rat | aflatoxin B1 | decreases expression | EXP | | 6480464 | Aflatoxin B1 results in decreased expression of RO60 mRNA | CTD | PMID:33354967 | Ro60 | Rat | aflatoxin B1 | increases expression | ISO | Ro60 (Mus musculus) | 6480464 | Aflatoxin B1 results in increased expression of RO60 mRNA | CTD | PMID:19770486 | Ro60 | Rat | all-trans-retinoic acid | decreases expression | ISO | RO60 (Homo sapiens) | 6480464 | Tretinoin results in decreased expression of TROVE2 mRNA | CTD | PMID:33167477 | Ro60 | Rat | alpha-pinene | multiple interactions | ISO | RO60 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of more ... | CTD | PMID:32699268 | Ro60 | Rat | arsane | affects methylation | ISO | RO60 (Homo sapiens) | 6480464 | Arsenic affects the methylation of RO60 gene | CTD | PMID:25304211 | Ro60 | Rat | arsenic atom | affects methylation | ISO | RO60 (Homo sapiens) | 6480464 | Arsenic affects the methylation of RO60 gene | CTD | PMID:25304211 | Ro60 | Rat | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of RO60 mRNA | CTD | PMID:25181051 | Ro60 | Rat | bisphenol A | increases expression | ISO | RO60 (Homo sapiens) | 6480464 | bisphenol A results in increased expression of RO60 protein | CTD | PMID:37567409 | Ro60 | Rat | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of RO60 mRNA | CTD | PMID:30816183|PMID:34947998 | Ro60 | Rat | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of RO60 mRNA | CTD | PMID:29097150|PMID:33296240 | Ro60 | Rat | bisphenol F | increases expression | ISO | Ro60 (Mus musculus) | 6480464 | bisphenol F results in increased expression of RO60 mRNA | CTD | PMID:38685157 | Ro60 | Rat | bisphenol F | increases expression | ISO | RO60 (Homo sapiens) | 6480464 | bisphenol F results in increased expression of RO60 protein | CTD | PMID:34186270 | Ro60 | Rat | cadmium dichloride | increases expression | ISO | RO60 (Homo sapiens) | 6480464 | Cadmium Chloride results in increased expression of RO60 protein | CTD | PMID:24527689 | Ro60 | Rat | cadmium dichloride | decreases expression | ISO | RO60 (Homo sapiens) | 6480464 | Cadmium Chloride results in decreased expression of RO60 mRNA | CTD | PMID:38568856 | Ro60 | Rat | chloroacetaldehyde | decreases expression | ISO | RO60 (Homo sapiens) | 6480464 | chloroacetaldehyde results in decreased expression of RO60 mRNA | CTD | PMID:25596134 | Ro60 | Rat | chloroprene | increases expression | EXP | | 6480464 | Chloroprene results in increased expression of RO60 mRNA | CTD | PMID:23125180 | Ro60 | Rat | chlorpyrifos | decreases expression | ISO | Ro60 (Mus musculus) | 6480464 | Chlorpyrifos results in decreased expression of RO60 mRNA | CTD | PMID:37019170 | Ro60 | Rat | choline | multiple interactions | ISO | Ro60 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation more ... | CTD | PMID:20938992 | Ro60 | Rat | cidofovir anhydrous | decreases expression | ISO | RO60 (Homo sapiens) | 6480464 | Cidofovir results in decreased expression of RO60 mRNA | CTD | PMID:25596134 | Ro60 | Rat | cisplatin | decreases expression | ISO | RO60 (Homo sapiens) | 6480464 | Cisplatin results in decreased expression of RO60 mRNA | CTD | PMID:25596134 | Ro60 | Rat | clobetasol | decreases expression | ISO | Ro60 (Mus musculus) | 6480464 | Clobetasol results in decreased expression of RO60 mRNA | CTD | PMID:27462272 | Ro60 | Rat | clodronic acid | decreases expression | ISO | RO60 (Homo sapiens) | 6480464 | Clodronic Acid results in decreased expression of RO60 mRNA | CTD | PMID:25596134 | Ro60 | Rat | cocaine | decreases expression | EXP | | 6480464 | Cocaine results in decreased expression of RO60 mRNA | CTD | PMID:17898221 | Ro60 | Rat | crotonaldehyde | decreases expression | ISO | RO60 (Homo sapiens) | 6480464 | 2-butenal results in decreased expression of RO60 mRNA | CTD | PMID:20471460 | Ro60 | Rat | Cuprizon | decreases expression | EXP | | 6480464 | Cuprizone results in decreased expression of RO60 mRNA | CTD | PMID:27523638 | Ro60 | Rat | Cuprizon | increases expression | ISO | RO60 (Homo sapiens) | 6480464 | Cuprizone results in increased expression of TROVE2 protein | CTD | PMID:34122009 | Ro60 | Rat | cyclosporin A | increases expression | ISO | RO60 (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of RO60 mRNA | CTD | PMID:25596134 | Ro60 | Rat | dicrotophos | decreases expression | ISO | RO60 (Homo sapiens) | 6480464 | dicrotophos results in decreased expression of RO60 mRNA | CTD | PMID:28302478 | Ro60 | Rat | dioxygen | increases expression | ISO | RO60 (Homo sapiens) | 6480464 | Oxygen deficiency results in increased expression of RO60 mRNA | CTD | PMID:25596134 | Ro60 | Rat | elemental selenium | decreases expression | ISO | RO60 (Homo sapiens) | 6480464 | Selenium results in decreased expression of RO60 mRNA | CTD | PMID:19244175 | Ro60 | Rat | enzyme inhibitor | multiple interactions | ISO | RO60 (Homo sapiens) | 6480464 | [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation more ... | CTD | PMID:23301498 | Ro60 | Rat | fenofibrate | decreases expression | ISO | RO60 (Homo sapiens) | 6480464 | Fenofibrate results in decreased expression of RO60 mRNA | CTD | PMID:25596134 | Ro60 | Rat | folic acid | multiple interactions | ISO | Ro60 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation more ... | CTD | PMID:20938992 | Ro60 | Rat | folic acid | decreases expression | ISO | Ro60 (Mus musculus) | 6480464 | Folic Acid results in decreased expression of TROVE2 mRNA | CTD | PMID:25629700 | Ro60 | Rat | FR900359 | increases phosphorylation | ISO | RO60 (Homo sapiens) | 6480464 | FR900359 results in increased phosphorylation of RO60 protein | CTD | PMID:37730182 | Ro60 | Rat | geldanamycin | increases expression | ISO | RO60 (Homo sapiens) | 6480464 | geldanamycin results in increased expression of TROVE2 mRNA | CTD | PMID:26705709 | Ro60 | Rat | gentamycin | decreases expression | EXP | | 6480464 | Gentamicins results in decreased expression of TROVE2 mRNA | CTD | PMID:33387578 | Ro60 | Rat | gold atom | decreases expression | ISO | RO60 (Homo sapiens) | 6480464 | Gold results in decreased expression of RO60 mRNA | CTD | PMID:25523186 | Ro60 | Rat | gold(0) | decreases expression | ISO | RO60 (Homo sapiens) | 6480464 | Gold results in decreased expression of RO60 mRNA | CTD | PMID:25523186 | Ro60 | Rat | hydrogen peroxide | affects expression | ISO | RO60 (Homo sapiens) | 6480464 | Hydrogen Peroxide affects the expression of RO60 mRNA | CTD | PMID:21179406 | Ro60 | Rat | ifosfamide | decreases expression | ISO | RO60 (Homo sapiens) | 6480464 | Ifosfamide results in decreased expression of RO60 mRNA | CTD | PMID:25596134 | Ro60 | Rat | indometacin | decreases expression | ISO | RO60 (Homo sapiens) | 6480464 | Indomethacin results in decreased expression of RO60 mRNA | CTD | PMID:16984733 | Ro60 | Rat | iron dichloride | increases expression | ISO | RO60 (Homo sapiens) | 6480464 | ferrous chloride results in increased expression of RO60 mRNA | CTD | PMID:35984750 | Ro60 | Rat | isoprenaline | increases expression | ISO | Ro60 (Mus musculus) | 6480464 | Isoproterenol results in increased expression of RO60 mRNA | CTD | PMID:20003209 | Ro60 | Rat | isotretinoin | decreases expression | ISO | RO60 (Homo sapiens) | 6480464 | Isotretinoin results in decreased expression of RO60 mRNA | CTD | PMID:20436886 | Ro60 | Rat | ivermectin | decreases expression | ISO | RO60 (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of RO60 protein | CTD | PMID:32959892 | Ro60 | Rat | L-methionine | multiple interactions | ISO | Ro60 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation more ... | CTD | PMID:20938992 | Ro60 | Rat | metformin | affects expression | EXP | | 6480464 | Metformin affects the expression of RO60 mRNA | CTD | PMID:25596134 | Ro60 | Rat | methylmercury chloride | decreases expression | ISO | RO60 (Homo sapiens) | 6480464 | methylmercuric chloride results in decreased expression of RO60 mRNA | CTD | PMID:28001369 | Ro60 | Rat | miconazole | decreases expression | ISO | Ro60 (Mus musculus) | 6480464 | Miconazole results in decreased expression of RO60 mRNA | CTD | PMID:27462272 | Ro60 | Rat | nickel dichloride | decreases expression | ISO | RO60 (Homo sapiens) | 6480464 | nickel chloride results in decreased expression of RO60 mRNA | CTD | PMID:17312168 | Ro60 | Rat | Nutlin-3 | multiple interactions | ISO | RO60 (Homo sapiens) | 6480464 | [Dactinomycin co-treated with nutlin 3] results in increased expression of RO60 protein | CTD | PMID:38460933 | Ro60 | Rat | omega-6 fatty acid | decreases expression | ISO | RO60 (Homo sapiens) | 6480464 | Fatty Acids, Omega-6 results in decreased expression of RO60 mRNA | CTD | PMID:16823509 | Ro60 | Rat | ozone | multiple interactions | ISO | RO60 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of more ... | CTD | PMID:32699268 | Ro60 | Rat | phenobarbital | affects expression | ISO | Ro60 (Mus musculus) | 6480464 | Phenobarbital affects the expression of RO60 mRNA | CTD | PMID:23091169 | Ro60 | Rat | resveratrol | multiple interactions | ISO | RO60 (Homo sapiens) | 6480464 | [Plant Extracts co-treated with Resveratrol] results in increased expression of RO60 mRNA | CTD | PMID:23557933 | Ro60 | Rat | SB 431542 | multiple interactions | ISO | RO60 (Homo sapiens) | 6480464 | [LDN 193189 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with FGF2 protein] results in increased expression of RO60 more ... | CTD | PMID:37664457 | Ro60 | Rat | selenium atom | decreases expression | ISO | RO60 (Homo sapiens) | 6480464 | Selenium results in decreased expression of RO60 mRNA | CTD | PMID:19244175 | Ro60 | Rat | sodium arsenate | increases expression | ISO | Ro60 (Mus musculus) | 6480464 | sodium arsenate results in increased expression of RO60 mRNA | CTD | PMID:21795629 | Ro60 | Rat | sodium arsenate | decreases expression | ISO | RO60 (Homo sapiens) | 6480464 | sodium arsenate results in decreased expression of RO60 protein | CTD | PMID:38348393 | Ro60 | Rat | succimer | multiple interactions | ISO | Ro60 (Mus musculus) | 6480464 | [Succimer co-treated with Magnetite Nanoparticles] affects the expression of RO60 mRNA | CTD | PMID:26378955 | Ro60 | Rat | thioacetamide | increases expression | EXP | | 6480464 | Thioacetamide results in increased expression of RO60 mRNA | CTD | PMID:34492290 | Ro60 | Rat | trichostatin A | decreases expression | ISO | RO60 (Homo sapiens) | 6480464 | trichostatin A results in decreased expression of RO60 mRNA | CTD | PMID:24935251 | Ro60 | Rat | triphenyl phosphate | affects expression | ISO | RO60 (Homo sapiens) | 6480464 | triphenyl phosphate affects the expression of TROVE2 mRNA | CTD | PMID:37042841 | Ro60 | Rat | urethane | increases expression | ISO | RO60 (Homo sapiens) | 6480464 | Urethane results in increased expression of RO60 mRNA | CTD | PMID:28818685 | Ro60 | Rat | valproic acid | decreases expression | ISO | RO60 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of RO60 mRNA | CTD | PMID:23179753 | Ro60 | Rat | valproic acid | decreases expression | EXP | | 6480464 | Valproic Acid results in decreased expression of RO60 mRNA | CTD | PMID:29427782 | Ro60 | Rat | valproic acid | affects splicing | EXP | | 6480464 | Valproic Acid affects the splicing of RO60 mRNA | CTD | PMID:29427782 | Ro60 | Rat | valproic acid | decreases methylation | ISO | RO60 (Homo sapiens) | 6480464 | Valproic Acid results in decreased methylation of RO60 gene | CTD | PMID:29154799 | Ro60 | Rat | vinclozolin | increases expression | EXP | | 6480464 | vinclozolin results in increased expression of RO60 mRNA | CTD | PMID:23555832 | Ro60 | Rat | vitamin E | decreases expression | ISO | RO60 (Homo sapiens) | 6480464 | Vitamin E results in decreased expression of RO60 mRNA | CTD | PMID:19244175 | Ro60 | Rat | zinc atom | decreases expression | ISO | RO60 (Homo sapiens) | 6480464 | Zinc results in decreased expression of RO60 mRNA | CTD | PMID:15226459 | Ro60 | Rat | zinc sulfate | decreases expression | ISO | RO60 (Homo sapiens) | 6480464 | Zinc Sulfate results in decreased expression of RO60 mRNA | CTD | PMID:15226459 | Ro60 | Rat | zinc(0) | decreases expression | ISO | RO60 (Homo sapiens) | 6480464 | Zinc results in decreased expression of RO60 mRNA | CTD | PMID:15226459 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||






















