Emc7 (ER membrane protein complex subunit 7) - Rat Genome Database

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Gene: Emc7 (ER membrane protein complex subunit 7) Rattus norvegicus
Analyze
Symbol: Emc7
Name: ER membrane protein complex subunit 7
RGD ID: 1305045
Description: Predicted to enable carbohydrate binding activity. Predicted to contribute to membrane insertase activity. Predicted to be involved in protein insertion into ER membrane by stop-transfer membrane-anchor sequence and tail-anchored membrane protein insertion into ER membrane. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of EMC complex. Orthologous to human EMC7 (ER membrane protein complex subunit 7); INTERACTS WITH 3-chloropropane-1,2-diol; acrylamide; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: chromosome 15 open reading frame 24 ortholog; hypothetical protein LOC296050; LOC296050; RGD1305045; similar to hypothetical protein; UPF0480 protein C15orf24 homolog
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83119,714,617 - 119,728,748 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3119,718,357 - 119,730,486 (+)EnsemblGRCr8
mRatBN7.2399,263,933 - 99,274,365 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl399,263,980 - 99,274,360 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3102,890,951 - 102,901,259 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03111,489,947 - 111,500,255 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03109,186,464 - 109,196,800 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03103,945,276 - 103,955,970 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3103,945,329 - 103,956,007 (+)Ensemblrn6Rnor6.0
Rnor_5.03110,539,143 - 110,549,811 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4398,305,981 - 98,316,324 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera398,249,397 - 98,259,736 (+)NCBICelera
RGSC_v3.1398,202,384 - 98,212,751 (+)NCBI
Cytogenetic Map3q35NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
EMC complex  (IBA,IEA,ISO)
endoplasmic reticulum membrane  (IEA,ISO)
membrane  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:22119785  


Genomics

Comparative Map Data
Emc7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83119,714,617 - 119,728,748 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3119,718,357 - 119,730,486 (+)EnsemblGRCr8
mRatBN7.2399,263,933 - 99,274,365 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl399,263,980 - 99,274,360 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3102,890,951 - 102,901,259 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03111,489,947 - 111,500,255 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03109,186,464 - 109,196,800 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03103,945,276 - 103,955,970 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3103,945,329 - 103,956,007 (+)Ensemblrn6Rnor6.0
Rnor_5.03110,539,143 - 110,549,811 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4398,305,981 - 98,316,324 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera398,249,397 - 98,259,736 (+)NCBICelera
RGSC_v3.1398,202,384 - 98,212,751 (+)NCBI
Cytogenetic Map3q35NCBI
EMC7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381534,084,017 - 34,101,862 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1534,083,980 - 34,101,910 (-)Ensemblhg38GRCh38
GRCh371534,376,218 - 34,394,063 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361532,163,515 - 32,181,345 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341532,163,517 - 32,181,345NCBI
Celera1511,178,721 - 11,196,565 (-)NCBICelera
Cytogenetic Map15q14NCBI
HuRef1511,239,746 - 11,257,648 (-)NCBIHuRef
CHM1_11534,494,168 - 34,512,016 (-)NCBICHM1_1
T2T-CHM13v2.01531,882,200 - 31,900,068 (-)NCBIT2T-CHM13v2.0
Emc7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392112,285,332 - 112,302,507 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2112,285,342 - 112,302,507 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm382112,455,014 - 112,472,163 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2112,454,997 - 112,472,162 (+)Ensemblmm10GRCm38
MGSCv372112,295,182 - 112,307,593 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv362112,255,864 - 112,268,275 (+)NCBIMGSCv36mm8
Celera2113,606,320 - 113,618,698 (+)NCBICelera
Cytogenetic Map2E3NCBI
cM Map257.02NCBI
Emc7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955416459,668 - 484,278 (+)Ensembl
ChiLan1.0NW_004955416459,668 - 482,562 (+)NCBIChiLan1.0ChiLan1.0
EMC7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21622,866,537 - 22,884,605 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11527,588,295 - 27,608,565 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01512,593,498 - 12,611,409 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11531,428,591 - 31,446,290 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1531,428,591 - 31,446,290 (-)EnsemblpanPan2panpan1.1
EMC7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.130952,354 - 965,924 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl30952,386 - 978,051 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha30996,998 - 1,010,580 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0301,050,229 - 1,063,820 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl301,050,264 - 1,075,950 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.130996,949 - 1,010,532 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0301,096,000 - 1,109,590 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0301,223,592 - 1,237,183 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Emc7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864079,510,865 - 79,526,939 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366732,622,472 - 2,641,266 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366732,624,900 - 2,640,973 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EMC7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl780,391,189 - 80,446,528 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1780,391,198 - 80,408,340 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2786,384,401 - 86,401,614 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EMC7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12648,804,520 - 48,822,904 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2648,804,573 - 48,825,820 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604892,082,753 - 92,101,088 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Emc7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624804210,645 - 233,503 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624804210,661 - 230,259 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Emc7
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1590,785,627 - 90,795,379 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Emc7
119 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:31
Count of miRNA genes:25
Interacting mature miRNAs:30
Transcripts:ENSRNOT00000008364
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)396509147141509147Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)373592512136118980Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)358601291153936591Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)349872657138829559Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1582219Bw63Body weight QTL 633.80.001body mass (VT:0001259)body weight (CMO:0000012)3116582412136118980Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)385062224136118980Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)385062224136118980Rat
7387306Bw124Body weight QTL 1243.20.0003body mass (VT:0001259)body weight (CMO:0000012)3104545086149545086Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)381425008141509147Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)370845569136091483Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)393829559138829559Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)3112250810157250810Rat
2302273Gluco35Glucose level QTL 355.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)3101255536134750886Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)396509147141509147Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)3117537367162537367Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3110225882155225882Rat
631200Cm25Cardiac mass QTL 254.80.0001heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)381541464126563126Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)390755164141509147Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)342158111124558371Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)398651826167012663Rat
1582252Sual1Serum uric acid level QTL 13.40.0123blood uric acid amount (VT:0010302)blood uric acid level (CMO:0000501)3116582412122654872Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)342158111124558371Rat
1331758Bp207Blood pressure QTL 2072.848arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3110634702155634702Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)3116188400161188400Rat

