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Gene: Drg1 (developmentally regulated GTP binding protein 1) Rattus norvegicus

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Symbol:

Drg1

Name:

developmentally regulated GTP binding protein 1

RGD ID:

1304993

Description:

Predicted to enable several functions, including GTP binding activity; identical protein binding activity; and potassium ion binding activity. Predicted to be involved in cytoplasmic translation; positive regulation of microtubule polymerization; and regulation of mitotic spindle assembly. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Orthologous to human DRG1 (developmentally regulated GTP binding protein 1); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; amitrole.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

developmentally-regulated GTP-binding protein 1; LOC305470; MGC94569

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	DRG1 (developmentally regulated GTP binding protein 1)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Drg1 (developmentally regulated GTP binding protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Drg1 (developmentally regulated GTP binding protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	DRG1 (developmentally regulated GTP binding protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	DRG1 (developmentally regulated GTP binding protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Drg1 (developmentally regulated GTP binding protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	DRG1 (developmentally regulated GTP binding protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	DRG1 (developmentally regulated GTP binding protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Drg1 (developmentally regulated GTP binding protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Drg1 (developmentally regulated GTP binding protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	DRG1 (developmentally regulated GTP binding protein 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	DRG1 (developmentally regulated GTP binding protein 1)	Alliance	DIOPT (HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Drg1 (developmentally regulated GTP binding protein 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Drg1 (developmentally regulated GTP binding protein 1)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	drg1 (developmentally regulated GTP binding protein 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	drg1 (developmentally regulated GTP binding protein 1)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	128up	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	128up	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	RBG1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	RBG1	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	T28D6.6	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	T28D6.6	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	drg1	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	drg1	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	82,328,320 - 82,344,416 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	14	82,328,320 - 82,344,348 (-)	Ensembl				GRCr8
mRatBN7.2	14	78,103,876 - 78,119,976 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	78,103,876 - 78,119,953 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	14	82,545,654 - 82,561,686 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	83,785,762 - 83,801,794 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	80,231,501 - 80,247,531 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	83,460,540 - 83,476,568 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	83,460,540 - 83,476,568 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	14	84,148,278 - 84,164,306 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	14	83,855,894 - 83,871,922 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	14	77,019,064 - 77,035,075 (-)	NCBI		Celera
RGSC_v3.1	14	83,866,172 - 83,882,201 (-)	NCBI
Cytogenetic Map	14	q21	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Contracture (ISO)

Neurodevelopmental Disorders (ISO)

TAN-ALMURSHEDI SYNDROME (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (EXP)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

3,3',5,5'-tetrabromobisphenol A (ISO)

4,4'-sulfonyldiphenol (ISO)

actinomycin D (ISO)

amitrole (EXP)

arsenite(3-) (ISO)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

beta-lapachone (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol AF (ISO)

bisphenol F (ISO)

cisplatin (ISO)

copper(II) sulfate (ISO)

diarsenic trioxide (ISO)

Dibutyl phosphate (ISO)

dicrotophos (ISO)

enzyme inhibitor (ISO)

ethanol (ISO)

flutamide (EXP)

folic acid (ISO)

GSK-J4 (ISO)

indole-3-methanol (EXP)

irinotecan (ISO)

ivermectin (ISO)

methimazole (EXP)

mono(2-ethylhexyl) phthalate (ISO)

Nutlin-3 (ISO)

ozone (ISO)

perfluorooctanoic acid (ISO)

pregnenolone 16alpha-carbonitrile (ISO)

SB 431542 (ISO)

Se-methyl-L-selenocysteine (ISO)

Se-methylselenocysteine (ISO)

sodium arsenite (ISO)

temozolomide (ISO)

thiram (ISO)

titanium dioxide (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

positive regulation of microtubule polymerization (IEA,ISO)

regulation of mitotic spindle assembly (IEA,ISO)

Cellular Component

cytoplasm (IEA,ISO)

cytosol (IEA,ISO)

nuclear body (IEA,ISO)

nucleoplasm (IEA,ISO)

nucleus (IEA,ISO)

Molecular Function

GTP binding (IEA)

GTPase activity (IEA,ISO)

hydrolase activity (IEA)

metal ion binding (IEA)

microtubule binding (IEA,ISO)

nucleotide binding (IEA)

potassium ion binding (IEA,ISO)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	GOA pipeline	RGD automated data pipeline
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:19819225	PMID:19946888	PMID:23711155	PMID:24625528	PMID:28855639	PMID:29915238

Genomics

Comparative Map Data

Drg1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	82,328,320 - 82,344,416 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	14	82,328,320 - 82,344,348 (-)	Ensembl				GRCr8
mRatBN7.2	14	78,103,876 - 78,119,976 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	78,103,876 - 78,119,953 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	14	82,545,654 - 82,561,686 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	83,785,762 - 83,801,794 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	80,231,501 - 80,247,531 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	83,460,540 - 83,476,568 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	83,460,540 - 83,476,568 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	14	84,148,278 - 84,164,306 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	14	83,855,894 - 83,871,922 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	14	77,019,064 - 77,035,075 (-)	NCBI		Celera
RGSC_v3.1	14	83,866,172 - 83,882,201 (-)	NCBI
Cytogenetic Map	14	q21	NCBI

DRG1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	22	31,399,604 - 31,434,452 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	22	31,399,560 - 31,528,740 (+)	Ensembl			hg38	GRCh38
GRCh37	22	31,795,590 - 31,830,438 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	22	30,125,539 - 30,160,172 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	22	30,120,092 - 30,154,725	NCBI
Celera	22	15,596,029 - 15,630,660 (+)	NCBI		Celera
Cytogenetic Map	22	q12.2	NCBI
HuRef	22	14,757,243 - 14,784,270 (+)	NCBI		HuRef
CHM1_1	22	31,755,375 - 31,789,984 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	22	31,864,208 - 31,899,052 (+)	NCBI		T2T-CHM13v2.0

Drg1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	3,199,907 - 3,221,882 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	3,137,360 - 3,216,415 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	11	3,249,907 - 3,266,464 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	3,187,360 - 3,266,415 (-)	Ensembl			mm10	GRCm38
MGSCv37	11	3,149,925 - 3,166,389 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	11	3,149,925 - 3,166,389 (-)	NCBI		MGSCv36	mm8
Celera	11	3,741,153 - 3,757,517 (-)	NCBI		Celera
Cytogenetic Map	11	A1	NCBI
cM Map	11	2.23	NCBI

Drg1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955455	5,588,313 - 5,610,964 (+)	Ensembl
ChiLan1.0	NW_004955455	5,588,313 - 5,608,091 (+)	NCBI	ChiLan1.0	ChiLan1.0

DRG1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	23	41,353,822 - 41,388,587 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	22	44,054,293 - 44,089,035 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	22	12,424,080 - 12,458,810 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	22	30,283,745 - 30,317,458 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	22	30,283,745 - 30,317,458 (+)	Ensembl			panPan2	panpan1.1

DRG1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	26	24,327,714 - 24,350,782 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	26	24,327,739 - 24,350,659 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	26	24,197,255 - 24,219,666 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	26	24,710,964 - 24,733,978 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	26	24,710,995 - 24,735,944 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	26	24,413,968 - 24,436,345 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	26	24,675,939 - 24,698,308 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	26	24,737,518 - 24,759,907 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Drg1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	117,300,259 - 117,325,599 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936755	557,903 - 583,192 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936755	557,862 - 583,204 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DRG1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	48,126,863 - 48,157,906 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	14	48,126,807 - 48,153,103 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	51,288,040 - 51,313,823 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

DRG1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	19	14,287,537 - 14,322,216 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	19	14,287,564 - 14,321,998 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666045	111,790,836 - 111,827,627 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Drg1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624747	7,869,570 - 7,895,220 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624747	7,869,544 - 7,895,231 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Drg1
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	11	72,225,876 - 72,243,365 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Drg1
112 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	290
Count of miRNA genes:	176
Interacting mature miRNAs:	203
Transcripts:	ENSRNOT00000025241
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2313089	Bss81	Bone structure and strength QTL 81	3.4	0.0001	body length (VT:0001256)	body length, nose to rump (CMO:0000079)	14	38023710	83023710	Rat
9590294	Uminl4	Urine mineral level QTL 4	5.66	0.001	urine mineral amount (VT:0015086)	urine electrolyte level (CMO:0000593)	14	59848686	104848686	Rat
1582236	Gluco22	Glucose level QTL 22	3.3	0.0164	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	14	77640071	96755654	Rat
2300197	Scl59	Serum cholesterol level QTL 59			blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	14	77914838	104348525	Rat
70214	Niddm28	Non-insulin dependent diabetes mellitus QTL 28	4.06		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	14	39009444	84009444	Rat
70153	Bp59	Blood pressure QTL 59	3.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	14	72970210	87582095	Rat
70187	Pancm5	Pancreatic morphology QTL 5	16.7		pancreas mass (VT:0010144)	pancreas weight to body weight ratio (CMO:0000630)	14	30674469	85041098	Rat
631523	Pia13	Pristane induced arthritis QTL 13	3.3		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	14	33424686	102238540	Rat
1582259	Gluco23	Glucose level QTL 23	3.1	0.0008	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	14	74255551	109089856	Rat
1582197	Gluco27	Glucose level QTL 27	3.4	0.0006	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	14	77640071	96755654	Rat
2313100	Bss82	Bone structure and strength QTL 82	3	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	14	38023710	83023710	Rat
634328	Hc5	Hypercalciuria QTL 5	2.3		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	14	62398852	107398852	Rat
1582250	Gluco26	Glucose level QTL 26	3.3	0.0009	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	14	77640071	100078267	Rat
2317879	Alcrsp27	Alcohol response QTL 27	3.3	0.63	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	14	60854936	105854936	Rat
1641900	Alcrsp11	Alcohol response QTL 11			alcohol metabolism trait (VT:0015089)	blood ethanol level (CMO:0000535)	14	74255551	109089856	Rat
631839	Niddm37	Non-insulin dependent diabetes mellitus QTL 37	3.37		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	14	11334716	100078267	Rat
1582255	Gluco29	Glucose level QTL 29	3.1	0.0025	blood glucose amount (VT:0000188)	absolute change in blood glucose level area under curve (CMO:0002034)	14	77640071	96755654	Rat
9589034	Epfw11	Epididymal fat weight QTL 11	6	0.001	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	14	59848686	104848686	Rat
1582209	Gluco20	Glucose level QTL 20	3.8	0.0005	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	14	77640071	96755654	Rat
2313048	Bss84	Bone structure and strength QTL 84	3.1	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	14	38023710	83023710	Rat
1300136	Rf22	Renal function QTL 22	3.9		renal blood flow trait (VT:2000006)	absolute change in renal vascular resistance (CMO:0001900)	14	42616258	99224555	Rat
1549834	Scl45	Serum cholesterol level QTL 45	5.8		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	14	65920283	99224555	Rat
738037	Hcas6	Hepatocarcinoma susceptibility QTL 6	2.93		liver integrity trait (VT:0010547)	liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)	14	39411170	87582095	Rat
2313084	Bss83	Bone structure and strength QTL 83	2.9	0.0001	tibia size trait (VT:0100001)	tibia midshaft endosteal cross-sectional area (CMO:0001716)	14	38023710	83023710	Rat

Markers in Region

RH138102

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	14	78,111,031 - 78,111,153 (+)	MAPPER	mRatBN7.2
Rnor_6.0	14	83,467,694 - 83,467,815	NCBI	Rnor6.0
Rnor_5.0	14	84,155,432 - 84,155,553	UniSTS	Rnor5.0
RGSC_v3.4	14	83,863,048 - 83,863,169	UniSTS	RGSC3.4
Celera	14	77,026,201 - 77,026,322	UniSTS
RH 3.4 Map	14	531.8	UniSTS
Cytogenetic Map	14	q21	UniSTS

RH139411

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	14	82,330,302 - 82,330,738 (+)	Marker Load Pipeline
mRatBN7.2	14	78,105,858 - 78,106,294 (+)	MAPPER	mRatBN7.2
Rnor_6.0	14	83,462,523 - 83,462,958	NCBI	Rnor6.0
Rnor_5.0	14	84,150,261 - 84,150,696	UniSTS	Rnor5.0
RGSC_v3.4	14	83,857,877 - 83,858,312	UniSTS	RGSC3.4
Celera	14	77,021,047 - 77,021,482	UniSTS
RH 3.4 Map	14	532.3	UniSTS
Cytogenetic Map	14	q21	UniSTS

BE107416

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	14	78,110,314 - 78,110,464 (+)	MAPPER	mRatBN7.2
Rnor_6.0	14	83,466,977 - 83,467,126	NCBI	Rnor6.0
Rnor_5.0	14	84,154,715 - 84,154,864	UniSTS	Rnor5.0
RGSC_v3.4	14	83,862,331 - 83,862,480	UniSTS	RGSC3.4
Celera	14	77,025,484 - 77,025,633	UniSTS
RH 3.4 Map	14	516.3	UniSTS
Cytogenetic Map	14	q21	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	356	192	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001009685	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039092003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC094950	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC088410	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473963	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000014	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000025241 ⟹ ENSRNOP00000025241

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	14	82,328,320 - 82,344,348 (-)	Ensembl
mRatBN7.2 Ensembl	14	78,103,876 - 78,119,179 (-)	Ensembl
Rnor_6.0 Ensembl	14	83,460,540 - 83,476,568 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000110909 ⟹ ENSRNOP00000081798

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	14	78,117,828 - 78,119,953 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000114311 ⟹ ENSRNOP00000097131

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	14	78,103,876 - 78,119,934 (-)	Ensembl

RefSeq Acc Id:

NM_001009685 ⟹ NP_001009685

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	14	82,328,320 - 82,344,348 (-)	NCBI
mRatBN7.2	14	78,103,876 - 78,119,908 (-)	NCBI
Rnor_6.0	14	83,460,540 - 83,476,568 (-)	NCBI
Rnor_5.0	14	84,148,278 - 84,164,306 (-)	NCBI
RGSC_v3.4	14	83,855,894 - 83,871,922 (-)	RGD
Celera	14	77,019,064 - 77,035,075 (-)	RGD

Sequence:

show sequence

GGAGGTCTAGCTAGTGTGAAGGCCGGTTCGGCTTTGAGCCCCTGCCACCATGAGTGGGACCTTA
GCGAAGATCGCGGAGATCGAAGCCGAGATGGCTCGGACTCAAAAGAACAAAGCTACAGCACATC
ACCTTGGACTGCTTAAGGCTCGCCTTGCTAAGCTTCGAAGAGAGCTTATCACTCCAAAAGGTGG
TGGTGGTGGTGGGCCAGGAGAAGGTTTTGATGTGGCCAAGACAGGCGATGCTCGAATTGGGTTT
GTGGGTTTTCCCTCTGTGGGGAAGTCAACTCTGCTAAGTAACTTAGCAGGAGTGTATTCTGAAG
TGGCAGCCTACGAGTTCACTACTTTGACCACAGTACCTGGTGTCATCAGATACAAAGGGGCCAA
GATCCAGCTCCTGGATCTCCCAGGTATCATTGAAGGTGCCAAGGATGGGAAAGGTAGAGGTCGT
CAGGTCATTGCAGTGGCCCGAACGTGTAATTTGATCTTGATTGTTCTGGATGTCCTAAAACCCT
TGGGGCACAAGAAGATAATTGAAAATGAGTTGGAAGGCTTTGGGATTCGTTTGAACAGCAAACC
CCCCAACATTGGCTTTAAGAAGAAAGACAAGGGAGGCATTAATCTCACAGCCACTTGTCCTCAG
AGTGAACTAGATGCTGAAACGGTGAAGAGCATTCTGGCTGAATATAAAATTCATAATGCTGATG
TAACTTTGCGTAGTGATGCCACAGCTGATGACCTCATCGACGTGGTTGAAGGAAACAGAGTTTA
TATTCCCTGTATCTATGTATTAAATAAGATTGATCAGATCTCCATTGAGGAGTTGGATATTATA
TATAAGGTGCCTCACTGTGTACCCATCTCTGCTCATCACCGCTGGAATTTTGATGACCTTTTGG
AGAAGATCTGGGACTATCTGAAACTAGTGAGAATTTACACTAAACCCAAAGGCCAGTTACCAGA
TTACACGTCTCCAGTAGTCCTGCCTTATTCTAGGACCACGGTGGAAGATTTCTGCATGAAGATT
CACAAAAATCTGATCAAAGAATTTAAATATGCTTTGGTCTGGGGTCTCTCTGTGAAACATAATC
CTCAGAAAGTGGGTAAAGACCATACGTTGGAAGATGAAGATGTCATTCAGATCGTGAAGAAGTG
AAATCCTGATCCGGTCTGCTGGCCGAGCACAGCAGTGTTCCTTATGACCAAGTACCTTCCTCAG
CCCCTTCTGTCTTTGGCAGCCTCTGGATTGGGATATAGGGATGGAGACTTCCAACTGAAACACC
ACTCTTTTTTTTTTTTTTTCTTTAAAGATAGGGTCTCATGTATTTCAGGCTGGCTTTGAACTCT
TTGCTGCTGAGGCTTGCCTTGAATTCTTTTTTTTTTTTTTTTCCTTTTTCTTTTTTTCGGAGCT
GGGGACTGAACCCAGGGCCTTGCGTTTGCTAGGCAAGCGCTCTACCACTGAGCTAAATCCCCAA
CCCCTTGCCTTGAATTCTTTATTCATCAGCCTCCATCTCAAGTGCTGATGCTGTGCCTGCAACA
CCTCAGCAACGTACCTTCCCTACTTTGGTGTCACTGTCATTGAGCTGTATAAAATCCTGGTGGG
CCCATTGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039092003 ⟹ XP_038947931

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	14	82,334,069 - 82,344,416 (-)	NCBI
mRatBN7.2	14	78,109,627 - 78,119,976 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001009685	(Get FASTA)	NCBI Sequence Viewer
	XP_038947931	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH88410	(Get FASTA)	NCBI Sequence Viewer
	EDM00158	(Get FASTA)	NCBI Sequence Viewer
	EDM00159	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000025241
	ENSRNOP00000025241.6

RefSeq Acc Id:

NP_001009685 ⟸ NM_001009685

- UniProtKB:

Q5I0F0 (UniProtKB/TrEMBL), F7ELI0 (UniProtKB/TrEMBL), A0A8J8YRV3 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSGTLAKIAEIEAEMARTQKNKATAHHLGLLKARLAKLRRELITPKGGGGGGPGEGFDVAKTGD
ARIGFVGFPSVGKSTLLSNLAGVYSEVAAYEFTTLTTVPGVIRYKGAKIQLLDLPGIIEGAKDG
KGRGRQVIAVARTCNLILIVLDVLKPLGHKKIIENELEGFGIRLNSKPPNIGFKKKDKGGINLT
ATCPQSELDAETVKSILAEYKIHNADVTLRSDATADDLIDVVEGNRVYIPCIYVLNKIDQISIE
ELDIIYKVPHCVPISAHHRWNFDDLLEKIWDYLKLVRIYTKPKGQLPDYTSPVVLPYSRTTVED
FCMKIHKNLIKEFKYALVWGLSVKHNPQKVGKDHTLEDEDVIQIVKK

hide sequence

Ensembl Acc Id:

ENSRNOP00000025241 ⟸ ENSRNOT00000025241

RefSeq Acc Id:	XP_038947931 ⟸ XM_039092003
- Peptide Label:	isoform X1

Ensembl Acc Id:

ENSRNOP00000097131 ⟸ ENSRNOT00000114311

Ensembl Acc Id:

ENSRNOP00000081798 ⟸ ENSRNOT00000110909

Protein Domains

OBG-type G TGS

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q5I0F0-F1-model_v2	AlphaFold	Q5I0F0	1-367	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13699421

Promoter ID:

EPDNEW_R9946

Type:

multiple initiation site

Name:

Drg1_1

Description:

developmentally regulated GTP binding protein 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	14	83,476,605 - 83,476,665	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1304993	AgrOrtholog
BioCyc Gene	G2FUF-15236	BioCyc
Ensembl Genes	ENSRNOG00000018590	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000025241	ENTREZGENE
	ENSRNOT00000025241.7	UniProtKB/TrEMBL
Gene3D-CATH	3.10.20.30	UniProtKB/TrEMBL
	6.10.140.1070	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7189810	IMAGE-MGC_LOAD
InterPro	Beta-grasp_dom	UniProtKB/TrEMBL
	DRG	UniProtKB/TrEMBL
	G_OBG	UniProtKB/TrEMBL
	GTP-binding_2	UniProtKB/TrEMBL
	GTP1-OBG_CS	UniProtKB/TrEMBL
	GTP1_OBG	UniProtKB/TrEMBL
	P-loop_NTPase	UniProtKB/TrEMBL
	Small_GTP_bd	UniProtKB/TrEMBL
	TGS	UniProtKB/TrEMBL
	TGS-like	UniProtKB/TrEMBL
KEGG Report	rno:305470	UniProtKB/TrEMBL
MGC_CLONE	MGC:94569	IMAGE-MGC_LOAD
NCBI Gene	305470	ENTREZGENE
PANTHER	PTHR43127	UniProtKB/TrEMBL
Pfam	MMR_HSR1	UniProtKB/TrEMBL
	MMR_HSR1_Xtn	UniProtKB/TrEMBL
	TGS	UniProtKB/TrEMBL
PhenoGen	Drg1	PhenoGen
PRINTS	GTP1OBG	UniProtKB/TrEMBL
PROSITE	G_OBG	UniProtKB/TrEMBL
	GTP1_OBG	UniProtKB/TrEMBL
	TGS	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000018590	RatGTEx
Superfamily-SCOP	SSF52540	UniProtKB/TrEMBL
	TGS-like	UniProtKB/TrEMBL
UniProt	A0A8J8YRV3	ENTREZGENE
	A6IK95_RAT	UniProtKB/TrEMBL
	F7ELI0	ENTREZGENE
	Q5I0F0	ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary	A0A8J8YRV3	UniProtKB/TrEMBL
	F7ELI0	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2005-12-06	Drg1	developmentally regulated GTP binding protein 1	Drg1_predicted	developmentally regulated GTP binding protein 1 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Drg1_predicted	developmentally regulated GTP binding protein 1 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - OMIM

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Imported Disease Annotations - ClinVar

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