Eef2kmt (eukaryotic elongation factor 2 lysine methyltransferase) - Rat Genome Database

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Gene: Eef2kmt (eukaryotic elongation factor 2 lysine methyltransferase) Rattus norvegicus
Analyze
Symbol: Eef2kmt
Name: eukaryotic elongation factor 2 lysine methyltransferase
RGD ID: 1304969
Description: Predicted to enable protein-lysine N-methyltransferase activity. Predicted to be involved in peptidyl-lysine trimethylation and regulation of translation. Predicted to be located in cytoplasm. Predicted to be part of protein-containing complex. Orthologous to several human genes including EEF2KMT (eukaryotic elongation factor 2 lysine methyltransferase); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; cadmium dichloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Fam86a; family with sequence similarity 86, member A; hypothetical protein LOC302931; LOC302931; protein-lysine N-methyltransferase EEF2KMT; RGD1304969; similar to RIKEN cDNA 2610015J01; uncharacterized protein LOC302931
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81010,843,429 - 10,853,800 (+)NCBIGRCr8
mRatBN7.21010,336,933 - 10,349,463 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1010,336,974 - 10,347,039 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1015,043,627 - 15,053,683 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01014,532,428 - 14,542,490 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01010,201,418 - 10,211,484 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01010,530,302 - 10,540,428 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1010,530,365 - 10,540,428 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0109,300,149 - 9,310,577 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41010,450,534 - 10,460,596 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11010,450,554 - 10,460,124 (+)NCBI
Celera109,303,038 - 9,313,101 (+)NCBICelera
Cytogenetic Map10q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:23349634   PMID:25231979  


Genomics

Comparative Map Data
Eef2kmt
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81010,843,429 - 10,853,800 (+)NCBIGRCr8
mRatBN7.21010,336,933 - 10,349,463 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1010,336,974 - 10,347,039 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1015,043,627 - 15,053,683 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01014,532,428 - 14,542,490 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01010,201,418 - 10,211,484 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01010,530,302 - 10,540,428 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1010,530,365 - 10,540,428 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0109,300,149 - 9,310,577 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41010,450,534 - 10,460,596 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11010,450,554 - 10,460,124 (+)NCBI
Celera109,303,038 - 9,313,101 (+)NCBICelera
Cytogenetic Map10q12NCBI
EEF2KMT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38165,084,284 - 5,097,795 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl165,084,284 - 5,097,795 (-)EnsemblGRCh38hg38GRCh38
GRCh37165,134,285 - 5,147,796 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36165,075,236 - 5,087,782 (-)NCBINCBI36Build 36hg18NCBI36
Celera165,343,693 - 5,357,187 (-)NCBICelera
Cytogenetic Map16p13.3NCBI
HuRef165,100,367 - 5,113,916 (-)NCBIHuRef
CHM1_1165,135,491 - 5,148,985 (-)NCBICHM1_1
T2T-CHM13v2.0165,113,786 - 5,127,302 (-)NCBIT2T-CHM13v2.0
Eef2kmt
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39165,062,019 - 5,073,820 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl165,062,016 - 5,073,847 (-)EnsemblGRCm39 Ensembl
GRCm38165,244,155 - 5,255,956 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl165,244,152 - 5,255,983 (-)EnsemblGRCm38mm10GRCm38
MGSCv37165,244,248 - 5,256,049 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36165,159,476 - 5,171,277 (-)NCBIMGSCv36mm8
Celera165,877,168 - 5,888,966 (-)NCBICelera
Cytogenetic Map16A1NCBI
cM Map162.51NCBI
Eef2kmt
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495544212,467,077 - 12,475,902 (+)NCBIChiLan1.0ChiLan1.0
EEF2KMT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2185,613,290 - 5,625,864 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1169,403,868 - 9,416,646 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0164,009,227 - 4,014,944 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1165,172,663 - 5,277,224 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl165,173,979 - 5,191,174 (-)Ensemblpanpan1.1panPan2
EEF2KMT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1636,353,626 - 36,370,466 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha637,744,735 - 37,763,681 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0636,554,792 - 36,573,955 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1636,353,667 - 36,372,607 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0636,244,755 - 36,263,844 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0636,644,889 - 36,664,041 (+)NCBIUU_Cfam_GSD_1.0
Eef2kmt
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344107,111,725 - 107,120,621 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365304,957,445 - 4,984,816 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EEF2KMT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1337,310,915 - 37,324,705 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2338,315,814 - 38,330,027 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EEF2KMT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.154,752,247 - 4,768,240 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366606825,889,562 - 25,902,921 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Eef2kmt
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248242,875,590 - 2,884,687 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Eef2kmt
43 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:262
Count of miRNA genes:164
Interacting mature miRNAs:187
Transcripts:ENSRNOT00000003843
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
631660Hcar1Hepatocarcinoma resistance QTL 13.40.0001liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)10615418215990232Rat
1576304Schws7Schwannoma susceptibility QTL 70.0115nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)10476552719816042Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142315980Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10538701450387014Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10124158324Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135225947Rat
7387235Uae41Urinary albumin excretion QTL 415.260.1874urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)10129497586Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1041834445418344Rat
737820Alc9Alcohol consumption QTL 92.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10514402719233348Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10538701450387014Rat
631828Alc5Alcohol consumption QTL 52.4consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10514402717245662Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138328221Rat

Markers in Region
D10Rat259  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21010,335,844 - 10,336,045 (+)MAPPERmRatBN7.2
Rnor_6.01010,529,236 - 10,529,436NCBIRnor6.0
Rnor_5.0109,299,100 - 9,299,300UniSTSRnor5.0
RGSC_v3.41010,449,404 - 10,449,605RGDRGSC3.4
RGSC_v3.41010,449,405 - 10,449,605UniSTSRGSC3.4
RGSC_v3.11010,449,404 - 10,449,605RGD
Celera109,301,907 - 9,302,109UniSTS
SHRSP x BN Map105.71UniSTS
SHRSP x BN Map105.71RGD
Cytogenetic Map10q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000003843   ⟹   ENSRNOP00000003843
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1010,336,974 - 10,347,039 (+)Ensembl
Rnor_6.0 Ensembl1010,530,365 - 10,540,428 (+)Ensembl
RefSeq Acc Id: NM_001106975   ⟹   NP_001100445
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81010,843,452 - 10,853,515 (+)NCBI
mRatBN7.21010,336,974 - 10,347,039 (+)NCBI
Rnor_6.01010,530,365 - 10,540,428 (+)NCBI
Rnor_5.0109,300,149 - 9,310,577 (+)NCBI
RGSC_v3.41010,450,534 - 10,460,596 (+)RGD
Celera109,303,038 - 9,313,101 (+)RGD
Sequence:
RefSeq Acc Id: XM_006245785   ⟹   XP_006245847
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81010,843,429 - 10,853,800 (+)NCBI
mRatBN7.21010,336,933 - 10,349,463 (+)NCBI
Rnor_6.01010,530,302 - 10,539,961 (+)NCBI
Rnor_5.0109,300,149 - 9,310,577 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039085837   ⟹   XP_038941765
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81010,843,429 - 10,853,800 (+)NCBI
mRatBN7.21010,336,933 - 10,349,463 (+)NCBI
RefSeq Acc Id: XR_005489785
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81010,843,429 - 10,852,892 (+)NCBI
mRatBN7.21010,336,933 - 10,346,413 (+)NCBI
RefSeq Acc Id: XR_010055166
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81010,843,429 - 10,851,641 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001100445 (Get FASTA)   NCBI Sequence Viewer  
  XP_006245847 (Get FASTA)   NCBI Sequence Viewer  
  XP_038941765 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL96258 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000003843.4
RefSeq Acc Id: NP_001100445   ⟸   NM_001106975
- UniProtKB: D3Z8P8 (UniProtKB/TrEMBL),   A6K4N6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006245847   ⟸   XM_006245785
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000003843   ⟸   ENSRNOT00000003843
RefSeq Acc Id: XP_038941765   ⟸   XM_039085837
- Peptide Label: isoform X2
Protein Domains
FAM86 N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3Z8P8-F1-model_v2 AlphaFold D3Z8P8 1-335 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696958
Promoter ID:EPDNEW_R7483
Type:multiple initiation site
Name:Eef2kmt_1
Description:eukaryotic elongation factor 2 lysine methyltransferase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01010,530,375 - 10,530,435EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1304969 AgrOrtholog
BioCyc Gene G2FUF-26065 BioCyc
Ensembl Genes ENSRNOG00000002876 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000003843.5 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.150 UniProtKB/TrEMBL
InterPro FAM86 UniProtKB/TrEMBL
  Methyltransferase-16_put UniProtKB/TrEMBL
  SAM-dependent_MTases-like UniProtKB/TrEMBL
KEGG Report rno:302931 UniProtKB/TrEMBL
NCBI Gene 302931 ENTREZGENE
PANTHER PROTEIN-LYSINE N-METHYLTRANSFERASE EEF2KMT UniProtKB/TrEMBL
  PTHR14614 UniProtKB/TrEMBL
Pfam FAM86 UniProtKB/TrEMBL
  Methyltransf_16 UniProtKB/TrEMBL
PhenoGen Eef2kmt PhenoGen
RatGTEx ENSRNOG00000002876 RatGTEx
Superfamily-SCOP SSF53335 UniProtKB/TrEMBL
UniProt A6K4N6 ENTREZGENE, UniProtKB/TrEMBL
  D3Z8P8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-12-01 Eef2kmt  eukaryotic elongation factor 2 lysine methyltransferase  Fam86a  family with sequence similarity 86, member A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-06 Fam86a  family with sequence similarity 86, member A  RGD1304969_predicted  similar to RIKEN cDNA 2610015J01 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 RGD1304969_predicted  similar to RIKEN cDNA 2610015J01 (predicted)  LOC302931_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC302931_predicted  similar to RIKEN cDNA 2610015J01 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL