hes-related family bHLH transcription factor with YRPW motif-like
RGD ID:
1305022
Description:
Predicted to enable several functions, including AF-1 domain binding activity; DNA-binding transcription factor activity, RNA polymerase II-specific; and protein homodimerization activity. Predicted to be involved in several processes, including heart development; nephron development; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within epithelial to mesenchymal transition involved in endocardial cushion formation; negative regulation of gene expression; and skeletal muscle cell differentiation. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Orthologous to human HEYL (hes related family bHLH transcription factor with YRPW motif like); PARTICIPATES IN Notch signaling pathway; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HEYL mRNA
[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HEYL mRNA
[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HEYL mRNA
Coordinate Notch3-hairy-related transcription factor pathway regulation in response to arterial injury. Mediator role of platelet-derived growth factor and ERK.