Markers in Region
AI709542  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2399,273,996 - 99,274,177 (+)MAPPERmRatBN7.2
Rnor_6.03103,955,602 - 103,955,782NCBIRnor6.0
Rnor_5.03110,549,443 - 110,549,623UniSTSRnor5.0
RGSC_v3.4398,315,960 - 98,316,140UniSTSRGSC3.4
Celera398,259,372 - 98,259,552UniSTS
RH 3.4 Map3870.7UniSTS
Cytogenetic Map3q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000008364   ⟹   ENSRNOP00000008364
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3119,718,357 - 119,730,486 (+)Ensembl
mRatBN7.2 Ensembl399,263,980 - 99,274,360 (+)Ensembl
Rnor_6.0 Ensembl3103,945,329 - 103,956,007 (+)Ensembl
RefSeq Acc Id: NM_001399270   ⟹   NP_001386199
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83119,718,412 - 119,728,748 (+)NCBI
mRatBN7.2399,264,029 - 99,274,365 (+)NCBI
RefSeq Acc Id: XM_017591570   ⟹   XP_017447059
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83119,714,617 - 119,728,743 (+)NCBI
mRatBN7.2399,263,933 - 99,274,360 (+)NCBI
Rnor_6.03103,945,276 - 103,955,965 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001386199 (Get FASTA)   NCBI Sequence Viewer  
  XP_017447059 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL79802 (Get FASTA)   NCBI Sequence Viewer  
  EDL79803 (Get FASTA)   NCBI Sequence Viewer  
  EDL79804 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000008364
  ENSRNOP00000008364.6
RefSeq Acc Id: XP_017447059   ⟸   XM_017591570
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000008364   ⟸   ENSRNOT00000008364
RefSeq Acc Id: NP_001386199   ⟸   NM_001399270
- Peptide Label: precursor
- UniProtKB: D3ZQL1 (UniProtKB/TrEMBL),   A6HP51 (UniProtKB/TrEMBL)
Protein Domains
ER membrane protein complex subunit 7 beta-sandwich

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZQL1-F1-model_v2 AlphaFold D3ZQL1 1-241 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692292
Promoter ID:EPDNEW_R2817
Type:initiation region
Name:Emc7_1
Description:ER membrane protein complex subunit 7
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03103,945,374 - 103,945,434EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305045 AgrOrtholog
BioCyc Gene G2FUF-48386 BioCyc
Ensembl Genes ENSRNOG00000005884 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000008364 ENTREZGENE
  ENSRNOT00000008364.9 UniProtKB/TrEMBL
InterPro Carb-bd-like_fold UniProtKB/TrEMBL
  DUF2012 UniProtKB/TrEMBL
  EMC7 UniProtKB/TrEMBL
NCBI Gene 296050 ENTREZGENE
PANTHER ER MEMBRANE PROTEIN COMPLEX SUBUNIT 7 UniProtKB/TrEMBL
  PTHR13605 UniProtKB/TrEMBL
Pfam DUF2012 UniProtKB/TrEMBL
PhenoGen Emc7 PhenoGen
RatGTEx ENSRNOG00000005884 RatGTEx
Superfamily-SCOP SSF49452 UniProtKB/TrEMBL
UniProt A6HP51 ENTREZGENE, UniProtKB/TrEMBL
  D3ZQL1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-08-14 Emc7  ER membrane protein complex subunit 7  RGD1305045  similar to hypothetical protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1305045  similar to hypothetical protein   RGD1305045_predicted  similar to hypothetical protein (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-20 RGD1305045_predicted  similar to hypothetical protein (predicted)  LOC296050_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC296050_predicted  similar to hypothetical protein (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL