Kctd5 (potassium channel tetramerization domain containing 5) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Kctd5 (potassium channel tetramerization domain containing 5) Rattus norvegicus
Analyze
Symbol: Kctd5
Name: potassium channel tetramerization domain containing 5
RGD ID: 1304990
Description: Predicted to enable cullin family protein binding activity and identical protein binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human KCTD5 (potassium channel tetramerization domain containing 5); INTERACTS WITH 2,4-dinitrotoluene; 3,3',5,5'-tetrabromobisphenol A; 4-amino-2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: BTB/POZ domain-containing protein KCTD5; LOC287109; potassium channel tetramerisation domain containing 5
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81013,583,781 - 13,609,762 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1013,583,781 - 13,610,062 (-)EnsemblGRCr8
mRatBN7.21013,079,216 - 13,105,197 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1013,079,214 - 13,105,209 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1017,823,951 - 17,850,039 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01017,312,783 - 17,338,871 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01012,811,434 - 12,837,441 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01013,420,152 - 13,446,323 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1013,420,154 - 13,446,135 (-)Ensemblrn6Rnor6.0
Rnor_5.01013,235,960 - 13,261,939 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41013,298,236 - 13,324,219 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1012,765,129 - 12,791,119 (-)NCBICelera
RGSC_v3.11013,299,034 - 13,324,284 (-)NCBI
Cytogenetic Map10q12NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
Cul3-RING ubiquitin ligase complex  (IBA)
cytoplasm  (IBA,IEA)
cytosol  (IEA,ISO,ISS)
nucleus  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:18573101   PMID:23209302   PMID:27152988  


Genomics

Comparative Map Data
Kctd5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81013,583,781 - 13,609,762 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1013,583,781 - 13,610,062 (-)EnsemblGRCr8
mRatBN7.21013,079,216 - 13,105,197 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1013,079,214 - 13,105,209 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1017,823,951 - 17,850,039 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01017,312,783 - 17,338,871 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01012,811,434 - 12,837,441 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01013,420,152 - 13,446,323 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1013,420,154 - 13,446,135 (-)Ensemblrn6Rnor6.0
Rnor_5.01013,235,960 - 13,261,939 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41013,298,236 - 13,324,219 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1012,765,129 - 12,791,119 (-)NCBICelera
RGSC_v3.11013,299,034 - 13,324,284 (-)NCBI
Cytogenetic Map10q12NCBI
KCTD5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38162,682,523 - 2,709,030 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl162,682,521 - 2,709,030 (+)Ensemblhg38GRCh38
GRCh37162,732,524 - 2,759,031 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36162,672,499 - 2,699,032 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34162,672,498 - 2,699,030NCBI
Celera162,932,069 - 2,958,601 (+)NCBICelera
Cytogenetic Map16p13.3NCBI
HuRef162,700,243 - 2,726,766 (+)NCBIHuRef
CHM1_1162,732,526 - 2,759,062 (+)NCBICHM1_1
T2T-CHM13v2.0162,702,754 - 2,729,246 (+)NCBIT2T-CHM13v2.0
Kctd5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391724,266,694 - 24,292,459 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1724,266,708 - 24,292,459 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381724,047,720 - 24,073,485 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1724,047,734 - 24,073,485 (-)Ensemblmm10GRCm38
MGSCv371724,184,687 - 24,210,452 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361723,775,360 - 23,801,059 (-)NCBIMGSCv36mm8
Celera1724,554,089 - 24,579,579 (-)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1712.22NCBI
Kctd5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544214,658,612 - 14,684,928 (-)Ensembl
ChiLan1.0NW_00495544214,658,612 - 14,684,928 (-)NCBIChiLan1.0ChiLan1.0
KCTD5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2183,187,571 - 3,214,196 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1166,968,567 - 6,995,206 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0161,542,488 - 1,569,044 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1162,796,117 - 2,822,819 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl162,796,117 - 2,822,819 (+)EnsemblpanPan2panpan1.1
KCTD5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1638,403,024 - 38,426,158 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl638,404,330 - 38,426,134 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha639,642,050 - 39,664,955 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0638,712,849 - 38,735,786 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl638,712,852 - 38,735,813 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1638,398,028 - 38,420,928 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0638,370,693 - 38,393,584 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0638,846,727 - 38,869,631 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Kctd5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344105,264,854 - 105,290,837 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366941,418,678 - 1,444,582 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366941,418,638 - 1,444,609 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCTD5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl339,403,987 - 39,429,588 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1339,403,985 - 39,429,608 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2342,764,109 - 42,777,244 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KCTD5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.152,451,537 - 2,468,686 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366606828,443,954 - 28,465,694 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kctd5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624824383,434 - 410,257 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624824383,389 - 411,824 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Kctd5
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v191,342,340 - 1,370,062 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Kctd5
43 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:920
Count of miRNA genes:337
Interacting mature miRNAs:445
Transcripts:ENSRNOT00000007849
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
631660Hcar1Hepatocarcinoma resistance QTL 13.40.0001liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)10666111835509383Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10589381150893811Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10589381150893811Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10687714251877142Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135730538Rat
7387235Uae41Urinary albumin excretion QTL 415.260.1874urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)10130004247Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1092219745922197Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)10210370847103708Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10589381150893811Rat
631828Alc5Alcohol consumption QTL 52.4consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10117749933Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138832698Rat

Markers in Region
AA924631  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21013,105,457 - 13,105,671 (+)MAPPERmRatBN7.2
Rnor_6.01013,446,396 - 13,446,609NCBIRnor6.0
Rnor_5.01013,262,200 - 13,262,413UniSTSRnor5.0
RGSC_v3.41013,324,480 - 13,324,693UniSTSRGSC3.4
Celera1012,791,380 - 12,791,593UniSTS
RH 3.4 Map10191.2UniSTS
Cytogenetic Map10q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 92 59 6 356 192 11 142 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000084991   ⟹   ENSRNOP00000073503
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1013,583,781 - 13,610,062 (-)Ensembl
mRatBN7.2 Ensembl1013,079,216 - 13,105,209 (-)Ensembl
Rnor_6.0 Ensembl1013,420,154 - 13,446,135 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000099302   ⟹   ENSRNOP00000086690
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1013,079,214 - 13,105,209 (-)Ensembl
RefSeq Acc Id: NM_001105768   ⟹   NP_001099238
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81013,583,781 - 13,609,762 (-)NCBI
mRatBN7.21013,079,216 - 13,105,197 (-)NCBI
Rnor_6.01013,420,154 - 13,446,135 (-)NCBI
Rnor_5.01013,235,960 - 13,261,939 (-)NCBI
RGSC_v3.41013,298,236 - 13,324,219 (-)RGD
Celera1012,765,129 - 12,791,119 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001099238 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI68712 (Get FASTA)   NCBI Sequence Viewer  
  B5DEL1 (Get FASTA)   NCBI Sequence Viewer  
  EDM03804 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000073503
  ENSRNOP00000073503.1
RefSeq Acc Id: NP_001099238   ⟸   NM_001105768
- UniProtKB: B5DEL1 (UniProtKB/Swiss-Prot),   A0A8I6A1Q5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000073503   ⟸   ENSRNOT00000084991
Ensembl Acc Id: ENSRNOP00000086690   ⟸   ENSRNOT00000099302
Protein Domains
BTB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B5DEL1-F1-model_v2 AlphaFold B5DEL1 1-234 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697001
Promoter ID:EPDNEW_R7526
Type:multiple initiation site
Name:Kctd5_1
Description:potassium channel tetramerization domain containing 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01013,446,143 - 13,446,203EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1304990 AgrOrtholog
BioCyc Gene G2FUF-25880 BioCyc
Ensembl Genes ENSRNOG00000057186 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000084991 ENTREZGENE
  ENSRNOT00000084991.2 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.70.2000 UniProtKB/Swiss-Prot
  6.10.140.750 UniProtKB/Swiss-Prot
  Potassium Channel Kv1.1, Chain A UniProtKB/Swiss-Prot
InterPro BTB/POZ_dom UniProtKB/Swiss-Prot
  SKP1/BTB/POZ_sf UniProtKB/Swiss-Prot
  T1-type_BTB UniProtKB/Swiss-Prot
KEGG Report rno:287109 UniProtKB/Swiss-Prot
NCBI Gene 287109 ENTREZGENE
PANTHER BTB/POZ DOMAIN-CONTAINING PROTEIN KCTD5 UniProtKB/Swiss-Prot
  POTASSIUM CHANNEL TETRAMERISATION DOMAIN CONTAINING PROTEIN UniProtKB/Swiss-Prot
Pfam BTB_2 UniProtKB/Swiss-Prot
PhenoGen Kctd5 PhenoGen
RatGTEx ENSRNOG00000057186 RatGTEx
SMART BTB UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54695 UniProtKB/Swiss-Prot
UniProt A0A8I6A1Q5 ENTREZGENE
  B5DEL1 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-07-09 Kctd5  potassium channel tetramerization domain containing 5  Kctd5  potassium channel tetramerisation domain containing 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Kctd5  potassium channel tetramerisation domain containing 5   Kctd5_predicted  potassium channel tetramerisation domain containing 5 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Kctd5_predicted  potassium channel tetramerisation domain containing 5 (predicted)      Symbol and Name status set to approved 70820 APPROVED