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Gene: Icam5 (intercellular adhesion molecule 5) Rattus norvegicus

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Symbol:

Icam5

Name:

intercellular adhesion molecule 5

RGD ID:

1305039

Description:

Predicted to enable integrin binding activity. Predicted to be involved in cell adhesion and regulation of synapse assembly. Predicted to act upstream of or within phagocytosis. Predicted to be located in membrane. Predicted to be active in glutamatergic synapse; plasma membrane; and postsynapse. Orthologous to human ICAM5 (intercellular adhesion molecule 5); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 17beta-estradiol 3-benzoate.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

intercellular adhesion molecule 5, telencephalin; LOC313785

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	ICAM5 (intercellular adhesion molecule 5)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Icam5 (intercellular adhesion molecule 5, telencephalin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Icam5 (intercellular adhesion molecule 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	ICAM5 (intercellular adhesion molecule 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	ICAM5 (intercellular adhesion molecule 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Icam5 (intercellular adhesion molecule 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	ICAM5 (intercellular adhesion molecule 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	ICAM5 (intercellular adhesion molecule 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Icam5 (intercellular adhesion molecule 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	ICAM5 (intercellular adhesion molecule 5)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Icam5 (intercellular adhesion molecule 5, telencephalin)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	si:ch211-74m13.3	Alliance	DIOPT (Hieranoid\|OrthoInspector\|PANTHER)
Danio rerio (zebrafish):	si:ch73-208g10.1	Alliance	DIOPT (Hieranoid\|OrthoInspector\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	LOC108644500	Alliance	DIOPT (OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	LOC100494743	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	LOC108646195	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	LOC100494743	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	LOC108646195	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	LOC100494903	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	27,843,563 - 27,851,767 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	8	27,844,780 - 27,857,104 (+)	Ensembl				GRCr8
mRatBN7.2	8	19,567,390 - 19,575,588 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	19,568,600 - 19,575,588 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	8	23,588,020 - 23,595,010 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	21,885,879 - 21,892,869 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	19,798,267 - 19,805,254 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	22,050,222 - 22,057,209 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	22,050,222 - 22,057,209 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	8	22,107,090 - 22,114,077 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	8	20,055,255 - 20,062,100 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	8	20,963,025 - 20,970,012 (+)	NCBI		Celera
RGSC_v3.1	8	20,052,605 - 20,062,100 (+)	NCBI
Cytogenetic Map	8	q13	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Breast Neoplasms (ISO)

Colorectal Neoplasms (ISO)

COVID-19 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

1-naphthyl isothiocyanate (EXP)

17beta-estradiol (EXP,ISO)

17beta-estradiol 3-benzoate (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

3,3',4,4',5-pentachlorobiphenyl (ISO)

4,4'-sulfonyldiphenol (EXP,ISO)

6-propyl-2-thiouracil (EXP)

acrylamide (ISO)

aflatoxin B1 (EXP,ISO)

aldehydo-D-glucose (ISO)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenite(3-) (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (EXP)

butanal (ISO)

cadmium dichloride (EXP,ISO)

carmustine (ISO)

choline (ISO)

Cuprizon (EXP)

D-glucose (ISO)

diazinon (ISO)

dimethylarsinic acid (ISO)

dioxygen (EXP)

ethanol (ISO)

ethylparaben (ISO)

fluoxetine (EXP)

folic acid (ISO)

fucoxanthin (ISO)

fulvestrant (ISO)

glucose (ISO)

GW 4064 (ISO)

ketamine (EXP)

L-methionine (ISO)

lead(0) (ISO)

mangiferin (ISO)

N-methyl-4-phenylpyridinium (ISO)

niclosamide (ISO)

paracetamol (EXP)

propanal (ISO)

serpentine asbestos (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

sodium fluoride (ISO)

Soman (EXP)

sunitinib (ISO)

testosterone (EXP)

thioacetamide (EXP)

titanium dioxide (ISO)

triclosan (ISO)

triptonide (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell adhesion (IBA,IEA)

cell-cell adhesion (IEA)

cell-cell adhesion mediated by integrin (IEA,ISO)

homophilic cell-cell adhesion (IEA,ISO)

phagocytosis (ISO)

protein homotetramerization (IEA,ISO)

regulation of synapse assembly (IEA,ISO)

Cellular Component

cell projection (IEA,ISO)

dendritic spine membrane (IEA,ISO)

glutamatergic synapse (IEA,ISO)

membrane (IEA)

plasma membrane (IBA,IEA,ISO)

postsynapse (IEA,ISO)

uropod membrane (IEA,ISO)

Molecular Function

integrin binding (IBA,IEA)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	GOA pipeline	RGD automated data pipeline
5.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:11719200	PMID:15452145	PMID:16820411	PMID:18223167	PMID:19733219	PMID:22187327

Genomics

Comparative Map Data

Icam5
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	27,843,563 - 27,851,767 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	8	27,844,780 - 27,857,104 (+)	Ensembl				GRCr8
mRatBN7.2	8	19,567,390 - 19,575,588 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	19,568,600 - 19,575,588 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	8	23,588,020 - 23,595,010 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	21,885,879 - 21,892,869 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	19,798,267 - 19,805,254 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	22,050,222 - 22,057,209 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	22,050,222 - 22,057,209 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	8	22,107,090 - 22,114,077 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	8	20,055,255 - 20,062,100 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	8	20,963,025 - 20,970,012 (+)	NCBI		Celera
RGSC_v3.1	8	20,052,605 - 20,062,100 (+)	NCBI
Cytogenetic Map	8	q13	NCBI

ICAM5
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	10,289,952 - 10,296,778 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	10,289,952 - 10,296,778 (+)	Ensembl			hg38	GRCh38
GRCh37	19	10,400,628 - 10,407,454 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	10,261,655 - 10,268,453 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	19	10,261,654 - 10,268,453	NCBI
Celera	19	10,296,051 - 10,302,851 (+)	NCBI		Celera
Cytogenetic Map	19	p13.2	NCBI
HuRef	19	9,980,634 - 9,987,434 (+)	NCBI		HuRef
CHM1_1	19	10,400,920 - 10,407,719 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	19	10,415,547 - 10,422,890 (+)	NCBI		T2T-CHM13v2.0

Icam5
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	20,943,372 - 20,950,331 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	20,943,369 - 20,950,332 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	9	21,032,038 - 21,039,036 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	21,032,073 - 21,039,036 (+)	Ensembl			mm10	GRCm38
MGSCv37	9	20,836,482 - 20,843,480 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	9	20,782,492 - 20,789,438 (+)	NCBI		MGSCv36	mm8
Celera	9	18,300,624 - 18,307,622 (+)	NCBI		Celera
Cytogenetic Map	9	A3	NCBI
cM Map	9	7.7	NCBI

Icam5
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955495	1,575,669 - 1,583,910 (+)	Ensembl
ChiLan1.0	NW_004955495	1,575,669 - 1,583,904 (+)	NCBI	ChiLan1.0	ChiLan1.0

ICAM5
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	15,206,390 - 15,213,763 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	14,205,008 - 14,212,378 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	9,839,821 - 9,847,198 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	10,502,185 - 10,511,936 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	10,504,037 - 10,511,716 (+)	Ensembl			panPan2	panpan1.1

ICAM5
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	50,809,065 - 50,816,015 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	50,802,151 - 50,815,621 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	50,678,819 - 50,685,773 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	51,330,697 - 51,337,648 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	51,330,683 - 51,337,798 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	50,536,837 - 50,543,787 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	50,965,597 - 50,972,542 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	51,206,727 - 51,213,680 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Icam5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	209,718,119 - 209,724,658 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936659	630,235 - 636,425 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936659	630,177 - 636,586 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ICAM5
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	69,111,309 - 69,118,164 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	2	69,111,223 - 69,118,170 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	69,445,639 - 69,452,522 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ICAM5
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	9,341,012 - 9,348,284 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	9,341,960 - 9,348,284 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666074	10,692,764 - 10,700,078 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Icam5
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624828	2,454,753 - 2,461,732 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624828	2,454,771 - 2,461,732 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Variants

Variants in Icam5
89 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	116
Count of miRNA genes:	94
Interacting mature miRNAs:	101
Transcripts:	ENSRNOT00000028096
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1357398	Slep3	Serum leptin concentration QTL 3	3.43		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	8	17994105	50763951	Rat
2317030	Wbc5	White blood cell count QTL 5	3.21	0.005	leukocyte quantity (VT:0000217)	white blood cell count (CMO:0000027)	8	16994642	61994642	Rat
12880044	Am9	Aortic mass QTL 9		0.007	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	8	10382540	55382540	Rat
2317032	Ginf2	Gastrointestinal inflammation QTL 2	3.21	0.005	liver integrity trait (VT:0010547)	liver granuloma severity score (CMO:0002157)	8	12964165	57964165	Rat
2301416	Bp315	Blood pressure QTL 315		0.008	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	15952279	60952279	Rat
2317036	Livw3	Liver weight QTL 3	2.43	0.01	liver mass (VT:0003402)	liver weight to body weight ratio (CMO:0000633)	8	12964165	57964165	Rat
1598824	Memor4	Memory QTL 4	2.5		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	8	17993862	62252873	Rat
12880023	Bw184	Body weight QTL 184		0.001	body mass (VT:0001259)	body weight (CMO:0000012)	8	10382540	55382540	Rat
9590084	Insglur5	Insulin/glucose ratio QTL 5	18.54	0.001	blood insulin amount (VT:0001560)	calculated plasma insulin level (CMO:0002170)	8	1	32882639	Rat
12880028	Cm103	Cardiac mass QTL 103		0.02	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	8	10382540	55382540	Rat
2317051	Aia18	Adjuvant induced arthritis QTL 18	2.42		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	8	16994642	61994642	Rat
2317048	Ginf1	Gastrointestinal inflammation QTL 1	3.52	0.005	cecum mucosa thickness (VT:0010234)	enterocolitis severity score (CMO:0002138)	8	12964165	57964165	Rat
2302367	Slep5	Serum leptin concentration QTL 5	3.43		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	8	17994105	50763951	Rat
12880025	Cm102	Cardiac mass QTL 102		0.044	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	8	10382540	55382540	Rat

Markers in Region

RH94539

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	19,565,254 - 19,565,417 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	22,046,877 - 22,047,039	NCBI	Rnor6.0
Rnor_5.0	8	22,103,745 - 22,103,907	UniSTS	Rnor5.0
RGSC_v3.4	8	20,051,767 - 20,051,929	UniSTS	RGSC3.4
Celera	8	20,959,680 - 20,959,842	UniSTS
RH 3.4 Map	8	206.11	UniSTS
Cytogenetic Map	8	q13	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
11	12	60	159	91	90	59	87	59	6	331	180	11	136	73	90	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001172079	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005487805	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC118115	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC135310	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473993	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000028096 ⟹ ENSRNOP00000028096

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	8	27,844,780 - 27,851,767 (+)	Ensembl
mRatBN7.2 Ensembl	8	19,568,600 - 19,575,588 (+)	Ensembl
Rnor_6.0 Ensembl	8	22,050,222 - 22,057,209 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000148902 ⟹ ENSRNOP00000103728

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	8	27,844,780 - 27,857,104 (+)	Ensembl

RefSeq Acc Id:

NM_001172079 ⟹ NP_001165550

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	27,844,780 - 27,851,767 (+)	NCBI
mRatBN7.2	8	19,568,600 - 19,575,588 (+)	NCBI
Rnor_6.0	8	22,050,222 - 22,057,209 (+)	NCBI
Rnor_5.0	8	22,107,090 - 22,114,077 (+)	NCBI
Celera	8	20,963,025 - 20,970,012 (+)	NCBI

Sequence:

show sequence

CCGGGAGCAGCCCAGTGCGCGCTCGCCTCCAGTCAGCTCGCCCCCGATCACCGCCTCTGTCACC
GCCCCCTCCTTGGAAACCAAGTTACCAACGTTTAAACCAATCCCTGGGCGCAATTCTGCCACCC
CCACACTCCACCCGCTGCGCTGCGCGGTCCTCCCAGCCCAGCTCTCCATCACTCGCGCTCCCCT
CGCCTTCTGCGCTCTCCCCTCCCTGGCAGCGGCGGCAATGCCGGGGCCTTCACCAGGGCTGCGC
CGAACGCTCCTCGGCCTCTGGGCTGCCCTGGGCCTGGGGATCCTAGGCATCTCAGCGGTCGCGC
TAGAACCTTTCTGGGCGGACCTTCAGCCCCGCGTGGCGCTCGTGGAGCGCGGGGGCTCGCTGTG
GCTCAACTGCAGCACTAACTGTCCGAGGCCGGAGCGCGGTGGCCTGGAGACCTCGCTACGCCGA
AACGGGACCCAGAGGGGTCTGCGCTGGCTGGCTCGACAGCTGGTGGACATCCGAGAGCCTGAAA
CCCAGCCGGTCTGCTTCTTCCGCTGCGCGCGCCGCACACTCCAAGCGCGTGGGCTCATCCGAAC
TTTCCAGCGACCGGATCGGGTAGAGCTAGTGCCTCTGCCTCCTTGGCAGCCTGTAGGTGAGAAC
TTCACCTTGAGCTGCAGGGTCCCGGGGGCAGGACCCCGAGCGAGCCTCACATTGACCTTGCTGC
GAGGCGGCCAGGAGCTGATTCGCCGAAGTTTCGTAGGCGAGCCACCCCGAGCTCGGGGTGCGAT
GCTCACCGCCACGGTCCTGGCGCGCAGAGAGGATCACAGGGCCAATTTCTCATGCCTCGCGGAG
CTTGACCTGCGGCCACACGGCTTGGGACTGTTTGCAAACAGCTCAGCCCCCAGACAGCTCCGCA
CGTTTGCCATGCCTCCACTTTCCCCGAGCCTTATTGCCCCACGATTCTTAGAAGTGGGCTCAGA
AAGGCCGGTGACTTGCACTTTGGATGGACTGTTTCCTGCCCCAGAAGCCGGGGTTTACCTCTCT
CTGGGAGATCAGAGGCTTCATCCTAATGTGACCCTCGACGGGGAGAGCCTTGTGGCCACTGCCA
CAGCTACAGCAAGTGAAGAACAGGAAGGCACCAAACAGCTGATGTGCATCGTGACCCTCGGGGG
CGAAAGCAGGGAGACCCAGGAAAACCTGACTGTCTACAGCTTCCCGGCTCCTCTTCTGACTTTA
AGTGAGCCAGAAGCCCCCGAGGGAAAGATGGTGACCGTAAGCTGCTGGGCAGGGGCCCGAGCCC
TTGTCACCTTGGAGGGAATTCCAGCTGCGGTCCCTGGGCAGCCCGCTGAGCTCCAGTTAAATGT
CACAAAGAATGACGACAAGCGGGGCTTCTTCTGCGACGCTGCCCTCGATGTGGACGGGGAAACT
CTGAGAAAGAACCAGAGCTCTGAGCTTCGTGTTCTGTACGCACCTCGGCTGGATGACTTGGACT
GTCCCAGGAGCTGGACGTGGCCAGAGGGTCCAGAGCAGACCCTCCACTGCGAGGCCCGTGGAAA
CCCTGAGCCCTCCGTGCACTGTGCAAGGCCTGACGGTGGGGCGGTGCTAGCGCTGGGCCTGTTG
GGTCCAGTGACCCGTGCCCTCGCGGGCACTTACCGATGTACAGCAATCAATGGGCAAGGCCAGG
CGGTCAAGGATGTGACCCTGACTGTGGAATATGCCCCAGCGCTGGACAGTGTAGGCTGCCCAGA
ACGTATTACTTGGCTGGAGGGGACAGAGGCATCGCTTAGCTGTGTGGCACACGGGGTCCCACCA
CCTAGCGTGAGCTGTGTGCGCTCTGGAAAGGAGGAAGTCATGGAAGGGCCCCTGCGTGTGGCCC
GGGAGCACGCTGGCACTTACCGATGCGAAGCCATCAACGCCAGGGGATCAGCGGCCAAAAATGT
GGCTGTCACGGTGGAATATGGTCCCAGTTTTGAGGAGTTGGGCTGCCCCAGCAACTGGACTTGG
GTAGAAGGATCTGGAAAACTGTTTTCCTGTGAAGTTGATGGGAAGCCGGAACCACGCGTGGAGT
GCGTGGGCTCGGAGGGTGCAAGCGAAGGGGTAGTGTTGCCCCTGGTGTCCTCGAACTCTGGTTC
CAGAAACTCTATGACTCCTGGTAACCTGTCACCGGGTATTTACCTCTGCAACGCCACCAACCGG
CATGGCTCCACAGTCAAAACAGTCGTCGTGAGCGCGGAATCACCGCCACAGATGGATGAATCCA
GTTGCCCGAGTCACCAGACATGGCTGGAAGGAGCCGAGGCTACTGCGCTGGCCTGCAGTGCCAG
AGGCCGCCCCTCTCCACGCGTGCGCTGTTCCAGGGAAGGTGCAGCCAGGCTGGAGAGGCTACAG
GTGTCCCGAGAGGATGCGGGGACCTACCTGTGTGTGGCTACCAACGCGCATGGCACGGATTCAC
GGACCGTCACTGTGGGTGTGGAATACCGGCCTGTGGTGGCTGAGCTGGCAGCCTCGCCCCCAAG
CGTGCGGCCTGGCGGAAACTTCACTCTGACCTGCCGTGCAGAGGCCTGGCCTCCAGCCCAGATC
AGCTGGCGCGCGCCCCCGGGAGCTCTCAACCTCGGTCTCTCCAGCAACAACAGCACGCTGAGCG
TGGCGGGTGCCATGGGCAGCCATGGTGGCGAGTATGAGTGCGCAGCCACCAATGCGCATGGGCG
CCACGCACGGCGCATCACGGTGCGCGTGGCCGGTCCATGGCTGTGGGTCGCTGTGGGCGGTGCG
GCAGGGGGCGCGGCGCTGCTGGCCGCAGGGGCCGGCCTGGCCTTCTACGTGCAGTCCACCGCTT
GCAAGAAGGGAGAGTACAACGTCCAGGAGGCTGAGAGCTCAGGCGAGGCGGTGTGTCTCAATGG
CGCGGGCGGGACACCGGGTGCAGAAGGCGGAGCAGAGACCCCCGGCACTGCCGAGTCACCTGCA
GATGGCGAGGTTTTCGCCATCCAGCTGACATCTTCCTGAGCCTGTATCCAGCTCCCCCAGGGGC
CTCGAAAGCACAGGGGTGGACGTATGTATTGTTCACTCTCTATTTATTCAACTCCAGGGGCGTC
GTCCCCGTTTTCTACCCATTCCCTTAATAAAGTTTTTATAAAGGA

hide sequence

RefSeq Acc Id:

XR_005487805

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	27,843,563 - 27,850,493 (+)	NCBI
mRatBN7.2	8	19,567,390 - 19,574,314 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001165550	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL78332	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000028096
	ENSRNOP00000028096.4
	ENSRNOP00000103728.1

RefSeq Acc Id:

NP_001165550 ⟸ NM_001172079

- UniProtKB:

D4A435 (UniProtKB/TrEMBL), A6JNN4 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MPGPSPGLRRTLLGLWAALGLGILGISAVALEPFWADLQPRVALVERGGSLWLNCSTNCPRPER
GGLETSLRRNGTQRGLRWLARQLVDIREPETQPVCFFRCARRTLQARGLIRTFQRPDRVELVPL
PPWQPVGENFTLSCRVPGAGPRASLTLTLLRGGQELIRRSFVGEPPRARGAMLTATVLARREDH
RANFSCLAELDLRPHGLGLFANSSAPRQLRTFAMPPLSPSLIAPRFLEVGSERPVTCTLDGLFP
APEAGVYLSLGDQRLHPNVTLDGESLVATATATASEEQEGTKQLMCIVTLGGESRETQENLTVY
SFPAPLLTLSEPEAPEGKMVTVSCWAGARALVTLEGIPAAVPGQPAELQLNVTKNDDKRGFFCD
AALDVDGETLRKNQSSELRVLYAPRLDDLDCPRSWTWPEGPEQTLHCEARGNPEPSVHCARPDG
GAVLALGLLGPVTRALAGTYRCTAINGQGQAVKDVTLTVEYAPALDSVGCPERITWLEGTEASL
SCVAHGVPPPSVSCVRSGKEEVMEGPLRVAREHAGTYRCEAINARGSAAKNVAVTVEYGPSFEE
LGCPSNWTWVEGSGKLFSCEVDGKPEPRVECVGSEGASEGVVLPLVSSNSGSRNSMTPGNLSPG
IYLCNATNRHGSTVKTVVVSAESPPQMDESSCPSHQTWLEGAEATALACSARGRPSPRVRCSRE
GAARLERLQVSREDAGTYLCVATNAHGTDSRTVTVGVEYRPVVAELAASPPSVRPGGNFTLTCR
AEAWPPAQISWRAPPGALNLGLSSNNSTLSVAGAMGSHGGEYECAATNAHGRHARRITVRVAGP
WLWVAVGGAAGGAALLAAGAGLAFYVQSTACKKGEYNVQEAESSGEAVCLNGAGGTPGAEGGAE
TPGTAESPADGEVFAIQLTSS

hide sequence

Ensembl Acc Id:

ENSRNOP00000028096 ⟸ ENSRNOT00000028096

Ensembl Acc Id:

ENSRNOP00000103728 ⟸ ENSRNOT00000148902

Protein Domains

Ig-like

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D4A435-F1-model_v2	AlphaFold	D4A435	1-917	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13695773

Promoter ID:

EPDNEW_R6297

Type:

single initiation site

Name:

Icam5_1

Description:

intercellular adhesion molecule 5

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	8	22,050,354 - 22,050,414	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1305039	AgrOrtholog
BioCyc Gene	G2FUF-31442	BioCyc
Ensembl Genes	ENSRNOG00000020694	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000028096	ENTREZGENE
	ENSRNOT00000028096.8	UniProtKB/TrEMBL
	ENSRNOT00000148902.1	UniProtKB/TrEMBL
Gene3D-CATH	2.60.40.10	UniProtKB/TrEMBL
InterPro	ICAM	UniProtKB/TrEMBL
	ICAM1_3_5_D2	UniProtKB/TrEMBL
	ICAM_N	UniProtKB/TrEMBL
	ICAM_VCAM	UniProtKB/TrEMBL
	ICAM_VCAM_N	UniProtKB/TrEMBL
	Ig-like	UniProtKB/TrEMBL
	Ig-like_dom_sf	UniProtKB/TrEMBL
	Ig-like_fold	UniProtKB/TrEMBL
	Ig_sub	UniProtKB/TrEMBL
	Ig_sub2	UniProtKB/TrEMBL
KEGG Report	rno:313785	UniProtKB/TrEMBL
NCBI Gene	313785	ENTREZGENE
PANTHER	INTERCELLULAR ADHESION MOLECULE	UniProtKB/TrEMBL
	INTERCELLULAR ADHESION MOLECULE 5	UniProtKB/TrEMBL
Pfam	ICAM1_3_5_D2	UniProtKB/TrEMBL
	ICAM_N	UniProtKB/TrEMBL
	Ig_3	UniProtKB/TrEMBL
PhenoGen	Icam5	PhenoGen
PRINTS	ICAM	UniProtKB/TrEMBL
	ICAMVCAM1	UniProtKB/TrEMBL
PROSITE	IG_LIKE	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000020694	RatGTEx
SMART	IGc2	UniProtKB/TrEMBL
	SM00409	UniProtKB/TrEMBL
Superfamily-SCOP	SSF48726	UniProtKB/TrEMBL
UniProt	A0ABK0LGI2_RAT	UniProtKB/TrEMBL
	A6JNN4	ENTREZGENE, UniProtKB/TrEMBL
	D4A435	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-12-09	Icam5	intercellular adhesion molecule 5	Icam5	intercellular adhesion molecule 5, telencephalin	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Icam5	intercellular adhesion molecule 5, telencephalin	Icam5_predicted	intercellular adhesion molecule 5, telencephalin (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Icam5_predicted	intercellular adhesion molecule 5, telencephalin (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD